{"id":2058,"date":"2013-11-04T08:12:19","date_gmt":"2013-11-04T00:12:19","guid":{"rendered":"http:\/\/wp.kmu.edu.tw\/rd\/?p=2058"},"modified":"2013-11-05T09:02:44","modified_gmt":"2013-11-05T01:02:44","slug":"%e8%ab%96%e6%96%87%e7%a0%94%e7%a9%b6%e8%88%87%e5%88%86%e4%ba%ab-7","status":"publish","type":"post","link":"https:\/\/wp.kmu.edu.tw\/rd\/archives\/2058","title":{"rendered":"\u8ad6\u6587\u7814\u7a76\u8207\u5206\u4eab"},"content":{"rendered":"<p style=\"text-align: right\"><a href=\"http:\/\/wp.kmu.edu.tw\/rd\/archives\/2054\">\u56de\u7b2c0014\u671f\u4e3b\u9801<\/a><\/p>\n<h1><span style=\"font-size: x-large;color: #c10000\">\u4e8c\u3001\u8ad6\u6587\u8207\u7814\u7a76\u5206\u4eab<\/span><\/h1>\n<p><a name=\"PaperRes1\"><\/a><\/p>\n<h1><span style=\"color: #0000ff\">\uff08\u4e00\uff09\u8ad6\u6587<\/span><\/h1>\n<ul>\n<li><span style=\"color: #3366ff\">\u984c\u76ee\uff1a<strong><br \/>\n\u76ee\u6a19\u5316\u5075\u6e2clegumain\u9175\u7d20\u4e4b\u78c1\u632f\u9020\u5f71\u5c0d\u6bd4\u5291\u53ca\u87a2\u5149\u5206\u5b50\u5f71\u50cf\u63a2\u91dd\u4e4b\u958b\u767c\u7814\u7a76<br \/>\nPeptide-based MRI contrast agent and near-infrared fluorescent probe for intratumoral legumain detection.<\/strong><\/span><br \/>\n<span style=\"color: #3366ff\"> \uff08\u4ea4\u901a\u5927\u5b78\u738b\u96f2\u9298\u6559\u6388\u63d0\u4f9b\u6458\u8981\uff09<\/span><\/li>\n<\/ul>\n<ul>\n<li>\u4f5c\u8005\uff1aChen YJ, Wu SC, Chen CY, Tzou SC, Cheng TL, Huang YF, Yuan SS, Wang YM. Biomaterials. 2013 Oct 10.doi:pii: S0142-9612(13)01200-3.10.1016\/j.biomaterials.2013.09.100<\/li>\n<\/ul>\n<ul>\u7814\u7a76\u6307\u51fa\uff0c\u7d30\u80de\u5167\u7684legumain\u5c0d\u65bc\u816b\u7624\u6709\u8457\u5f88\u5927\u7684\u5f71\u97ff\u3002Legumain \u9175\u7d20\u70ba\u4e00\u534a\u80f1\u6c28\u9178\u86cb\u767d\u9176 (cysteine protease)\uff0c\u5176\u5728\u591a\u7a2e\u816b\u7624\u4e0a\u5747\u80fd\u904e\u5ea6\u8868\u73fe\u3002\u56e0\u6b64\uff0c\u672c\u7814\u7a76\u8a2d\u8a08\u5408\u6210\u4e00\u78c1\u632f\u9020\u5f71\u5c0d\u6bd4\u5291 ([Gd-NBCB-TTDA-Leg(L)]) \u53ca\u4e00\u8fd1\u7d05\u5916\u5149\u87a2\u5149\u63a2\u91dd (CyTE777-(L)-Leg-CyTE807)\u3002\u5176\u4e2d\u78c1\u632f\u9020\u5f71\u5c0d\u6bd4\u5291\u662f\u5728TTDA\u7684\u9aa8\u67b6\u4e19\u70f7\u93c8\u4e2d\u9593\u78b3\u4e0a\u4fee\u98fe\u56db\u5143\u74b0(cyclobutyl)\u53ca\u82ef\u74b0(benzyl)\uff0c\u4e26\u9375\u7d50\u5c0dlegumain\u5177\u6709\u5c08\u4e00\u6027\u7684\u80dc\u80bd ((L)-Leg)\uff0c\u4ee5\u5f62\u6210\u4e00\u78c1\u632f\u9020\u5f71\u5c0d\u6bd4\u5291 ([Gd-NBCB-TTDA-Leg(L)])\uff1b\u800c\u8fd1\u7d05\u5916\u5149\u87a2\u5149\u63a2\u91dd\u662f\u85c9\u7531\u5728 ((L)-Leg) \u5169\u7aef\u9375\u7d50\u8fd1\u7d05\u5916\u5149\u87a2\u5149\u5718 (CyTE777\u53caCyTE807)\uff0c\u4ee5\u5f62\u6210\u4e00\u8fd1\u7d05\u5916\u5149\u87a2\u5149\u63a2\u91dd(CyTE777-(L)-Leg-CyTE807)\u3002\u78c1\u632f\u9020\u5f71\u5c0d\u6bd4\u5291\u4e0a\u7684\u80dc\u80bd\u88ablegumain\u8fa8\u8a8d\u5207\u5272\u5f8c\uff0c\u5c07\u6703\u589e\u52a0\u5176\u89aa\u8102\u6027\u53ca\u8f49\u52d5\u76f8\u95dc\u6642\u9593 (\u03c4R)\u3002\u800c\u8fd1\u7d05\u5916\u5149\u87a2\u5149\u63a2\u91dd\u4e0a\u7684CyTE807\u53ef\u5438\u6536CyTE777\u7684\u767c\u5c04\u80fd\u91cf\uff0c\u9054\u5230\u6291\u5236\u87a2\u5149\u653e\u5c04\u4e4b\u6548\u61c9 (quench effect)\uff0c\u7576\u63a2\u91dd\u8207legumain\u53cd\u61c9\u5f8c\uff0c\u7531\u87a2\u5149\u5149\u8b5c\u5100\u89c0\u5bdf\u5230CyTE777\u539f\u672c\u88ab\u6291\u5236\u7684\u87a2\u5149\u88ab\u91cb\u653e\u3002\u85c9\u7531T1 relexometric \u53ca\u87a2\u5149\u5149\u8b5c\u5100\u5c0d\u65bclegumain\u8fa8\u8a8d\u5207\u5272\u80dc\u80bd\u9032\u884c\u7814\u7a76\u3002\u5728in vivo MR imaging\u7814\u7a76\uff0c\u53ef\u770b\u5230\u5728CT-26 (legumain+)\u816b\u7624\u4e2d\uff0c\u76f8\u8f03\u65bc\u5c0d\u7167\u7d44\u5c0d\u6bd4\u5291([Gd-NBCB-TTDA-Leg(D)])\uff0c\u5be6\u9a57\u7d44\u5c0d\u6bd4\u5291([Gd-NBCB-TTDA-Leg(L)])\u5177\u6709\u7d0455.3\u500d\u7684\u76f8\u5c0d\u5c0d\u6bd4\u589e\u5f37 (254.2% versus 4.6%, at 2.0 h post-injection)\uff1b\u800c\u8fd1\u7d05\u5916\u5149\u87a2\u5149\u63a2\u91dd\u4ea6\u6709\u76f8\u4f3c\u7684\u7d50\u679c\uff0c\u76f8\u8f03\u65bc\u5c0d\u7167\u7d44\u63a2\u91dd CyTE777-(D)-Leg-CyTE807\uff0c\u5be6\u9a57\u7d44\u63a2\u91ddCyTE777-(L)-Leg-CyTE807\u670915.2\u500d\u7684\u76f8\u5c0d\u5f71\u50cf\u589e\u5f37 (3.34 \u00d7 109 photons\/min versus 0.22 \u00d7 109 photons\/min, at 24.0 h post-injection)\u3002\u7d9c\u5408\u4ee5\u4e0a\u7d50\u679c\uff0c\u672c\u7814\u7a76\u6240\u8a2d\u8a08\u5408\u6210\u4e4b\u78c1\u632f\u9020\u5f71\u5c0d\u6bd4\u5291 ([Gd-NBCB-TTDA-Leg(L)]) \u53ca\u8fd1\u7d05\u5916\u5149\u87a2\u5149\u63a2\u91dd (CyTE777-(L)-Leg-CyTE807) \u5747\u5c0dlegumain\u5177\u6709\u9ad8\u5ea6\u7279\u7570\u6027\uff0c\u53ef\u61c9\u7528\u65bclegumain\u8868\u73fe\u4e4b\u816b\u7624\u9032\u884c\u8a3a\u65b7\u53ca\u8ffd\u8e64\u3002<\/ul>\n<p><a name=\"PaperRes2\"><\/a><\/p>\n<ul>\n<li><span style=\"color: #3366ff\">\u984c\u76ee\uff1a<strong><br \/>\nThe volume-outcome relationship in laparoscopic cholecystectomy: a population-based study using propensity score matching.<\/strong><\/span><br \/>\n<span style=\"color: #3366ff\"> \uff08\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u91ab\u52d9\u7ba1\u7406\u66a8\u91ab\u7642\u8cc7\u8a0a\u5b78\u7cfb \u8a31\u5f18\u6bc5\u526f\u6559\u6388\u63d0\u4f9b\u6458\u8981\uff09<\/span><\/li>\n<\/ul>\n<ul>\n<li>\u4f5c\u8005\uff1aHon-Yi Shi, Hao-Hsien Lee, Chong-Chi Chiu, King-Teh Lee* SURGICAL ENDOSCOPY 2013; 27(9): 3139-3145\uff08IF=3.427, SURGERY 16\/199\uff09<\/li>\n<\/ul>\n<ul>\u7814\u7a76\u80cc\u666f\u8207\u76ee\u7684\uff1a\u904e\u53bb\u76f8\u95dc\u6587\u737b\u5df2\u7d93\u8b49\u5be6\u624b\u8853\u91cf\u8207\u7642\u6548\u4e4b\u76f8\u95dc\u6027\uff0c\u7136\u800c\u5c0d\u65bc\u9577\u671f\u8ffd\u8e64\u53ca\u6709\u7cfb\u7d71\u6027\u63a2\u8a0e\u81bd\u56ca\u5207\u9664\u624b\u8853\u624b\u8853\u91cf\u8207\u7642\u6548\u4e4b\u76f8\u95dc\u7814\u7a76\u5f88\u5c11\uff0c\u56e0\u6b64\u672c\u7814\u7a76\u5c07\u63a2\u8a0e\u81bd\u6518\u5207\u9664\u624b\u8853\u624b\u8853\u91cf\u8207\u91ab\u7642\u7e3d\u8cbb\u7528\u4e4b\u76f8\u95dc\u6027\u3002<\/ul>\n<ul>\u7814\u7a76\u8a2d\u8a08\u8207\u65b9\u6cd5\uff1a\u672c\u7814\u7a76\u63a1\u56de\u6eaf\u6027\u7814\u7a76\u8a2d\u8a08\uff0c\u91dd\u5c0d\u5168\u570b1998-2009\u5e74247,751\u4f8b\u81bd\u56ca\u5207\u9664\u624b\u8853\u500b\u6848\u70ba\u7814\u7a76\u6a23\u672c\u3002\u672c\u7814\u7a76\u4ee5\u5e73\u5747\u6bcf\u5e74\u91ab\u9662\u624b\u8853\u91cf1-29\u300130-84\u3001\u226585\u4f86\u5340\u5206\u70ba\u4f4e\u3001\u4e2d\u3001\u9ad8\u91ab\u9662\u624b\u8853\u91cf\uff0c\u4ee5\u5e73\u5747\u6bcf\u5e74\u91ab\u5e2b\u624b\u8853\u91cf1-10\u300111-24\u3001\u226525\u4f86\u5340\u5206\u70ba\u4f4e\u3001\u4e2d\u3001\u9ad8\u91ab\u5e2b\u624b\u8853\u91cf\u3002\u672c\u7814\u7a76\u5229\u7528\u968e\u5c64\u56de\u6b78\u5206\u6790\u6a21\u5f0f(Hierarchical linear regression model)\u63a7\u5236\u91ab\u9662\u5c64\u7d1a\u985e\u5225(\u56e0\u70ba\u6bcf\u5bb6\u91ab\u9662\u5c64\u7d1a\u985e\u5225\u7d66\u4ed8\u4e0d\u540c)\uff0c\u4e26\u5229\u7528\u50be\u5411\u914d\u5c0d\u5206\u6578(Propensity score matching)\u4f86\u8a55\u4f30\u624b\u8853\u91cf\u8207\u91ab\u7642\u7e3d\u8cbb\u7528\u4e4b\u76f8\u95dc\u6027\u3002<\/ul>\n<ul>\u7814\u7a76\u7d50\u679c\uff1a\u7814\u7a76\u7d50\u679c\u767c\u73fe\u5e73\u5747\u57f7\u884c\u81bd\u56ca\u5207\u9664\u624b\u8853\u4e4b\u91ab\u7642\u7e3d\u8cbb\u7528\u70ba\u6bcf\u4ef6\u7f8e\u91d12,504.53\u5143\uff0c\u9ad8\u624b\u8853\u91cf\u91ab\u9662\/\u91ab\u5e2b\u4e4b\u91ab\u7642\u7e3d\u8cbb\u7528\u986f\u8457\u8f03\u4f4e\u624b\u8853\u91cf\u91ab\u9662\/\u91ab\u5e2b\u6e1b\u5c1133%\/47%\u91ab\u7642\u7e3d\u8cbb\u7528\uff0c\u5229\u7528\u50be\u5411\u914d\u5c0d\u5206\u6578\u4ea6\u767c\u73fe\u9ad8\u624b\u8853\u91cf\u91ab\u9662\/\u91ab\u5e2b\u986f\u8457\u8f03\u4e2d\/\u4f4e\u624b\u8853\u91cf\u91ab\u9662\/\u91ab\u5e2b\u6709\u8f03\u4f4e\u4e4b\u91ab\u7642\u7e3d\u8cbb\u7528($2,073.70 vs. $2,350.91\/$2,056.73 vs. $2,553.76, P &lt; 0.001)\u3002\u6574\u9ad4\u800c\u8a00\uff0c\u5728\u53f0\u7063\u5730\u5340\u6bcf\u5e74\u57f7\u884c\u9ad8\u624b\u8853\u91cf\u91ab\u9662\/\u91ab\u5e2b\u4e4b\u91ab\u7642\u7e3d\u8cbb\u7528\u5c07\u8f03\u4f4e\u624b\u8853\u91cf\u91ab\u9662\/\u91ab\u5e2b\u6e1b\u5c112.05~2.92\u5104\u7f8e\u5143\u4e4b\u91ab\u7642\u7e3d\u8cbb\u7528(Economic Burdens)\u3002<\/ul>\n<ul>\u7d50\u8ad6\uff1a\u672c\u7814\u7a76\u5229\u7528\u968e\u5c64\u56de\u6b78\u5206\u6790\u6a21\u5f0f\u53ca\u50be\u5411\u914d\u5c0d\u5206\u6790-\u91dd\u5c0d\u81bd\u56ca\u5207\u9664\u624b\u8853\u767c\u73fe\u6709\u624b\u8853\u91cf\u8207\u91ab\u7642\u7e3d\u8cbb\u7528\u4e4b\u76f8\u95dc\u6027\uff1b\u518d\u8005\uff0c\u75c5\u4eba\u5e74\u9f61\u3001\u6027\u5225\u3001\u5408\u4f75\u75c7\u3001\u91ab\u9662\u5c64\u7d1a\u3001\u91ab\u9662\u624b\u8853\u91cf\u53ca\u91ab\u5e2b\u624b\u8853\u91cf\u7686\u6703\u986f\u8457\u5f71\u97ff\u81bd\u56ca\u5207\u9664\u624b\u8853\u4e4b\u91ab\u7642\u8cc7\u6e90\u8017\u7528\uff1b\u6700\u5f8c\uff0c\u9ad8\u624b\u8853\u91cf\u91ab\u9662\u53ca\u91ab\u5e2b\u53ef\u4ee5\u986f\u8457\u6539\u5584\u75c5\u4eba\u4e4b\u91ab\u7642\u6210\u672c\uff0c\u5efa\u8b70\u9ad8\u624b\u8853\u91cf\u91ab\u9662\/\u91ab\u5e2b\u61c9\u5c07\u5176\u7d93\u9a57\u50b3\u627f\u7d66\u76f8\u5c0d\u8f03\u4f4e\u624b\u8853\u91cf\u4e4b\u91ab\u9662\/\u91ab\u5e2b\u3002<\/ul>\n<p style=\"text-align: right\"><a href=\"http:\/\/wp.kmu.edu.tw\/rd\/archives\/2054\">\u56de\u7b2c0014\u671f\u4e3b\u9801<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u56de\u7b2c0014\u671f\u4e3b\u9801 \u4e8c\u3001\u8ad6\u6587\u8207\u7814\u7a76\u5206\u4eab \uff08\u4e00\uff09\u8ad6\u6587 \u984c\u76ee\uff1a \u76ee\u6a19\u5316\u5075\u6e2clegum &hellip; <a href=\"https:\/\/wp.kmu.edu.tw\/rd\/archives\/2058\">\u95b1\u8b80\u5168\u6587 <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[22],"tags":[],"class_list":["post-2058","post","type-post","status-publish","format-standard","hentry","category-22"],"_links":{"self":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/2058","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/comments?post=2058"}],"version-history":[{"count":5,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/2058\/revisions"}],"predecessor-version":[{"id":2090,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/2058\/revisions\/2090"}],"wp:attachment":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/media?parent=2058"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/categories?post=2058"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/tags?post=2058"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}