Hello world!

Name:   Ying-Chu Lin

E-mail: chulin@kmu.edu.te

Tel: 886-7-312-1101 ext.2753

Education

PhD         1996-2002       Institute of Basic Medical Sciences, College of Medicine, National                                              Cheng-Kung University, Taiwan

MS          1990-1992       Graduate Institute of Biology, Fu-Jen University, Taiwan

BS           1986-1990       Department of Biology, Fu-Jen University, Taiwan

Current position and relevant experience

2014.08-date           Professor, School of Dentistry, College of Dental Medicine, Kaohsiung                                      Medical University, Taiwan

Specialty 

1. Cancer genomics;
2. Molecular Epidemiology;
3. Environmental Medicine;

Publication:

 Chen KK, Minakuchi M, Wuputra K, Ku CC, Pan JB, Kuo KK, Lin YC, Saito S, Lin CS, Yokoyama KK. Redox control in the pathophysiology of influenza virus infection. BMC Microbiol. 2020;20(1):214. doi: 10.1186/s12866-020-01890-9.

Ku CC, Wuputra K, Kato K, Lin WH, Pan JB, Tsai SC, Kuo CJ, Lee KH, Lee YL, Lin YC, Saito S, Noguchi M, Nakamura Y, Miyoshi H, Eckner R, Nagata K, Wu DC, Lin CS, Yokoyama KK. Jdp2-deficient granule cell progenitors in the cerebellum are resistant to ROS-mediated apoptosis through xCT/Slc7a11 activation. Sci Rep. 18;10(1):4933. doi: 10.1038/s41598-020-61692-x. corrected at 2020;10(1):9858. doi:10.1038/s41598-020-66843- 8.

Wuputra K, Ku CC, Wu DC, Lin YC, Saito S, Yokoyama KK. Prevention of tumor risk associated with the reprogramming of human pluripotent stem cells. J Exp Clin Cancer Res. 2020;39(1):100. doi: 10.1186/s13046-020-01584-0.

Chiang TC, Huang MS, Lu PL, Huang ST, Lin YC. The effect of oral care intervention on pneumonia hospitalization, Staphylococcus aureus distribution, and salivary bacterial concentration in Taiwan nursing home residents: a pilot study. BMC Infect Dis. 2020;20(1):374. doi: 10.1186/s12879-020-05061-z.

Hsu YJ, Lin KD, Chen JH, Lee MY, Lin YC, Yen FC, Huang HL. Periodontal Treatment Experience Associated with Oral Health-Related Quality of Life in Patients with Poor Glycemic Control in Type 2 Diabetes: A Case-Control Study. Int J Environ Res Public Health. 2019;16(20). pii: E4011. doi: 10.3390/ijerph16204011.

Lee MK, Lin YC^*, Ho KY. The Comparisons in Treatment Outcomes of Chronic Periodontitis between Two Nonsurgical Periodontal Treatment Protocols and Their Correlations with Saliva Levels of Matrix Metalloproteinases. J Periodontics & Implants Dentistry 2019;2:25-34 (non-SCI)

Tsai CC, Lin YC. Evolution of the Serotypes of Aggregatibacter actinomycetemcomitans In Relation to Aggressive Periodontitis and Geographic Origin of Individuals – A Review of the Literature. Mod Res Dent. 3(5). MRD.000572.2019. DOI: 10.31031/MRD.2019.03.000572

Huang HI, Chen CH, Wang SH, Wang LH, Lin YC. Effects of APE1 Asp148Glu polymorphisms on OPMD malignant transformation, and on susceptibility to and overall survival of oral cancer in Taiwan. Head &Neck 2019 Jun;41(6):1557-1564

Saito S, Lin YC, Nakamura Y, Eckner R, Wuputra K, Kuo KK, Lin CS, Yokoyama KK. Potential application of cell reprogramming techniques for cancer research Cell Mol Life Sci. 2019 Jan;76(1):45-65, doi: 10.1007/s00018-018-2924-7

Wu DC, Wang SSW, Liu CJ, Wuputra K, Kato K, Lee YL, Lin YC, Tsai MH, Ku CC, Lin WH, Wang SW, Kishikawa S, Noguchi M, Wu CC, Chen YT, Chai CY, Lin CS, Kuo KK, Yang YH, Miyoshi H, Nakamura Y, Saito S, Nagata K, Lin CS, Yokoyama KK. Reprogramming Antagonizes the Oncogenicity of HOXA13-Long Noncoding RNA HOTTIP Axis in Gastric Cancer Cells. Stem Cells. 2017 Oct;35(10):2115-2128. doi: 10.1002/stem.2674

Pan XY, Tsai MH, Wuputra K, Ku CC, Lin WH, Lin YC, Kishikawa S, Noguchi M, Saito S, Lin CS, Yokoyama KK. Application of Cancer Cell Reprogramming Technology to Human Cancer Research. Anticancer Res. 2017 Jul;37:3367-3377

Lin YC, Hour TC, Tsai YC, Huang SP, Wu WJ, Chen CH, Pu YS, Chung SD, Huang CY. Preliminary evidence of polymorphisms of cell cycle regulatory genes and their roles in urinary tract urothelial cancer susceptibility and prognosis in a Taiwan population. Urol Oncol. 2017 Sep;35(9):543.e7-543.e16

Ho YP, Lin YC, Yang YH, Chou YH, Ho KY, Wu YM, Tsai CC. Association of vitamin D receptor gene polymorphisms and periodontitis in a Taiwanese Han population. J Dent Science 2017;12(4):360-367. https://doi.org/10.1016/j.jds.2017.07.001

Hu KF, Lin YC, Ho KY, Chou YH.  Compliance with supportive treatment in dental implant patients. Int J Oral Maxillofac Implants. 2017 November/December;32(6):1364–1370. doi: 10.11607/jomi.5457.

Hsiao YF, Yang LC, Chou YS, Ho YP, Lin YC, Ho KY, Wu YM, Tsai CC. Matrix metalloproteinase-2, -9, and tissue inhibitor of MMP-2 gene polymorphisms in Taiwanese periodontitis patients. J Dent Sciences 2016;11:411-18

Kuo KK, Lee KT, Chen KK, Yang YH, Lin YC, Tsai MH, Wuputra K, Lee YL, Ku CC, Miyoshi H, Nakamura Y, Saito S, Wu CC, Chai CY, Eckner R, Steve Lin CL, Wang SS, Wu DC, Lin CS, Yokoyama KK. Positive Feedback Loop of OCT4 and c-JUN Expedites Cancer Stemness in Liver Cancer. Stem Cells. 2016; 34:2613-24. doi: 10.1002/stem.2447.

Wang SS, Wuputra K, Liu CJ, Lin YC, Chen YT, Chai CY, Lin CS, Kuo KK, Tsai MH, Wang SW, Chen KK, Miyoshi H, Nakamura Y, Saito S, Hanafusa T, Wu DC, Lin CS, Yokoyama KK. Oncogenic function of the homeobox A13-long noncoding RNA HOTTIP-insulin growth factor-binding protein 3 axis in human gastric cancer. Oncotarget. 2016;14;7(24):36049-36064

Tsai MH, Wuputra K, Lin YC, Lin CS, Yokoyama KK. Multiple functions of the histone chaperone Jun dimerization protein 2. Gene. 2016;590(2):193-200 doi: 10.1016/j.gene. 2016.03.048.

Ho YP, Lin YC, Yang YH, Chou YH, Ho KY, Wu YM, Tsai CC. Analysis of tumor necrosis factor-α⁻³⁰⁸ and lymphotoxin-α⁺²⁵² gene polymorphisms in Taiwanese patients with periodontitis. J Dental Sciences, 2015;10(3): p316–322

Wu TL, Tsai CC, Wang YY, Ho KY, Wu YM, Hung HC, Lin YC. The association between the RAGE G82S polymorphism, sRAGE and chronic periodontitis in Taiwanese individuals with and without diabetes. J Periodontal Res 2015; 50(6):881-9

Chen KC, Liao YC, Wang JY, Lin YC, Chen CH, Juo SH. Oxidized low-density lipoprotein is a common risk factor for cardiovascular diseases and gastroenterological cancers via epigenomical regulation of microRNA-210. Oncotarget. 2015;6(27):24105-18

Tseng LS, Chen SH, Lin MT, Lin YC. Transplantation of human dental pulp-derived stem cells protects against heat stroke in mice. Cell Transplanat 2015;24(5):921-37.

Saito S, Lin YC, Tsai MH, Lin CS, Murayama Y, Sato R, Yokoyama KK. Emerging roles of hypoxia-inducible factors and reactive oxygen species in cancer and pluripotent stem cells. Kaohsiung J Med Sci 2015;31(6):279-86.

Hour TC, Chung SD, Kang WY, Lin YC, Chuang SJ, Huang AM, Wu WJ, Huang SP, Huang CY, Pu YS. EGFR mediates docetaxel resistance in human castration‑resistant prostate cancer through the Akt-dependent expression of ABCB1 (MDR1) Arch Toxicol 2015;89(4):591-605

Wang SH, Hung HC, Tsai CC, Huang MC, Ho KY, Wu YM, Wang YY, LinYC. Plasma polyunsaturated fatty acids and periodontal recovery in Taiwanese with periodontitis: A significant relationship. Archives of Oral Biology 2014 Aug;59:800-807

Tseng LS, Chen SH, Lin M-T, Lin YC. Umbilical cord blood-derived stem cells improve heat tolerance and hypothalamic damage in heat stressed mice. Biomed Res Int (formerly: Journal of Biomedicine and Biotechnology). 2014;2014:685683. doi: 10.1155/2014/685683

Lin YC, Murayama Y, Hashimoto K, Nakamura Y, Lin CS, Yokoyama KK, Saito S. Role of tumor suppressor genes in the cancer-associated reprogramming of human induced pluripotent stem cells. Stem Cell Res Ther. 2014;5(2):58

Lin YC, Kuo KK, Wuputra K, Lin SH, Ku CC, Yang YH, Wang SW, Wang SW, Wu DC, Wu CC, Chai CY, Lin CL, Lin CS, Kajitani M, Miyoshi H, Nakamura Y, Hashimoto S, Matsushima K, Jin C, Huang SK, Saito S, Yokoyama KK. Bovine Induced Pluripotent Stem Cells Are More Resistant to Apoptosis than Testicular Cells in Response to Mono-(2- ethylhexyl) Phthalate. Int J Mol Sci.2014;15(3):5011-31. doi: 10.3390/ijms15035011.

Tanigawa S, Lin CH, Lin CS, Ku CC, Hasegawa H, Qin S, Kawahara A, Korenori Y, Miyamori K, Noguchi M, Lee LH, Lin YC, Lin CL, Nakamura Y, Jin C, Yamaguchi N, Eckner R, HouDX, and Yokoyama KK. Jun dimerization protein 2 is a critical component of the Nrf2/MafK complex regulating the response to ROS homeostasis. Cell Death & Disease 2013;4:e921. doi:10.1038/cddis.2013.448

Wang SW, Wang S, Wu DC, Lin YC, Wu CC, Chai CY, Lee JN, Tsai EM, Lin CL, Yang RC, Ko YC, Yu HY, Murayama Y, Nakamura Y, Hashimoto SI, Jin C, Matsushima K, Eckner R, Saito S, Lin CS, Huo C, Chuu CP, Ku CC and Yokoyama KK. Androgen receptor-mediated apoptosis in bovine testicular induced pluripotent stem cells in response to phthalate esters. Cell Death and Disease 2013;4:e907. doi: 10.1038/cddis.2013.420

Cheng BH, Wang TH, Kang HY, Lin YC, Huang CC, Hsu TY, Kung FT, Huang KE. Association between single nucleotide polymorphisms of the estrogen receptor 1 and receptor activator of nuclear factor kappa B ligand genes and bone mineral density in postmenopausal Taiwanese. Taiwan J Obstet Gynecol. 2013;52(2):197-203

Chiou SS, Wang SW, Wu DC, Lin YC, Kao LP, Kuo KK, Wu CC, Chai CY, Lin CL S, Lee CY, Liao YM, Wuputra K, Yang YH, Wang SW, Ku CC, Nakamura Y, Saito S, Hasegawa H, Yamaguchi N, Miyoshi H, Lin CS, Eckner R, and Yokoyama KK. Control of Oxidative Stress and Generation of Induced Pluripotent Stem Cell-like Cells by Jun Dimerization Protein 2. Cancers (Basel). 2013, 5(3), 959-984

Wang YY, Lin YC, Hung HC, Tien WY, Shieh TY. Polymorphisms in Kallikrein7 and 10 genes and oral cancer risks in Taiwan betel quid chewers and smokers. Oral Dis. 2013; 19(8):824-32

Saito S, Lin YC, Murayama Y, Hashimoto K, Yokoyama KK. Human Amnion-derived Cells as a Reliable Source of Stem Cells. Curr Mol Med. 2012;12:1340-49

Lin YC, Lee CW, Yeh CJ, Wang LH, Chen CH The effects of polymorphisms in cyclin D1 and vascular endothelial growth factor genes on oral cancer and disease-free survival in a Taiwan population. Oral Oncology, 2012;48(6):535-40

Pu YS, Huang CY, Chen JY, Kang WY, Lin YC, Shiu YS, Chuang SJ, Yu HJ, Lai MK, Tsai YC, Wu WJ, Hour TC. Down-regulation of PKCζ in renal cell carcinoma and its clinicopathological implications. J Biomed Sci. 2012;5:19:39

Chuang FH, Tsai CC, Chen JH, Chen KK, Chen YK, Lin YC Long-term sequential receptor activator of NF-κB ligand (RANKL) and osteoprotegrin (OPG) expression in lipopolysaccharide-induced rat periapical lesions. J Oral Pathol Med. 2012;41(2):186-93

Chou YH, Ho YP, Lin YC, Hu KF, Yang YH, Ho KY, Wu YM, Hsi E, Tsai CC. MMP-8 -799C>T genetic polymorphism is associated with the susceptibility to chronic and aggressive periodontitis in Taiwanese. J Clin Periodontol 2011;38(12):1078-84

Wen HJ, Wang YJ, Lin YC, Chang CC, Shieh CC, Lung FW, Guo YL. Prediction of atopic dermatitis in 2-yr-old children by cord blood IgE, genetic polymorphisms in cytokine genes, and maternal mentality during pregnancy. Pediatr Allergy Immunol. 2011;22(7):695-703

Huang YC, Hasegawa H, Wang SW, Lin YC, Chiou SS, Wu DC, Tsai EM, Saito S, Yamaguchi N, Yokoyama K, Ku CC, Hou MF. Jun dimerization protein 2 controls senescence and differentiation via regulating histone modification. J Biomed Biotechnol 2011. doi:10.1155/2011/ 569034.

Wang LH, Ting SC, Chen CH, Tsai CC, Lung Oliver, Wang YY, Lee CW, Tsai CL, Lin YC. Polymorphisms in the apoptosis-associated genes FAS and FASL and risks of oral cancer and malignant potential of oral leukoplakia and oral submucosal fibrosis in a Taiwan population. J Oral Path Med 2010;39:155-61.

Yua IL, Lin YC, Robinson JH Lung Oliver. Pseudotyping gp64-null Autographa californica MNPV with the F protein from Spodoptera exidua MNPV diminishes transduction efficiency into vertebrate cells. J Gen Vrio 2009: 90:2282-7

Yua IL, Braya Doug, Lin YC, Lung Oliver. Autographa californica multiple nucleopolyhedrovirus (AcMNPV) ORF 23 null mutant produces occlusion-derived virions with fewer nucleocapsids. J Gen Vrio 2009;90:1499-1504.

Hu KF, Huang KC, Ho YP, Lin YC, Ho KY, Wu YM, Yang YH, Tsai CC. Interleukin-10 (−592 C/A) and interleukin-12B (+16974 A/C) gene polymorphisms and the interleukin-10 ATA haplotype are associated with periodontitis in a Taiwanese population. J Periodontal Res 2009;44:378-35

Chiang SL, Chen PH, Lee CHung, Ko Albert, Lee KW, Lin YC, Ho PS, Tu HP, Wu DC, Shieh TY, Ko YC. Upregulation of inflammatory signalings by areca nut extract and role of cyclooxygenase-2 -1195G>A polymorphism revealed risk of oral cancer. Cancer Res 2008;68:8489-98.

Lin YC, Huang HI, Wang LH, Tsai CC, Lung O, Dai CY, Yu ML, Ho CK, Chen CH. Polymorphisms of COX-2 -765G > C and p53 codon 72 and risks of oral squamous cell carcinoma in a Taiwan population. Oral Oncology 2008;44: 798-804

Ho YP, Lin YC, Yang YH, Ho KY, Wu YM, Tsai CC. Cyclooxygenase-2 Gene -765 single nucleotide polymorphism as a protective factor against periodontitis in Taiwanese. J Clin Periodontol. 2008;35:1-8

Yen CY, Liu SY, Chen CH, Tseng HF, Chuang LY, Yang CH, Lin YC, Wen CH, Chiang WF, Ho CH, Chen HC, Wang ST, Lin CW, Chang HW. Combinational polymorphisms of four DNA repair genes XRCC1, XRCC2, XRCC3, and XRCC4 and their association with oral cancer in Taiwan. J Oral Pathol Med 2008,37:271-77.

Chen PH, Lin YC, Tu HP, Chiang SL, Ko MSA, Hsu CL, Chang YF, Ko YC. Important prognostic factors for the long-term survival of subjects with primary liver cancer in Taiwan:A hyperendemic area. Eur J Cancer 2007;43:1076-84

Lee YL, Hwang BF, Lin YC, Guo YL, Taiwan ISAAC Study Group. Time trend of asthma prevalence among school children in Taiwan: ISAAC phase I and III surveys. Pediatr Allergy Immunol 2007;18(3):188-95

Chen PH, Shieh TY, Ho PS, Tsai CC, Yang YH, Lin YC, Ko MS, Tsai PC, Chiang SL, Tu HP, Ko YC. Prognostic factors associated with the survival of oral and pharynx carcinoma in Taiwan. BMC Cancer 2007, 7:101.

Wen HJ, Lin YC, Lee YL, Guo YL. Association between Cord Blood IgE and genetic polymorphisms of Interleukin-4, the beta subunit of the high-affinity receptor for IgE, lymphotoxin-alpha, and tumor necrosis factor-alpha. Pediatr Allergy Immunol 2006;17:489-94

Lin YC, Pan CH, Chen CJ, Wu KY, Chang-Chien GP, Ho CK, Wu TN, Chuang HY, Kuo HW, Wu MT. Associations between Exposure to Polycyclic Aromatic Hydrocarbons and Temporal Change of Urinary 1-Hydroxypyrene Levels in Taiwan Coke-Oven Workers. J Occup Environ Med 2006;48:930-36

Hwang BF, Jaakkola JJK, Lee YL, Lin YC, GuoYLL. Air Pollution and Allergic Rhinitis in Taiwanese Schoolchildren. Respiratory Research 2006;7:23.

Chen PH, Tsai CC, Lin YC, Ko YC, Yang YH, Shieh TY, Ho PS, Li CM, Ko MSA, Chen CH. Ingredients contribute to variation in production of reactive oxygen species by areca quid. J Toxicol Environ Health A 2006;69:1055-69.

Lin YC, Wu DC, Lee JM, Hsu HK, Kao EL, Yang CH, Wu MT. The association between microsomal epoxide hydrolase genotypes and esophageal squamous-cell-carcinoma in Taiwan: interaction between areca chewing and smoking. Cancer Letter 2006;237:256-263

Lee YL, Hsiue TR, Lee YC, Wang JY, Lin YC, Guo YLL. The Association between Glutathione S-transferase P1, M1 Polymorphisms and Asthma in Taiwanese Schoolchildren. Chest 2005; 128:1156-1162

Hwang BF, Lee YL, Lin YC, Jaakkola JJK, Guo YLL. Traffic-related air pollution as a determinant of asthma among Taiwanese school children. Thorax 2005;60:467–473.

Lee YL, Lin YC, Hwang BF, Guo YL. Changing Prevalence of Asthma in Taiwanese Adolescents: Two surveys six years apart. Pediatr Allergy and Immunol 2005; 16: 157–164.

Lee YL, Lin YC, Lee YC, Wang JY, Hsiue TR, Guo YL. Glutathione S-Transferase P1 Gene Polymorphism and air Pollution as interactive risk factors for childhood asthma. Clin Exp Allergy 2004;34:1707-1713.

Chen PH, Ko YC, Yang YH, Lin YC, Shieh TY, Tsai CC. Important prognostic factors of long-term oropharyngeal carcinoma survivors in Taiwan. Oral Oncology 2004;40:847-855

Lin YC, Wen HJ, Lee YL, Guo YL. Are maternal psychosocial factors associated with cord IgE in addition to family atopic history and mother IgE? Clin Exp Allergy 2004;34:548-544

Lee YL, Lin YC, Hsiue TR, Hwang BF, Guo YL. Indoor and outdoor environmental exposures, parental atopy, and physician-diagnosed asthma in Taiwanese schoolchildren. Pediatrics 2003;112:e389-e395

Lin YC, Lu CC, Shen CY, Lei HY, Guo YL, Su HJ. Roles of genotypes of b₂-adrenergic receptor in the relationship between eosinophil counts and lung function in Taiwanese adolescents. J Asthma 2003;40:265-272

Lin YC, Lu CC, Su HJ, Shen CY, Lei HY, Guo YL. The association among tumor necrosis factor, HLA-DR alleles, and asthma in Taiwanese adolescents. Allergy 2002;57:831-834

Lin YC, Su HJ, Hsiue TR, Lee CH, Chen CW, Guo YL. Levels of house dust-specific IgE and cockroach-specific IgE and their association with lower pulmonary function in Taiwanese children. Chest, 2002;121:347-353.

Tsuang HC, Guo YL, Lin YC, Su HJ. School type, stress and sport-related injuries in middle school students in central Taiwan. Safety Sci, 2001;39:137-144

Guo YL, Lin YC, Su HJ, Huang SL, Shaw CK, Lai JS, Ko YC, Sung FC, Lin RS, Dockery D.  Climate, traffic-related air pollutants and asthma prevalence in middle school children: A multicenter study. Environ Health Perspect, 1999;107:1001-1006.

Hwang SH, Tsou MF, Lin YC, and Liu CH. The Zebrafish BMP4 Gene: sequence analysisand expression pattern during embryonic development. DNA Cell Biol, 1997, 16(8):1003-1011.