{"id":2217,"date":"2014-01-03T14:17:50","date_gmt":"2014-01-03T06:17:50","guid":{"rendered":"http:\/\/wp.kmu.edu.tw\/rd\/?p=2217"},"modified":"2014-01-06T15:19:51","modified_gmt":"2014-01-06T07:19:51","slug":"%e7%a0%94%e7%a9%b6%e6%96%b0%e7%9f%a5-14","status":"publish","type":"post","link":"https:\/\/wp.kmu.edu.tw\/rd\/archives\/2217","title":{"rendered":"\u7814\u7a76\u65b0\u77e5"},"content":{"rendered":"<p style=\"text-align: right\"><a href=\"http:\/\/wp.kmu.edu.tw\/rd\/archives\/2215\">\u56de\u7b2c0016\u671f\u4e3b\u9801<\/a><\/p>\n<h1><span style=\"font-size: x-large;color: #c10000\">\u4e00\u3001\u7814\u7a76\u65b0\u77e5<\/span><\/h1>\n<p><a name=\"ResNew1\"><\/a><\/p>\n<ul>\n<li>\n<h1><span style=\"color: #0000ff\">2013\u5e74\u5316\u5b78\u9818\u57df\u8afe\u8c9d\u723e\u5f97\u734e\u8005\u7814\u7a76\u5167\u5bb9\u7c21\u4ecb<br \/>\n<\/span><\/h1>\n<p>\uff08\u8cc7\u6599\u8f49\u8f09\u65bc\u53f0\u5927\u79d1\u5b78\u6559\u80b2\u767c\u5c55\u4e2d\u5fc3 \u8521\u860a\u660e\u81fa\u5927\u5316\u5b78\u7cfb\u540d\u8b7d\u6559\u6388\u540c\u610f\u8f49\u8f09\uff09<\/p>\n<p><strong>\u5316\u5b78\u53cd\u61c9\u4ee5\u9583\u96fb\u7684\u901f\u5ea6\u9032\u884c\u8457\uff1b\u96fb\u5b50\u5728\u539f\u5b50\u6838\u9593\u8df3\u8e8d\uff0c\u9583\u907f\u8457\u5316\u5b78\u5bb6\u5011\u864e\u8996\u7708\u7708\u7684\u96d9\u773c\u30022013\u5e74\u7684\u8afe\u8c9d\u723e\u5316\u5b78\u6842\u51a0\u5f97\u4e3b\u5011\u5229\u7528\u96fb\u8166\uff0c\u8b93\u5316\u5b78\u7684\u795e\u7955\u8def\u5f91\u5f97\u4ee5\u73fe\u5f62\u3002\u5c0d\u65bc\u5316\u5b78\u904b\u4f5c\u7684\u7d30\u90e8\u66b8\u89e3\uff0c\u4f7f\u5f97\u50ac\u5316\u5291\u3001\u85e5\u7269\u4ee5\u53ca\u592a\u967d\u80fd\u96fb\u6c60\u7684\u6700\u4f73\u5316\u8b8a\u5f97\u66f4\u6709\u6548\u7387\u3002<\/strong><\/p>\n<p>\u5168\u4e16\u754c\u7684\u8a31\u591a\u5316\u5b78\u5bb6\u5e7e\u4e4e\u6bcf\u5929\u5728\u96fb\u8166\u4e0a\u8a2d\u8a08\u4ee5\u53ca\u57f7\u884c\u5be6\u9a57\uff0c\u900f\u904e\u99ac\u4e01\u02d9\u5361\u666e\u62c9\u65af(Martin Karplus)\u3001\u9ea5\u53ef\u02d9\u674e\u7dad\u7279(Michael Levitt)\u4ee5\u53ca\u827e\u745e\u02d9\u74e6\u6b47\u723e(Arieh Warshel)\u65bc1970\u5e74\u4ee3\u6240\u767c\u5c55\u7684\u65b9\u6cd5\uff0c\u5316\u5b78\u5bb6\u5011\u6aa2\u8996\u8457\u7528\u8089\u773c\u7121\u6cd5\u770b\u5230\u7684\u8907\u96dc\u5316\u5b78\u904e\u7a0b\u4e2d\u4e4b\u6bcf\u4e00\u500b\u5c0f\u5c0f\u7684\u6b65\u9a5f\u3002<\/p>\n<p>\u7232\u4e86\u8b93\u8b80\u8005\u611f\u53d7\u5230\u4eba\u985e\u5982\u4f55\u56e0\u6b64\u800c\u53d7\u60e0\uff0c\u8b93\u6211\u5011\u7528\u4e00\u500b\u4f8b\u5b50\u4f86\u958b\u982d\u3002\u8acb\u7a7f\u4e0a\u4f60\u7684\u5be6\u9a57\u8863\uff0c\u56e0\u70ba\u6211\u5011\u8981\u7d66\u4f60\u4e00\u500b\u6311\u6230\uff1a\u5275\u9020\u4eba\u5de5\u5149\u5408\u4f5c\u7528\u3002\u9019\u500b\u5728 \u7da0\u8449\u4e2d\u9032\u884c\u7684\u5316\u5b78\u53cd\u61c9\uff0c\u8b93\u5927\u6c23\u5145\u586b\u4e86\u6c27\u6c23\uff0c\u4e5f\u662f\u5730\u7403\u4e0a\u6709\u751f\u547d\u5b58\u5728\u7684\u5fc5\u8981\u689d\u4ef6\u4e4b\u4e00\u3002\u4f46\u662f\u5f9e\u74b0\u5883\u7684\u89d2\u5ea6\u4f86\u770b\uff0c\u9019\u662f\u5f88\u6709\u610f\u7fa9\u7684\uff0c\u56e0\u70ba\u5982\u679c\u4f60\u80fd\u5920\u6a21\u64ec\u5149\u5408\u4f5c\u7528\uff0c\u5c31 \u80fd\u5275\u9020\u66f4\u6709\u6548\u7387\u7684\u592a\u967d\u80fd\u96fb\u6c60\u3002\u7576\u6c34\u5206\u89e3\u6642\u6703\u7522\u751f\u6c27\u6c23\uff0c\u4f46\u96a8\u4f34\u7522\u751f\u7684\u6c2b\u6c23\u5247\u53ef\u4ee5\u7528\u65bc\u9a45\u52d5\u6211\u5011\u7684\u8eca\u8f1b\u3002\u56e0\u6b64\u4f60\u6709\u5341\u8db3\u5145\u5206\u7684\u7406\u7531\u53c3\u8207\u9019\u500b\u8a08\u756b\uff0c\u5047\u82e5\u4f60\u6210\u529f\u4e86\uff0c\u4f60 \u4e5f\u6703\u5c0d\u89e3\u6c7a\u6eab\u5ba4\u6548\u61c9\u7684\u554f\u984c\u6709\u6240\u8ca2\u737b\u3002<\/p>\n<p><strong>\u4e00\u5f35\u5716\u8d85\u904e\u5343\u8a00\u842c\u8a9e \u2014 \u4f46\u4e26\u975e\u5168\u90e8<\/strong><\/p>\n<p>\u505a\u70ba\u7b2c\u4e00\u6b65\uff0c\u4f60\u61c9\u8a72\u6703\u4e0a\u7db2\u53bb\u627e\u5c0b\u90a3\u4e9b\u63a7\u5236\u5149\u5408\u4f5c\u7528\u7684\u86cb\u767d\u8cea\u7684\u4e09\u7dad\u7d50\u69cb\u5716\u50cf\u3002\u7db2\u8def\u88cf\u9019\u4e9b\u5716\u50cf\u5747\u53ef\u81ea\u7531\u7684\u53d6\u5f97\uff0c\u5728\u4f60\u7684\u96fb\u8166\u4e0a\u53ef\u5c07\u5716\u50cf\u96a8\u610f\u65cb \u8f49\u548c\u626d\u66f2\uff0c\u5b83\u63ed\u9732\u4e86\u5de8\u5927\u7684\u86cb\u767d\u8cea\u5206\u5b50\u88cf\u6578\u4ee5\u842c\u8a08\u7684\u539f\u5b50\u3002\u5728\u5176\u4e2d\u5fc3\u67d0\u8655\uff0c\u6709\u4e00\u500b\u5c0f\u5c0f\u7684\u5340\u57df\uff0c\u88ab\u7a31\u70ba\u53cd\u61c9\u4e2d\u5fc3\uff0c\u9019\u5c31\u662f\u6c34\u5206\u5b50\u88ab\u88c2\u89e3\u7684\u5730\u65b9\u3002\u4e0d\u904e\u53ea\u6709\u5e7e\u500b\u539f\u5b50\u662f \u76f4\u63a5\u53c3\u8207\u9019\u500b\u53cd\u61c9\u7684\uff0c\u5716\u50cf\u5f88\u6e05\u695a\u7684\u986f\u793a\u4e86\u539f\u5b50\u8207\u96e2\u5b50\u76f8\u4e92\u5750\u843d\u7684\u4f4d\u7f6e\uff0c\u4f46\u537b\u7121\u6cd5\u8aaa\u51fa\u9019\u4e9b\u539f\u5b50\u8207\u96e2\u5b50\u5982\u4f55\u904b\u4f5c\uff0c\u9019\u5c31\u662f\u4f60\u9700\u8981\u641e\u6e05\u695a\u7684\u3002\u4e0d\u77e5\u5982\u4f55\u7684\uff0c\u96fb\u5b50\u5fc5\u9808\u5f9e \u6c34\u5206\u5b50\u4e2d\u53d6\u51fa\uff0c\u53e6\u6709\u56db\u500b\u8cea\u5b50(H+)\u5fc5\u9808\u8655\u7406\uff0c\u9019\u5230\u5e95\u5982\u4f55\u767c\u751f\u5462\uff1f<br \/>\n\u9019\u500b\u904e\u7a0b\u7528\u50b3\u7d71\u7684\u5316\u5b78\u65b9\u6cd5\u57fa\u672c\u4e0a\u662f\u7121\u6cd5\u5f04\u6e05\u695a\u7684\uff0c\u6709\u592a\u591a\u7684\u4e8b\u60c5\u767c\u751f\u5728\u4e00\u500b\u6beb\u79d2(10-3\u79d2)\u4e4b\u5167 \u2013 \u9019\u7a2e\u901f\u5ea6\u6392\u9664\u4e86\u7528\u8a66\u7ba1\u5be6\u9a57\u4f86\u7814\u7a76\u4e4b\u53ef\u80fd\u3002\u5f9e\u4f60\u7684\u96fb\u8166\u5716\u50cf\u4e5f\u4ecd\u7136\u5f88\u96e3\u731c\u6e2c\u53cd\u61c9\u7684\u904e\u7a0b\uff0c\u56e0\u70ba\u5716\u50cf\u662f\u5728\u975c\u614b\u53d6\u5f97\u7684\uff0c\u7136\u800c\u7576\u592a\u967d\u7167\u5c04\u5728\u7da0\u8449\u4e0a\u6642\uff0c\u90a3\u4e9b\u86cb\u767d\u8cea\u5145\u6eff\u4e86\u80fd\u91cf\u800c\u6574\u500b\u5206\u5b50\u7684\u7d50\u69cb\u6539\u8b8a\u4e86\u3002\u70ba\u4e86\u77ad\u89e3\u9019\u500b\u5316\u5b78\u53cd\u61c9\uff0c\u4f60\u9700\u8981\u77e5\u9053\u5145\u586b\u4e86\u80fd\u91cf\u7684\u5206\u5b50\u7d50\u69cb\u662f\u4ec0\u9ebc\u6a23\u5b50\u3002<br \/>\n\u9019\u5c31\u662f\u9700\u8981\u53ec\u559a\u96fb\u8166\u7a0b\u5f0f\u4f86\u5e6b\u52a9\u4f60\u7684\u6642\u523b\uff0c\u800c\u9019\u4e9b\u96fb\u8166\u7a0b\u5f0f\u5c31\u662f\u57fa\u65bc2013\u5e74\u7684\u8afe\u8c9d\u723e\u5316\u5b78\u734e\u5f97\u4e3b\u5011\u6240\u5960\u5b9a\u7684\u57fa\u77f3\u3002<\/p>\n<p><strong>\u7406\u8ad6\u8207\u5be6\u8e10 \u2014 \u4e00\u500b\u6210\u529f\u7684\u76f8\u8f14\u76f8\u6210<\/strong><\/p>\n<p>\u5229\u7528\u9019\u7a2e\u96fb\u8166\u7a0b\u5f0f\uff0c\u4f60\u53ef\u4ee5\u8a08\u7b97\u5404\u7a2e\u53ef\u80fd\u7684\u53cd\u61c9\u8def\u5f91\uff0c\u9019\u88ab\u7a31\u70ba\u6a21\u64ec(simulation or modeling)\uff0c\u6b64\u6cd5\u8b93\u4f60\u5c0d\u90a3\u4e9b\u539f\u5b50\u5728\u5316\u5b78\u53cd\u61c9\u7684\u4e0d\u540c\u968e\u6bb5\u626e\u6f14\u7684\u89d2\u8272\u6709\u4e9b\u6982\u5ff5\uff0c\u800c\u7576\u4f60\u6709\u4e00\u500b\u53ef\u80fd\u7684\u53cd\u61c9\u8def\u5f91\u6642\uff0c\u6703\u8f03\u5bb9\u6613\u57f7\u884c\u771f\u5be6\u7684\u5be6\u9a57\u4f86\u8b49\u5be6\u96fb\u8166\u7684\u5c0d \u932f\uff0c\u9019\u4e9b\u5be6\u9a57\u53cd\u904e\u4f86\u63d0\u4f9b\u4e86\u65b0\u7684\u7dda\u7d22\u4ee5\u5c0e\u81f4\u66f4\u597d\u7684\u96fb\u8166\u6a21\u64ec\u7d50\u679c\uff1b\u7406\u8ad6\u8207\u5be6\u8e10\u9054\u5230\u76f8\u8f14\u76f8\u6210\u7684\u6548\u679c\u3002\u7d50\u679c\u662f\uff0c\u5316\u5b78\u5bb6\u5011\u82b1\u5728\u96fb\u8166\u524d\u9762\u7684\u6642\u9593\uff0c\u8207\u82b1\u5728\u8a66\u7ba1\u4e4b\u9593\u7684\u6642\u9593 \u5e7e\u4e4e\u4e00\u6a23\u591a\uff01<br \/>\n\u90a3\u9ebc\u9019\u6b21\u8afe\u8c9d\u723e\u5316\u5b78\u734e\u5f97\u4e3b\u5011\u767c\u5c55\u7684\u96fb\u8166\u7a0b\u5f0f\uff0c\u5230\u5e95\u6709\u4f55\u795e\u5947\u4e4b\u8655\u5462\uff1f<\/p>\n<p><strong>\u5c07\u5169\u500b\u4e16\u754c\u6700\u597d\u7684\u6574\u5408\u8d77\u4f86<\/strong><\/p>\n<p>\u904e\u53bb\uff0c\u7576\u79d1\u5b78\u5bb6\u5011\u8981\u5728\u96fb\u8166\u4e0a\u6a21\u64ec\u5206\u5b50\u6642\uff0c\u4ed6\u5011\u64c1\u6709\u7684\u7a0b\u5f0f\u4e0d\u662f\u57fa\u65bc\u53e4\u5178\u725b\u9813\u7269\u7406\uff0c\u5c31\u662f\u57fa\u65bc\u91cf\u5b50\u7269\u7406\uff0c\u4e8c\u8005\u5404\u6709\u5176\u9577\u8655\u8207\u77ed\u8655\u3002\u57fa\u65bc\u53e4\u5178\u7269\u7406 \u7684\u7a0b\u5f0f\u80fd\u8a08\u7b97\u8207\u8655\u7406\u5927\u7684\u5316\u5b78\u5206\u5b50\uff0c\u5b83\u5011\u53ea\u80fd\u986f\u793a\u975c\u614b\u7684\u5206\u5b50\uff0c\u4f46\u662f\u7d66\u4e88\u5316\u5b78\u5bb6\u5011\u95dc\u65bc\u5206\u5b50\u5167\u7684\u539f\u5b50\u7684\u76f8\u5c0d\u4f4d\u7f6e\u5f88\u597d\u7684\u5716\u50cf\uff0c\u53ef\u662f\u4f60\u7121\u6cd5\u7528\u9019\u4e9b\u7a0b\u5f0f\u53bb\u6a21\u64ec\u5316\u5b78\u53cd \u61c9\u3002\u5728\u5316\u5b78\u53cd\u61c9\u6642\uff0c\u5206\u5b50\u662f\u5145\u6eff\u80fd\u91cf\u7684\uff0c\u8655\u5728\u6fc0\u767c\u7684\u72c0\u614b\uff0c\u53e4\u5178\u7269\u7406\u5c31\u662f\u7121\u6cd5\u7406\u89e3\u9019\u4e9b\u72c0\u614b\uff0c\u800c\u9019\u5c31\u6210\u70ba\u4e00\u500b\u56b4\u91cd\u7684\u9650\u5236\u3002<a href=\"http:\/\/wp.kmu.edu.tw\/rd\/files\/2013\/12\/\u7b2c\u5341\u516d\u671f.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-2220\" alt=\"\u7b2c\u5341\u516d\u671f\" src=\"http:\/\/wp.kmu.edu.tw\/rd\/files\/2013\/12\/\u7b2c\u5341\u516d\u671f-300x138.png\" width=\"300\" height=\"138\" srcset=\"https:\/\/wp.kmu.edu.tw\/rd\/files\/2013\/12\/\u7b2c\u5341\u516d\u671f-300x138.png 300w, https:\/\/wp.kmu.edu.tw\/rd\/files\/2013\/12\/\u7b2c\u5341\u516d\u671f.png 631w, https:\/\/wp.kmu.edu.tw\/rd\/files\/2013\/12\/\u7b2c\u5341\u516d\u671f-500x231.png 500w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u57162\uff1a\u725b\u9813\u8207\u859b\u4e01\u683c\u7684\u8c93\uff1a\u5f9e\u524d\uff0c\u53e4\u5178\u7269\u7406\u8207\u91cf\u5b50\u5316\u5b78\u5206\u5c6c\u5169\u500b\u76f8\u4e92\u5c0d\u6297\u7684\u4e16\u754c\uff0c2013\u5e74\u7684\u8afe\u8c9d\u723e\u5316\u5b78\u734e\u5f97\u4e3b\u5011\u66ff\u9019\u5169\u500b\u4e16\u754c\u6253\u958b\u4e86\u4e00\u6247\u5927\u9580\uff0c\u5e36\u4f86\u4e86\u66a2\u65fa\u7684\u5408\u4f5c\u3002<\/p>\n<p>\u7576\u79d1\u5b78\u5bb6\u5011\u8981\u6a21\u64ec\u5316\u5b78\u53cd\u61c9\u6642\uff0c\u4ed6\u5011\u9700\u8981\u8f49\u800c\u6c42\u52a9\u91cf\u5b50\u7269\u7406\uff1b\u5176\u4e8c\u5143\u7406\u8ad6(dualistic theory)\u5c07\u96fb\u5b50\u8996\u70ba\u540c\u6642\u5177\u6709\u7c92\u5b50\u8207\u6ce2\u52d5\u7684\u96d9\u91cd\u6027\u8cea\uff0c\u5176\u4e2d\u8457\u540d\u7684\u859b\u4e01\u683c\u7684\u8c93\uff0c\u85cf\u5728\u76d2\u4e2d\uff0c\u53ef\u80fd\u662f\u6d3b\u7684\u4e5f\u53ef\u80fd\u662f\u6b7b\u7684\u3002\u91cf\u5b50\u7269\u7406\u7684\u5f37\u9805\u5728\u65bc\u5b83\u662f\u6c92\u6709\u504f\u898b\u7684\uff0c \u5176\u6a21\u578b\u4e0d\u5305\u62ec\u79d1\u5b78\u5bb6\u5011\u7684\u9810\u6e2c\uff0c\u56e0\u6b64\u9019\u6a23\u7684\u6a21\u64ec\u8f03\u70ba\u771f\u5be6\u3002\u4f46\u5176\u7f3a\u9ede\u5728\u65bc\u8a08\u7b97\u9700\u8981\u8017\u8cbb\u9f90\u5927\u7684\u96fb\u8166\u8cc7\u6e90\uff0c\u56e0\u70ba\u96fb\u8166\u9700\u8981\u8655\u7406\u5206\u5b50\u4e2d\u7684\u6bcf\u4e00\u500b\u96fb\u5b50\u4ee5\u53ca\u539f\u5b50\u6838\u3002\u9019\u5c31\u597d 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\/>\n\u6240\u4ee5\u53e4\u5178\u7269\u7406\u8207\u91cf\u5b50\u5316\u5b78\u662f\u5169\u500b\u672c\u8cea\u4e0a\u4e0d\u540c\uff0c\u800c\u4e14\u5728\u67d0\u4e9b\u65b9\u9762\u76f8\u4e92\u885d\u7a81\u7684\u4e16\u754c\u3002\u4f46\u662f2013\u5e74\u7684\u8afe\u8c9d\u723e\u5316\u5b78\u734e\u5f97\u4e3b\u5011\uff0c\u66ff\u9019\u5169\u500b\u4e16\u754c\u6253\u958b\u4e86\u4e00\u6247\u5927\u9580\uff0c\u5728\u4ed6\u5011\u7684\u6a21\u578b\u7406\uff0c\u725b\u9813\u8207\u4ed6\u7684\u860b\u679c\uff0c\u8ddf\u859b\u4e01\u683c\u548c\u4ed6\u7684\u8c93\u5408\u4f5c\u3002<\/p>\n<p><strong>\u91cf\u5b50\u5316\u5b78\u8207\u53e4\u5178\u7269\u7406\u5408\u4f5c<\/strong><\/p>\n<p>\u57281970\u5e74\u4ee3\uff0c\u5728\u7f8e\u570b\u528d\u6a4b\u54c8\u4f5b\u5927\u5b78\u5361\u666e\u62c9\u65af\u7684\u5be6\u9a57\u5ba4\u88e1\uff0c\u958b\u5c55\u4e86\u5408\u4f5c\u7684\u7b2c\u4e00\u6b65\u3002\u5361\u666e\u62c9\u65af\u5177\u6709\u6df1\u539a\u7684\u91cf\u5b50\u80cc\u666f\uff0c\u4ed6\u7684\u7814\u7a76\u5c0f\u7d44\u767c\u5c55\u7684\u96fb\u8166\u7a0b\u5f0f\uff0c\u85c9\u8457\u91cf\u5b50\u7269\u7406\u7684\u5e6b\u52a9\u53ef\u4ee5\u6a21\u64ec\u5316\u5b78\u53cd\u61c9\u3002\u4ed6\u4e5f\u767c\u5c55\u4e86\u6240\u8b02\u7684\u201c\u5361\u666e\u62c9\u65af\u65b9\u7a0b\u5f0f\u201d\u61c9\u7528\u65bc\u6838\u78c1\u5171\u632f(NMR)\uff0c\u90a3\u662f\u4e00\u500b\u5316\u5b78\u5bb6\u719f\u77e5\u7684\u65b9\u6cd5\uff0c\u4e43\u57fa\u65bc\u5206\u5b50\u7684\u91cf\u5b50\u5316\u5b78\u6027\u8cea\u6240\u5efa\u7acb\u7684\u3002\u7576\u74e6\u6b47\u723e\u5b8c\u6210\u4ed6\u7684\u535a\u58eb\u5b78\u4f4d\u5f8c\uff0c\u4ed6\u57281970\u5e74\u9032\u5165\u4e86\u5361\u666e\u62c9\u65af\u7684\u5be6\u9a57\u5ba4\u3002\u4ed6\u7684\u535a\u58eb\u5b78\u4f4d\u662f\u5728\u4ee5\u8272\u5217Rehovot\u7684Weismann\u79d1\u5b78\u7814\u7a76\u9662\u6240\u7372\u5f97\u7684\uff0c\u8a72\u7814\u7a76\u9662\u64c1\u6709\u4e00\u53f0\u80fd\u529b\u5f37\u5927\u7684\u96fb\u8166\uff0c\u88ab\u7a31\u70baGolem\uff0c\u90a3\u662f\u53d6\u81ea\u7336\u592a\u50b3\u8aaa\u4e2d\u7684\u4e00\u4f4d\u6709\u751f\u547d\u7684\u6ce5\u4eba\u7684\u540d\u5b57\u3002\u900f\u904eGolem\u7684\u5e6b\u52a9\uff0c\u74e6\u6b47\u723e\u8207\u674e\u7dad\u7279\u57fa\u65bc\u53e4\u5178\u7406\u8ad6\uff0c\u767c\u5c55\u4e86\u4e00\u500b\u7a81\u7834\u6027\u7684\u96fb\u8166\u7a0b\u5f0f\uff0c\u6b64\u7a0b\u5f0f\u80fd\u5920\u6a21\u64ec\u5404\u7a2e\u5206\u5b50\uff0c\u751a\u81f3\u65bc\u771f\u6b63\u5f88\u5927\u7684\u751f\u7269\u5206\u5b50\u3002<br 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\/>\n\u6700\u5f8c\u5361\u666e\u62c9\u65af\u8207\u74e6\u6b47\u723e\u7d42 \u65bc\u80fd\u5920\u8655\u7406\u8996\u7db2\u919b\uff0c\u4e0d\u904e\u4ed6\u5011\u662f\u5f9e\u5177\u6709\u7c21\u55ae\u7d50\u69cb\u7684\u985e\u4f3c\u5206\u5b50\u958b\u59cb\u7684\u3002\u4ed6\u5011\u767c\u5c55\u4e86\u4e00\u500b\u96fb\u8166\u7a0b\u5f0f\uff0c\u904b\u7528\u91cf\u5b50\u7269\u7406\u4f86\u8655\u7406\u81ea\u7531\u96fb\u5b50\u7684\u8a08\u7b97\uff0c\u4f46\u662f\u7528\u7c21\u55ae\u7684\u53e4\u5178\u7406\u8ad6\u4f86\u8655\u7406 \u5176\u5b83\u7684\u96fb\u5b50\u4ee5\u53ca\u6240\u6709\u7684\u539f\u5b50\u6838\u3002\u57281972\u5e74\uff0c\u4ed6\u5011\u767c\u8868\u4e86\u7814\u7a76\u7d50\u679c\uff0c\u9019\u4e43\u662f\u7b2c\u4e00\u6b21\u6709\u4eba\u80fd\u5920\u900f\u904e\u53e4\u5178\u8207\u91cf\u5b50\u7269\u7406\u7684\u5408\u4f5c\u4f86\u8655\u7406\u5316\u5b78\u76f8\u95dc\u7684\u554f\u984c\uff0c\u4f46\u662f\u6b64\u6cd5\u50c5\u80fd\u8655\u7406 \u5177\u6709\u93e1\u9762\u5c0d\u7a31\u6027\u7684\u5206\u5b50(\u50cf\u4eba\u4e00\u822c\u6709\u4e00\u9762\u93e1\u5b50\u5728\u8eab\u9ad4\u6b63\u4e2d\u592e\u800c\u5de6\u53f3\u5c0d\u6620)\u3002<\/p>\n<p><strong>\u4e00\u500b\u842c\u7528\u7a0b\u5f0f\u4f86\u8a08\u7b97\u751f\u547d\u7684\u5316\u5b78<\/strong><\/p>\n<p>\u5728\u54c8\u4f5b\u5927\u5b78\u5f85\u4e86\u5169\u5e74\u4e4b\u5f8c\uff0c\u74e6\u6b47\u723e\u53c8\u8207\u674e\u7dad\u7279\u5408\u4f5c\u3002\u6b64\u6642\u674e\u7dad\u7279\u5df2\u7d93\u5b8c\u6210\u4e86\u82f1\u570b\u528d\u6a4b\u5927\u5b78\u7684\u535a\u58eb\u8a13\u7df4\uff0c\u6b63\u503c\u5168\u7403\u5c16\u7aef\u7684\u7814\u7a76\u90fd\u5728\u65bc\u63a2\u8a0e\u50cf\u662fDNA\u3001RNA\u4ee5\u53ca\u86cb\u767d\u8cea\u9019\u985e\u7684\u751f\u7269\u5206\u5b50\uff0c\u4ed6\u4f01\u5716\u7528\u4ed6\u7684\u53e4\u5178\u96fb\u8166\u7a0b\u5f0f\u4f86\u5c0d\u751f\u7269\u5206\u5b50\u7684\u7d50\u69cb\u505a\u9032\u4e00\u6b65\u7684\u77ad\u89e3\uff0c\u7136\u800c\u9650\u5236\u4ecd\u7136\u5b58\u5728\uff0c\u50c5\u80fd\u89c0\u5bdf\u975c\u614b\u7684\u5206\u5b50\u3002<br \/>\n\u674e\u7dad\u7279\u8207\u74e6\u6b47\u723e\u7784\u6e96\u4e86\u4e00\u500b\u5f88\u9ad8\u7684\u76ee\u6a19\uff0c\u4ed6\u5011\u60f3\u8981\u767c\u5c55\u4e00\u500b\u7a0b\u5f0f\u7528\u4f86\u7814\u7a76\u9175\u7d20\uff1b\u4e5f\u5c31\u662f\u751f\u547d\u6d3b\u9ad4\u4e2d\u63a7\u5236\u8207\u50ac\u5316\u5316\u5b78\u53cd\u61c9\u7684\u8a31\u591a\u86cb\u767d\u8cea\u3002\u65e9\u5728\u74e6\u6b47\u723e\u9084\u662f\u4e00\u4f4d\u5e74\u8f15\u7684\u5b78\u751f\u6642\uff0c\u4ed6\u5c31\u5c0d\u65bc\u9175\u7d20\u5982\u4f55\u904b\u4f5c\u5f88\u597d\u5947\u3002\u900f\u904e\u9175\u7d20\u9593\u7684\u76f8\u4e92\u5408\u4f5c\uff0c\u751f\u547d\u624d\u53ef\u80fd\u5b58\u5728\uff0c\u5b83\u5011\u63a7\u5236\u4e86\u57fa\u672c\u4e0a\u6240\u6709\u751f\u547d\u9ad4\u5167\u7684\u5404\u7a2e\u5316\u5b78\uff0c\u5982\u679c\u4f60\u60f3\u8981\u77ad\u89e3\u751f\u547d\uff0c\u4f60\u5c31\u5fc5\u9808\u77ad\u89e3\u9175\u7d20\u3002<br \/>\n\u7232\u4e86\u80fd\u5920\u6a21\u64ec\u9175\u7d20\u7684\u53cd\u61c9\uff0c\u674e\u7dad\u7279\u8207\u74e6\u6b47\u723e\u5fc5\u9808\u8b93\u53e4\u5178\u8207\u91cf\u5b50\u7269\u7406\u7684\u5408\u4f5c\u66f4\u70ba\u9806\u66a2\uff0c\u9019\u82b1\u4e86\u4ed6\u5011\u8a31\u591a\u5e74\u53bb\u514b\u670d\u5404\u7a2e\u969c\u7919\u3002\u4ed6\u5011\u7684\u63a2\u7d22\u59cb\u65bcWeismann\u79d1\u5b78\u7814\u7a76\u9662\uff0c\u4f46\u662f\u7576\u674e\u7dad\u7279\u5728\u6578\u5e74\u5f8c\u5b8c\u6210\u4e86\u4ed6\u7684\u535a\u58eb\u5f8c\u7814\u7a76\u7684\u8a13\u7df4\uff0c\u4ed6\u56de\u5230\u4e86\u528d\u6a4b\uff0c\u5728\u90a3\u88e1\u74e6\u6b47\u723e\u4e5f\u4f86\u52a0\u5165\u3002\u57281976\u5e74\uff0c\u4ed6\u5011\u9054\u6210\u4e86\u76ee\u6a19\u4e26\u767c\u8868\u4e86\u7b2c\u4e00\u500b\u9175\u7d20\u53cd\u61c9\u7684\u96fb\u8166\u6a21\u64ec\uff0c\u4ed6\u5011\u7684\u7a0b\u5f0f\u662f\u9769\u547d\u6027\u7684\uff0c\u56e0\u70ba\u5b83\u53ef\u4ee5\u7528\u5728\u5404\u7a2e\u5206\u5b50\u4e0a\uff0c\u5728\u6a21\u64ec\u5316\u5b78\u53cd\u61c9\u6642\uff0c\u5927\u5c0f\u5df2\u7d93\u4e0d\u6210\u554f\u984c\u3002<\/p>\n<p><strong>\u805a\u7126\u65bc\u904b\u4f5c\u7684\u5fc3\u81df<\/strong><\/p>\n<p>\u73fe\u5728\u7576\u5316\u5b78\u5bb6\u6a21\u64ec\u5316\u5b78\u53cd\u61c9\u6642\uff0c\u4ed6\u5011\u9700\u8981\u6642\u5c31\u6703\u904b\u7528\u9019\u7a2e\u529b\u91cf\u3002\u4ed6\u5011\u5c0d\u6bcf\u4e00\u500b\u76f4\u63a5\u5f71\u97ff\u5316\u5b78\u904e\u7a0b\u7684\u96fb\u5b50\u8207\u539f\u5b50\u6838\uff0c\u9032\u884c\u5403\u529b\u7684\u91cf\u5b50\u7269\u7406\u8a08\u7b97\uff0c\u9019\u6a23\uff0c\u4ed6\u5011\u53d6\u5f97\u95dc\u9375\u6240\u5728\u5118\u53ef\u80fd\u6700\u4f73\u7684\u89e3\u6790\uff0c\u5206\u5b50\u5176\u5b83\u7684\u90e8\u4efd\u5247\u7528\u53e4\u5178\u7684\u65b9\u7a0b\u5f0f\u4f86\u6a21\u64ec\u3002<br \/>\n\u7232\u4e86\u4e0d\u6d6a\u8cbb\u96fb\u8166\u7684\u80fd\u529b\uff0c\u674e\u7dad\u7279\u8207\u74e6\u6b47\u723e\u5c07\u8a08\u7b97\u7684\u8ca0\u8f09\u9032\u4e00\u6b65\u4fee\u6e1b\uff0c\u96fb\u8166\u4e0d\u9700\u8981\u4e00\u76f4\u8655\u7406\u5206\u5b50\u4e2d\u4e0d\u91cd\u8981\u90e8\u5206\u7684\u6bcf\u4e00\u500b\u539f\u5b50\uff0c\u4ed6\u5011\u5c55\u793a\u4e86\u53ef\u4ee5\u5c07\u591a\u500b\u539f\u5b50\u5408\u4f75\u8a08\u7b97\u3002<br \/>\n\u73fe\u5728\u7684\u8a08\u7b97\u4e2d\uff0c\u79d1\u5b78\u5bb6\u9084\u5728\u6a21\u64ec\u6642\u52a0\u5165\u4e86\u7b2c\u4e09\u500b\u5c64\u6b21\u3002\u7c21\u55ae\u7684\u4f86\u8aaa\uff0c\u96fb\u8166\u53ef\u5c07\u96e2\u5316\u5b78\u53cd\u61c9\u4e2d\u5fc3\u5f88\u9060\u7684\u539f\u5b50\u5011\u5305\u88f9\u5728\u4e00\u8d77\uff0c\u6210\u70ba\u4e00\u500b\u5747\u52fb\u7684\u8cea\u9ad4\uff0c\u5728\u79d1\u5b78\u5708\u5167\uff0c\u9019\u88ab\u7a31\u70ba\u4ecb\u96fb\u4ecb\u8cea(dielectric medium)\u3002<a href=\"http:\/\/wp.kmu.edu.tw\/rd\/files\/2013\/12\/\u7b2c\u5341\u516d\u671f_2.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-2221\" alt=\"\u7b2c\u5341\u516d\u671f_2\" src=\"http:\/\/wp.kmu.edu.tw\/rd\/files\/2013\/12\/\u7b2c\u5341\u516d\u671f_2-300x160.png\" width=\"300\" height=\"160\" srcset=\"https:\/\/wp.kmu.edu.tw\/rd\/files\/2013\/12\/\u7b2c\u5341\u516d\u671f_2-300x160.png 300w, https:\/\/wp.kmu.edu.tw\/rd\/files\/2013\/12\/\u7b2c\u5341\u516d\u671f_2-500x267.png 500w, https:\/\/wp.kmu.edu.tw\/rd\/files\/2013\/12\/\u7b2c\u5341\u516d\u671f_2.png 573w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u57163\uff1a\u73fe\u4eca\u5316\u5b78\u5bb6\u5011\u6a21\u64ec\u5206\u5b50\u7684\u904b\u4f5c\u6642\uff0c\u82e5\u6709\u9700\u8981\u5c31\u6703\u904b\u7528\u96fb\u8166\u7684\u529b\u91cf\u3002\u91cf\u5b50\u7269\u7406\u7684\u8a08\u7b97\u6210\u70ba\u4e86\u6b64\u4e00\u7cfb\u7d71\u7684\u6838\u5fc3\uff0c\u5176\u5916\u5247\u662f\u57fa\u65bc\u53e4\u5178\u7269\u7406\u7684\u8655\u7406\uff0c\u800c\u5728\u6700\u5916\u5c64\u7684\u539f\u5b50\u548c\u5206\u5b50\u5247\u8996\u70ba\u805a\u96c6\u5728\u4e00\u8d77\u7684\u4e00\u5718\u5747\u52fb\u7269\u8cea\uff0c\u9019\u7a2e\u7c21\u5316\u7684\u65b9\u5f0f\uff0c\u8b93\u6211\u5011\u80fd\u7528\u8a08\u7b97\u4f86\u8655\u7406\u90a3\u4e9b\u5de8\u5927\u7684\u5316\u5b78\u9ad4\u7cfb\u3002<\/p>\n<p><strong>\u6a21\u64ec\u5c07\u5e36\u6211\u5011\u9032\u5c55\u81f3\u591a\u9060\u6c7a\u5b9a\u5728\u672a\u4f86<\/strong><\/p>\n<p>\u56e0\u70ba\u73fe\u4eca\u7684\u79d1\u5b78\u5bb6\u53ef\u4ee5\u7528\u96fb\u8166\u4f86\u9032\u884c\u5be6\u9a57\uff0c\u9019\u8b93\u6211\u5011\u5c0d\u5316\u5b78\u53cd\u61c9\u5982\u4f55\u7684\u9032\u884c\u5f97\u5230\u4e86\u66f4\u6df1\u7684\u7406\u89e3\u3002\u5361\u666e\u62c9\u65af\u3001\u674e\u7dad\u7279\u4ee5\u53ca\u74e6\u6b47\u723e\u767c\u5c55\u7684\u65b9\u6cd5\u7684\u5f37\u5ea6\u5728\u65bc\u5b83\u5011\u662f\u842c\u7528\u7684\uff0c\u5b83\u5011\u53ef\u4ee5\u7528\u4f86\u7814\u7a76\u5404\u7a2e\u5316\u5b78\uff1b\u5f9e\u751f\u547d\u7684\u5206\u5b50\u5230\u5de5\u696d\u4e0a\u7684\u5316\u5b78\u53cd\u61c9\uff0c\u79d1\u5b78\u5bb6\u53ef\u4ee5\u5c07\u592a\u967d\u80fd\u96fb\u6c60\u3001\u6c7d\u8eca\u7528\u7684\u50ac\u5316\u5291\u6216\u751a\u81f3\u65bc\u85e5\u7269\u6700\u4f73\u5316\uff0c\u800c\u9019\u50c5\u662f\u8209\u5e7e\u500b\u4f8b\u5b50\u800c\u5df2\u3002<br \/>\n\u4e0d\u904e\u9032\u5c55\u4e0d\u6703\u505c\u5728\u90a3\u88e1\uff0c\u5728\u674e\u7dad\u7279\u7684\u4e00\u7bc7\u8ad6\u6587\u4e2d\uff0c\u5beb\u5230\u4e86\u4ed6\u7684\u5922\u60f3\uff1a\u5728\u5206\u5b50\u7684\u5c64\u6b21\u6a21\u64ec\u751f\u547d\u9ad4\uff0c\u90a3\u771f\u662f\u500b\u6975\u70ba\u8a98\u4eba\u7684\u60f3\u6cd5\u3002\u75312013\u5e74\u7684\u8afe\u8c9d\u723e\u5316\u5b78\u734e\u5f97\u4e3b\u5011\u767c\u5c55\u7684\u96fb\u8166\u6a21\u64ec\uff0c\u662f\u6975\u70ba\u6709\u529b\u7684\u5de5\u5177\uff0c\u5230\u5e95\u5b83\u53ef\u5c07\u6211\u5011\u7684\u77e5\u8b58\u63a8\u9032\u5230\u591a\u9060\uff0c\u53ea\u6709\u672a\u4f86\u624d\u80fd\u6c7a\u5b9a\u3002<\/p>\n<p><strong>\u53c3\u8003\u8cc7\u6599<\/strong><\/p>\n<p>1.\u672c\u6587\u8b6f\u81ea\u8afe\u8c9d\u723e\u5316\u5b78\u734e\u59d4\u54e1\u6703\u516c\u4f48\u7d66\u5927\u773e\u7684\u65b0\u805e\u7a3f\uff0c\u539f\u6587\u53ef\u81ea\u4ee5\u4e0b\u5b98\u65b9\u7db2\u7ad9\u53d6\u5f97\uff1ahttp:\/\/www.nobelprize.org\/nobel_prizes\/chemistry\/laureates\/2013\/popular-chemistryprize2013.pdf<br \/>\n2.\u82e5\u6709\u8208\u8da3\u95b1\u8b80\u9032\u968e\u7684\u8cc7\u6599\uff0c\u8acb\u7531\u4e0b\u5217\u7db2\u5740\u53d6\u5f97\uff1a<br \/>\nhttp:\/\/www.nobelprize.org\/nobel_prizes\/chemistry\/laureates\/2013\/advanced-chemistryprize2013.pdf<br \/>\n3.\u7279\u5225\u611f\u8b1d\u73fe\u65bc\u7f8e\u570b\u5fb7\u5dde\u8fb2\u5de5\u5927\u5b78\u653b\u8b80\u535a\u58eb\u7684\u66f9\u4e00\u5141(\u8521\u8001\u5e2b2008\u5e74\u7684\u5c08\u984c\u751f)\u71b1\u8840\u76f8\u633a\uff0c\u5c07\u5176\u5716\u7247\u4e2d\u6587\u5316\u3002<br \/>\n\u25cf\u7279\u5225\u611f\u8b1d\u8521\u860a\u660e\u6559\u6388\u63d0\u4f9b\u6b64\u8b6f\u7a3f\u3002\u904e\u53bb\u6b77\u5e74\u8afe\u8c9d\u723e\u5316\u5b78\u734e\u8b6f\u7a3f\u53ef\u898b\u65bc\u8521\u860a\u660e\u6559\u6388\u7684\u500b\u4eba\u7db2\u7ad9<br \/>\n\u8cac\u4efb\u7de8\u8f2f\uff1aVita Chen<\/p>\n<p><a name=\"ResNew2\"><\/a><br \/>\n<span style=\"color: #0000ff\"><strong>\u53f0\u7063\u91ab\u5b78\u4e4b\u5149\uff0c\u751f\u7269\u91ab\u5b78\u91cd\u5927\u7a81\u7834<\/strong><\/span><\/p>\n<p><strong> \u5353\u5919\u822a\u6559\u6388\u7684\u7814\u7a76\u5718\u968a\u767c\u73fe\u5fae\u5c0fRNA\u53ef\u6291\u5236\u81bd\u56fa\u9187\u9032\u5165\u8840\u7ba1<\/strong><\/p>\n<p>\u91ab\u5b78\u7cfb\u91ab\u5b78\u907a\u50b3\u5b78\u79d1\u5353\u5919\u822a\u4e3b\u4efb<br \/>\n\u53f0\u7063\u751f\u7269\u91ab\u5b78\u7814\u7a76\u7684\u91cd\u5927\u7a81\u7834\uff0c\u4e5f\u662f\u570b\u969b\u751f\u7269\u91ab\u5b78\u7684\u91cd\u8981\u767c\u73fe\u3002\u53ef\u4ee5\u6291\u5236\u81bd\u56fa\u9187\u9032\u5165\u8840\u7ba1\uff0c\u800c\u9054\u5230\u6297\u52d5\u8108\u786c\u5316\u7684\u4f5c\u7528\u7684let-7g microRNA(\u5fae\u5c0fRNA)\uff0c\u7531\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u5353\u5919\u822a\u6559\u6388\u7684\u7814\u7a76\u5718\u968a\u767c\u73fe\uff0c\u6b64\u7814\u7a76\u767c\u8868\u65bc\u301d\u7f8e\u570b\u5fc3\u81df\u5b78\u9662\u671f\u520a(Journal of the American College of Cardiology)\u301e\u3002<a href=\"http:\/\/wp.kmu.edu.tw\/rd\/files\/2013\/12\/\u7b2c\u5341\u516d\u671f_3.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-2222\" alt=\"\u7b2c\u5341\u516d\u671f_3\" src=\"http:\/\/wp.kmu.edu.tw\/rd\/files\/2013\/12\/\u7b2c\u5341\u516d\u671f_3.png\" width=\"270\" height=\"154\" \/><\/a><br \/>\n\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u5353\u5919\u822a\u6559\u6388\u7684\u7814\u7a76\u5718\u968a\u767c\u73fe\u4e00\u7a2e\u5fae\u5c0fRNA \u7a31\u4e4b\u70balet-7g\uff0clet-7g \u53ef\u4ee5\u6291\u5236\u81bd\u56fa\u9187\u9032\u5165\u8840\u7ba1\uff0c\u800c\u9054\u5230\u6297\u52d5\u8108\u786c\u5316\u7684\u4f5c\u7528\u3002\u5353\u6559\u6388\u6240\u9818\u5c0e\u7684\u5718\u968a\u66f4\u767c\u73felet-7g\u9084\u53ef\u4ee5\u4fdd\u8b77\u8840\u7ba1\u5167\u76ae\u7d30\u80de\uff0c\u9632\u6b62\u6b64\u7d30\u80de\u8001\u5316\uff0c\u589e\u9032\u8840\u7ba1\u5167\u76ae\u7d30\u80de\u7684\u529f 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2013\u5e74\u5316\u5b78\u9818\u57df\u8afe\u8c9d\u723e\u5f97\u734e\u8005\u7814\u7a76\u5167\u5bb9\u7c21\u4ecb \uff08 &hellip; <a href=\"https:\/\/wp.kmu.edu.tw\/rd\/archives\/2217\">\u95b1\u8b80\u5168\u6587 <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[24],"tags":[],"class_list":["post-2217","post","type-post","status-publish","format-standard","hentry","category-24"],"_links":{"self":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/2217","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/comments?post=2217"}],"version-history":[{"count":7,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/2217\/revisions"}],"predecessor-version":[{"id":2274,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/2217\/revisions\/2274"}],"wp:attachment":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/media?parent=2217"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/categories?post=2217"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/tags?post=2217"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}