{"id":1022,"date":"2013-02-23T14:07:59","date_gmt":"2013-02-23T06:07:59","guid":{"rendered":"http:\/\/wp.kmu.edu.tw\/rd\/?p=1022"},"modified":"2013-03-05T11:54:47","modified_gmt":"2013-03-05T03:54:47","slug":"%e7%a0%94%e7%a9%b6%e6%96%b0%e7%9f%a5-4","status":"publish","type":"post","link":"https:\/\/wp.kmu.edu.tw\/rd\/archives\/1022","title":{"rendered":"\u7814\u7a76\u65b0\u77e5"},"content":{"rendered":"<p style=\"text-align: right\"><a href=\"http:\/\/wp.kmu.edu.tw\/rd\/archives\/1037\">\u56de\u7b2c0006\u671f\u4e3b\u9801<\/a><\/p>\n<h1>\u4e00\u3001\u7814\u7a76\u65b0\u77e5<\/h1>\n<p><a name=\"ResNew1\"><\/a><\/p>\n<ul>\n<li>\n<h1>OTUD7B controls non-canonical NF-\u03baB activation through deubiquitination of TRAF3(\u6797\u82f1\u52a9\u526f\u6559\u6388\u6458\u8b6f)<\/h1>\n<p>Hu H, Brittain GC, Chang JH, Puebla-Osorio N, Jin J, Zal A, Xiao Y, Cheng X, Chang M, Fu YX, Zal T, Zhu C, Sun SC. Nature. 2013 Jan 20. doi: 10.1038\/nature11831. [Epub ahead of print]\n<p>NF-\u03baB\u53c3\u8207\u5169\u689d\u660e\u986f\u4e0d\u540c\u7684\u8a0a\u606f\u50b3\u905e\u8def\u5f91: canonical \u548cnon-canonical \u8a0a\u606f\u50b3\u905e\u8def\u5f91\u3002Canonical NF-\u03baB\u8a0a\u606f\u50b3\u905e\u8def\u5f91\u8207\u767c\u708e\u53cd\u61c9\u6709\u95dc(Cell Res. 2011;21: 86-102.)\uff1bnon-canonical NF-\u03baB\u8a0a\u606f\u50b3\u905e\u8def\u5f91\u53c3\u8207\u91cd\u8981\u7684\u751f\u7269\u529f\u80fd\u6709\u6dcb\u5df4\u5668\u5b98\u5f62\u6210\uff08lymphoid organogenesis\uff09\u3001B\u7d30\u80de\u7684\u529f\u80fd\u548c\u514d\u75ab\u7d30\u80de\u7684\u751f\u9577\u8207\u5b58\u6d3b\u3002 Non-canonical NF-\u03baB \u8a0a\u606f\u50b3\u905e\u8def\u5f91\u7684\u6d3b\u5316\u8207\u6291\u5236\u86cb\u767d\u56e0\u5b50\u5373\u816b\u7624\u58de\u6b7b\u56e0\u53d7\u5668\u76f8\u95dc\u56e0\u5b503 (TNF receptor- associated factor 3; TRAF3) \u7684\u5206\u89e3\u6709\u95dc\uff0c\u4f46\u9019\u6a23\u7684\u8a0a\u606f\u50b3\u905e\u5982\u4f55\u88ab\u8abf\u63a7\u4ecd\u7136\u4e0d\u6e05\u695a\u3002\u672c\u7814\u7a76\u4e2d\u6211\u5011\u627e\u5230\u5206\u89e3\u6cdb\u86cb\u767d\u9175\u7d20\uff08deubiquitinase\uff09OTUD7B \u662fnon-canonical NF-\u03baB \u8a0a\u606f\u50b3\u905e\u8def\u5f91\u7684\u95dc\u9375\u8abf\u7bc0\u56e0\u5b50\u3002\u5728OTUD7B \u7f3a\u640d\u7684\u8001\u9f20\u4e26\u6c92\u6709\u767c\u73fecanonical NF-\u03baB \u8a0a\u606f\u50b3\u905e\u8def\u5f91\u7684\u6d3b\u5316\u53d7\u5230\u660e\u986f\u7684\u5f71\u97ff\uff0c\u4f46\u537b\u6703\u5f15\u8d77 non- canonical NF-\u03baB\u8a0a\u606f\u50b3\u905e\u8def\u5f91\u7684\u904e\u5ea6\u6d3b\u5316\u3002\u5728non-canonical NF-\u03baB \u8a0a\u606f\u50b3\u905e\u8def\u5f91\u7684\u523a\u6fc0\u53cd\u61c9\uff0c\u767c\u73feOTUD7B\u6703\u8207TRAF3\u7d50\u5408\u5c0e\u81f4\u5176\u53d7\u5230\u5206\u89e3\uff0c\u4f46\u6291\u5236TRAF3\u7684\u5206\u89e3\u53ef\u4ee5\u9810\u9632non-canonical NF-\u03baB\u8a0a\u606f\u50b3\u905e\u8def\u5f91\u4e0d\u6b63\u5e38\u7684\u6d3b\u5316\u3002\u56e0\u6b64OTUD7B\u7684\u7f3a\u640d\u5c0e\u81f4B\u7d30\u80de\u7684\u5c0d\u6297\u539f\u7684\u904e\u5ea6\u53cd\u61c9\u3001\u8178\u9ecf\u819c\u4e0a\u7684\u6dcb\u5df4\u6ffe\u6ce1\u589e\u751f\uff08lymphoid follicular hyperplasia\uff09\u548c\u5bbf\u4e3b\u5c0d\u8178\u9053\u56d3\u9f52\u67b8\u693d\u9178\u83cc\uff08Citrobacter rodentium\uff09\u75c5\u539f\u9632\u79a6\u80fd\u529b\u589e\u52a0\u3002\u9019\u4e9b\u767c\u73fe\u53ef\u4ee5\u5efa\u7acb\u8d77OTUD7B\u662f\u8a0a\u606f\u50b3\u905e\u8a98\u767cnon-canonical NF-\u03baB\u8def\u5f91\u6d3b\u5316\u7684\u91cd\u8981\u8abf\u7bc0\u56e0\u5b50\uff0c\u4e5f\u986f\u793a\u514d\u75ab\u8abf\u7bc0\u6a5f\u8f49\u8207OTUD7B\u53c3\u8207\u6cdb\u86cb\u767d\u7684\u6c34\u89e3\u548cTRAF3\u7684\u7a69\u5b9a\u6709\u95dc\u3002<\/li>\n<\/ul>\n<p style=\"text-align: right\"><a href=\"http:\/\/wp.kmu.edu.tw\/rd\/archives\/1037\">\u56de\u7b2c0006\u671f\u4e3b\u9801<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u56de\u7b2c0006\u671f\u4e3b\u9801 \u4e00\u3001\u7814\u7a76\u65b0\u77e5 OTUD7B controls non-can &hellip; <a href=\"https:\/\/wp.kmu.edu.tw\/rd\/archives\/1022\">\u95b1\u8b80\u5168\u6587 <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[14],"tags":[],"class_list":["post-1022","post","type-post","status-publish","format-standard","hentry","category-14"],"_links":{"self":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/1022","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/comments?post=1022"}],"version-history":[{"count":9,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/1022\/revisions"}],"predecessor-version":[{"id":1042,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/1022\/revisions\/1042"}],"wp:attachment":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/media?parent=1022"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/categories?post=1022"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/tags?post=1022"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}