{"id":1191,"date":"2013-03-28T11:05:25","date_gmt":"2013-03-28T03:05:25","guid":{"rendered":"http:\/\/wp.kmu.edu.tw\/rd\/?p=1191"},"modified":"2013-04-03T09:53:15","modified_gmt":"2013-04-03T01:53:15","slug":"%e7%a0%94%e7%a9%b6%e6%96%b0%e7%9f%a5-5","status":"publish","type":"post","link":"https:\/\/wp.kmu.edu.tw\/rd\/archives\/1191","title":{"rendered":"\u7814\u7a76\u65b0\u77e5"},"content":{"rendered":"<p style=\"text-align: right\"><a href=\"http:\/\/wp.kmu.edu.tw\/rd\/archives\/1206\">\u56de\u7b2c0007\u671f\u4e3b\u9801<\/a><\/p>\n<h1><span style=\"font-size: x-large;color: #c10000\">\u4e00\u3001\u7814\u7a76\u65b0\u77e5<\/span><\/h1>\n<p><a name=\"ResNew1\"><\/a><\/p>\n<ul>\n<li>\n<h1>Variant of TREM2 Associated with the Risk of Alzheimer\u2019s Disease<br \/>\n(\u738b\u59ff\u4e43\u6559\u6388\u3001\u8521\u6613\u73ca\u5c0f\u59d0\u6458\u8b6f)<\/h1>\n<p>N Engl J Med 2013;368:107-16.<br \/>\nTREM2 Variants in Alzheimer\u2019s Disease. N Engl J Med 2013;368:117-27.<br \/>\nGenetic Associations with Valvular Calcification and Aortic Stenosis. N Engl J Med 2013;368:503-12.<\/p>\n<p>\u7531\u4eba\u985e\u57fa\u56e0\u9ad4\u8a08\u756b(Human Genome Project\uff1bHGP)\u63ed\u958b\u4eba\u985e\u57fa\u56e0\u5716\u8b5c\u5b9a\u5e8f\u5f8c\uff0c\u70ba\u4e86\u5927\u91cf\u7814\u7a76\u57fa\u56e0\u7684\u55ae\u6838\u82f7\u9178\u591a\u578b\u6027\uff08Single Nucleotide Polymorphism\uff0c\u7c21\u7a31SNP\uff09\u8207\u75be\u75c5\u7684\u95dc\u4fc2\uff0c\u767c\u5c55\u4e86\u4eba\u985e\u5168\u57fa\u56e0\u7d44\u95dc\u806f\u6027\u7814\u7a76(genome-wide association study ; GWAS)\uff0c\u76ee\u7684\u8a66\u8457\u5f9e\u75be\u75c5\u65cf\u7fa4\u8207\u5065\u5eb7\u5c0d\u7167\u65cf\u7fa4\u4e2d\u627e\u51fa\u9ad8\u98a8\u96aa\u907a\u50b3\u6a19\u8a18\u7684\u57fa\u56e0SNPs\u8207\u75be\u75c5\u9593\u95dc\u806f\uff0c\u4e26\u96a8\u8457\u5168\u7403\u5b9a\u5e8f\u7684\u516c\u53f8\u5982:Illumina Genome analyzer\u3001Roche454 sequencer\u3001Life Technologies SOLiD\u7b49\u5927\u5ee0\u767c\u5c55\u51fa\u66f4\u5feb\u901f\u8207\u9ad8\u901a\u91cf\u7684\u5b9a\u5e8f\u65b9\u5f0f\u63ed\u958b\u4e86next-generation sequencing\u4e4b\u5e8f\u5e55\uff0c\u5176\u65b9\u5f0f\u5f9e\u5168\u7d44\u57fa\u56e0\u5b9a\u5e8f\u65b9\u5f0f\u5230\u5916\u986f\u5b50\u5b9a\u5e8f(exome sequencing)\u66f4\u52a0\u901f\u4e86\u7814\u7a76\u57fa\u56e0SNPs\u8207\u75be\u75c5\u767c\u751f\u7684\u95dc\u806f\u3002\u81ea\u7b2c\u4e00\u7bc7\u57282005\u5e74Science\u671f\u520a\u767c\u8868\u5e74\u9f61\u8207\u9ec3\u6591\u75c5\u8b8a\u7684GWAS\uff0c\u723e\u5f8c\u5728\u51a0\u5fc3\u75c5\u3001\u7b2c1\u30012\u578b\u7cd6\u5c3f\u75c5\u3001\u80a5\u80d6\u7b49\u6578\u767e\u7a2e\u75be\u75c5\u6db5\u84cb\u5c07\u8fd1\u4e00\u5343\u591a\u7bc7\u7684GWAS\u7814\u7a76\uff0c\u627e\u51fa\u8207\u75be\u75c5\u76f8\u95dc\u7684\u9ad8\u98a8\u96aa\u8b8a\u7570\u57fa\u56e0\u7684\u6a19\u8a18\uff0c\u5118\u7ba1\u96e2\u81e8\u5e8a\u904b\u7528\u4ecd\u6709\u4e00\u6bb5\u8def\uff0c\u4f46\u82e5\u80fd\u540c\u6642\u671d\u5411\u8f49\u8b6f\u529f\u80fd(Translation phase)\u767c\u5c55\u500b\u4eba\u5316\u65e9\u671f\u8a3a\u65b7\u7684\u6aa2\u9a57\u8207\u6cbb\u7642\u6676\u7247\u4ecd\u662f\u4e3b\u8981\u52aa\u529b\u7684\u65b9\u5411\u3002<\/p>\n<p>GWAS\u7814\u7a76\u6cd5\u672c\u8eab\u6709\u5176\u9650\u5236\uff0c\u5fc5\u9808\u907f\u514d\u5047\u967d\u6027\u7684\u7d50\u679c\u800c\u9020\u6210\u7684\u5047\u76f8\u95dc\uff0c\u4e14\u518d\u73fe\u6027\u5dee\uff0c\u76ee\u524d\u7d71\u8a08\u63a1\u7528Bonferroni P\u503c\u9054 10\u22127\uff0c\u624d\u5177\u986f\u8457\u610f\u7fa9\uff0c\u76f8\u5c0d\u4e0a\u5c31\u76f8\u7576\u6d88\u8017\u7814\u7a76\u6210\u672c\uff1b\u518d\u8005\u5927\u90e8\u5206\u6709\u8b8a\u7570\u7684\u6a19\u8a18\u5176\u75be\u75c5\u7684\u5371\u96aa\u52dd\u7b97\u503c(Odds ratio) \u5e73\u5747\u70ba1.33\u3002\u7d71\u5408\u5206\u6790\u6cd5(Meta-analysis)\u9700\u56b4\u8b39\u5730\u63a2\u8a0e\u7d71\u6574\u7684\u7814\u7a76\u4e2d\u662f\u5426\u5b58\u5728\u7570\u8cea\u6027(Heterogeneity)\u4ee5\u907f\u514d\u53d6\u6a23\u8aa4\u5dee\u8207\u520a\u767b\u504f\u5dee\uff08publication bias\uff09\uff0c\u800c\u5f97\u4e00\u500b\u6574\u9ad4\u7684effect size\u820795% CI (confidence intervals)\uff1b\u4eca\u5e742013\u81f3\u4eca\u4e09\u500b\u6708\u5167\u65b0\u82f1\u683c\u862d\u96dc\u8a8c\u5df2\u6709\u4e09\u7bc7\u8ad6\u6587\uff0c\u900f\u904e\u7d71\u5408\u5206\u6790\u6cd5(Meta-analysis)\u6574\u5408\u5176\u4ed6\u7684GWAS\u7814\u7a76\u7d50\u679c\uff0c\u63d0\u4f9b\u518d\u73fe\u6027\u7684\u89e3\u6c7a\u65b9\u5f0f\uff1b\u767c\u73feTREM2(rs75932628)\u7684\u8b8a\u7570(R47H) 2.83 (1.45\u20135.40)\u70ba\u7f79\u60a3\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u9ad8\u98a8\u96aa\u91cd\u8981\u6a19\u8a18\uff1bLipoprotein a (LPA) rs10455872 OR=2.05 (95%CI, 1.63-2.57, p=9.0\u00d710\u221210) \u70ba\u5fc3\u81df\u74e3\u819c\u9223\u5316\u548c\u4e3b\u52d5\u8108\u74e3\u72f9\u7a84\u7684\u91cd\u8981\u6a19\u8a18\u3002<\/li>\n<\/ul>\n<p style=\"text-align: right\"><a href=\"http:\/\/wp.kmu.edu.tw\/rd\/archives\/1206\">\u56de\u7b2c0007\u671f\u4e3b\u9801<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u56de\u7b2c0007\u671f\u4e3b\u9801 \u4e00\u3001\u7814\u7a76\u65b0\u77e5 Variant of TREM2 Associ &hellip; <a href=\"https:\/\/wp.kmu.edu.tw\/rd\/archives\/1191\">\u95b1\u8b80\u5168\u6587 <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[15],"tags":[],"class_list":["post-1191","post","type-post","status-publish","format-standard","hentry","category-15"],"_links":{"self":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/1191","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/comments?post=1191"}],"version-history":[{"count":14,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/1191\/revisions"}],"predecessor-version":[{"id":1292,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/1191\/revisions\/1292"}],"wp:attachment":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/media?parent=1191"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/categories?post=1191"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/tags?post=1191"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}