{"id":34,"date":"2013-08-14T13:47:36","date_gmt":"2013-08-14T05:47:36","guid":{"rendered":"http:\/\/wp.kmu.edu.tw\/ckwang\/?page_id=34"},"modified":"2026-08-19T20:30:46","modified_gmt":"2026-08-19T12:30:46","slug":"research","status":"publish","type":"page","link":"https:\/\/wp.kmu.edu.tw\/ckwang\/research\/","title":{"rendered":"Research(\u7814\u7a76\u5167\u5bb9)"},"content":{"rendered":"

Research Interests(\u7814\u7a76\u9818\u57df)<\/strong><\/h3>\n
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  1. Design and fabrication of scaffold materials for tissue engineering of bone & cartilage (Especially we have developed 3D ceramic bio-ink for 3D Printing)<\/li>\n
  2. Polymeric micelle micro-, nano-particle system for drug\/gene delivery<\/li>\n
  3. Other interesting at advanced materials \u2026.<\/li>\n<\/ol>\n
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    1. \u7528\u65bc\u9aa8\u3001\u8edf\u9aa8\u7d44\u7e54\u5de5\u7a0b\u7684\u65b0\u578b\u652f\u67b6\u751f\u7269\u6750\u6599\u7684\u8a2d\u8a08\u8207\u88fd\u9020<\/li>\n
    2. \u7528\u65bc\u85e5\u7269\u50b3\u905e\u4e4b\u5fae\u5948\u7c73\u8f09\u9ad4\u7cfb\u7d71<\/li>\n
    3. 3D\u7a4d\u5c64\u88fd\u9020\u751f\u7269\u9676\u74f7\u61c9\u7528\u65bc\u5ba2\u88fd\u5316\/\u500b\u4eba\u5316\u91ab\u7642\u9aa8\u690d\u5165\u7269\u3002<\/li>\n
    4. 3D \u751f\u7269\u5217\u5370\u4e4b\u58a8\u6c34\u7684\u8a2d\u8a08\u8207\u958b\u767c\u7528\u65bc\u8edf\u9aa8\u7d44\u7e54\u5de5\u7a0b\u7684\u518d\u751f\u7814\u7a76\u3002<\/li>\n<\/ol>\n
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      Major Research <\/strong>Results(\u4e3b\u8981\u7814\u7a76\u6210\u679c)<\/strong><\/h3>\n
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      • The National Science Council has developed a micron-sized drug delivery system (PLGA\/HAp microsphere) and joined the Kaohsiung Medical University Bone Research Center’s collaborative academic research project, obtaining 2 Republic of China patents and 2 US patents. This drug delivery system can carry oil-soluble drugs. Our team commissioned Taiwan Tungyang Pharmaceutical Co., Ltd. to scale up the GMP-like Simvastin\/PLGA\/HAp micron composite carrier process, enabling it to locally release simvastatin to promote bone growth. In September 2015, we entered into an industry-academia collaboration project with Hokang Biotechnology Co., Ltd., with a technology transfer fee of NT$6.5 million. In addition, related BMP-2\/HAp\/PLGA carrier patents were also developed in 2016 with Bosheng Biotechnology Co., Ltd. to evaluate the efficacy of the company’s sustained-release formulation of its bone growth factor product in mice for bone healing. The results showed that in addition to the sustained-release capability and bone growth promotion effect, there was no inflammatory response. The company is currently evaluating the need for technology transfer and subsequent large animal evaluations. There are four related academic papers (1. Optimized bone regeneration based on sustained release from three-dimensional fibrous PLGA\/HAp composite scaffolds loaded with BMP-2, Biotech & Bioeng, 99: 996-1006, 2008. 2. Controlled release carrier of BSA made by W\/O\/W emulsion method containing PLGA and hydroxyapatite, J Control Release, 128: 142-148, 2008. 3. Preparation of porous bioceramics using reverse thermo-responsive hydrogels in combination with rhBMP-2 carriers: In Vitro and In Vivo evaluation, J Mechanl Behav Biomed Mater, 27:64-76, 2013. 4. Local delivery of controlled-release simvastatin\/PLGA\/HAp microspheres enhances bone repair, Internat J Nanomed, 8:3895-3905, (2013) My personal experience participating in academic research at the Kaohsiung Medical University Bone Research Center includes: conducting three phases of academic research (currently running for 11 years), establishing mechanisms for industry-academia collaboration, intellectual property applications, and technology transfer, pooling resources, and achieving the goal of translational medicine. In 2015, one technology transfer was completed to Ho-Kang Biotechnology Co., Ltd. (a non-exclusive technology transfer fee of NT$6 million, with my contribution at 25%).<\/li>\n
      • The project leader’s integrated development project on laminated ceramic technology under the Ministry of Science and Technology. The results of 2016-2017 have demonstrated the potential for clinical application in commercialization. This technology is also being developed in collaboration with the National Applied Research Laboratories’ Instrumentation Technology Center to develop a dedicated 3D bioprinting machine for clinical application testing and validation in 2018-2019. In the first quarter of 2019, there are already collaborating companies discussing industry-academia collaboration to develop bone material products, with the expectation of technology transfer to domestic medical device companies or matchmaking with venture capital firms for startups. Ultimately, it is hoped that this technology will benefit the health of patients. (Related industry-academia collaboration projects include: 1. Development of bone contact areas for cartilage plugs using negative temperature-sensitive hydrogel-assisted 3D printing bioceramic technology, Kaohsiung Medical University \u2013 Bosheng Biomedical Co., Ltd. Industry-academia collaboration project. 2. Physicochemical analysis project of gradient color all-ceramic materials, Kaohsiung Medical University \u2013 Palmwood Co., Ltd. Industry-academia collaboration project, 2016\/06\/16 to 2017\/01\/30 (S-S104021 450,000 NT). (Principal Investigator) 3. Efficacy evaluation of sustained-release bone growth factor carriers, Kaohsiung Medical University \u2013 Bosheng Biomedical Co., Ltd. Industry-academia collaboration project, 2016\/09\/01 to 2017\/04\/30 (1,200,000 NT). (Co-Principal Investigator)<\/li>\n
      • The project leader, Yu Guoke, developed a negative temperature-sensitive hydrogel system and created a new process for “applying negative temperature-sensitive hydrogel to prepare porous bioceramic scaffolds.” This resulted in patents from the Republic of China and the United States (Republic of China Patent No.: I411595 and US Patent No.: US 8940203 B2). A paper was published in the international journal *J Mech Behav Biomed Mater*, 27:64-76, 2013. Furthermore, utilizing the uniform pressure shrinkage properties of this negative temperature-sensitive hydrogel, a molding technology for three-dimensional lamination ceramic extrusion printing was developed by mixing it with ceramic powder. Since 2017, this technology has successively obtained patents in Taiwan (application number 105139918) and major patents in various countries worldwide (USA, China, Europe, Japan). This technology has also been published in the international journal *Ceramics International*, 47, 5464-5476. (2021); In 2016, the team received the 13th National Innovation Award and the Academic Innovation Award (Innovative Ceramic Lamination Manufacturing Technology, National Biotechnology and Medical Industry Promotion Association, 105\/12\/22); in 2018, the team received the Ministry of Science and Technology-Taiwan Innovative Technology Expo-Innovation Invention Award and second place in the Entrepreneurship Group of the 7th Campus Entrepreneurship Competition of Kaohsiung Medical University. In 2019, the team further developed the process technology for photocuring negative temperature-sensitive water-based ceramic slurry, obtaining more precise and complex ceramic structural components, and obtaining a Republic of China patent and applying for a PCT patent. This photocuring technology is also part of an industry-academia collaboration project with the listed company Bosheng Biomedical (totaling NT$2.8 million), with further cooperation pending. Timing. The related photopolymerization technology also won the 16th National Innovation Award for Academic and Research Innovation Excellence in 2019 and the 17th National Innovation Award in 2020. The team also won the Outstanding Entrepreneurship Award in the 2020 FITI Competition (109-2nd cohort) held by the Ministry of Science and Technology, and established Pinyi Medical Technology Startup Company in May 2021. Subsequently, in November 2021 and November 2022, they received funding from the National Science Council’s Industry Foresight – Applied Research Seedling Project for “Laminated Manufacturing of 3D Bioceramic Skull Drilling Cap Bone Graft Substitutes”. (I)(II)\u201d. This technology should first be clinically validated using standardized, specialized 3D bone graft substitutes (such as drilled skull cap bone or wedge-shaped bone with a special angle in the high tibia) before it can be strategically deployed in the future blue ocean business model of customized and precise 3D bone graft medical devices and the development of emerging medical industries. Kaohsiung Medical University completed a technology licensing agreement worth 20 million NTD to Pinyi Medical Technology Startup Company on September 23, 2023, and completed its first angel round of fundraising of 20 million NTD on May 10, 2024, to facilitate subsequent commercialization.<\/li>\n
      • Regarding the application of bio-hydraulic gel in the fields of 3D bioprinting and tissue regeneration, three related SCI papers have been published (J. Biol. Eng. ,17,74, 2023, Polymers, 14, 2003, 2022, Mater. Sci. Eng.: C, 124, 112072, (2021) The research project developed a three-dimensional biomimetic hybrid hydrogel mainly composed of hyaluronic acid methacryloyl and gelatin methacryloyl copolymers. Innovatively, it utilized inorganic crosslinking agents (acrylate functionalized nano-silica, acrylate functionalized reduction graphene oxide) and PEGDA to enhance the mechanical properties of the hybrid hydrogel and slow down its degradation rate in organisms. This novel hybrid hydrogel system is expected to enhance cartilage differentiation and repair cartilage tissue. A patent layout for this hybrid bio-hydrogel system in cartilage regeneration was obtained (Republic of China Patent No.: 798084). Currently, the project leader is continuing to study the stability characteristics of photocurable bio-hydrogel systems in in vitro culture of stem cell phenotypes and their regulation of exosomes, as well as their application in the regeneration of soft and hard tissues.<\/li>\n<\/ul>\n
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        • \u570b\u79d1\u6703\u767c\u5c55\u51fa\u5fae\u7c73\u85e5\u7269\u8f09\u9ad4\u7cfb\u7d71(PLGA\/HAp microsphere)\u52a0\u5165\u9ad8\u91ab\u9aa8\u7814\u4e2d\u5fc3\u7684\u5408\u4f5c\u7684\u5b78\u754c \u79d1\u5c08\u8a08\u5283\uff0c\u5df2\u7372\u5f97 2 \u4ef6\u4e2d\u83ef\u6c11\u570b\u5c08\uf9dd\u8207 2 \u4ef6\u7f8e\u570b\u5c08\uf9dd\uff1a\u6b64\u85e5\u7269\u8f09\u9ad4\u53ef\u651c\u5e36\u6cb9\u6eb6\u6027\u85e5\u7269\uff0c\u672c\u5718\u968a\u59d4\u8a17\u53f0\u7063\u6771\u6d0b\u85e5\u5ee0\u9032\ufa08 GMP-like \u4e4b Simvastin\/PLGA\/HAp \u5fae\u7c73\u8907\u5408\u8f09\u9ad4\u88fd\u7a0b\u653e\u5927\u958b \u767c\uff0c\u4f7f\u5176\u5177\u6709\u5c40\u90e8\u7de9\u91cb\u5bf8\u9032\u9aa8\u751f\u9577 simvastatin \u7684\u7528\u9014\uff0c\u4e26\u65bc 104 \uf98e 9 \u6708\u8207\u548c\u5eb7\u751f\u6280\u80a1\u4efd\u6709 \u9650\u516c\u53f8\u9032\ufa08\u7522\u5b78\u5408\u4f5c\u8a08\u756b\u8207\u5168\u7a0b\u6280\u8f49\uf90a 650 \u842c\u3002\u6b64\u5916\u76f8\u95dc BMP-2\/HAp\/PLGA\u8f09\u9ad4\u5c08\u5229\uff0c\u4e5f\u65bc105\u5e74\u8207\u535a\u665f\u751f\u6280\u516c\u53f8\u9032\u884c\u7522\u5b78\u5408\u4f5c\u8a08\u756b\uff0c\u8a55\u4f30\u516c\u53f8\u4fc3\u9032\u9aa8\u751f\u9577OIF growth factor\u7522\u54c1\u7684\u7de9\u91cb\u88fd\u5291\u65bc\u5c0f\u9f20\u7684\u9aa8\u7652\u5408\u7642\u6548\uff0c\u7d50\u679c\u9664\u4e86\u5177\u6709\u7de9\u91cb\u7684\u80fd\u529b\u8207\u4fc3\u9032\u9aa8\u751f\u9577\u6548\u679c\u5916\u4e14\u7121\u767c\u708e\u53cd\u61c9\uff0c\u516c\u53f8\u6b63\u5728\u8a55\u4f30\u6280\u8f49\u9700\u6c42\u8207\u5f8c\u7e8c\u7684\u884d\u4f38\u5927\u52d5\u7269\u8a55\u4f30\u3002\u76f8\u95dc\u5b78\u8853\u8ad6\u6587\u6709\u56db\u7bc7( Optimized bone regeneration based on sustained release from three-dimensional fibrous PLGA\/HAp composite scaffolds loaded with BMP-2, Biotech & Bioeng, 99: 996-1006, 2008. 2. Controlled release carrier of BSA made by W\/O\/W emulsion method containing PLGA and hydroxyapatite, J Control Release, 128: 142-148, 2008. 3. Preparation of porous bioceramics using reverse thermo-responsive hydrogels in combination with rhBMP<\/em>–2<\/em> carriers: In Vitro<\/em> and In Vivo<\/em> evaluation, J Mechanl Behav Biomed Mater, 27:64-76, 2013. 4. Local delivery of controlled-release simvastatin\/PLGA\/HAp microspheres enhances bone repair, Internat J Nanomed, 8:3895-3905, 2013.) \u500b\u4eba\u53c3\u8207\u9ad8\u91ab\u9aa8\u7814\u4e2d\u5fc3\u5728\u5b78\u754c\u79d1\u5c08\u7814\u7a76\u7d93\u9a57\u4e2d\uff1a\u9032\ufa08\uf9ba\u4e09\u671f\u5b78\u754c\u79d1\u5c08\u7814\u7a76(\u81f3\u76ee\u524d\u5df2\u57f7\ufa08\u517111 \uf98e)\uff0c\u5efa\uf9f7\uf9ba\u7522\u5b78\u5408\u4f5c\u3001\u667a\u8ca1\u7533\u8acb\u3001\u6280\u8853\u8f49\u79fb\u7b49\u7814\u767c\u7522\u54c1\u7684\u6a5f\u5236\uff0c\u532f\u96c6\uf9ba\u80fd\uf97e\u4ee5\u53ca\uf918\u5be6\uf9ba\u8f49\u8b6f\u91ab\u5b78\u7684\u76ee\u6a19\u3002104\u5e74\u5df2\u5b8c\u62101 \u4ef6\u6280\u8853\u79fb\u8f49\u7d66\u548c\u5eb7\u751f\u6280\u516c\u53f8(\u5168\u671f\u975e\u5c08\u5c6c\u6388\u6b0a\u6280\u8f49\u91d1600\u842c\uff0c\u672c\u4eba\u8ca2\u737b\u5ea625%)\u3002<\/li>\n
        • \u4e3b\u6301\u4eba\u65bc\u79d1\u6280\u90e8\u7a4d\u5c64\u88fd\u9020\u9676\u74f7\u6280\u8853\u958b\u767c\u7684\u6574\u5408\u578b\u8a08\u756b\u6210\u679c\uff0c105-106\u5169\u5e74\u7684\u6210\u679c\u5df2\u8b49\u660e\u6280\u8853\u5546\u54c1\u5316\u7684\u81e8\u5e8a\u61c9\u7528\u6f5b\u529b\uff0c\u672c\u6280\u8853\u4e5f\u8207\u570b\u7814\u9662\u5100\u79d1\u4e2d\u5fc3\u5408\u4f5c\uff0c\u958b\u767c\u5c08\u5c6c\u76843D\u751f\u7269\u5217\u5370\u6a5f\u53f0\uff0c\u4ee5\u5229107-108\u5e74\u9032\u884c\u81e8\u5e8a\u61c9\u7528\u7684\u4f7f\u7528\u7684\u6e2c\u8a66\u8207\u9a57\u8b49\u3002108\u7b2c\u4e00\u5b63\u76ee\u524d\u5df2\u6709\u5408\u4f5c\u5ee0\u5546\u6d3d\u8ac7\u7522\u5b78\u5408\u4f5c\u958b\u767c\u516c\u53f8\u7684\u9aa8\u6750\u7522\u54c1\uff0c\u9810\u671f\u53ef\u6280\u8f49\u7d66\u570b\u5167\u91ab\u6750\u516c\u53f8\u6216\u8207\u5275\u6295\u9032\u884c\u65b0\u5275\u516c\u53f8\u7684\u5a92\u5408\u3002\u6700\u7d42\u671f\u671b\u6b64\u4e00\u6280\u8853\u53ef\u9020\u798f\u50b7\u60a3\u7684\u5065\u5eb7\u3002(\u76f8\u95dc\u7522\u5b78\u8a08\u756b\u67091:\u8ca0\u6eab\u611f\u6c34\u81a0\u8f14\u52a93D\u5217\u5370\u751f\u7269\u9676\u74f7\u6280\u8853\u958b\u767c\u8edf\u9aa8\u6813\u7684\u9aa8\u63a5\u89f8\u5340\u57df, \u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\uff0d\u535a\u665f\u751f\u91ab\u80a1\u4efd\u6709\u9650\u516c\u53f8 \u7522\u5b78\u5408\u4f5c\u8a08\u756b\u3002 \u6f38\u5c64\u8272\u7cfb\u4e4b\u5168\u74f7\u6750\u6599\u7269\u5316\u6027\u5206\u6790\u8a08\u756b, \u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\uff0d\u68d5\u61cb\u516c\u53f8\u7522\u5b78\u5408\u4f5c\u8a08\u756b, 2016\/06\/16\u81f32017\/01\/30 (S-S104021 450,000 NT)\u3002(\u4e3b\u6301\u4eba) 3. \u7de9\u91cb\u578b\u9aa8\u751f\u9577\u56e0\u5b50\u8f09\u9ad4\u4e4b\u78ba\u6548\u8a55\u4f30, \u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\uff0d\u535a\u665f\u751f\u91ab\u7522\u5b78\u5408\u4f5c\u8a08\u756b, 2016\/09\/01\u81f32017\/04\/30 (1,200,000 NT)\u3002(\u5171\u540c\u4e3b\u6301\u4eba)<\/li>\n
        • \u4e3b\u6301\u4eba\u65bc\u570b\u79d1\u6703\u8a08\u756b\u767c\u5c55\u51fa\u8ca0\u6eab\u611f\u6c34\u81a0\u7cfb\u7d71\u7814\u88fd\u51fa\u4ee5\u201d\u8ca0\u6eab\u611f\u6c34\u81a0\u61c9\u7528\u5728\u88fd\u5099\u591a\u5b54\u6027\u751f\u7269\u9676\u74f7\u652f\u67b6\u201d\u7684\u65b0\u88fd\u7a0b\u3002\u7372\u5f97\u4e2d\u83ef\u6c11\u570b\u5c08\uf9dd\u8207\u7f8e\u570b\u5c08\uf9dd(\u4e2d\u83ef\u6c11\u570b\u5c08\uf9dd\u865f\uff1aI411595 \u8207\u7f8e\u570b\u5c08\uf9dd\u865f\uff1aUS 8940203 B2)\u3002102 \uf98e\u767c\u8868\u4e00\u7bc7\u570b\u969b\u671f\u520a: J Mech Behav Biomed Mater, 27:64-76, 2013\u3002\u6b64\u5916\uff0c\u4e5f\u904b\u7528\u767c\u5c55\u6b64\u8ca0\u6eab\u611f\u6c34\u81a0\u5747\u58d3\u6536\u7e2e\u7684\u7279\u6027\uff0c\u6df7\u5408\u9676\u74f7\u7c89\u672b\u9032\ufa08\u4e09\u7dad\u7a4d\u5c64\u9676\u74f7\u64e0\u51fa\uf99c\u5370\u7684\u6210\u578b\u6280\u8853\u958b\u767c\uff0c\u4e26\u65bc2017\u5e74\u8d77\u9678\u7e8c\u7372\u5f97\u53f0\u7063\u5c08\u5229(\u7533\u8acb\u865f105139918)\u8207\u5168\u7403\u91cd\u8981\u5404\u570b\u5c08\u5229(\u7f8e\u570b\u3001\u4e2d\u570b\u3001\u6b50\u6d32\u3001\u65e5\u672c)\u3002\u672c\u6280\u8853\u9664\u767c\u8868\u4e00\u7bc7\u7a4d\u5c64\u88fd\u90203D\u9676\u74f7\u7684\u570b\u969b\u671f\u520a(Ceramics International, 47, 5464-5476, 2021)\uff1b2016\u5e74\u7372\u5f97\u7b2c\u5341\u4e09\u5c46\u570b\u5bb6\u65b0\u5275\u734e\u3001\u5b78\u7814\u65b0\u5275\u734e(\u5275\u65b0\u9676\u74f7\u7a4d\u5c64\u88fd\u9020\u6280\u8853, \u793e\u5718\u6cd5\u4eba\u570b\u5bb6\u751f\u6280\u91ab\u7642\u7522\u696d\u7b56\u9032\u6703, 105\/12\/22)\u30012018\u5e74\u7372\u5f97\u79d1\u6280\u90e8-\u53f0\u7063\u5275\u65b0\u6280\u8853\u535a\u89bd\u6703-\u5275\u65b0\u767c\u660e\u734e\u8207\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u7b2c\u4e03\u5c46\u6821\u5712\u5275\u696d\u7af6\u8cfd\u5275\u696d\u7d44\u7b2c\u4e8c\u540d\u30022019\u5e74\u5718\u968a\u66f4\u9032\u4e00\u6b65\u958b\u767c\u5149\u56fa\u5316\u8ca0\u6eab\u611f\u6c34\u81a0\u9676\u74f7\u6f3f\u9ad4\u7684\u88fd\u7a0b\u6280\u8853\uff0c\u7372\u5f97\u66f4\u7cbe\u5bc6\u8207\u8907\u96dc\u7684\u9676\u74f7\u7d50\u69cb\u5143\u4ef6\uff0c\u4e26\u53d6\u5f97\u4e2d\u83ef\u6c11\u570b\u5c08\u5229\u8207\u7533\u8acbPCT\u5c08\u5229\u3002\u6b64\u5149\u56fa\u5316\u6280\u8853\u4e5f\u8207\u4e0a\u6ac3\u516c\u53f8\u535a\u665f\u751f\u91ab\u9032\u884c\u7522\u5b78\u5408\u4f5c\u8a08\u756b(\u5171\u8a08\u9054280\u842c)\uff0c\u5f85\u5f8c\u7e8c\u5408\u4f5c\u6642\u6a5f\u3002\u76f8\u95dc\u5149\u56fa\u5316\u6280\u8853\u4ea6\u7372\u5f972019\u5e74\u7b2c\u5341\u516d\u30012020\u5e74\u7b2c\u5341\u4e03\u5c46\u570b\u5bb6\u65b0\u5275\u734e\u4e4b\u5b78\u7814\u65b0\u5275\u7cbe\u9032\u734e\u3002\u5718\u968a\u4e26\u65bc2020\u5e74\u69ae\u7372\u79d1\u6280\u90e8109-2\u671fFITI\u7af6\u8cfd\u69ae\u7372\u5275\u696d\u5091\u51fa\u734e\uff0c\u4e26\u65bc2021\u5e745\u6708\u6210\u7acb\u54c1\u91ab\u751f\u6280\u65b0\u5275\u516c\u53f8\u3002\u63a5\u8457\u5206\u57282021\u5e7411\u6708\u82072022\u5e7411\u6708\u7372\u5f97\u570b\u79d1\u6703\u7522\u696d\u524d\u77bb-\u61c9\u7528\u578b\u7814\u7a76\u80b2\u82d7\u5c08\u6848\u8a08\u756b\u4e4b\u300c\u7a4d\u5c64\u88fd\u90203D\u751f\u7269\u9676\u74f7\u9871\u9aa8\u947d\u5b54\u84cb\u9aa8\u79fb\u690d\u66ff\u4ee3\u7269 (I)(II)\u300d\u3002\u6b64\u6280\u8853\u5b9c\u5148\u4ee5\u6a19\u6e96\u5316\u7279\u6b8a3D\u9aa8\u79fb\u690d\u66ff\u4ee3\u7269\u5728\u81e8\u5e8a\u7372\u5f97\u9a57\u8b49(\u5982 \u982d\u84cb\u9aa8\u947d\u5b54\u84cb\u9aa8\u6750\u6216\u9ad8\u4f4d\u811b\u9aa8\u7279\u6b8a\u89d2\u5ea6\u6954\u5f62\u9aa8\u6750)\uff0c\u65b9\u53ef\u5728\u672a\u4f86\u5ba2\u88fd\u5316\u8207\u7cbe\u6e96\u53163D\u9aa8\u79fb\u690d\u91ab\u6750\u7684\u85cd\u6d77\u5546\u696d\u6a21\u5f0f\u4e4b\u9032\u884c\u7b56\uf976\u6027\u5e03\u5c40\u53ca\u65b0\u8208\u91ab\u7642\u7522\u696d\u767c\u5c55\u3002\u9ad8\u91ab\u5927\u65bc2023\u5e749\u670823\u65e5\u5b8c\u62102000\u842c\u6280\u8853\u4f5c\u50f9\u6388\u6b0a\u65bc\u54c1\u91ab\u751f\u6280\u65b0\u5275\u516c\u53f8\u3001113\u5e745\u670810\u65e5\u5b8c\u6210\u7b2c\u4e00\u6b21\u5929\u4f7f\u502b\u52df\u8cc72,000\u842c\u5143\uff0c\u4ee5\u5229\u5f8c\u7e8c\u5546\u54c1\u5316\u3002<\/li>\n
        • \u6709\u95dc\u751f\u7269\u6c34\u81a0\u61c9\u7528\u57283D\u751f\u7269\u5217\u5370\u8207\u7d44\u7e54\u518d\u751f\u7684\u9818\u57df\uff0c\u76f8\u95dcSCI paper\u5df2\u767c\u88683\u7bc7( Biol. Eng. ,17,74, 2023, Polymers, 14, 2003, 2022, Mater. Sci. Eng.: C, 124, 112072, 2021)\uff0c\u5176\u4e2d\u7814\u88fd\u4e09\u7dad\u4eff\u751f\u6df7\u5408\u6c34\u51dd\u81a0\u4e3b\u8981\u7531hyaluronic acid methacryloyl\u8207gelatin methacryloyl\u5171\u805a\u7d44\u6210\uff0c\u4e26\u5275\u65b0\u7a4e\u904b\u7528\u7121\u6a5f\u4ea4\u806f\u5291(acrylate functionalized nano-silica\u3001acrylate functionalized reduction graphene oxide)\u8207PEGDA\u7b49\u589e\u5f37\u6df7\u5408\u6c34\u51dd\u81a0\u7684\u6a5f\u68b0\u6027\u80fd\u4e26\u6e1b\u7de9\u751f\u7269\u9ad4\u7684\u964d\u89e3\u901f\u5ea6\uff0c\u4f7f\u9019\u7a2e\u65b0\u578b\u7684\u6df7\u5408\u6c34\u51dd\u81a0\u7cfb\u7d71\u6709\u671b\u589e\u5f37\u8edf\u9aa8\u5206\u5316\u548c\u4fee\u5fa9\u8edf\u9aa8\u7d44\u7e54\u3002\u4e26\u7372\u5f97\u6b64\u6df7\u5408\u751f\u7269\u6c34\u81a0\u7cfb\u7d71\u5728\u8edf\u9aa8\u751f\u6210\u7684\u5c08\u5229\u4f48\u5c40(\u4e2d\u83ef\u6c11\u570b\u5c08\u5229\u865f\uff1a798084)\u3002\u76ee\u524d\u4e3b\u6301\u4eba\u6301\u7e8c\u7814\u7a76\u5149\u56fa\u5316\u751f\u7269\u6c34\u51dd\u81a0\u7cfb\u7d71\u5c0d\u65bc\u5e79\u7d30\u80dephenotype\u9ad4\u5916\u57f9\u990a\u7684\u7a69\u5b9a\u6027\u7279\u6027\u8207\u5176\u5916\u6ccc\u9ad4\u7684\u8abf\u63a7\u5206\u6790\uff0c\u4e26\u65bc\u8edf\u786c\u7d44\u7e54\u518d\u751f\u7684\u7814\u7a76\u3002<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

          Research Interests(\u7814\u7a76\u9818\u57df) Design and fabrication of scaf … \u95b1\u8b80\u5168\u6587 Research(\u7814\u7a76\u5167\u5bb9)<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":20,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_exactmetrics_skip_tracking":false,"footnotes":""},"class_list":["post-34","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/wp.kmu.edu.tw\/ckwang\/wp-json\/wp\/v2\/pages\/34","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.kmu.edu.tw\/ckwang\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/wp.kmu.edu.tw\/ckwang\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/ckwang\/wp-json\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/ckwang\/wp-json\/wp\/v2\/comments?post=34"}],"version-history":[{"count":12,"href":"https:\/\/wp.kmu.edu.tw\/ckwang\/wp-json\/wp\/v2\/pages\/34\/revisions"}],"predecessor-version":[{"id":170,"href":"https:\/\/wp.kmu.edu.tw\/ckwang\/wp-json\/wp\/v2\/pages\/34\/revisions\/170"}],"wp:attachment":[{"href":"https:\/\/wp.kmu.edu.tw\/ckwang\/wp-json\/wp\/v2\/media?parent=34"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}