{"id":1871,"date":"2013-09-02T22:24:00","date_gmt":"2013-09-02T14:24:00","guid":{"rendered":"http:\/\/wp.kmu.edu.tw\/rd\/?p=1871"},"modified":"2013-09-04T16:48:24","modified_gmt":"2013-09-04T08:48:24","slug":"%e8%ab%96%e6%96%87%e7%a0%94%e7%a9%b6%e8%88%87%e5%88%86%e4%ba%ab-5","status":"publish","type":"post","link":"https:\/\/wp.kmu.edu.tw\/rd\/archives\/1871","title":{"rendered":"\u8ad6\u6587\u7814\u7a76\u8207\u5206\u4eab"},"content":{"rendered":"<p style=\"text-align: right\"><a href=\"http:\/\/wp.kmu.edu.tw\/rd\/archives\/1865\">\u56de\u7b2c0012\u671f\u4e3b\u9801<\/a><\/p>\n<h1><span style=\"font-size: x-large;color: #c10000\">\u4e8c\u3001\u8ad6\u6587\u8207\u7814\u7a76\u5206\u4eab<\/span><\/h1>\n<p><a name=\"PaperRes1\"><\/a><\/p>\n<h1><span style=\"color: #0000ff\">\uff08\u4e00\uff09\u8ad6\u6587<\/span><\/h1>\n<ul>\n<li><span style=\"color: #3366ff\">\u984c\u76ee\uff1a<strong><br \/>\nPhthalic Acid Chemical Probes Synthesized for Protein-Protein Interaction Analysis. <\/strong><\/span><br \/>\n<span style=\"color: #3366ff\"> \uff08\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u751f\u7269\u79d1\u6280\u7cfb\u6881\u4e16\u6b23\u52a9\u7406\u6559\u6388\u63d0\u4f9b\u6458\u8981\uff09<\/span><\/li>\n<\/ul>\n<ul>\n<li>\u4f5c\u8005\uff1aShih-Shin Liang, Wei-Ting Liao, Chao-Jen Kuo, Chi-Hsien Chou, Chin-Jen Wu and Hui-Min Wang. International Journal of Molecular Sciences (IF: 2.464) 2013, 14, 12914-12930.<\/li>\n<\/ul>\n<ul>\u80cc\u666f: \u86cb\u767d\u9ad4\u7814\u7a76\u56e0\u70ba\u5206\u96e2\u65b9\u6cd5\u8207\u8cea\u8b5c\u5100\u7684\u767c\u5c55\u800c\u6709\u9577\u8db3\u9032\u6b65\u3002\u4f9d\u76ee\u524d\u6700\u5148\u9032\u7684\u5206\u6790\u5100\u5668\uff0c\u5728\u4e03\u5341\u5206\u9418\u7684\u5206\u6790\u6642\u9593\u4e2d\uff0c\u627e\u5230\u4e0a\u5343\u500b\u86cb\u767d\u8cea\u5df2\u7d93\u662f\u5bb9\u6613\u7684\u4e8b\u60c5\u3002\u4f46\u662f\uff0c\u5982\u4f55\u5f9e\u5de8\u91cf\u8cc7\u6599\u4e2d\u5c0b\u627e\u6709\u7528\u7684\u8cc7\u8a0a\uff0c\u505a\u70ba\u65e5\u5f8c\u5ef6\u7e8c\u7814\u7a76\u7684\u8ab2\u984c\uff0c\u5f80\u5f80\u56f0\u64fe\u8457\u79d1\u5b78\u5bb6\u3002\u6240\u4ee5\uff0c\u5229\u7528\u5316\u5b78\u63a2\u91dd\u7684\u5206\u6790\u6a21\u5f0f\u4fbf\u56e0\u61c9\u800c\u751f\u3002<\/ul>\n<ul>\u65b9\u6cd5: \u6b64\u65b9\u6cd5\u985e\u4f3c\u6297\u539f\u8207\u6297\u9ad4\u6216\u9175\u7d20\u8207\u76ee\u6a19\u86cb\u767d\u8cea\u7684\u4f5c\u7528\uff0c\u53ea\u9700\u6578\u500b\u80fa\u57fa\u9178\u7d50\u69cb\u4fbf\u80fd\u5920\u7522\u751f\u89aa\u5408\u4f5c\u7528\u3002\u67d0\u4e9b\u4eba\u9020\u5316\u5408\u7269\uff0c\u53ef\u80fd\u5177\u6709\u751f\u6b96\u6bd2\u6027\u7684\u74b0\u5883\u8377\u723e\u8499(EDCs)\uff0c\u5373\u662f\u56e0\u70ba\u5b98\u80fd\u57fa\u5177\u6709\u548c\u8377\u723e\u8499\u985e\u4f3c\u7684\u7d50\u69cb\u3002\u4f9d\u5faa\u6b64\u6982\u5ff5\uff0c\u5c07EDCs\u5229\u7528\u5316\u5b78\u4fee\u98fe\uff0c\u63a5\u5408\u5728\u67d0\u985e\u8f09\u53f0\u4e0a\uff0c\u5408\u6210\u51fa\u5316\u5b78\u63a2\u91dd\u3002\u6b64\u60f3\u6cd5\u985e\u4f3c\u91e3\u9b5a\u7684\u9b5a\u7aff\uff0c\u800c\u6b64\u985e\u9b5a\u7aff\u53ef\u4f9d\u7814\u7a76\u4e0d\u540c\uff0c\u88dd\u7f6e\u4e0a\u4e0d\u540c\u7684\u990c(\u5316\u5408\u7269)\u3002\u5229\u7528\u8a72\u5316\u5408\u7269\u8207\u67d0\u985e\u86cb\u767d\u8cea\u5177\u6709\u8f03\u5f37\u89aa\u5408\u529b\uff0c\u812b\u9644\u86cb\u767d\u4e4b\u5f8c\u4fbf\u53ef\u9032\u884c\u86cb\u767d\u8cea\u9ad4\u5b78\u7684\u5206\u6790\u3002\u8a72\u7814\u7a76\u6709\u52a9\u65bc\u91d0\u6e05\u8a72\u5316\u5408\u7269\u9032\u5165\u7d30\u80de\u5f8c\uff0c\u53ef\u80fd\u5f71\u97ff\u7684\u6a5f\u5236\u6240\u5c0e\u81f4\u7684\u75be\u75c5\uff0c\u4e26\u9032\u800c\u767c\u5c55\u51fa\u5c0d\u6cbb\u7684\u65b9\u6cd5\u3002<\/ul>\n<ul>\u7d50\u8ad6:\u5229\u7528\u8cea\u8b5c\u5100\u9032\u884c\u4e0d\u540c\u4e09\u76e4\u7684\u7d30\u80de\u86cb\u767d\u8403\u53d6\u7269\uff0c\u6b64\u4e09\u91cd\u8907\u4e14\u8207\u78f7\u82ef\u4e8c\u7532\u9178\u8102\u985e\u6709\u8f03\u5f37\u89aa\u5408\u529b\u7684\u86cb\u767d\u8cea\u6709\uff1aprotein disulfide-isomerase A6, heat shock proteins,\u8207Serpin H1\u3002\u518d\u5229\u7528IPA\u5efa\u7acb\u86cb\u767d\u8cea\u4e4b\u9593\u7684\u7db2\u7d61\u95dc\u4fc2\u3002\u9a57\u8b49\u65b9\u9762\uff0c\u53ef\u518d\u5229\u7528\u8cea\u8b5c\u5100\u591a\u91cd\u53cd\u61c9\u76e3\u63a7\u6a21\u5f0f\u9032\u884c\u5206\u6790\u3002<\/ul>\n<p><a name=\"PaperRes2\"><\/a><\/p>\n<ul>\n<li><span style=\"color: #3366ff\">\u984c\u76ee\uff1a<strong><br \/>\nBrazilein suppresses migration and invasion of MDA-MB-231 breast cancer cells. <\/strong><br \/>\n<span style=\"color: #3366ff\"> (\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u91ab\u85e5\u66a8\u61c9\u7528\u5316\u5b78\u7cfb\u6797\u4fe1\u4ec1\u6559\u6388\u63d0\u4f9b\u6458\u8981)<\/span><\/span><\/li>\n<\/ul>\n<ul>\n<li>\u4f5c\u8005\uff1aHsieh CY, Tsai PC, Chu CL, Chang FR, Chang LS, Wu YC*, Lin SR*. Chemico-Biological Interactions, 2013, July, 204 (2), 105-115.<br \/>\n[IF:2.967,PHARMACOLOGY &amp; PHARMACY 75\/260 (28.9%)]<\/li>\n<\/ul>\n<ul>Brazilein\uff0c\u662f\u5f9eCaesalpinia sappan L.\u5206\u96e2\u7684\u751f\u7269\u6d3b\u6027\u5316\u5408\u7269\uff0c\u5728\u6771\u65b9\u6c11\u9593\u5e38\u4f7f\u7528\u85e5\u7269\u3002\u7528\u5283\u75d5\u5be6\u9a57\u548c Boyden chamber \u5206\u6790\u986f\u793a\u5728\u7121\u6bd2\u5291\u91cf\u4e0b Brazilein \u6291\u5236\u7d30\u80de\u9077\u79fb\u548c\u4fb5\u8972\u80fd\u529b\u3002\u7d93\u7531 Western blot, Reversed transcription-PCR \u548cGelatin zymography \u6aa2\u6e2c\uff0cBrazilein \u9078\u64c7\u6027\u7684\u6291\u5236MMP-2 \u7684\u6d3b\u6027\u548c\u86cb\u767d\u8868\u73fe\u3002\u6b64\u5916\uff0cBrazilein \u660e\u986f\u964d\u4f4e NF-\u03baB \u7684\u86cb\u767d\u8868\u73fe\uff0c\u540c\u6642\u589e\u52a0 I\u03baB\u03b1 \u4e14\u6291\u5236IKK \u7684\u78f7\u9178\u5316\u3002\u52a0\u5165 NF-\u03baB \u6291\u5236\u5291 ( PDTC )\uff0c\u4e5f\u6291\u5236 MMP-2 \u7684\u6d3b\u6027\u548c\u7d30\u80de\u7684\u9077\u79fb\u80fd\u529b\u3002 \u4f9d\u5be6\u9a57\u7d50\u679c\uff0cBrazilein \u6709\u6548\u7684\u6291\u5236 p38 MAPK \u86cb\u767d\u8207 PI3K\/Akt \u7684\u78f7\u9178\u5316\uff0c\u4f46\u4e0d\u5f71\u97ffERK1\/2 \u548cJNK \u7684\u78f7\u9178\u5316\u3002\u6b64\u5916\uff0c\u7528 p38 MAPK \u6291\u5236\u5291 ( SB203580 )\u6216 PI3K \u6291\u5236\u5291 ( Wortmannin )\u8655\u7406 MDA-MB-231 \u7d30\u80de\uff0c\u4ea6\u5c0e\u81f4 MMP-2 \u7684\u86cb\u767d\u8868\u73fe\u6e1b\u5c11\uff0c\u4e14\u6291\u5236\u7d30\u80de\u9077\u79fb\u3002\u4ee5\u4e0a\u7d50\u679c\u986f\u793a\uff0c Brazliein \u7d93\u7531\u6291\u5236 PI3K\/Akt \u548cp38 MAPK \u4fe1\u865f\u901a\u8def\u548c\u6291\u5236 NF-\u03baB \u7684\u6d3b\u6027\uff0c\u6e1b\u5c11 MMP-2 \u7684\u6d3b\u6027\u4e26\u6291\u5236MDA-MB-231 \u7d30\u80de\u7684\u9077\u79fb\u548c\u4fb5\u8972\u3002<\/ul>\n<p style=\"text-align: right\"><a href=\"http:\/\/wp.kmu.edu.tw\/rd\/archives\/1865\">\u56de\u7b2c0012\u671f\u4e3b\u9801<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u56de\u7b2c0012\u671f\u4e3b\u9801 \u4e8c\u3001\u8ad6\u6587\u8207\u7814\u7a76\u5206\u4eab \uff08\u4e00\uff09\u8ad6\u6587 \u984c\u76ee\uff1a Phthalic A &hellip; <a href=\"https:\/\/wp.kmu.edu.tw\/rd\/archives\/1871\">\u95b1\u8b80\u5168\u6587 <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[20],"tags":[],"class_list":["post-1871","post","type-post","status-publish","format-standard","hentry","category-20"],"_links":{"self":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/1871","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/comments?post=1871"}],"version-history":[{"count":5,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/1871\/revisions"}],"predecessor-version":[{"id":1907,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/1871\/revisions\/1907"}],"wp:attachment":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/media?parent=1871"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/categories?post=1871"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/tags?post=1871"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}