{"id":2294,"date":"2014-02-08T20:44:09","date_gmt":"2014-02-08T12:44:09","guid":{"rendered":"http:\/\/wp.kmu.edu.tw\/rd\/?p=2294"},"modified":"2014-02-10T17:28:39","modified_gmt":"2014-02-10T09:28:39","slug":"%e7%a0%94%e7%a9%b6%e6%96%b0%e7%9f%a5-15","status":"publish","type":"post","link":"https:\/\/wp.kmu.edu.tw\/rd\/archives\/2294","title":{"rendered":"\u7814\u7a76\u65b0\u77e5"},"content":{"rendered":"<p style=\"text-align: right\"><a href=\"http:\/\/wp.kmu.edu.tw\/rd\/archives\/2292\">\u56de\u7b2c0017\u671f\u4e3b\u9801<\/a><\/p>\n<h1><span style=\"font-size: x-large;color: #c10000\">\u4e00\u3001\u7814\u7a76\u65b0\u77e5<\/span><\/h1>\n<p><a name=\"ResNew1\"><\/a><\/p>\n<ul>\n<li>\n<h1><span style=\"color: #0000ff\">Emerging Principles for the Therapeutic Exploitation of Glycosylation<br \/>\n<\/span><\/h1>\n<p>Martin Dalziel, Max Crispin, Christopher N. Scanlan, Nicole Zitzmann, and Raymond A. Dwek, Science 343, 1235681 (2014) Science 3 January 2014: l. 343 no. 6166\uff08\u611f\u8b1d\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u9644\u8a2d\u4e2d\u548c\u7d00\u5ff5\u91ab\u9662 \u8840\u8102\u751f\u79d1\u7814\u7a76\u4e2d\u5fc3 \u9673\u5fd7\u6770\u535a\u58eb \u6458\u8b6f\uff09<\/p>\n<p>\u7cd6\u57fa\u5316(glycosylation)\u5728\u8a31\u591a\u7684\u751f\u5316\u53cd\u61c9\u4e2d\u626e\u6f14\u8457\u91cd\u8981\u7684\u89d2\u8272\u3002\u805a\u7cd6(glycan)\u4e0d\u50c5\u80fd\u5354\u52a9\u7cd6\u86cb\u767d\u7684\u647a\u758a(glycoprotein folding)\u3001\u7dad\u6301\u7d30\u80de\u6046\u5b9a(cellular homeostasis)\u53ca\u514d\u75ab\u8abf\u63a7(immune regulation)\u5916\uff0c\u4e5f\u548c\u8a31\u591a\u75be\u75c5\u6709\u95dc\u3002\u6b64\u7bc7\u8ad6\u6587\u6574\u7406\u4e86\u4e00\u4e9b\u805a\u7cd6\u548c\u75be\u75c5\u6cbb\u7642\u76f8\u95dc\u7684\u6700\u65b0\u77e5\u8b58\u3002<br \/>\n\u7cd6\u86cb\u767d(glycoproteins)\u548c\u7cd6\u8102(glycolipids)\u5b58\u5728\u8a31\u591a\u4e0d\u540c\u7cd6\u57fa\u5316\u7684\u5f62\u5f0f(glycoforms)\u3002\u7279\u5b9a\u7684\u7cd6\u57fa\u5316\u5f62\u5f0f\u53ef\u4ee5\u76f4\u63a5\u7531\u5468\u570d\u7684\u74b0\u5883\u4f86\u8abf\u6574\uff0c\u4e26\u4e14\u5728\u8a31\u591a\u7684\u751f\u5316\u53cd\u61c9\u4e2d\u626e\u6f14\u8457\u91cd\u8981\u7684\u89d2\u8272\u3002\u7cd6\u57fa\u5316\u4e5f\u51fa\u73fe\u5728\u8a31\u591a\u75c5\u7406\u7684\u689d\u4ef6\u4e2d\uff0c\u4f8b\u5982\uff1a\u7cd6\u57fa\u7684\u7d50\u69cb\u53ef\u4ee5\u8207\u75c5\u539f\u9ad4\u7d50\u5408\uff0c\u4e26\u53c3\u8207\u67d0\u4e9b\u75be\u75c5\u7684\u968e\u6bb5\u3002\u56e0\u6b64\uff0c\u589e\u52a0\u5c0d\u7cd6\u57fa\u5206\u5b50\u548c\u7d50\u69cb\u7684\u4e86\u89e3\u53ca\u5176\u5728\u75c5\u7406\u7684\u904e\u7a0b\u4e2d\u6240\u626e\u6f14\u7684\u89d2\u8272\uff0c\u5fc5\u5b9a\u53ef\u4ee5\u589e\u9032\u75be\u75c5\u7684\u6cbb\u7642\u53ca\u627e\u5230\u65b0\u7684\u85e5\u7269\u8a2d\u8a08\u6a19\u9776\u3002<br \/>\n\u7531\u65bc\u91cd\u7d44\u53ca\u7d30\u80de\u751f\u5408\u6210\u6280\u8853\u7684\u9032\u6b65\uff0c\u523a\u6fc0\u4e86\u6cbb\u7642\u6027\u7cd6\u86cb\u767d(therapeutic glycoproteins)\u7684\u767c\u5c55\uff0c\u76ee\u524d\u6700\u65b0\u7684\u6280\u8853\u5df2\u7d93\u53ef\u4ee5\u5408\u6210\u7279\u5b9a\u5f62\u5f0f\u7684\u7cd6\u86cb\u767d\u3002\u76f8\u95dc\u7684\u7814\u7a76\u5df2\u986f\u793a\uff0c\u7d93\u904e\u7cd6\u57fa\u5316\u4fee\u98fe\u7684\u55ae\u682a\u6297\u9ad4(momoclonal antibody)\u80fd\u589e\u5f37\u5176\u5728\u9ad4\u5167\u7684\u7279\u6027\u3002\u5728\u81e8\u5e8a\u524d\u7684\u7814\u7a76\u8b49\u64da\u4e5f\u986f\u793a\uff0c\u8840\u6e05\u4e2d\u53c3\u8207\u81ea\u9ad4\u514d\u75ab\u53cd\u61c9\u7684\u6297\u9ad4\uff0c\u53ef\u501f\u7531\u53bb\u9664\u7cd6\u57fa\u7684\u65b9\u5f0f\uff0c\u4f7f\u5176\u5931\u53bb\u6d3b\u6027\u3002\u7cd6\u86cb\u767d\u80fd\u523a\u6fc0\u9ad4\u6db2\u514d\u75ab(humoral immunity)\u548c\u7d30\u80de\u514d\u75ab(cellular immunity)\u53cd\u61c9\u7684\u7522\u751f\uff0c\u56e0\u6b64\u7cd6\u86cb\u767d\u4e5f\u63d0\u4f9b\u767c\u5c55\u6297\u764c\u75ab\u82d7\u7684\u53ef\u80fd\u6027\u3002\u6b64\u5916\uff0cHIV glycan shield\u5728\u6297\u9ad4\u7684\u4e2d\u548c\u3001\u75ab\u82d7\u8a2d\u8a08\u548c\u611f\u67d3\u63a7\u5236\u90fd\u80fd\u63d0\u4f9b\u6210\u70ba\u6709\u6548\u7684\u6a19\u9776\u3002<br \/>\n\u96d6\u7136\u76ee\u524d\u4ee5\u805a\u7cd6\u70ba\u8a2d\u8a08\u57fa\u790e\u7684\u6297\u764c\u75ab\u82d7\u6216\u6297HIV\u75ab\u82d7\u9084\u672a\u6210\u529f\uff0c\u4e0d\u904e\u7531\u65bc\u7cd6\u86cb\u767d\u53ca\u514d\u75ab\u76f8\u95dc\u77e5\u8b58\u8207\u6280\u8853\u7684\u6210\u719f\uff0c\u8fd1\u671f\u5167\u5f88\u53ef\u80fd\u6703\u7814\u767c\u51fa\u65b0\u7684\u805a\u7cd6\u7684\u7d44\u6210\uff0c\u7528\u65bc\u6297\u75c5\u6bd2\u6cbb\u7642\u3002\u672a\u4f86\uff0c\u7cd6\u57fa\u5316\u7684\u4fee\u98fe\u4ecd\u6703\u6301\u7e8c\u5f15\u9818\u6cbb\u7642\u6027\u7cd6\u86cb\u767d\u7684\u7814\u7a76\uff0c\u5229\u7528\u7d30\u83cc\u7684\u9175\u7d20\u4f86\u6e05\u9664\u6297\u9ad4\u4e0a\u7684\u7cd6\u57fa\u6216\u8a31\u5c07\u6210\u70ba\u4e00\u7a2e\u65b0\u7684\u6cbb\u7642\u65b9\u5f0f\u3002<\/li>\n<\/ul>\n<p style=\"text-align: right\"><a href=\"http:\/\/wp.kmu.edu.tw\/rd\/archives\/2219\">\u56de\u7b2c0017\u671f\u4e3b\u9801<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u56de\u7b2c0017\u671f\u4e3b\u9801 \u4e00\u3001\u7814\u7a76\u65b0\u77e5 Emerging Principles for &hellip; <a href=\"https:\/\/wp.kmu.edu.tw\/rd\/archives\/2294\">\u95b1\u8b80\u5168\u6587 <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[25],"tags":[],"class_list":["post-2294","post","type-post","status-publish","format-standard","hentry","category-25"],"_links":{"self":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/2294","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/comments?post=2294"}],"version-history":[{"count":2,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/2294\/revisions"}],"predecessor-version":[{"id":2296,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/2294\/revisions\/2296"}],"wp:attachment":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/media?parent=2294"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/categories?post=2294"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/tags?post=2294"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}