{"id":1614,"date":"2013-07-01T09:46:22","date_gmt":"2013-07-01T01:46:22","guid":{"rendered":"http:\/\/wp.kmu.edu.tw\/rd\/?p=1614"},"modified":"2013-07-05T09:39:42","modified_gmt":"2013-07-05T01:39:42","slug":"%e8%ab%96%e6%96%87%e7%a0%94%e7%a9%b6%e8%88%87%e5%88%86%e4%ba%ab-3","status":"publish","type":"post","link":"https:\/\/wp.kmu.edu.tw\/rd\/archives\/1614","title":{"rendered":"\u8ad6\u6587\u7814\u7a76\u8207\u5206\u4eab"},"content":{"rendered":"<p style=\"text-align: right\"><a href=\"http:\/\/wp.kmu.edu.tw\/rd\/archives\/1608\">\u56de\u7b2c0010\u671f\u4e3b\u9801<\/a><\/p>\n<h1><span style=\"font-size: x-large;color: #c10000\">\u4e8c\u3001\u8ad6\u6587\u8207\u7814\u7a76\u5206\u4eab<\/span><\/h1>\n<p><a name=\"PaperRes1\"><\/a><\/p>\n<h1><span style=\"color: #0000ff\">\uff08\u4e00\uff09\u8ad6\u6587<\/span><\/h1>\n<ul>\n<li><span style=\"color: #3366ff\">\u984c\u76ee\uff1a<strong><br \/>\nBetel-quid dependence and oral potentially malignant disorders in six Asian countries. <\/strong><\/span><br \/>\n<span style=\"color: #3366ff\"> \uff08\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u516c\u885b\u7cfb\u674e\u5efa\u5b8f\u6559\u6388\u63d0\u4f9b\u6458\u8981\uff09<\/span><\/li>\n<\/ul>\n<ul>\n<li>\u4f5c\u8005\uff1aLee CH, Ko AM, Yen CF, Chu KS, Gao YJ, Warnakulasuriya S, Sunarjo, Ibrahim SO, Zain RB, Patrick WK, Ko YC. Br J Psychiatry. 2012 Nov;201(5):383-91. Epub 2012 Sep 20.\u80cc\u666f:\u5118\u7ba1\u56bc\u98df\u6ab3\u6994\u5f15\u8d77\u4e4b\u591a\u91cd\u5065\u5eb7\u6548\u61c9\u5df2\u9010\u6f38\u77ad\u89e3\uff0c\u4f46\u6709\u95dc\u6ab3\u6994\u4f9d\u8cf4\u6027\u4e4b\u7cbe\u795e\u75c5\u5b78\u6240\u77e5\u4ecd\u7136\u5341\u5206\u6709\u9650\u3002\u76ee\u7684:\u63a2\u8a0e\u4e9e\u6d32\u516d\u500b\u65cf\u7fa4\u4e4b12\u500b\u6708\u6ab3\u6994\u4f9d\u8cf4\u6027\u4e4b\u76db\u884c\u7387\u53ca\u5176\u5c0d\u53e3\u8154\u6f5b\u5728\u60e1\u6027\u75c5\u8b8a\u4e4b\u6548\u61c9\u3002\u65b9\u6cd5\uff1a\u4ee5\u591a\u6b65\u9a5f\u96a8\u6a5f\u62bd\u6a23\u6cd5\u7531\u53f0\u7063\u3001\u4e2d\u570b\u5927\u9678\u3001\u5370\u5c3c\u3001\u99ac\u4f86\u897f\u4e9e\u3001\u65af\u91cc\u862d\u5361\u548c\u5c3c\u6cca\u723e\u7b496\u500b\u4e9e\u6d32\u570b\u5bb6\u4e2d\u62db\u52df8922\u540d\u53c3\u8207\u8005\u3002\u4f7f\u7528DSM-IV\u548cICD-10\u8a55\u4f30\u7269\u8cea\u6210\u766e\u6027\u4e4b\u65b9\u6cd5\u6e2c\u91cf\u53c3\u8207\u8005\u5c0d\u6ab3\u6994\u56bc\u98df\u4e4b\u4f9d\u8cf4\u6027\uff0c\u4e26\u65bd\u884c\u53e3\u8154\u6f5b\u5728\u60e1\u6027\u75c5\u8b8a\u4e4b\u53e3\u8154\u6aa2\u67e5\u3002\u7d50\u679c:6\u500b\u4e9e\u6d32\u570b\u5bb612\u500b\u6708\u6ab3\u6994\u4f9d\u8cf4\u6027\u4e4b\u76db\u884c\u7387\u70ba2.8-39.2\uff05\uff0c\u5176\u4e2d\uff0c20.9-99.6%\u4e4b\u6ab3\u6994\u4f7f\u7528\u8005\u5177\u6709\u56bc\u98df\u4f9d\u8cf4\u6027\u3002\u5728\u6771\u4e9e\u4e4b\u7fa4\u9ad4\u4e2d\uff0c\u6ab3\u6994\u4f9d\u8cf4\u6027\u76db\u884c\u65bc\u7537\u6027\uff0c\u4f46\u65bc\u6771\u5357\u4e9e\u4e4b\u7fa4\u9ad4\uff0c\u4f9d\u8cf4\u6027\u5247\u76db\u884c\u65bc\u5973\u6027\u3002\u300c\u9577\u6642\u9593\u56bc\u98df\u300d\u548c\u300c\u6e34\u671b\u300d\u5206\u5225\u70ba\u83ef\u4eba\u8207\u6771\u5357\/\u5357\u4e9e\u7fa4\u9ad4\u4e3b\u8981\u7684\u4f9d\u8cf4\u6027\u75c7\u72c0\uff0c\u800c\u5c3c\u6cca\u723e\u7fa4\u9ad4\u4e4b\u4f9d\u8cf4\u6027\u75c7\u72c0\u8868\u73fe\u65bc\u300c\u8010\u53d7\u6027\u300d\u548c\u300c\u6212\u65b7\u300d\u3002\u7814\u7a76\u767c\u73fe\uff0c\u6ab3\u6994\u4f9d\u8cf4\u6027\u4e4b\u76db\u884c\u7387\u8207\u5e74\u9f61\u3001\u6027\u5225\u3001\u53d7\u6559\u80b2\u5e74\u6578\u3001\u98f2\u9152\u3001\u5438\u83f8\u3001\u56bc\u98df\u542b\u83f8\u6ab3\u6994\u4ee5\u53ca\u6ab3\u6994\u7372\u53d6\u4e4b\u74b0\u5883\u53ef\u8fd1\u6027\u6709\u95dc\u30026\u500b\u4e9e\u6d32\u7fa4\u9ad4\u4e4b\u4e2d\uff0c\u6ab3\u6994\u4f9d\u8cf4\u6027\u8005(adjusted OR, 8.0-51.3)\u8207\u975e\u4f9d\u8cf4\u6027\u8005(adjusted OR, 4.5-5.9)\u5747\u8f03\u4e0d\u56bc\u98df\u8005\u5177\u6709\u986f\u8457\u8f03\u9ad8\u7684\u53e3\u8154\u524d\u764c\u75c7\u98a8\u96aa\uff0c\u4f46\u4f9d\u8cf4\u6027\u8005\u4e4b\u98a8\u96aa\u53c8\u9ad8\u65bc\u975e\u4f9d\u8cf4\u6027\u8005\u3002\u7d50\u8ad6:\u85c9\u7531\u63a2\u8a0e\u6ab3\u6994\u4f9d\u8cf4\u6027\u75c7\u72c0\u4e4b\u5dee\u7570\u6027\uff0c\u4ee5\u53ca\u500b\u9ad4\u8207\u74b0\u5883\u4e4b\u76f8\u95dc\u56e0\u7d20\uff0c\u6b64\u7814\u7a76\u63ed\u9732\u6ab3\u6994\u56bc\u98df\u65bc\u4e9e\u6d32\u7fa4\u9ad4\u4e4b\u7cbe\u795e\u75c5\u5b78\u554f\u984c\uff0c\u4e26\u8aaa\u660e\u6b64\u73fe\u8c61\u4e4b\u56b4\u91cd\u6027\uff0c\u56e0\u70ba\u6b64\u70ba\u4fb5\u8755\u6ab3\u6994\u56bc\u98df\u8005\u5065\u5eb7\uff0c\u5f15\u767c\u53e3\u8154\u6f5b\u5728\u60e1\u6027\u75c5\u8b8a\u4e4b\u96b1\u6027\u554f\u984c\u3002<\/li>\n<\/ul>\n<p><a name=\"PaperRes2\"><\/a><\/p>\n<h1><span style=\"color: #0000ff\">(\u4e8c)\u7814\u7a76\u5206\u4eab<\/span><\/h1>\n<ul>\n<li><span style=\"color: #3366ff\">\u984c\u76ee\uff1a<strong><br \/>\n\u5851\u5316\u5291\u7b49\u74b0\u5883\u6c61\u67d3\u7269\u8207\u82b3\u9999\u70f4\u53d7\u9ad4\u9593\u7684\u76f8\u4e92\u4f5c\u7528\u8abf\u63a7\u514d\u75ab\u8abf\u7bc0\u6027\u7d30\u80de\u53ca\u6d3b\u9ad4\u904e\u654f\u6027\u53cd\u61c9<\/strong><br \/>\n<span style=\"color: #3366ff\"> KMU &amp; NHRI report functional impacts of common environmental pollutants (including phthalates) and aryl hydrocarbon receptor on allergic and inflammatory responses<\/span><br \/>\n<span style=\"color: #3366ff\"> (\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u5c0f\u5152\u79d1\u6d2a\u5fd7\u8208\u6559\u6388\u3001\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u91ab\u5b78\u7814\u7a76\u6240\u5b6b\u662d\u73b2\u526f\u6559\u6388\u3001\u74b0\u5883\u885b\u751f\u8207\u8077\u696d\u91ab\u5b78\u7814\u7a76\u7d44\u66fe\u7b71\u837a\u535a\u58eb\u5f8c\u7814\u7a76\u54e1)<\/span><br \/>\n<\/span><\/li>\n<\/ul>\n<ul>\n<li>\u6c23\u5598\u53ca\u904e\u654f\u6027\u75be\u75c5\u4e00\u76f4\u662f\u53f0\u7063\u91cd\u8981\u7684\u74b0\u5883\u91ab\u5b78\u8207\u516c\u5171\u885b\u751f\u554f\u984c\u3002\u6839\u64da\u4e2d\u592e\u5065\u4fdd\u5c40\u516c\u5e03\u4e4b\u300c100\u5e74\u5168\u6c11\u5065\u5eb7\u4fdd\u96aa\u91ab\u7642\u7d71\u8a08\u5e74\u5831\u300d\u8cc7\u6599\u986f\u793a\uff0c2011\u5e74\u53f0\u7063\u5730\u5340\u56e0\u6c23\u5598\u75be\u75c5\u5c31\u8a3a\u4e4b\u4eba\u6578\u9ad8\u905489.2\u842c\u4eba\u4e4b\u591a\uff0c\u6bcf\u5e74\u6d88\u8017\u4e4b\u91ab\u7642\u8cbb\u7d0427\u5104\u5143\u3002\u5c24\u5176\u5728\u53f0\u7063\u65e5\u6f38\u983b\u7e41\u7684\u75c5\u6bd2\u611f\u67d3\u8207\u904e\u654f\u75be\u75c5\uff0c\u5df2\u662f\u75c5\u7ae5\u6c42\u8a3a\u6700\u91cd\u8981\u7684\u539f\u56e0\u3002\u76ee\u524d\u4e26\u4e0d\u77ad\u89e3\u6c23\u5598\u767c\u751f\u7387\u589e\u52a0\u7684\u539f\u56e0\uff0c\u4f46\u6d41\u884c\u75c5\u5b78\u7684\u7814\u7a76\u986f\u793a\u5176\u61c9\u8207\u66b4\u9732\u65bc\u74b0\u5883\u6c61\u67d3\u7269\u6709\u95dc\u806f\u6027\u3002\u7279\u5225\u662f\u8fd1\u4e8c\u5341\u5e74\u4f86\u5de5\u696d\u5316\u7684\u904e\u7a0b\u5f71\u97ff\u3001\u90fd\u5e02\u5316\u7684\u751f\u6d3b\u53ca\u74b0\u5883\u8b8a\u9077\u5f8c\uff0c\u7f79\u75c5\u4eba\u53e3\u540c\u6642\u5feb\u901f\u589e\u52a0\u3002\u800c\u74b0\u5883\u4e2d\u4e4b\u7d30\u61f8\u6d6e\u5fae\u7c92\uff0c\u4f8b\u5982\u591a\u74b0\u82b3\u9999\u70f4\uff08PAHs\uff09\u53ca\u5167\u5206\u6ccc\u5e72\u64fe\u7269\u74b0\u5883\u8377\u723e\u8499\uff08\u5982\u9130\u82ef\u4e8c\u7532\u9178\u916f\u985e\uff08DEHP\uff09\u7b49\uff09\uff0c\u53ef\u80fd\u662f\u9020\u6210\u6c23\u5598\u53ca\u904e\u654f\u6027\u75be\u75c5\u7684\u539f\u56e0\u4e4b\u4e00\uff0c\u5f71\u97ff\u4e86\u75be\u75c5\u7684\u8868\u73fe\u8207\u5176\u56b4\u91cd\u7a0b\u5ea6\u3002\u5c24\u5176\u5728\u4e0d\u8096\u5ee0\u5546\u7684\u63a8\u6ce2\u52a9\u703e\u4e0b\uff0c\u5c0e\u81f4\u53f0\u7063\u7684\u74b0\u5883\u8377\u723e\u8499\u7121\u6240\u4e0d\u5728\uff0c\u5176\u4e2d\u5851\u5316\u5291\u4ee5\u53ca\u58ec\u57fa\u82ef\u915a\u7686\u662f\u5ee3\u6cdb\u5b58\u5728\u65bc\u74b0\u5883\u8207\u98df\u7269\u4e2d\u7684\u74b0\u5883\u8377\u723e\u8499\u3002\u4f46\u662f\uff0c\u4ecd\u5c1a\u672a\u91d0\u6e05\u9019\u4e9b\u5e38\u898b\u7684\u74b0\u5883\u6c61\u67d3\u7269\u5728\u6c23\u5598\u53ca\u904e\u654f\u6027\u75be\u75c5\u6240\u626e\u6f14\u7684\u75c5\u7406\u89d2\u8272\u3002\u70ba\u6b64\uff0c\u672c\u6821\uff08\u9ad8\u91ab\u5927\uff09\u8207\u570b\u885b\u9662\u74b0\u5883\u885b\u751f\u8207\u8077\u696d\u91ab\u5b78\u7814\u7a76\u7d44\uff08\u570b\u885b\u9662\u74b0\u8077\u7d44\uff09\u9032\u884c\u9577\u671f\u7684\u5b78\u8853\u5408\u4f5c\uff0c\u5f9e\u81e8\u5e8a\u89d2\u5ea6\u5230\u57fa\u790e\u6a5f\u5236\u7684\u63a2\u8a0e\uff0c\u8a66\u5716\u91d0\u6e05\u74b0\u5883\u6c61\u67d3\u7269\u5c0d\u570b\u4eba\u6c23\u5598\u53ca\u904e\u654f\u6027\u75be\u75c5\u7684\u6a5f\u5236\u76f8\u95dc\u6027\uff0c\u540c\u6642\u5728\u767c\u5c55\u6709\u6548\u7684\u6cbb\u7642\u548c\u9810\u9632\u7b56\u7565\u4e0a\uff0c\u63d0\u4f9b\u4e00\u500b\u5408\u7406\u7684\u57fa\u790e\u3002\u8fd1\u671f\uff0c\u672c\u6821\u3001\u570b\u885b\u9662\u4ee5\u53ca\u7f8e\u570b\u7d04\u7ff0\u970d\u666e\u91d1\u65af\u5927\u5b78\u6c23\u5598\u514d\u75ab\u91ab\u5b78\u4e2d\u5fc3\u5171\u540c\u767c\u88683\u7bc7\u521d\u6b65\u6210\u679c\u3002\u5176\u4e2d\u7531\u9ad8\u91ab\u5927\u5c0f\u5152\u79d1\u6d2a\u5fd7\u8208\u6559\u6388\u4e3b\u5c0e\u8207\u91ab\u5b78\u7814\u7a76\u6240\u5b6b\u662d\u73b2\u526f\u6559\u6388\u53ca\u570b\u885b\u9662\u9ec3\u562f\u8c37\u7279\u8058\u7814\u7a76\u54e1\u7684\u5171\u540c\u7814\u7a76\uff0c\u4ee5\u5148\u524d\u570b\u5167\u7206\u767c\u4e4b\u6709\u6bd2\u5851\u5316\u5291DEHP\u70ba\u4e3b\u89d2\uff0c\u4e26\u8207\u4eba\u985e\u6700\u91cd\u8981\u514d\u75ab\u8abf\u7bc0\u53ca\u6297\u75c5\u6bd2\u514d\u75ab\u7d30\u80de\uff08\u985e\u6f3f\u6a39\u7a81\u7d30\u80de\uff08plasmacytoid dendritic cells\uff09\u9023\u7d50\uff0c\u7814\u7a76\u5851\u5316\u5291\u5c0d\u985e\u6f3f\u6a39\u7a81\u7d30\u80de\u514d\u75ab\u529f\u80fd\u7684\u5f71\u97ff\u3002\u6b64\u7814\u7a76\u7d50\u679c\u9996\u6b21\u8b49\u660e\u4e86\u5851\u5316\u5291\u900f\u904e\u8868\u89c0\u57fa\u56e0\u8abf\u63a7\u6a5f\u5236\uff0c\u6291\u5236\u985e\u6f3f\u6a39\u7a81\u7d30\u80de\u8868\u73fe\u7b2c\u4e00\u578b\u5e72\u64fe\u7d20\uff08Type I interferon; IFN-\u03b1 and -\u03b2\uff09\uff0c\u9032\u800c\u4fc3\u9032\u4e86\u904e\u654f\u767c\u708e\u53cd\u61c9\u3002\u6b64\u7bc7\u8ad6\u6587\u520a\u767b\u65bc\u5168\u4e16\u754c\u904e\u654f\u9818\u57df\u6392\u7b2c\u4e8c\u4e4b Allergy \uff08impact factor: 6.27\uff09\u671f\u520a\u4e2d\u3002<br \/>\n\u985e\u6f3f\u6a39\u7a81\u7d30\u80de\u662f\u4eba\u9ad4\u4e2d\u4e3b\u8981\u5206\u6ccc\u5177\u6709\u6297\u75c5\u6bd2\u4f5c\u7528\u7684\u7b2c\u4e00\u578b\u5e72\u64fe\u7d20\u4e4b\u7d30\u80de\uff0c\u4e5f\u662f\u91cd\u8981\u7684\u6297\u539f\u5448\u73fe\u7d30\u80de\uff0c\u80fd\u8abf\u7bc0\u5f8c\u5929\u514d\u75ab\u7cfb\u7d71\u8207\u904e\u654f\u53cd\u61c9\u3002\u7814\u7a76\u767c\u73feDEHP\u4ee5\u53ca\u9130\u82ef\u4e8c\u7532\u9178\u4e01\u57fa\u8290\u916f\uff08benzyl butyl phthalate, BBP\uff09\u53ef\u4ee5\u900f\u904eAhR\u6291\u5236\u985e\u9438\u53d7\u9ad4\u7b2c\u4e5d\u578b\uff08toll-like receptor 9\uff09\u523a\u6fc0\u7269CpG\u6240\u8a98\u767c\u7684\u7b2c\u4e00\u578b\u5e72\u64fe\u7d20\u5206\u6ccc\uff0c\u800c\u5176\u4f5c\u7528\u6a5f\u5236\u662f\u900f\u904e\u6291\u5236\u7d30\u80de\u5167MAPK\uff08ERK\uff09\u53caNF-\u03baB\u8a0a\u865f\u50b3\u905e\uff0c\u4ee5\u53ca\u7532\u57fa\u8f49\u79fb\u9175\u7d20WDR5\u5f9e\u7d30\u80de\u6838\u5916\u5230\u6838\u5167\u7684\u79fb\u52d5\uff0c\u9032\u800c\u6291\u5236\u5728\u5e72\u64fe\u7d20\u8abf\u7bc0\u56e0\u5b50-7\uff08interferon regulatory factor-7, IRF-7\uff09\u57fa\u56e0\u555f\u52d5\u5340\u7684\u7d44\u7e54\u86cb\u767d\u4e09\u7532\u57fa\u5316\uff08tri-me-H3K4\uff09\uff0c\u800c\u6e1b\u5c11\u4e86IRF-7\u7684\u8868\u73fe\u3002\u9019\u4e9b\u8868\u89c0\u57fa\u56e0\u8abf\u63a7\u6a5f\u5236\uff0c\u6291\u5236\u4e86IRF-7\u5728IFN\u57fa\u56e0\u555f\u52d5\u5340\u7684\u7d50\u5408\uff0c\u5c0e\u81f4\u7b2c\u4e00\u578b\u5e72\u64fe\u7d20\u5206\u6ccc\u986f\u8457\u6e1b\u5c11\u3002DEHP\u8207BBP\u524d\u8655\u7406\u4e4b\u985e\u6f3f\u6a39\u7a81\u7d30\u80de\u6703\u6291\u5236CD4+ T\u7d30\u80de\u5206\u6ccc\u4e19\u578b\u5e72\u64fe\u7d20\uff08IFN-\u03b3\uff09\u800c\u4e14\u6703\u4fc3\u9032CD4+ T\u7d30\u80de\u5206\u6ccc\u7d30\u80de\u4ecb\u7d20-13\uff08IL-13\uff09\uff08\u5716(A)\uff09\u3002\u53e6\u5916\uff0c\u7d9c\u5408\u4e0d\u540c\u5be6\u9a57\u7d50\u679c\u767c\u73fe\u985e\u6f3f\u6a39\u7a81\u7d30\u80de\u8868\u73fe\u7b2c\u4e00\u578b\u5e72\u64fe\u7d20\u7684\u6291\u5236\u7d50\u679c\uff0c\u964d\u4f4e\u4e86\u5c0d\u6297\u75c5\u6bd2\u4e4b\u80fd\u529b\u3002\u672c\u7814\u7a76\u70ba\u9ad4\u5916\u5be6\u9a57\u63d0\u4f9b\u4e86\u4e00\u500b\u5f88\u597d\u7684\u57fa\u790e\uff0c\u80fd\u7814\u7a76\u5f8c\u7e8c\u5851\u5316\u5291\u5728\u9ad4\u5167\u7684\u4f5c\u7528\uff0c\u4e26\u9032\u4e00\u6b65\u63d0\u4f9b\u5851\u5316\u5291\u6bd2\u6027\u53ca\u7ba1\u5236\u6a19\u6e96\u7684\u53c3\u8003\u3002\u53e6\u5916\uff0c\u9ad8\u91ab\u5927\u5b6b\u662d\u73b2\u526f\u6559\u6388\u5be6\u9a57\u5ba4\u8207\u9ec3\u562f\u8c37\u7279\u8058\u7814\u7a76\u54e1\u5408\u4f5c\uff0c\u5efa\u7acb\u4e86\u6a21\u64ec\u4eba\u985e\u9577\u671f\u8207\u4f4e\u5291\u91cf\u66b4\u9732\u58ec\u57fa\u82ef\u915a\uff084-nonylphenol, NP\uff09\u7684\u6c23\u5598\u5c0f\u9f20\u6a21\u5f0f\uff0c\u8b49\u660e\u58ec\u57fa\u82ef\u915a\u5728\u5c0f\u9f20\u6d3b\u9ad4\u4e2d\u6703\u900f\u904eAhR\u6539\u8b8a\u6a39\u7a81\u7d30\u80de\u529f\u80fd\uff0c\u9032\u800c\u4fc3\u9032\u904e\u654f\u6027\u7b2c\u4e8c\u578bT\u6dcb\u5df4\u7403\uff08Th2\uff09\u7684\u5206\u5316\u8207\u529f\u80fd\uff0c\u5c0e\u81f4\u5c0f\u9f20\u7684\u80ba\u90e8\u6709\u904e\u654f\u6027\u767c\u708e\u73fe\u8c61\uff08\u5716(B)\uff09\u3002\u6b64\u7814\u7a76\u986f\u793a\u4eba\u985e\u9577\u671f\u66b4\u9732\u5728\u74b0\u5883\u8377\u723e\u8499\u4e2d\uff0c\u96d6\u7136\u6bcf\u5929\u7684\u66b4\u9732\u5291\u91cf\u5f88\u4f4e\uff0c\u4f46\u7531\u65bc\u9019\u985e\u8102\u6eb6\u6027\u74b0\u5883\u8377\u723e\u8499\uff0c\u6975\u53ef\u80fd\u85c9\u7531\u751f\u7269\u7d2f\u7a4d\u6548\u61c9\u800c\u5f71\u97ff\u514d\u75ab\u7cfb\u7d71\uff0c\u6b64\u7814\u7a76\u4e5f\u5efa\u7acb\u4e86\u58ec\u57fa\u82ef\u915a\u9577\u671f\u66b4\u9732\u8207\u904e\u654f\u6027\u75be\u75c5\u7684\u56e0\u679c\u95dc\u4fc2\u3002\u7814\u7a76\u7d50\u679c\u520a\u767b\u65bcAllergy\u671f\u520a\u4e2d\uff08 impact factor: 6.27\uff09\u3002\u9019\u4e9b\u7814\u7a76\u8b49\u5be6\u74b0\u5883\u8377\u723e\u8499\u4e0d\u53ea\u5f71\u97ff\u751f\u6b96\u7cfb\u7d71\uff0c\u4e5f\u6703\u6539\u8b8a\u514d\u75ab\u7cfb\u7d71\uff0c\u800c\u514d\u75ab\u7cfb\u7d71\u7684\u6539\u8b8a\u53ef\u80fd\u8207\u4eba\u985e\u767c\u708e\u6027\u75be\u75c5\u7684\u767c\u5c55\u6709\u6975\u5927\u7684\u95dc\u4fc2\u3002\u6b64\u5916\uff0c\u74b0\u8077\u7d44\u9ec3\u562f\u8c37\u7279\u8058\u7814\u7a76\u54e1\u5be6\u9a57\u5ba4\u4e3b\u5c0e\u4e4b\u7814\u7a76\u8a08\u756b\u767c\u73fe\u82b3\u9999\u70f4\u53d7\u9ad4\uff08aryl hydrocarbon receptor, AhR\uff09\u5c0d\u65bc\u8abf\u63a7\u80a5\u5927\u7d30\u80de\uff08mast cell\uff09\u7684\u751f\u9577\u3001\u5206\u5316\u4ee5\u53ca\u529f\u80fd\u5177\u6709\u95dc\u9375\u6027\u7684\u5f71\u97ff\u529b\u3002\u6b64\u8ad6\u6587\u767c\u8868\u5728Blood\uff08impact factor: 9.898\uff09\u671f\u520a\u4e0a\u3002\u80a5\u5927\u7d30\u80de\u4f4d\u65bc\u4eba\u9ad4\u514d\u75ab\u7b2c\u4e00\u9053\u9632\u7dda\u7684\u9ecf\u819c\u4e0a\uff0c\u662f\u7522\u751f\u904e\u654f\u767c\u708e\u73fe\u8c61\u7684\u91cd\u8981\u7d30\u80de\u3002\u5be6\u9a57\u8b49\u5be6AhR\u7684\u6d3b\u5316\u6703\u589e\u5f37\u4eba\u985e\u548c\u5c0f\u9f20\u80a5\u5927\u7d30\u80de\u7684\u767c\u708e\u53cd\u61c9\uff1a\u8af8\u5982\u7d44\u7e54\u80fa\u7684\u91cb\u653e\u3001\u8102\u8cea\u4ecb\u8cea\u767d\u4e09\u70efC4\uff08LTC4\uff09\u4e4b\u5206\u6ccc\u9084\u6709\u7d30\u80de\u4ecb\u7d20IL-13\u7684\u7522\u751f\u3002\u7814\u7a76\u5718\u968a\u8b49\u5be6\u5176\u5b78\u7406\u6a5f\u5236\u70baAhR\u914d\u9ad4\uff08ligand\uff09\u6d3b\u5316AhR\u4e4b\u5f8c\u6703\u4fc3\u9032\u6d3b\u6027\u6c27\u5316\u7269\u7684\u751f\u6210\u53ca\u7d30\u80de\u5167\u9223\u96e2\u5b50\u6fc3\u5ea6\u589e\u52a0\uff0c\u4e14\u9032\u4e00\u6b65\u6d3b\u5316\u4e0b\u6e38\u7684\u86cb\u767d\u8cea\u6fc0\u9176\uff0c\u4f7f\u5f97\u78f7\u9178\u6c34\u89e3\u9175\u7d20\uff08SHP-2\uff09\u56e0\u70ba\u5f62\u6210\u6c27\u5316\u614b\uff08oxSHP-2\uff09\u800c\u964d\u4f4e\u6d3b\u6027\uff0c\u6b64\u4e00\u53cd\u61c9\u52a0\u5f37\u4e86\u86cb\u767d\u6fc0\u9176\u7684\u8a0a\u865f\u50b3\u905e\uff0c\u800c\u9019\u4e9b\u53cd\u61c9\u5c0e\u81f4\u80a5\u5927\u7d30\u80de\u7684\u767c\u708e\u73fe\u8c61\u3002\u9664\u4e86\u4ee5\u914d\u9ad4\u8655\u7406\u7d30\u80de\u6d3b\u5316AhR\u4f86\u7814\u7a76\u5176\u6548\u61c9\uff0c\u7814\u7a76\u767c\u73fe\u5728AhR\u57fa\u56e0\u5254\u9664\u7684\u80a5\u5927\u7d30\u80de\u4e2d\uff0c\u9223\u96e2\u5b50\u8207c-kit\/IL-3\u8a0a\u865f\u50b3\u905e\u53ca\u7c92\u7dda\u9ad4\u529f\u80fd\u7686\u7522\u751f\u7f3a\u9677\u3002\u540c\u6642\uff0c\u7d30\u80de\u5167\u6c27\u5316\u58d3\u529b\u53ca\u7d30\u80de\u51cb\u4ea1\u6bd4\u6b63\u5e38\u7684\u7d30\u80de\u56b4\u91cd\uff0c\u96a8\u5f8c\u5c0e\u81f4\u9ad4\u5167\u9ecf\u819c\u80a5\u5927\u7d30\u80de\u7684\u6578\u76ee\u986f\u8457\u6e1b\u5c11\uff08\u5716(C)\uff09\u3002\u53e6\u5916\uff0c\u7d9c\u5408\u4e0d\u540c\u5be6\u9a57\u7b56\u7565\u6240\u9a57\u8b49\u7684\u7d50\u679c\u9996\u5ea6\u767c\u73fe\uff0cAhR\u5f71\u97ff\u80a5\u5927\u7d30\u80de\u7c92\u7dda\u9ad4\u7684\u819c\u96fb\u4f4d\u4ee5\u53ca\u7d30\u80de\u5167\u9223\u96e2\u5b50\u52d5\u614b\u5e73\u8861\uff0c\u4ee5\u81f4\u6539\u8b8a\u7d30\u80de\u5167\u5c0f\u5206\u5b50\u4ee3\u8b1d\u53ca\u6c27\u5316\u58d3\u529b\u7684\u589e\u52a0\u3002\u7814\u7a76\u5718\u968a\u8a8d\u70baAhR\u53ef\u4ee5\u540c\u6642\u611f\u61c9\u5916\u5728\u74b0\u5883\u7684\u6c61\u67d3\u7269\u4ee5\u53ca\u9ad4\u5167\u672c\u8eab\u5b58\u5728\u7684\u5c0f\u5206\u5b50\u4ee3\u8b1d\u7269\uff0c\u4e26\u85c9\u7531\u7d30\u80de\u6838\u5167\u6216\u6838\u5916\u7684\u9014\u5f91\u4f86\u4fc3\u6210\u7d30\u80de\u5167\u7684\u5c0f\u5206\u5b50\u4ee3\u8b1d\u7269\u5e73\u8861\u3002\u56e0\u6b64\uff0cAhR\u7684\u529f\u80fd\u9664\u4e86\u50b3\u7d71\u8a8d\u77e5\u7684\u8f14\u52a9\u7d30\u80de\u89e3\u6bd2\u4ee3\u8b1d\u4e4b\u5916\uff0c\u4e5f\u5f71\u97ff\u8457\u514d\u75ab\u53ca\u4ee3\u8b1d\u7cfb\u7d71\u8207\u767c\u708e\u904e\u654f\u53cd\u61c9\u3002<br \/>\n<img loading=\"lazy\" decoding=\"async\" alt=\"\" src=\"http:\/\/wp.kmu.edu.tw\/rd\/files\/2013\/07\/0010PaperRes-01.jpg\" width=\"566\" height=\"426\" \/><br \/>\n\u9ad8\u91ab\u5927\u7814\u7a76\u5718\u968a\u8207\u570b\u885b\u9662\u5df2\u806f\u5408\u591a\u5bb6\u91ab\u5b78\u4e2d\u5fc3\u3001\u4e2d\u5c71\u5927\u5b78\u53ca\u53f0\u7063\u5927\u5b78\u96fb\u6a5f\u5de5\u7a0b\u5b78\u7cfb\uff0c\u7d44\u6210\u53f0\u7063\u6c23\u5598\u7814\u7a76\u806f\u76df\uff08Consortium for Taiwan Asthma Study, CTAS\uff09\uff0c\u5c07\u6301\u7e8c\u7d9c\u5408\u591a\u5b78\u79d1\u9818\u57df\uff0c\u5305\u62ec\u81e8\u5e8a\u7814\u7a76\u3001\u74b0\u5883\u6c61\u67d3\u7269\u66b4\u9732\u8a55\u4f30\u3001\u74b0\u5883\u57fa\u56e0\u9ad4\u5b78\u3001\u4ee3\u8b1d\u8cea\u9ad4\u5b78\u8207\u7cfb\u7d71\u751f\u7269\u5b78\u7684\u65b9\u6cd5\uff0c\u4f86\u63a2\u8a0e\u74b0\u5883\u6c61\u67d3\u7269\u5982\u4f55\u5f71\u97ff\u767c\u708e\u53ca\u6c27\u5316\u61c9\u6fc0\u53cd\u61c9\u8207\u76f8\u95dc\u75be\u75c5\u3002\u671f\u671b\u7814\u7a76\u6210\u679c\u5c07\u4f86\u53ef\u4f5c\u70ba\u653f\u5e9c\u5236\u5b9a\u653f\u7b56\u7684\u91cd\u8981\u4f9d\u64da\uff0c\u9032\u800c\u5c0d\u53f0\u7063\u4e00\u822c\u6c11\u773e\u5728\u74b0\u5883\u8207\u5065\u5eb7\u7684\u95dc\u806f\u4e0a\u6709\u76f4\u63a5\u4e14\u91cd\u5927\u7684\u52a9\u76ca\u3002<\/li>\n<\/ul>\n<p style=\"text-align: right\"><a href=\"http:\/\/wp.kmu.edu.tw\/rd\/archives\/1608\">\u56de\u7b2c0010\u671f\u4e3b\u9801<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u56de\u7b2c0010\u671f\u4e3b\u9801 \u4e8c\u3001\u8ad6\u6587\u8207\u7814\u7a76\u5206\u4eab \uff08\u4e00\uff09\u8ad6\u6587 \u984c\u76ee\uff1a Betel-quid &hellip; <a href=\"https:\/\/wp.kmu.edu.tw\/rd\/archives\/1614\">\u95b1\u8b80\u5168\u6587 <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[18],"tags":[],"class_list":["post-1614","post","type-post","status-publish","format-standard","hentry","category-18"],"_links":{"self":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/1614","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/comments?post=1614"}],"version-history":[{"count":12,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/1614\/revisions"}],"predecessor-version":[{"id":1698,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/1614\/revisions\/1698"}],"wp:attachment":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/media?parent=1614"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/categories?post=1614"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/tags?post=1614"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}