教師資訊

研究室:N832實驗室
電 話:073121101 ext 2217
E-maillfwang@kmu.edu.tw

學歷:
清華大學化學系學士 (1979 – 1983)
清華大學化工研究所碩士 (1983 – 1985)
紐約科技大學高分子化學博士 (1986 – 1990)
美國約翰霍布金斯醫學院博士後研究 (1990 – 1991)

經歷:
高雄醫學大學醫藥暨應用化學系副教授 (1991 – 2000)
現任高雄醫學大學醫藥暨應用化學系教授 (2000 -)
高雄醫學大學研發處研究發展組長 (2003 – 2004)
美國約翰霍布金斯醫學院訪問教授 (2004 – 2005)
高雄醫學大學生物科技系教授兼系主任 (2006 -2009 )
現任高雄醫學大學生命科學院院長(2012-)

Scientific Activities and Honors:
1991-             Committee Board for Chinese Biomaterials and Drug Delivery Society
1991-             Grant Review Board for Ministry of Science and Technology of Taiwan
2006-2009  Panel Review Board for Taiwan National Science Council
2011-             Executive committee for Chinese Chemical Society of Taipei, Kaohsiung Local
Chapter
2014-             Vice president of Controlled Release Society Taiwan Local Chapter
2014-             Panel Review Board for SBIR projects of Taiwan

Awards:
1997                         Best Teaching Award from Kaohsiung Medical University
2012, 2013, 2014  Excellence in Research Award from Kaohsiung Medical University
2012, 2013, 2014  Outstanding Research Award from the KMU Alumni Association
2014                         Excellence in Research Award from Li Chio Zen (李昭仁) Biomaterial                                   Research Foundation
2009-2014              Outstanding Paper Research Award from Kaohsiung Medical University
2014                         Outstanding Patent Application Award from Kaohsiung Medical
University

研究興趣:
1. Development of polymeric nanoparticles based on natural polysaccharides for
anticancer drug and/or nucleic acid drug delivery
2. Construction of magnetic iron oxides for theranostic applications
3. Synthesis of amphiphilic block copolymers containing disulfides via ROP and ATRP for
multifunctional biomedical applications

Membership:
1. American Chemical Society
2. Controlled Release Society
3. Controlled Release Society Taiwan Local Chapter
4. Chinese Chemical Society of Taipei
5. Chinese Polymer Society of Taipei

 

Publication lists

2014

  1. Yu-Sheng Liu1, Hsuan-Ying Chen1, Jay-An Yeh1, and Li-Fang Wang*, 2014, “Folate-mediated and doxorubicin-conjugated poly(ε-caprolactone)-g-chondroitin sulfate copolymers for enhanced intracellular drug delivery”, RSC Adv. 4, 59548-59557. (IF= 3.708, 35/148, Chemistry: Multidisciplinary).

 

  1. Yu-Lun Lo, Pei-Chi Lo, Chien-Chih Chiu, and Li-Fang Wang*, 2014, “Folic acid linked chondroitin sulfate-polyethyleneimine copolymer based gene delivery system” Journal of Biomedical Nanotechnology (Accepted: Sep 9, 2014, doi:10.1166/jbn.2015.2081). (IF= 7.578, 2/32 Mater Sci: Biomater).

 

  1. Yu-Chih Su, Yu-Lun Lo, Chi-Ching Hwang, Li-Fang Wang, Min Hui Wu, Eng-Chi Wang, Yun-Ming Wang and Tzu-Pin Wang*, 2014 “Azide–alkyne cycloaddition for universal post-synthetic modifications of nucleic acids and effective synthesis of bioactive nucleic acid conjugates” Biomol. Chem., 12, 6624-6633.

 

  1. Guo-Jing Chen, Ying-Zhen Su, Chin Hsu, Yu-Lun Lo, Shih-Jer Huang, Jyun-Han Ke, Yung-Chih Kuo, Li-Fang Wang*, 2014, “Angiopep-pluronic F127-conjugated superparamagnetic iron oxide nanoparticles as a nanotheranostic agent for BBB targeting”, J. Material Chem. B., 2(34), 5666-5675. (IF=6.626, 22/251, Material Sci: Multidisciplinary).

 

  1. Shih-Jer Huang, Zhi-Rong Hsu, and Li-Fang Wang*, 2014, “Synthesis and Characterization of Pluronic-block-Poly(N,N-dimethylamino-2-ethyl methacrylate) Pentablock Copolymers for Drug/Gene Co-delivery Systems”, RSC Adv., 4, 31552-31563. (IF= 3.708, 35/148, Chemistry: Multidisciplinary).

 

  1. Yu-Shiang Peng, Po-Liang Lai, Sydney Peng, His-Chin Wu, Siang Yu, Tsan-Yun Tseng, Li-Fang Wang*, I-Ming Chu*, 2014, “Glial cell line-derived neurotrophic factor gene delivery via a polyethylene imine grafted chitosan carrier”, J. Nanomed, 9, 3163–3174. (IF=4.195, 32/254, Pharmacology & Pharmacy).

 

  1. Guo-Jing Chen, Jyun-Han Ke, Chin Hsu, and Li-Fang Wang*, 2014, “Comparison of chemically and physically coated iron oxide nanoparticles with poly(ethylene glycol)-b– poly(ε-caprolactone)- g-poly(acrylic acid) for imaging and chemotherapy” Journal of Biomedical Nanotechnology, (doi:10.1166/jbn.2014.2012) (IF= 7.578, 2/32 Mater Sci: Biomater).

 

  1. Yu-Sheng Liu, Chien-Chih Chiu, Hsuan-Ying Chen, Su-Hwei Chen* and Li-Fang Wang*, 2014 “Preparation of Chondroitin Sulfate-g-Poly(ε-Caprolactone) Copolymers as a CD44-Targeted Vehicle for Enhanced Intracellular Uptake” Molecular Pharmaceutics,11(4), 1164–1175 (IF= 4.782, 27/261).

 

  1. Chih Su, Hsing-Yin Chen, Ni Chien Ko, Chi-Ching Hwang, Min Hui Wu, Li-Fang Wang, Yun-Ming Wang, Sheng-Nan Chang, Eng-Chi Wang, Tzu-Pin Wang*, 2014 “Effective and site-specific phosphoramidation reaction for universally labeling nucleic acids” Analytical Biochemistry, 449, 118–128 (IF= 2.582, 26/75).

 

  1. Yu-Lun Lo, Guo-Jing Chen, Tzu-Hwa Feng, Ming-Han Li and Li-Fang Wang*, 2014 “Synthesis and characterization of S-PCL-PDMAEMA for co-delivery of pDNA and DOX” RSC Adv., 4, 11089–11098 (IF= 3.708, 35/148, Chemistry: Multidisciplinary).

 

2013

  1. Shih-Jer Huang, Jyun-Han Ke, Guo-Jing Chen, and Li-Fang Wang*, 2013 “One-pot synthesis of poly(2-dimethyl amino)ethyl methacrylate-bound iron oxide nanoparticles for magnetofection” Mater. Chem. B, 1, 5916-5924 (IF=6.626, 22/251, Material Sci: Multidisciplinary).

 

  1. Yu-Lun Lo, Kuo-Hsun Sung, Chien-Chih Chiu, Li-Fang Wang*, 2013 “Chemically Conjugating Polyethylenimine with Chondroitin sulfate to Promote CD44-Mediated Endocytosis for Gene Delivery" Molecular Pharmaceutics, 10(2), 664-676 (IF= 4.787, 24/254, Pharmacology & Pharmacy)

 

  1. Yu-Lun Lo,Yao-Sheng Wang, and Li-Fang Wang*, 2013 “The Copolymer of Poly(2-dimethylaminoethyl methacrylate) and Methacrylated Chondroitin Sulfate with Low Cytotoxicity for Gene Delivery” Advanced Healthcare Materials, 2(11), 1458-1468. (IF=4.880, 5/32, Material Sci: Biomaterials)

 

  1. Shih-Jer Huang, Tzu-Pin Wang, Sheng-I Lue, and Li-Fang Wang*, 2013 “ Pentablock Copolymers of Pluronic F127 and Modified Poly(2-dimethyl amino)ethyl Methacrylate for Internalization Mechanism and Gene Transfection Studies” Int J Nanomedicine, 8, 2011-2027. (IF=4.195, 32/254, Pharmacology & Pharmacy)

 

  1. Shih-Jer Huang, Shou-Li Sun, Chien-Chih Chiu, and Li-Fang Wang*, 2013 Retinol- encapsulated water-soluble succinated chitosan nanoparticles for antioxidant applications” J Biomater Sci. Polym. Edn. 24, 315-329 (IF= 1.357, 48/82, Polymer Sci).

 

 

2012

  1. Yue-Jin Lin, Yu-Sheng Liu, Hsin-Hwa Yeh, Tian-Lu Cheng, Li-Fang Wang*, 2012 Self-assembled poly(epsilon-caprolactone)-g-chondroitin sulfate copolymers as an intracellular doxorubicin delivery carrier against lung cancer cells” Int J Nanomedicine, 7, 4169-4183 (IF= 4.976, 18/249).

 

  1. Shuo-Li Sun, Yu-Lun Lo, Hsing-Yin Chen, and Li-Fang Wang*, 2012 “Hybrid Polyethylenimine and Polyacrylic Acid-bound Iron Oxide as a Magnetoplex for Gene Delivery” Langmuir 28(7), 3542- 3552 ( IF=4.269, 26/225)

 

  1. Shao-Yun Wei, Li-Fang Wang, Yuan-Han Yang, Hsin-Hu Yeh, Yi-Chin Chen, Su-Hwei Chen*, 2012,” Sample stacking by field-amplified sample injection and sweeping for simultaneous analysis of acidic and basic components in clinic application” Electrophoresis, 33, 1571-1581 (IF= 3.569, 12/73).

 

  1. Li-Fang Wang*, Hsiao-Chen Ni, Yue-Jin Lin, and Yu-Shen Liu, 2012 “Chondroitin Sulfate-g-Poly(ε-caprolactone) Copolymer Aggregates as a Targeting Drug Carrier” J Biomater Sci. Polym. Edn. 23(14), 1821-1842 (IF= 1.842, 25/79)

 

  1. Li-Fang Wang*, Jenn-Shing Chen, and Yu-Lun Lo, 2012 “Novel Nanoparticles to encapsulate microRNA for the treatment of stroke” Ther. 20 (Suppl 1), S160-161. (IF= 6.873, 9/158, based on Biotechnology and microbiology)

 

  1. Hsiu-Wen Hsiao, Ke-Li Tsai, Li-Fang Wang, Yen-Hsu Chen, Pei-Chi Chiang, Shu-Mien Chuang, Chin Hsu*, 2012, “The Decline of Autophagy Contributes to Proximal Tubular Dysfunction During Sepsis” Shock, 37(3), 289-296 (IF= 3.203, 20/188)

 

2011

  1. Guo-Jing Chen and Li-Fang Wang*, 2011 “Design of Magnetic Nanoparticles-Assisted Drug Delivery System” Curr Pharm Design, 17(22), 2331-2351 (SCI, IF=4.774, 22/249)

 

 

  1. Hun-Yu Tsai, Chien-Chih Chiu, Ping-Chih Lin, Su-Hwei Chen, Shih-Jer Huang, and Li-Fang Wang*, 2011, “The Antitumor Efficacy of Released Doxorubicin From Crosslinked Nanoparticulate Chondroitin Sulfate/Chitosan Polyelectrolyte Complexes” Macromol. Biosci., 11(5), 680-688 (SCI, IF=3.458, 12/79).

 

  1. Elsie Khai-Woon Toh, Hsing-Yin Chen, Yu-Lung Lo, Shih-Jer Huang, Li-Fang Wang*, 2011 “Succinated Chitosan as a Gene Carrier for Improved Chitosan Solubility and Gene Transfection” Nanomedicine: NBM 7, 174-183. (SCI, IF= 6.930, 14/106)

 

  1. Chien-Chih Chiu, Yin-Tzu Lin, Shuo-Li Sun, Kuo-Hsun Sung Li-Fang Wang*, and Jenn-Shing Chen, 2011, “Folate-mediated chondroitin sulfate/chitosan nanoparticulate polyelectrolyte complex as a drug carrier for doxorubicin delivery” J Biomaterial Sci: Polym. Edn. 22, 1487-1507 (SCI, IF= 1.842, 25/79).

 

2010
 

  1. Jyun-Han Ke, Jia-Jyun Lin, James, R Carey, Jenn-Shing Chen, Chiao-Yun Chen, and Li-Fang Wang*, 2010,”A Specific Tumor-Targeting Magnetofluorescent Nanoprobe for Dual-Modality Molecular Imaging”, Biomaterials, 31, 1707-1715. (SCI, IF= 7.882, 2/69)

 

2009
 

27.  Jia-Jyun Lin, Jenn-Shing Chen, Shih-Jer Huang, Jyun-Han Ko, Yu-Ming Wang, Ting-         Lung Chen, and Li-Fang Wang*, 2009, ” Folic acid-Pluronic F127 magnetic                         nanoparticle clusters for combined targeting, diagnosis, and therapy applications”                 Biomaterials, 30, 5114-5124. (SCI, IF= 7.882, 2/69)

28.  L. Lo, Y.S. Peng, B.H. Chen, L.F. Wang*, and K.W. Leong, 2009 “Poly(ethylene                   imine)-g-Chitosan Using EX-810 as a Spacer for Non-viral Gene Delivery Vectors” J             Biomed Mater Res: Part A , 88A, 1058-1068. (SCI, IF= 3.044, 12/70)

29.  Shih-Jer Huang, Shuo-Li Sun, Tzu-Hua Feng, Kuo-Hsun Sung, Wen-Ling Lui, and               Li-Fang Wang*, 2009 “Folate-Mediated Chondroitin Sulfate-Pluronic® 127                         Nanogels as a Drug Carrier” Eur. J. Pharm. Sci., 38, 64-73. (SCI, IF= 3.291, 68/249)