{"id":34,"date":"2013-08-14T13:47:36","date_gmt":"2013-08-14T05:47:36","guid":{"rendered":"http:\/\/wp.kmu.edu.tw\/ckwang\/?page_id=34"},"modified":"2021-10-25T11:54:59","modified_gmt":"2021-10-25T03:54:59","slug":"research","status":"publish","type":"page","link":"https:\/\/wp.kmu.edu.tw\/ckwang\/research\/","title":{"rendered":"Research(\u7814\u7a76\u5167\u5bb9)"},"content":{"rendered":"

Research Interests(\u7814\u7a76\u9818\u57df)<\/strong><\/h3>\n
    \n
  1. Design and fabrication of scaffold materials for tissue engineering of bone & cartilage (Especially we have developed 3D ceramic bio-ink for 3D Printing)<\/li>\n
  2. Polymeric micelle micro-, nano-particle system for drug\/gene delivery<\/li>\n
  3. Other interesting at advanced materials \u2026.<\/li>\n<\/ol>\n
      \n
    1. \u7528\u65bc\u9aa8\u3001\u8edf\u9aa8\u7d44\u7e54\u5de5\u7a0b\u7684\u65b0\u578b\u652f\u67b6\u751f\u7269\u6750\u6599\u7684\u8a2d\u8a08\u8207\u88fd\u9020<\/li>\n
    2. \u7528\u65bc\u85e5\u7269\u50b3\u905e\u4e4b\u5fae\u5948\u7c73\u8f09\u9ad4\u7cfb\u7d71<\/li>\n
    3. 3D\u7a4d\u5c64\u88fd\u9020\u751f\u7269\u9676\u74f7\u61c9\u7528\u65bc\u5ba2\u88fd\u5316\/\u500b\u4eba\u5316\u91ab\u7642\u9aa8\u690d\u5165\u7269\u3002<\/li>\n
    4. 3D \u751f\u7269\u5217\u5370\u4e4b\u58a8\u6c34\u7684\u8a2d\u8a08\u8207\u958b\u767c\u7528\u65bc\u8edf\u9aa8\u7d44\u7e54\u5de5\u7a0b\u7684\u518d\u751f\u7814\u7a76\u3002<\/li>\n<\/ol>\n
      \n

      Major Research <\/strong>Results(\u4e3b\u8981\u7814\u7a76\u6210\u679c)<\/strong><\/h3>\n
        \n
      1. \u570b\u79d1\u6703\u767c\u5c55\u51fa\u5fae\u7c73\u85e5\u7269\u8f09\u9ad4\u7cfb\u7d71(PLGA\/HAp microsphere)\u52a0\u5165\u9ad8\u91ab\u9aa8\u7814\u4e2d\u5fc3\u7684\u5408\u4f5c\u7684\u5b78\u754c \u79d1\u5c08\u8a08\u5283\uff0c\u5df2\u7372\u5f97 2 \u4ef6\u4e2d\u83ef\u6c11\u570b\u5c08\uf9dd\u8207 2 \u4ef6\u7f8e\u570b\u5c08\uf9dd\uff1a\u6b64\u85e5\u7269\u8f09\u9ad4\u53ef\u651c\u5e36\u6cb9\u6eb6\u6027\u85e5\u7269\uff0c\u672c\u5718\u968a\u59d4\u8a17\u53f0\u7063\u6771\u6d0b\u85e5\u5ee0\u9032\ufa08 GMP-like \u4e4b Simvastin\/PLGA\/HAp \u5fae\u7c73\u8907\u5408\u8f09\u9ad4\u88fd\u7a0b\u653e\u5927\u958b \u767c\uff0c\u4f7f\u5176\u5177\u6709\u5c40\u90e8\u7de9\u91cb\u5bf8\u9032\u9aa8\u751f\u9577 simvastatin \u7684\u7528\u9014\uff0c\u4e26\u65bc 104 \uf98e 9 \u6708\u8207\u548c\u5eb7\u751f\u6280\u80a1\u4efd\u6709 \u9650\u516c\u53f8\u9032\ufa08\u7522\u5b78\u5408\u4f5c\u8a08\u756b\u8207\u5168\u7a0b\u6280\u8f49\uf90a 650 \u842c\u3002\u6b64\u5916\u76f8\u95dc BMP-2\/HAp\/PLGA\u8f09\u9ad4\u5c08\u5229\uff0c\u4e5f\u65bc105\u5e74\u8207\u535a\u665f\u751f\u6280\u516c\u53f8\u9032\u884c\u7522\u5b78\u5408\u4f5c\u8a08\u756b\uff0c\u8a55\u4f30\u516c\u53f8\u4fc3\u9032\u9aa8\u751f\u9577OIF growth factor\u7522\u54c1\u7684\u7de9\u91cb\u88fd\u5291\u65bc\u5c0f\u9f20\u7684\u9aa8\u7652\u5408\u7642\u6548\uff0c\u7d50\u679c\u9664\u4e86\u5177\u6709\u7de9\u91cb\u7684\u80fd\u529b\u8207\u4fc3\u9032\u9aa8\u751f\u9577\u6548\u679c\u5916\u4e14\u7121\u767c\u708e\u53cd\u61c9\uff0c\u516c\u53f8\u6b63\u5728\u8a55\u4f30\u6280\u8f49\u9700\u6c42\u8207\u5f8c\u7e8c\u7684\u884d\u4f38\u5927\u52d5\u7269\u8a55\u4f30\u3002\u76f8\u95dc\u5b78\u8853\u8ad6\u6587\u6709\u56db\u7bc7( Optimized bone regeneration based on sustained release from three-dimensional fibrous PLGA\/HAp composite scaffolds loaded with BMP-2, Biotech & Bioeng, 99: 996-1006, 2008. 2.<\/strong> Controlled release carrier of BSA made by W\/O\/W emulsion method containing PLGA and hydroxyapatite, J Control Release, 128: 142-148, 2008. 3. <\/strong>Preparation of porous bioceramics using reverse thermo-responsive hydrogels in combination with rhBMP<\/em>–2<\/em> carriers: In Vitro<\/em> and In Vivo<\/em> evaluation, J Mechanl Behav Biomed Mater, 27:64-76, 2013. 4. Local delivery of controlled-release simvastatin\/PLGA\/HAp microspheres enhances bone repair, Internat J Nanomed, 8:3895-3905, 2013.)<\/li>\n
      2. \u4e3b\u6301\u4eba\u65bc\u570b\u79d1\u6703\u767c\u5c55\u51fa\u8ca0\u6eab\u611f\u6c34\u81a0\u7cfb\u7d71\u52a0\u5165\u9ad8\u91ab\u9aa8\u7814\u4e2d\u5fc3\u7684\u5408\u4f5c\u7684\u5b78\u754c\u79d1\u5c08\u8a08\u5283\uff1a\u767c\u5c55\u51fa\u4ee5\u201d\u8ca0\u6eab\u611f\u6c34\u81a0\u61c9\u7528\u5728\u88fd\u5099\u591a\u5b54\u6027\u751f\u7269\u9676\u74f7\u652f\u67b6\u201d\u7684\u65b0\u88fd\u7a0b\u3002\u6b64\u65b0\u88fd\u7a0b\u53ef\u7c21\uf9e0\u5730\u7d93\u5e38\u58d3\u652a\u62cc\u904e\u7a0b\u8207\u71d2\u7d50\u88fd\u9020\u51fa\u5747\u52fb\u6027\uf97c\u597d\u4e14\u5177\u9ad8\u5b54\u6027\ufa01\u6027(~65%)\u8207\u6a5f\u68b0\u6027(>4~7 MPa)\u7684\u591a\u5b54\u6027\u751f\u7269\u9676\u74f7\uff0c\u4e26\u5df2\u7372\u5f97\u4e2d\u83ef\u6c11\u570b\u5c08\uf9dd\u8207\u7f8e\u570b\u5c08\uf9dd(\u4e2d\u83ef\u6c11\u570b\u5c08\uf9dd\u865f\uff1aI411595 \u8207\u7f8e\u570b\u5c08\uf9dd\u865f\uff1aUS 8940203 B2)\u3002 \u6b64\u5916 102 \uf98e\u5df2\u63a5\u53d7\u4e00\u7bc7\u570b\u969b\u671f\u520a: J Mech Behav Biomed Mater, 27:64-76, 2013. (IF:3.048 at 2013; 19.4%)\u3002\u672c\u65b9\u6cd5\u53ef\u88fd\u5099\u8f03\u5177\u6a5f\u68b0\u6027\u7684\u9ad8\ufa01\u591a\u5b54\u6027\u751f\u7269\u9676\u74f7\uff0c\u85c9\u7531\u6b64\u6280\u8853\u5c07\u8207\uf90c\u7c73\u85e5\u7269\u8f09\u9ad4\u7d50\u5408\u9032\ufa08\u542b\u85e5\u6027\u9aa8\u6750\u958b\u767c\uff0c\u4e5f\u5df2\u7533\u8acb\u65b0\u5c08\u5229\u4e2d(\u81fa\u7063\u767c\u660e\u5c08\u5229\u7b2c106116285\u865f)\u4e26\u5c0b\u6c42\u76f8\u95dc\u5ee0\u5546\u9032\ufa08\u6280\u8f49\u8a55\u4f30\u3002\u76ee\u524d\u4e5f\u6b63\u5728\u64b0\u5bebSCI \uf941\u6587\u4e2d\u3002\u6b64\u5916\uff0c\u4e5f\u904b\u7528\u767c\u5c55\u6b64\u8ca0\u6eab\u611f\u6c34\u81a0\u5747\u58d3\u6536\u7e2e\u7684\u7279\u6027\uff0c\u771f\u7a7a\u6df7\u5408\u9676\u74f7\u7c89\u672b\u9032\ufa08\u4e09\u7dad\u7a4d\u5c64\u9676\u74f7\u64e0\u51fa\uf99c\u5370\u7684\u6210\u578b\u6280\u8853\u958b\u767c\uff0c\u4e26\u65bc2017\u5e7411\u670822\u65e5\u5df2\u7372\u5f97\u53f0\u7063\u5c08\u5229(\u7533\u8acb\u865f105139918)\uff0c\u540c\u6642\u4e5f\u5e03\u5c40\u5168\u7403\u5e02\u5834\u5c08\u5229(PCT\/CN2016\/ 108373, Dec 2, 2016\uff1b\u7f8e\u570b\u3001\u4e2d\u570b\u3001\u6b50\u6d32\u3001\u65e5\u672c)\u3002\u6b643D\u9676\u74f7\u7a4d\u5c64\u6280\u8853\u4e5f\u5c07\u7d50\u5408\u81ea\u4e3b\u958b\u767c3D\u7a4d\u5c64\u5217\u5370\u6a5f\u53f0(\u570b\u7814\u9662\u5100\u79d1\u4e2d\u5fc3\u5df2\u5354\u52a9\u5b8c\u6210\u539f\u578b\u6a5f)\uff0c\u9810\u8a08spin in \u6216\u6280\u8f49\u7d66\u76f8\u95dc\u91ab\u6750\u5ee0\u5546\u3002\u6545\u672a\u4f86\u7522\u696d\u61c9\u7528\u5982\uff0c\u9871\u9762\u9aa8\u4fee\uf966\u3001\u811b\u9aa8\u6821\u6b63\u5207\u9aa8\u8207\u690d\u7259\u4e4b\u5168\u74f7\u7259\u51a0\u7b49\u7b49\u3002\u672c\u6280\u88532016\u5e74\u7372\u5f97\u7b2c\u5341\u4e09\u5c46\u570b\u5bb6\u65b0\u5275\u734e\u3001\u5b78\u7814\u65b0\u5275\u734e<\/strong>(\u5275\u65b0\u9676\u74f7\u7a4d\u5c64\u88fd\u9020\u6280\u8853, \u793e\u5718\u6cd5\u4eba\u570b\u5bb6\u751f\u6280\u91ab\u7642\u7522\u696d\u7b56\u9032\u6703, 105\/12\/22)\u30012018<\/strong>\u5e74\u7372\u5f97\u79d1\u6280\u90e8<\/strong>–<\/strong>\u53f0\u7063\u5275\u65b0\u6280\u8853\u535a\u89bd\u6703<\/strong>–<\/strong>\u5275\u65b0\u767c\u660e\u734e\u8207<\/strong>\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u7b2c\u4e03\u5c46\u6821\u5712\u5275\u696d\u7af6\u8cfd<\/strong>\u5275\u696d\u7d44\u7b2c\u4e8c\u540d<\/strong>, 3D\u9aa8\u529b\u5168\u958b-3D\u751f\u7269\u5217\u5370\u6280\u8853\u9032\u884c\u9f52\u69fd, 2018\/06\/01-2018\/11\/30.\u3002109\u5e74\u5718\u968a\u66f4\u9032\u4e00\u6b65\u958b\u767c\u5149\u56fa\u5316\u8ca0\u6eab\u611f\u6c34\u81a0\u9676\u74f7\u6f3f\u9ad4\u7684\u88fd\u7a0b\u6280\u8853\u53ef\u7372\u5f97\u66f4\u7cbe\u5bc6\u8207\u8907\u96dc\u7684\u9676\u74f7\u7d50\u69cb\u5143\u4ef6\uff0c\u4e26\u5df2\u4f48\u5c40\u7f8e\u570b\u81e8\u6642\u6848(62\/798,481; 2019\/01\/30)\uff0c\u4e26\u4ee5\u6b64\u4e0a\u62c9\u5f0f\u5149\u56fa\u5316\u6280\u8853\u6b63\u8207\u665f\u5fb7\u96c6\u5718\u5b50\u516c\u53f8\u535a\u665f\u751f\u91ab\u9032\u884c\u7522\u5b78\u5408\u4f5c\u8a08\u756b(\u8ca0\u6eab\u611f\u6c34\u81a0\u8f14\u52a93D\u5217\u5370\u751f\u7269\u9676\u74f7\u6280\u8853\u958b\u767c\u8edf\u9aa8\u6813\u7684\u9aa8\u63a5\u89f8\u5340\u57df\uff1b80\u842c)\uff0c\u4ee5\u9a57\u8b49\u5176\u9aa8\u652f\u67b6\u7684\u6a5f\u68b0\u6027\u8cea\u8207\u751f\u7269\u5b89\u5168\u6027\u3002<\/li>\n
      3. \u500b\u4eba\u53c3\u8207\u9ad8\u91ab\u9aa8\u7814\u4e2d\u5fc3\u5728\u5b78\u754c\u79d1\u5c08\u7814\u7a76\u7d93\u9a57\u4e2d\uff1a\u9032\ufa08\uf9ba\u4e09\u671f\u5b78\u754c\u79d1\u5c08\u7814\u7a76(\u81f3\u76ee\u524d\u5df2\u57f7\ufa08\u517111 \uf98e)\uff0c\u5efa\uf9f7\uf9ba\u7522\u5b78\u5408\u4f5c\u3001\u667a\u8ca1\u7533\u8acb\u3001\u6280\u8853\u8f49\u79fb\u7b49\u7814\u767c\u7522\u54c1\u7684\u6a5f\u5236\uff0c\u532f\u96c6\uf9ba\u80fd\uf97e\u4ee5\u53ca\uf918\u5be6\uf9ba\u8f49\u8b6f\u91ab\u5b78\u7684\u76ee\u6a19\u3002104\u5e74\u5df2\u5b8c\u62101 \u4ef6\u6280\u8853\u79fb\u8f49\u7d66\u548c\u5eb7\u751f\u6280\u516c\u53f8<\/strong>(<\/strong>\u5168\u671f\u975e\u5c08\u5c6c\u6388\u6b0a\u6280\u8f49\u91d1<\/strong>600<\/strong>\u842c\uff0c\u672c\u4eba\u8ca2\u737b\u5ea6<\/strong>25%)<\/strong>\uff0c106\u5e74\u8207\u9ad8\u91ab\u9aa8\u7814\u5718\u968a\u5171\u540c\u5b8c\u6210\u53e6\u4e00\u4ef6\u6280\u8853\u79fb\u8f49\u7d66\u83ef\u91ab\u5eb7\u516c\u53f8<\/strong>(<\/strong>\u5168\u671f<\/strong>2<\/strong>\u5104\u5143\u6388\u6b0a\u91d1<\/strong>\u6280\u8f49\u91d1\uff0c\u672c\u4eba\u8ca2\u737b\u5ea6<\/strong>5%)<\/strong>\u3002<\/li>\n
      4. \u4e3b\u6301\u4eba\u65bc\u79d1\u6280\u90e8\u7a4d\u5c64\u88fd\u9020\u9676\u74f7\u6280\u8853\u958b\u767c\u7684\u6574\u5408\u578b\u8a08\u756b\u6210\u679c\uff0c105-106\u5169\u5e74\u7684\u6210\u679c\u5df2\u8b49\u660e\u6280\u8853\u5546\u54c1\u5316\u7684\u81e8\u5e8a\u61c9\u7528\u6f5b\u529b\uff0c\u672c\u6280\u8853\u4e5f\u8207\u570b\u7814\u9662\u5100\u79d1\u4e2d\u5fc3\u5408\u4f5c\uff0c\u958b\u767c\u5c08\u5c6c\u76843D\u751f\u7269\u5217\u5370\u6a5f\u53f0\uff0c\u4ee5\u5229107-108\u5e74\u9032\u884c\u81e8\u5e8a\u61c9\u7528\u7684\u4f7f\u7528\u7684\u6e2c\u8a66\u8207\u9a57\u8b49\u3002108\u7b2c\u4e00\u5b63\u76ee\u524d\u5df2\u6709\u5408\u4f5c\u5ee0\u5546\u6d3d\u8ac7\u7522\u5b78\u5408\u4f5c\u958b\u767c\u516c\u53f8\u7684\u9aa8\u6750\u7522\u54c1\uff0c\u9810\u671f\u53ef\u6280\u8f49\u7d66\u570b\u5167\u91ab\u6750\u516c\u53f8\u6216\u8207\u5275\u6295\u9032\u884c\u65b0\u5275\u516c\u53f8\u7684\u5a92\u5408\u3002\u6700\u7d42\u671f\u671b\u6b64\u4e00\u6280\u8853\u53ef\u9020\u798f\u50b7\u60a3\u7684\u5065\u5eb7\u3002(\u76f8\u95dc\u7522\u5b78\u8a08\u756b\u67091:\u8ca0\u6eab\u611f\u6c34\u81a0\u8f14\u52a93D\u5217\u5370\u751f\u7269\u9676\u74f7\u6280\u8853\u958b\u767c\u8edf\u9aa8\u6813\u7684\u9aa8\u63a5\u89f8\u5340\u57df, \u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\uff0d\u535a\u665f\u751f\u91ab\u80a1\u4efd\u6709\u9650\u516c\u53f8 \u7522\u5b78\u5408\u4f5c\u8a08\u756b\u3002 \u6f38\u5c64\u8272\u7cfb\u4e4b\u5168\u74f7\u6750\u6599\u7269\u5316\u6027\u5206\u6790\u8a08\u756b, \u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\uff0d\u68d5\u61cb\u516c\u53f8\u7522\u5b78\u5408\u4f5c\u8a08\u756b, 2016\/06\/16\u81f32017\/01\/30 (S-S104021 450,000 NT)\u3002(\u4e3b\u6301\u4eba) 3. \u7de9\u91cb\u578b\u9aa8\u751f\u9577\u56e0\u5b50\u8f09\u9ad4\u4e4b\u78ba\u6548\u8a55\u4f30, \u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\uff0d\u535a\u665f\u751f\u91ab\u7522\u5b78\u5408\u4f5c\u8a08\u756b, 2016\/09\/01\u81f32017\/04\/30 (1,200,000 NT)\u3002(\u5171\u540c\u4e3b\u6301\u4eba)<\/li>\n<\/ol>\n

        \n","protected":false},"excerpt":{"rendered":"

        Research Interests(\u7814\u7a76\u9818\u57df) Design and fabrication of scaf … \u95b1\u8b80\u5168\u6587 Research(\u7814\u7a76\u5167\u5bb9)<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":20,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-34","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/wp.kmu.edu.tw\/ckwang\/wp-json\/wp\/v2\/pages\/34","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.kmu.edu.tw\/ckwang\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/wp.kmu.edu.tw\/ckwang\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/ckwang\/wp-json\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/ckwang\/wp-json\/wp\/v2\/comments?post=34"}],"version-history":[{"count":9,"href":"https:\/\/wp.kmu.edu.tw\/ckwang\/wp-json\/wp\/v2\/pages\/34\/revisions"}],"predecessor-version":[{"id":147,"href":"https:\/\/wp.kmu.edu.tw\/ckwang\/wp-json\/wp\/v2\/pages\/34\/revisions\/147"}],"wp:attachment":[{"href":"https:\/\/wp.kmu.edu.tw\/ckwang\/wp-json\/wp\/v2\/media?parent=34"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}