{"id":1341,"date":"2013-04-26T09:29:28","date_gmt":"2013-04-26T01:29:28","guid":{"rendered":"http:\/\/wp.kmu.edu.tw\/rd\/?p=1341"},"modified":"2013-05-06T14:16:14","modified_gmt":"2013-05-06T06:16:14","slug":"%e7%a0%94%e7%a9%b6%e6%96%b0%e7%9f%a5-7","status":"publish","type":"post","link":"https:\/\/wp.kmu.edu.tw\/rd\/archives\/1341","title":{"rendered":"\u7814\u7a76\u65b0\u77e5"},"content":{"rendered":"<p style=\"text-align: right\"><a href=\"http:\/\/wp.kmu.edu.tw\/rd\/archives\/1339\">\u56de\u7b2c0008\u671f\u4e3b\u9801<\/a><\/p>\n<h1><span style=\"font-size: x-large;color: #c10000\">\u4e00\u3001\u7814\u7a76\u65b0\u77e5<\/span><\/h1>\n<p><a name=\"ResNew1\"><\/a><\/p>\n<ul>\n<ul>\n<li>\n<h1><span style=\"color: #0000ff\">GNMT (\u82f7\u6c28\u9178-\u6c2e-\u7532\u57fa\u8f49\u79fb\u9176, glycine N-methyltransferase) \u5728\u53bb\u6bd2\u8def\u5f91\u53ca\u809d\u764c\u884c\u6210\u6240\u626e\u6f14\u7684\u89d2\u8272<br \/>\n\uff08\u9673\u5b9c\u6c11\u526f\u6821\u9577\uff0c\u984f\u5609\u5b8f\u535a\u58eb\u6458\u8b6f\uff09<\/span><\/h1>\n<p>The Multi-functional roles of GNMT in toxicology and cancer. Toxicol Appl Pharmacol, 266:67-75, 2013.<\/p>\n<p>\u82f7\u6c28\u9178-\u6c2e-\u7532\u57fa\u8f49\u79fb\u9176\uff08EC 2.1.1.20\uff0cGNMT\uff09\u5c07\u82f7\u6c28\u9178\u8207SAM\u50ac\u5316\u5f62\u6210\u808c\u6c28\u9178\u3002 GNMT\u5728\u809d\u80de\u8cea\u6eb6\u81a0\u4e2d\u662f\u4e00\u7a2e\u8c50\u5bcc\u7684\u9176\uff0c\u5927\u7d04\u662f\u4f54\u4e86\u809d\u81df\u4e2d0.9\uff05\u81f33\uff05\u7684\u53ef\u6eb6\u6027\u86cb\u767d\u8cea\u3002GNMT\u4e5f\u662f\u4e00\u500b\u809d\u81df\u4e2d\u4e3b\u8981\u7684\u8449\u9178\u7d50\u5408\u86cb\u767d\u8cea\uff0cGNMT\u6703\u82075 -\u7532\u57fa\u56db\u6c2b\u8449\u9178\u7d50\u5408\uff0c\u4e26\u96a8\u5f8c\u88ab\u5176\u6291\u5236\u3002\u9664\u4e86\u7532\u57fa\u8f49\u79fb\u9176\u6d3b\u6027\uff0cRaha\u7b49\u4eba\uff0c\u767c\u73fe4S\u591a\u74b0\u82b3\u9999\u65cf\u78b3\u6c2b\u5316\u5408\u7269\uff08PAH\uff09\u7684\u7d50\u5408\u86cb\u767d\u5373\u70baGNMT\u3002\u8d8a\u4f86\u8d8a\u591a\u7684\u8b49\u64da\u986f\u793aGNMT\u662f\u4e00\u500b\u5177\u6709\u591a\u500b\u529f\u80fd\u89d2\u8272\u7684\u86cb\u767d\u3002\u6211\u5011\u8a8d\u70baGNMT\u662fmoonlighting\u86cb\u767d\u7684\u4e00\u500b\u4f8b\u5b50\u3002 GNMT\u80fd\u85c9\u7531\u5176\u78f7\u9178\u5316\u72c0\u614b\u7684\u6539\u8b8a\uff0c\u5f9e\u800c\u6539\u8b8a\u86cb\u767d\u5167\u5b50\u55ae\u5143\u914d\u7f6e\u7684\u5207\u63db\uff0c\u5c07\u5176\u529f\u80fd\u7531\u7532\u57fa\u8f49\u79fb\u9176\u4ee3\u8b1d\u9176\u8f49\u63db\u62104S PAH\u3002GNMT\u900f\u904e\u6539\u8b8a\u7d30\u80de\u5167\u7684\u4f4d\u7f6e\uff0c\u5f9e\u7d30\u80de\u8cea\u8f49\u79fb\u81f3\u7d30\u80de\u6838\uff0cGNMT\u6709\u53ef\u80fd\u4f5c\u70ba\u4e00\u7a2e\u8f49\u9304\u8f14\u52a9\u56e0\u5b50\uff0c\u8abf\u7bc0\u89e3\u6bd2\uff08\u548c\/\u6216\u5176\u4ed6\u76ee\u6a19\uff09\u57fa\u56e0\u7684\u8868\u9054\u3002\u6b64\u5916\uff0c\u901a\u904e\u6539\u8b8a\u5728\u5176\u7d50\u5408\u7684\u86cb\u767d\uff0cGNMT\u80fd\u5920\u53c3\u8207\u7d30\u80de\u5167\u7684\u4fe1\u865f\u50b3\u905e\uff0c\u5982mTOR\u8a0a\u606f\u50b3\u5c0e\u9014\u5f91\u53ca\u5176\u4ed6\u7d30\u80de\u5167\u7684\u53cd\u61c9\uff0c\u4f8b\u5982\u81bd\u56fa\u9187\u7684\u52d5\u614b\u5e73\u8861\u548c\u7d30\u80de\u9031\u671f\u8abf\u63a7\u3002\u6700\u8fd1\u7684\u7814\u7a76\u9084\u767c\u73fe\uff1aa\uff09\u5728GNMT\u57fa\u56e0\u5254\u9664\u5c0f\u9f20\u9ad4\u5167\uff0cNK\u7d30\u80de\u6703\u81ea\u767c\u6027\u7684\u6d3b\u5316\uff0cNK\u7d30\u80de\u8868\u9054\u66f4\u591a\u7684TRAIL\uff0c\u4e26\u5177\u6709\u5f37\u7684\u7d30\u80de\u6bd2\u6d3b\u6027\uff0c\u9019\u986f\u793a\u5b83\u5011\u6709\u52a9\u65bc\u7522\u751f\u5728\u809d\u81df\u767c\u708e\u7684\u74b0\u5883\uff1bb\uff09\u5728\u8f09\u8102\u86cb\u767dE\u7f3a\u5931\u7684\u5c0f\u9f20\u4e2d\uff0cGNMT\u7684\u7f3a\u4e4f\u6703\u52a0\u5287\u9ad8\u8102\u8840\u75c7\uff0c\u767c\u708e\u548c\u52d5\u8108\u7ca5\u6a23\u786c\u5316\u7684\u767c\u5c55\uff1b\u4ee5\u53cac\uff09GNMT\u5728\u7dad\u6301\u5927\u8166\u6b63\u5e38\u751f\u7406\u529f\u80fd\u6709\u91cd\u8981\u7684\u4f5c\u7528\u3002\u4e0a\u8ff0\u7814\u7a76\u7d50\u679c\u986f\u793aGNMT\u5728\u4e0d\u540c\u985e\u578b\u7684\u7d30\u80de\u4e2d\u6703\u6709\u4e0d\u540c\u7684\u89d2\u8272\u3002\u7d9c\u5408\u4f86\u8aaa\uff0c\u7531\u65bcGNMT\u7f3a\u4e4f\u548c\u809d\u81df\u75be\u75c5\u5982\u8102\u80aa\u809d\u7b49\u4e4b\u9593\u7684\u95dc\u806f\u6027\u4ee5\u53caGNMT\u5c0d\u65bc\u809d\u81df\u764c\u5316\u904e\u7a0b\u7684\u4fdd\u8b77\u4f5c\u7528\uff0c\u6211\u5011\u8a8d\u70ba\u5c0b\u627e\u8abf\u63a7GNMT\u57fa\u56e0\u8868\u73fe\u4e0b\u964d\u7684\u56e0\u5b50\uff0c\u4ee5\u53ca\u5c0b\u627e\u80fd\u5920\u63d0\u9ad8GNMT\u8868\u9054\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\uff0c\u5c07\u5c0d\u65bc\u7684\u809d\u81df\u75be\u75c5\uff0c\u5982\u8102\u80aa\u809d\u548c\u809d\u7d30\u80de\u764c\u7684\u9810\u9632\u548c\u6cbb\u7642\u7684\u767c\u5c55\u6709\u91cd\u8981\u7684\u52a9\u76ca\u3002<\/li>\n<\/ul>\n<\/ul>\n<p><img decoding=\"async\" alt=\"\" src=\"http:\/\/wp.kmu.edu.tw\/rd\/files\/2013\/05\/123.jpg\" \/><br \/>\n<span style=\"font-size: small\">\u57161. GNMT\u5728\u89e3\u6bd2\u8def\u5f91\u4e2d\u53ef\u80fd\u7684\u89d2\u8272\u3002<\/span><\/p>\n<ul>\u5916\u6e90\u6027\u5316\u5b78\u7269\u8cea\u5982\u82ef\u4e26[\u03b1]\u8298\uff08BaP\uff09\u548c\u9ec3\u9eb4\u6bd2\u7d20B1\uff08AFB1\uff09\u4e00\u65e6\u9032\u5165\u7d30\u80de\u8cea\u4e2d\uff0c\u4ed6\u5011\u6703\u88ab\u89e3\u6bd2\u8def\u5f91\u7684\u7b2c\u4e00\u968e\u6bb5\u7684\u9175\u7d20\u4ee3\u8b1d\u3002\u63a5\u8457\u7b2c\u4e8c\u968e\u6bb5\u7684\u9175\u7d20\u5c07\u9019\u4e9b\u4ee3\u8b1d\u7269\u9032\u4e00\u6b65\u7d50\u5408\u4e0a\u5f62\u6210\u4e86\u591a\u7a2e\u6eb6\u65bc\u6c34\u7684\u4ee3\u8b1d\u7522\u7269\u3002\u7136\u5f8c\u9019\u4e9b\u6c34\u6eb6\u6027\u8907\u5408\u7269\u518d\u88ab\u7b2c\u4e09\u968e\u6bb5\u7684\u9175\u7d20\u904b\u51fa\u7d30\u80de\u3002\u4f46\u662f\uff0c\u7b2c\u4e00\u968e\u6bb5\u9175\u7d20\u540c\u6642\u6703\u7522\u751f\u5177\u6709\u57fa\u56e0\u6bd2\u6027\u4ee3\u8b1d\u7522\u7269\uff0c\u5c0e\u81f4\u6025\u6027\u7d30\u80de\u6bd2\u6027\uff0c\u81f4\u7a81\u8b8a\u6027\u548c\u81f4\u764c\u6027\u3002\u5728GNMT\u7684\u5b58\u5728\u4e0b\uff08\u5716A\uff09\uff0c\u80fd\u66ab\u6642\u7d50\u5408\u82ef\u4e26\uff08a\uff09\u8298\uff08\u548c\/\u6216AFB1\uff09\uff0c\u9019\u6703\u964d\u4f4e\u9019\u4e9b\u5316\u5408\u7269\u7684\u6fc3\u5ea6\uff0c\u6e1b\u5c11\u6709\u57fa\u56e0\u6bd2\u6027\u4ee3\u8b1d\u7522\u7269\u7684\u7522\u751f\uff0c\u6e1b\u5c11\u9ad4\u5167DNA\u52a0\u5408\u7269\u7684\u5f62\u6210\u548c\u6291\u5236\u7d30\u80de\u6bd2\u6027\u548c\u81f4\u764c\u6027\u3002\u76f8\u53cd\u7684\uff0c\u5728\u7d30\u80de\u7f3a\u4e4fGNMT\u8868\u9054\u6642\uff08\u5716B\uff09\uff0c\u7b2c\u4e00\u968e\u6bb5\u9175\u7d20\u6703\u7522\u751f\u8a31\u591a\u7684\u57fa\u56e0\u6bd2\u6027\u4ee3\u8b1d\u7522\u7269\uff0c\u9019\u5c07\u5c0e\u81f4\u6025\u6027\u7d30\u80de\u6bd2\u6027\u3001\u81f4\u7a81\u8b8a\u548c\u81f4\u764c\u4f5c\u7528\u3002\u96d6\u7136GNMT\u5df2\u88ab\u8b49\u660e\u5b58\u5728\u65bc\u7d30\u80de\u6838\uff0c\u4f46\u5176\u6838\u5167\u529f\u80fd\u548c\u6838\u904b\u8f38\u7684\u6a5f\u5236\u4ecd\u4e0d\u6e05\u695a\uff0c\u4f46\u63a8\u6e2cGNMT\u53ef\u80fd\u4f5c\u70ba\u4e00\u7a2e\u8f14\u52a9\u56e0\u5b50\uff0c\u6709\u52a9\u65bc\u8abf\u7bc0\u89e3\u6bd2\u9014\u5f91\u57fa\u56e0\u7684\u8868\u9054\uff1b\u800cGNMT\u78f7\u9178\u5316\u7684\u4fee\u98fe\u5247\u5c0d\u65bc\u5176\u6838\u904b\u8f38\u626e\u6f14\u91cd\u8981\u89d2\u8272\u3002<\/ul>\n<p><img decoding=\"async\" alt=\"\" src=\"http:\/\/wp.kmu.edu.tw\/rd\/files\/2013\/05\/1231.jpg\" \/><br \/>\n<span style=\"font-size: small\">\u57162. GNMT\u53c3\u8207mTOR\u8a0a\u606f\u50b3\u5c0e\u9014\u5f91\u548c\u7d30\u80de\u9031\u671f\u8abf\u63a7\u3002<\/span><\/p>\n<ul>\u6700\u8fd1\u767c\u73fe\u4e86\u5169\u500bGNMT\u76f8\u4e92\u4f5c\u7528\u7684\u86cb\u767d\u3002\u4e00\u500b\u76f8\u4e92\u4f5c\u7528\u7684\u86cb\u767d\uff0c\u540d\u70baDEPTOR\uff0c\u5df2\u88ab\u8b49\u660e\u662f\u4e00\u500bmTOR\u6291\u88fd\u5291\u3002GNMT\u7684\u85c9\u7531\u963b\u65b7DEPTOR -mTOR\u7684\u4e4b\u9593\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u6d3b\u5316mTORC1\u7684\u4e0b\u6e38\u4fe1\u865f\u50b3\u905e\uff0c\u53e6\u5916\u4e00\u500bGNMT\u76f8\u4e92\u4f5c\u7528\u7684\u86cb\u767d\u662fNPC2\u3002\u9019\u662f\u53c3\u8207\u8abf\u7bc0\u81bd\u56fa\u9187\u904b\u9001\u7684\u4e00\u500b\u91cd\u8981\u56e0\u5b50\u3002GNMT\u85c9\u7531\u7d50\u5408NPC2\u8abf\u7bc0\u81bd\u56fa\u9187\u52d5\u614b\u5e73\u8861\u3002\u6709\u8da3\u7684\u662f\uff0c\u6700\u8fd1\u7684\u4e00\u9805\u7814\u7a76\u8868\u660e\uff0c\u81bd\u56fa\u9187\u904b\u9001\u9700\u8981\u9069\u7576\u7684\u6d3b\u5316mTOR\u7684\u8a0a\u606f\u50b3\u905e\u3002\u9019\u4e9b\u7d50\u679c\u986f\u793a\uff0cGNMT\u53ef\u80fd\u900f\u904e\u4e00\u4e9b\u4e0d\u540c\u7684\u6a5f\u5236\u5f71\u97ffmTORC1\u7684\u8a0a\u606f\u50b3\u905e\u3002\u6b64\u5916\uff0c\u900f\u904e\u8abf\u7bc0\u81bd\u56fa\u9187\u5e73\u8861\uff0cGNMT\u4e5f\u53ef\u80fd\u6703\u5f71\u97ff\u5176\u4ed6\u8a0a\u606f\u50b3\u905e\u8def\u5f91\u3002\u6b64\u5916\uff0c\u5118\u7ba1\u7684\u6a5f\u5236\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\uff0cGNMT\u7684\u904e\u5ea6\u8868\u9054\u5728\u809d\u764c\u7d30\u80de\u4e2d\u9020\u6210G2\/ M\u671f\u7684\u963b\u6eef\u3002\u7576\u9019\u7a2e\u60c5\u6cc1\u767c\u751f\u8207mTORC1\u7684\u6d3b\u5316\u540c\u6642\u767c\u751f\u6642\uff0c\u5c07\u5c0e\u81f4\u7d30\u80de\u8870\u8001\u3002\u56e0\u6b64\uff0c\u9019\u4e9b\u7814\u7a76\u7d50\u679c\u8868\u660e\uff0cGNMT\u80fd\u5920\u85c9\u7531\u8207\u4e0d\u540c\u4f46\u767d\u4ea4\u4e92\u4f5c\u7528\u53c3\u8207\u5404\u7a2e\u7d30\u80de\u5167\u53cd\u61c9\u3002<\/ul>\n<p style=\"text-align: right\"><a href=\"http:\/\/wp.kmu.edu.tw\/rd\/archives\/1339\">\u56de\u7b2c0008\u671f\u4e3b\u9801<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u56de\u7b2c0008\u671f\u4e3b\u9801 \u4e00\u3001\u7814\u7a76\u65b0\u77e5 GNMT (\u82f7\u6c28\u9178-\u6c2e-\u7532\u57fa\u8f49\u79fb\u9176, glyc &hellip; <a href=\"https:\/\/wp.kmu.edu.tw\/rd\/archives\/1341\">\u95b1\u8b80\u5168\u6587 <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[16],"tags":[],"class_list":["post-1341","post","type-post","status-publish","format-standard","hentry","category-16"],"_links":{"self":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/1341","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/comments?post=1341"}],"version-history":[{"count":10,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/1341\/revisions"}],"predecessor-version":[{"id":1470,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/1341\/revisions\/1470"}],"wp:attachment":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/media?parent=1341"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/categories?post=1341"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/tags?post=1341"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}