{"id":2342,"date":"2014-03-03T17:47:50","date_gmt":"2014-03-03T09:47:50","guid":{"rendered":"http:\/\/wp.kmu.edu.tw\/rd\/?p=2342"},"modified":"2014-04-02T10:01:19","modified_gmt":"2014-04-02T02:01:19","slug":"%e8%ab%96%e6%96%87%e7%a0%94%e7%a9%b6%e8%88%87%e5%88%86%e4%ba%ab-10","status":"publish","type":"post","link":"https:\/\/wp.kmu.edu.tw\/rd\/archives\/2342","title":{"rendered":"\u8ad6\u6587\u7814\u7a76\u8207\u5206\u4eab"},"content":{"rendered":"<p style=\"text-align: right\"><a href=\"http:\/\/wp.kmu.edu.tw\/rd\/archives\/2338\">\u56de\u7b2c0018\u671f\u4e3b\u9801<\/a><\/p>\n<h1><span style=\"font-size: x-large;color: #c10000\">\u4e8c\u3001\u8ad6\u6587\u8207\u7814\u7a76\u5206\u4eab<\/span><\/h1>\n<p><a name=\"PaperRes1\"><\/a><\/p>\n<h1><span style=\"color: #0000ff\">\uff08\u4e00\uff09\u8ad6\u6587<\/span><\/h1>\n<ul>\n<li><span style=\"color: #3366ff\">\u984c\u76ee\uff1a<strong><br \/>\nMicroemulsion electrokinetic chromatography for analysis of phthalates in soft drinks<\/strong><\/span><br \/>\n<span style=\"color: #3366ff\"> \uff08\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u5433\u79c0\u6885\u6559\u6388\u63d0\u4f9b\u6458\u8981\uff09<\/span><\/li>\n<\/ul>\n<ul>\n<li>\u4f5c\u8005\uff1aSung-Yu Hsieh\u3001Chun-Chi Wang\u3001Shou-Mei Wu Food Chemistry (2013), 141, 3486-3491<\/li>\n<\/ul>\n<ul>\n<li>\u52d5\u6a5f<br \/>\n\u8fd1\u5e74\u4f86\u53f0\u7063\u767c\u751f\u591a\u8d77\u975e\u6cd5\u6dfb\u52a0\u7269\u5371\u5bb3\u4eba\u9ad4\u7684\u56b4\u91cd\u4e8b\u4ef6\uff0c\u56e0\u6b64\u76f8\u95dc\u5206\u6790\u6280\u8853(\u5982HPLC\u3001GC\u3001MS\u7b49)\u61c9\u7528\u65bc\u6aa2\u6e2c\u9019\u4e9b\u5371\u5bb3\u7269\u8cea\u5373\u986f\u5f97\u76f8\u7576\u91cd\u8981\u3002\u672c\u7814\u7a76\u4fc2\u5229\u7528\u6bdb\u7d30\u7ba1\u96fb\u6cf3\u6cd5(capillary electrophoresis, CE)\u65bc\u5206\u6790\u6280\u8853\u4e0a\u7684\u512a\u52e2\uff0c\u5efa\u7acb\u5075\u6e2c\u98f2\u54c1\u4e2d\u9130\u82ef\u4e8c\u7532\u9178\u916f\u985e\u542b\u91cf\u3002<br \/>\n\u9130\u82ef\u4e8c\u7532\u9178\u916f\u985e(phthalate esters, PAEs)\u76ee\u524d\u88ab\u5ee3\u6cdb\u7528\u65bc\u5851\u81a0\u88fd\u54c1\uff0c\u53ef\u6539\u8b8a\u5851\u81a0\u6210\u5f62\u6642\u7684\u7269\u7406\u6027\u8cea\uff0c\u4f7f\u5176\u8b8a\u70ba\u8f03\u70ba\u67d4\u8edf\u3001\u6613\u65bc\u52a0\u5de5\uff0c\u56e0\u6b64\u6709\u300c\u5851\u5316\u5291\u300d\u4e4b\u540d\u3002PAEs\u5177\u4e9b\u8a31\u82b3\u9999\u6c23\u5473\u6216\u7121\u6c23\u5473\u7684\u7121\u8272\u6db2\u9ad4\uff0c\u4e2d\u7b49\u9ecf\u5ea6\u3001\u9ad8\u7a69\u5b9a\u6027\u3001\u8102\u6eb6\u6027\u9ad8\u3001\u6210\u672c\u4f4e\u5ec9\uff0c\u7279\u5225\u662f\u9130\u82ef\u4e8c\u7532\u9178\u4e8c\u4e01\u916f(dibutyl phthalate, DBP)\u8207\u9130\u82ef\u4e8c\u7532\u9178\u4e8c(2-\u4e59\u57fa\u5df1\u57fa)\u916f(bis(2-ethylhexyl) phthalate, DEHP)\u662f\u6700\u88ab\u983b\u7e41\u4f7f\u7528\u7684PAEs\uff0c\u6587\u737b\u5831\u5c0e\u6307\u51faDBP\u8207DEHP\u6703\u5371\u5bb3\u751f\u7269\u9ad4\u751f\u6b96\u6a5f\u80fd\u3002\u800c\u8fd1\u4f86\u50b3\u51fa\u6709\u696d\u8005\u5229\u7528\u5176\u7279\u6027\u5c07\u4e4b\u6dfb\u52a0\u65bc\u98df\u54c1\u3001\u85e5\u7269\u6216\u5316\u599d\u54c1\u7b49\u7269\u8cea\u4e2d\uff0c\u9020\u6210\u56b4\u91cd\u7684\u6050\u614c\uff0c\u7531\u65bc\u9130\u82ef\u4e8c\u7532\u9178\u916f\u985e\u70ba\u74b0\u5883\u6c61\u67d3\u7269\uff0c\u4e5f\u662f\u4e00\u7a2e\u74b0\u5883\u8377\u723e\u8499\uff0c\u9032\u5165\u9ad4\u5167\u5f8c\u6703\u9020\u6210\u5167\u5206\u6ccc\u5931\u8abf\uff0c\u5f15\u767c\u60e1\u6027\u816b\u7624\u8207\u81f4\u7578\u80ce\u7684\u98a8\u96aa\u3002\u76f8\u95dc\u6587\u737b\u5df2\u8b49\u660e\uff0c\u9577\u671f\u8655\u5728\u542b\u9130\u82ef\u4e8c\u7532\u9178\u916f\u985e\u7684\u74b0\u5883\u4e2d\uff0c\u53ef\u80fd\u5f15\u767c\u6c23\u5598\u73fe\u8c61\u548c\u4e73\u817a\u764c\uff1bPAEs\u9032\u5165\u9ad4\u5167\u5f8c\u96d6\u7136\u4e5d\u6210\u96a8\u5c3f\u6db2\u6216\u6392\u6cc4\u7269\u6392\u6cc4\u51fa\u9ad4\u5916\uff0c\u4f46\u4ecd\u6709\u90e8\u5206\u7d93\u904e\u751f\u7269\u5206\u89e3\uff0c\u5f9e\u809d\u81df\u3001\u8178\u3001\u80c3\u548c\u814e\u81df\u5438\u6536\u9032\u5165\u9ad4\u5167\uff0c\u5c0d\u8eab\u9ad4\u5177\u76f8\u7576\u7684\u5371\u5bb3\u6027\u3002<br \/>\n\u76ee\u524d\u5206\u6790\u9130\u82ef\u4e8c\u7532\u9178\u916f\u985e\u4e4b\u65b9\u6cd5\u4ee5GC\u548cHPLC\u70ba\u4e3b\uff0c\u5176\u4e2dGC \u642d\u914d\u8cea\u8b5c\u5075\u6e2c\u5668\u70ba\u8f03\u5e38\u7528\u4e4b\u65b9\u6cd5\uff0c\u4f46\u7531\u65bcGC\u5206\u6790\u6a23\u54c1\u6642\uff0c\u5fc5\u9808\u5148\u9032\u884c\u524d\u8655\u7406\uff0c\u56e0\u6b64\u5df2\u9010\u6f38\u88abHPLC\u4e4b\u5206\u6790\u65b9\u6cd5\u6240\u53d6\u4ee3\u3002\u76ee\u524dHPLC\u5df2\u88ab\u5ee3\u6cdb\u5730\u61c9\u7528\u65bc\u5075\u6e2c\u5404\u985e\u7269\u8cea\u4e2dPAEs\u4e4b\u542b\u91cf\uff0c\u61c9\u7528\u4e4b\u6aa2\u54c1\u5305\u542b\u5316\u599d\u54c1\u3001\u5c3f\u6db2\u3001\u8840\u6f3f\u3001\u6c34\u3001\u5851\u81a0\u5305\u88dd\u98f2\u6599\u3001\u85e5\u7269\u548c\u73a9\u5177\u7b49\u7269\u8cea\uff0c\u4ee5\u4e0aHPLC\u4e4b\u65b9\u6cd5\u5927\u90fd\u61c9\u7528UV\u4f5c\u70ba\u5075\u6e2c\u5668\uff0c\u56e0\u6b64\u5728\u611f\u5ea6\u4e0a\u6703\u6709\u6240\u9650\u5236\uff0c\u70ba\u514b\u670d\u6b64\u4e00\u7f3a\u9ede\uff0c\u6709\u4e9b\u6587\u737b\u5c07\u8cea\u8b5c\u642d\u914dHPLC\u4f5c\u70ba\u5075\u6e2c\u65b9\u6cd5\uff0c\u4e0d\u50c5\u53ef\u589e\u52a0\u611f\u5ea6\u4e5f\u53ef\u76f4\u63a5\u9054\u5230\u5b9a\u6027\u4e4b\u6548\u679c\uff0c\u7136\u800c\u8cea\u8b5c\u5100\u4fdd\u990a\u4e0d\u6613\u8207\u50f9\u683c\u6602\u8cb4\uff0c\u4e26\u4e0d\u9069\u7528\u65bc\u4e00\u822c\u5be6\u9a57\u5ba4\u3002\u800cCE\u5728\u5206\u6790\u4e0a\u5177\u6709\u8a31\u591a\u512a\u52e2\uff0c\u56e0\u6b64\u6709\u76f8\u95dc\u7814\u7a76\u5229\u7528CE\u4f86\u5206\u6790\u9130\u82ef\u4e8c\u7532\u9178\u916f\u985e\uff0c\u5305\u62ec\u4f7f\u7528NA-MEKC (nonaqueous-MEKC)\u6280\u8853\u4f86\u5206\u96e2PAEs\uff1b\u6216\u4ee5MEKC\u4e4b\u65b9\u5f0f\u5206\u6790PAEs\uff1b\u751a\u81f3\u4ee5MEEKC\u642d\u914d\u5feb\u901f\u6eb6\u5291\u8403\u53d6\u5100\u6aa2\u6e2c\u571f\u58e4\u4e2d\u7684PAEs\uff0c\u96d6\u7136\u4ee5\u4e0a\u5229\u7528CE\u65b9\u6cd5\u5206\u6790\u4e4b\u7814\u7a76\u5747\u9054\u5230\u826f\u597d\u7684\u5206\u96e2\u6548\u679c\uff0c\u4f46\u7e41\u7463\u7684\u6a23\u54c1\u524d\u8655\u7406\u904e\u7a0b\u76f8\u7576\u8cbb\u6642\u3002\u672c\u7814\u7a76\u4ea6\u61c9\u7528\u5fae\u4e73\u5316\u96fb\u52d5\u5c64\u6790\u6cd5(microemulsion electrokinetic chromatography, MEEKC)\u4f86\u5206\u6790PAEs\uff0cMEEKC\u70baCE\u4e2d\u7684\u4e00\u7a2e\u5206\u96e2\u6a21\u5f0f\uff0c\u5176\u539f\u7406\u8207MEKC(micellar electrokinetic chromatography)\u76f8\u4f3c\uff0c\u4f46\u4e3b\u8981\u5dee\u7570\u5728\u65bcMEEKC\u70ba\u5229\u7528\u5fae\u4e73\u6db2(microemulsions, MEs)\u5176\u7368\u7279\u7684\u6027\u8cea\u4f86\u7576\u4f5c\u507d\u975c\u76f8\uff0c\u4ee5\u9054\u5230\u5206\u96e2\u7684\u6548\u679c\uff0c\u6700\u4e3b\u8981\u7528\u65bc\u5206\u96e2\u8f03\u8102\u6eb6\u6027\u4e4b\u7269\u8cea\uff0c\u800c\u76ee\u524dCE-MEEKC\u6b64\u6280\u8853\u4e5f\u5df2\u61c9\u7528\u65bc\u5404\u500b\u5206\u6790\u9818\u57df\u4e0a\u3002MEs\u5f62\u6210\u7684\u5fae\u80de\u70ba\u5948\u7c73\u5c3a\u5bf8\uff0c\u662f\u5149\u5b78\u53ef\u7a7f\u900f\u7684\u6f84\u6e05\u900f\u660e\u6db2\u9ad4\uff0c\u6709\u5169\u7a2e\u4e3b\u8981\u985e\u578b\u7684MEs\u88ab\u4f7f\u7528\u65bcMEEKC\u4e2d\uff0c\u5206\u5225\u662f\u6c34\u5305\u6cb9\u578b(oil-in-water, O\/W)\u8207\u6cb9\u5305\u6c34\u578b(water-in-oil, W\/O)\uff0c\u4f46O\/W\u6bd4W\/O\u7684\u5fae\u4e73\u6db2\u66f4\u5e38\u88ab\u7528\u65bcMEEKC\u4e2d\u3002O\/W\u7684MEs\u6700\u4e3b\u8981\u7531\u4e09\u7a2e\u6210\u4efd\u6240\u7d44\u6210\uff0c\u5176\u5fae\u80de\u7684\u6838\u5fc3\u70ba\u6cb9\u6ef4(\u5982octane)\uff0c\u800c\u754c\u9762\u6d3b\u6027\u5291(\u5982SDS)\u548c\u5171\u754c\u9762\u6d3b\u6027\u5291(\u59821-butanol)\u8986\u84cb\u65bc\u6cb9\u6ef4\u5916\u90e8\u6e1b\u5c11\u8868\u9762\u5f35\u529b\u5f62\u6210\u5fae\u4e73\u6db2\u7d50\u69cb\u3002<br \/>\nMEEKC\u88ab\u8a8d\u70ba\u662fMEKC (micellar electrokinetic chromatography)\u7684\u5ef6\u4f38\uff0c\u5728MEKC\u4e2d\uff0c\u754c\u9762\u6d3b\u6027\u5291\u7684\u5fae\u80de\u88ab\u7576\u4f5c\u507d\u975c\u76f8\u8207\u6eb6\u8cea\u9032\u884c\u5206\u914d\u6a5f\u5236\u4ee5\u9054\u5230\u5206\u96e2\u7684\u6548\u679c\uff0cMEEKC\u4e5f\u662f\u985e\u4f3c\u7684\u6a5f\u5236\uff0c\u5148\u524d\u7684\u7814\u7a76\u5f37\u8abf\uff0c\u7531\u65bcMEEKC\u662f\u4ee5\u5fae\u4e73\u6db2\u7576\u4f5c\u507d\u975c\u76f8\uff0c\u8102\u6eb6\u6027\u7269\u8cea\u80fd\u66f4\u6709\u6548\u7387\u7684\u88ab\u5206\u914d\u5230MEEKC\u7684MEs\u5fae\u80de\u4e2d\uff0c\u76f8\u95dc\u7814\u7a76\u6307\u51faMEEKC\u6703\u6bd4MEKC\u66f4\u9069\u5408\u4f5c\u70ba\u9ad8\u5ea6\u8102\u6eb6\u6027\u5316\u5408\u7269\u7684\u5206\u96e2\uff0c\u56e0\u6b64\u76f8\u7576\u9069\u5408\u61c9\u7528\u65bc\u5206\u6790PAEs\u6b64\u7b49\u9ad8\u8102\u6eb6\u6027\u4e4b\u7269\u8cea\u3002<br \/>\n\u672c\u7814\u7a76\u4ee5MEEKC\u65b9\u6cd5\u5206\u6790\u9ad8\u8102\u6eb6\u6027PAEs\uff0c\u5176\u4e2d\u767c\u73fe\u65bc\u88fd\u4f5c\u5fae\u4e73\u6db2(microemulsions, MEs)\u7684\u904e\u7a0b\u4e2d\uff0c\u82e5\u52a0\u5165\u53e6\u4e00\u5171\u540c\u754c\u9762\u6d3b\u6027\u5291(Pluronic\u00ae F-127, F127)\u53ef\u589e\u52a0MEs\u4e4b\u7a69\u5b9a\u6027\u8207\u9078\u64c7\u6027\u3002F127\u70ba\u4e00\u7a2e\u805a\u919a\u591a\u5143\u9187-\u4e09\u5d4c\u6bb5\u5171\u805a\u7269(polyethylene-polypropylene three-block copolymer, MW12600 )\uff0c\u5176\u7d50\u69cb\u70baEO106\uff0dPO70\uff0dEO106\uff0c\u4e2d\u9593\u70ba\u758f\u6c34\u7684\u74b0\u6c27\u4e19\u70f7\u6bb5(poly(propylene oxide) block, PO)\uff0c\u5169\u7aef\u70ba\u89aa\u6c34\u7684\u74b0\u6c27\u4e59\u70f7\u6bb5(poly(ethylene oxide) blocks, EO)\uff0c\u662f\u6eab\u5ea6\u654f\u611f\u578b\u7684\u9ad8\u5206\u5b50(thermoresponsive polymers)\uff0c\u4e5f\u662f\u7a2e\u88ab\u805a\u6c27\u4e59\u70ef\u5316\u7684\u975e\u96e2\u5b50\u578b\u754c\u9762\u6d3b\u6027\u5291\u3002F127\u7684CMC\u503c\u70ba2.8 \u03bcM\uff0cHLB\u70ba22\uff0c\u5728\u6c34\u6eb6\u6db2\u4e2d\u6703\u81ea\u884c\u805a\u96c6\u5f62\u6210\u7a69\u5b9a\u7684\u5fae\u80de\uff0c\u4e14\u56e0\u70ba\u6b64\u7279\u6027\uff0c\u4ee5F127\u5305\u8986\u85e5\u7269\u5f8c\u6709\u826f\u597d\u7684\u751f\u9ad4\u53ef\u7528\u7387\u3002\u76ee\u524dF127\u5df2\u88ab\u5ee3\u6cdb\u5730\u61c9\u7528\u5728\u85e5\u7269\u88fd\u5291\u4e2d\u505a\u70ba\u8f09\u9ad4\uff0c\u4e5f\u6709\u76f8\u95dc\u7814\u7a76\u6307\u51faF127\u88ab\u61c9\u7528\u5728\u6bdb\u7d30\u7ba1\u81a0\u9ad4\u96fb\u6cf3\u4f86\u5206\u6790DNA\uff0cpeptide \u8207\u86cb\u767d\u8cea\uff0c\u7531\u65bc\u5177\u6709\u754c\u9762\u6d3b\u6027\u5291\u4e4b\u7279\u6027\uff0c\u56e0\u6b64\u672c\u7814\u7a76\u5e0c\u671b\u85c9\u7531\u6dfb\u52a0F127\u505a\u70ba\u5171\u540c\u754c\u9762\u6d3b\u6027\u5291\uff0c\u4ee5\u6539\u5584MEs\u4e4b\u69cb\u578b\uff0c\u5e0c\u671b\u53ef\u589e\u52a0\u5c0d\u8102\u6eb6\u6027\u7269\u8cea\u4e4b\u5206\u96e2\u6548\u7387\u3002<br \/>\n\u5148\u524d\u5c1a\u672a\u6709\u4efb\u4f55\u7814\u7a76\u767c\u8868\u61c9\u7528\u5171\u805a\u5408\u7269F127\u65bcCE-MEEKC\u7684\u6280\u8853\u4e2d\u4f86\u505a\u70ba\u5171\u754c\u9762\u6d3b\u6027\u5291\uff0c\u800c\u672c\u7814\u7a76\u9810\u671fF127\u5c07\u6703\u7a69\u5b9aMEEKC\u7684MEs\u4e26\u589e\u52a0\u8102\u6eb6\u6027\u5206\u6790\u7269\u7684\u5206\u96e2\u6548\u7387\u8207\u89e3\u6790\u5ea6\u3002\u800c\u672c\u7814\u7a76\u8207\u5176\u4ed6CE\u65b9\u6cd5\u6bd4\u8f03\u6642\uff0c\u672c\u6cd5\u5229\u7528SDS\u5305\u8986\u6a23\u54c1\uff0c\u53ef\u5c07\u6aa2\u54c1\u76f4\u63a5\u6ce8\u5165\u65bc\u6bdb\u7d30\u7ba1\u4e2d\uff0c\u518d\u4ee5MEEKC\u7684\u6280\u8853\u5206\u96e2PAEs\uff0c\u80fd\u7bc0\u7701\u6a23\u54c1\u524d\u8655\u7406\u904e\u7a0b\u7684\u6642\u9593\u3002<\/li>\n<li>\u6210\u679c<br \/>\n\u672c\u7814\u7a76\u4ee5CE-MEEKC\u4e4b\u5206\u96e2\u6a21\u5f0f\u540c\u6642\u52a0\u5165\u5177\u6709\u9ad8\u5206\u5b50\u8207\u754c\u9762\u6d3b\u6027\u5291\u6027\u8cea\u7684F-127\u505a\u70ba\u5171\u754c\u9762\u6d3b\u6027\u5291\uff0c\u65bc\u7814\u7a76\u7d50\u679c\u4e2d\u8b49\u660eF-127\u78ba\u5be6\u80fd\u7a69\u5b9a\u5fae\u4e73\u6db2\u7684\u5fae\u80de\u4e26\u589e\u52a0\u758f\u6c34\u6027\u5316\u5408\u7269DBP\u8207DEHP\u7684\u5206\u96e2\u6548\u7387\u8207\u89e3\u6790\u5ea6\u3002\u800c\u758f\u6c34\u6027\u5316\u5408\u7269PAEs\u88abSDS\u5fae\u80de\u5305\u8986\u5f8c\uff0c\u6bd4\u8f03\u96fb\u52d5\u53d6\u6a23(-10 kV, 20s)\u8207\u58d3\u529b\u9032\u6a23(1 psi, 10s)\u7684\u611f\u5ea6\uff0c\u7d50\u679c\u6307\u51fa\u5728MEEKC\u4e2d\uff0c\u4ee5\u96fb\u52d5\u53d6\u6a23\u80fd\u986f\u8457\u589e\u52a025\u500d\u7684\u611f\u5ea6\u3002\u65b9\u6cd5\u78ba\u6548\u65b9\u9762\uff0cDBP\u548cDEHP \u7684\u6aa2\u91cf\u7dda\u7bc4\u570d\u5206\u5225\u662f75-500 ng\/mL\u548c150-1000 ng\/mL\uff0c\u5176\u76f8\u95dc\u4fc2\u6578\u7686\u5927\u65bc0.99\uff0c\u800c\u7279\u5b9a\u6fc3\u5ea6\u4e4bRSD\u8207RE\u503c\u5747\u5c0f\u65bc4.93%\uff0c\u7531\u7d50\u679c\u53ef\u77e5\u6b64\u65b9\u6cd5\u5177\u6709\u826f\u597d\u4e4b\u7dda\u6027\u3001\u7cbe\u78ba\u5ea6\u8207\u6e96\u78ba\u5ea6\u3002\u5c07\u672c\u5206\u6790\u65b9\u6cd5\u61c9\u7528\u65bc\u516d\u7a2e\u4e0d\u540c\u54c1\u724c\u7684\u5e02\u552e\u904b\u52d5\u98f2\u6599\u4e2d\uff0c\u6e2c\u5b9a\u758f\u6c34\u6027\u5316\u5408\u7269DBP \u8207DEHP\uff0c\u5176\u4e2d\u4e00\u7a2e\u5e02\u552e\u904b\u52d5\u98f2\u6599\u4e2d\uff0c\u88ab\u767c\u73fe\u542b\u6709453.67 ng\/mL\u7684DEHP (Figure 1)\uff0c\u63a5\u8457\u5c07\u6b64\u98f2\u54c1\u4ee5LC-MS\u5b9a\u6027\uff0c\u8b49\u5be6\u542b\u6709DEHP (MW 390.56)\u5851\u5316\u5291\u6210\u4efd\u3002\u6b64\u4e9b\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u672c\u7814\u7a76\u85c9\u7531\u52a0\u5165F127\u7684MEEKC\u5206\u6790\u65b9\u6cd5\u78ba\u5be6\u53ef\u88ab\u61c9\u7528\u65bc\u5206\u6790\u9ad8\u5ea6\u758f\u6c34\u6027\u7684\u5316\u5408\u7269\u3002<br \/>\n<img decoding=\"async\" alt=\"\" src=\"http:\/\/wp.kmu.edu.tw\/rd\/files\/2014\/03\/0018PR01.png\" \/><\/li>\n<\/ul>\n<p><a name=\"PaperRes2\"><\/a><\/p>\n<ul>\n<li><span style=\"color: #3366ff\">\u984c\u76ee\uff1a<strong><br \/>\nEnhancements on skin cell proliferations and migrations via 6-dehydrogingerdione.<\/strong><\/span><br \/>\n<span style=\"color: #3366ff\"> \uff08\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u738b\u60e0\u6c11\u526f\u6559\u6388\u63d0\u4f9b\u6458\u8981\uff09<\/span><\/li>\n<\/ul>\n<ul>\n<li>\u4f5c\u8005\uff1a Chen CY1, Chiu CC, Wu CP, Chou YT, Wang HM. J Agric Food Chem. 2013 Feb 13;61(6):1349-56. doi: 10.1021\/jf304340q. Epub 2013 Jan 31.<\/li>\n<\/ul>\n<ul>\n<li>\u751f\u8591\u7adf\u4e5f\u80fd\u5e6b\u52a9\u50b7\u53e3\u7652\u5408\uff1f\u6bcf\u7576\u53d7\u50b7\u6642\uff0c\u4efb\u4f55\u79d8\u65b9\u3001\u85e5\u7269\uff0c\u7e3d\u88ab\u62ff\u4e86\u5c31\u5f80\u50b7\u53e3\u62b9\uff0c\u56e0\u70ba\u8ab0\u90fd\u5bb3\u6015\u50b7\u53e3\u6240\u5e36\u4f86\u7684\u75bc\u75db\u611f\uff0c\u4e5f\u64d4\u5fc3\u592a\u9577\u7684\u7652\u5408\u6642\u9593\u5176\u662f\u5426\u6703\u9010\u6f38\u7559\u4e0b\u96e3\u770b\u7684\u75a4\u3002\u800c\u5728\u671f\u671b\u80fd\u5e6b\u52a9\u50b7\u8005\u6e1b\u7de9\u4e0d\u9069\u7684\u7cbe\u795e\u4e0b\uff0c\u6211\u5011\u767c\u73fe\u4e86\u5e73\u6642\u8f9b\u8fa3\u7684\u300e\u751f\u8591\u300f\u7adf\u6709\u80fd\u5feb\u901f\u7652\u5408\u5275\u50b7\u7684\u80fd\u529b\u3002<br \/>\n\u751f\u8591\u6642\u5e38\u5728\u70f9\u98ea\u4e2d\u4f5c\u70ba\u8abf\u5473\u5291\uff0c\u5728\u4e2d\u91ab\u85e5\u5b78\u88e1\u5177\u6709\u767c\u6c57\u3001\u6b62\u54b3\u7b49\u529f\u6548\uff0c\u4f46\u6709\u5225\u65bc\u9019\u4e9b\u529f\u7528\uff0c\u6211\u5011\u5f9e\u751f\u8591\u4e2d\u7d14\u5316\u5f97\u51fa\u7684\u5316\u5408\u72696-dehydrogingerdione\uff086-DG\uff09\u767c\u73fe\u53ef\u4ee5\u4fc3\u9032\u4eba\u985e\u76ae\u819a\u7d30\u80de\u7684\u751f\u9577\uff0c\u4f5c\u70ba\u65b0\u578b\u7684\u751f\u7269\u6027\u7652\u5408\u5291\u3002\u5be6\u9a57\u4e2d\u9032\u884c\u4e00\u7cfb\u5217\u7684\u7d30\u80de\u751f\u9577\/\u722c\u884c\u79fb\u690d\u3001\u751f\u9577\u56e0\u5b50\u5206\u6ccc\u3001\u81a0\u539f\u86cb\u767d\u751f\u7522\u7b49\u8a55\u4f30\uff0c\u767c\u73fe6-DG\u9664\u4e86\u80fd\u52a0\u901f\u7d30\u80de\u589e\u6b96\u5916\uff0c\u540c\u6642\u80fd\u63d0\u9ad8transforming growth factor-\u03b2 (TGF-\u03b2)\u3001platelet-derived growth factor-\u03b1\u03b2 (PDGF-\u03b1\u03b2)\u548cvascular endothelial growth factors (VEGF)\u7684\u91cf\uff0c\u4e14\u7e96\u7dad\u6bcd\u7d30\u80de\u6240\u5206\u6ccc\u7684\u81a0\u539f\u86cb\u767d\u4e5f\u96a8\u84576-DG\u6fc3\u5ea6\u4e0a\u5347\u800c\u589e\u52a0\uff0c\u9664\u6b64\u4e4b\u5916\uff0c\u5728\u4e00\u500b\u4e0d\u597d\u7684\u56e0\u5b50phorbol 12-myristate 13-acetate (PMA)\u524d\u8655\u7406\u4e0b(\u523b\u610f\u52a0\u5165)\uff0c6-DG\u4e5f\u6709\u6548\u5730\u53cd\u8f49\u4e86matrix metalloproteinase-1 (MMP-1)\u7684\u86cb\u767d\u8868\u73fe\u91cf\u53ca\u6d3b\u6027\uff0c\u6062\u5fa9\u4e86metalloproteinase-1 (TIMP-1)\u7684\u7522\u91cf\uff0c\u4e5f\u8b49\u660e\u4e866-DG\u80fd\u964d\u4f4ec-Jun\u7684\u86cb\u767d\u542b\u91cf\u548c\u7d30\u80de\u5916\u4fe1\u865f\u8abf\u7bc0\u6fc0\u9176\uff08ERK\uff09\u7684\u78f7\u9178\u5316\uff0c\u4ee5\u6291\u5236\u7d72\u88c2\u539f\u6d3b\u5316\u86cb\u767d\u6fc0\u9176(MAPK) pathway\u3002<br \/>\n\u6211\u5011\u56e0\u6b64\u8a8d\u70ba6-DG\u6709\u6a5f\u6703\u80fd\u6210\u70ba\u65b0\u7a4e\u7684\u76ae\u819a\u5275\u50b7\u4fee\u5fa9\u85e5\u7269\uff0c\u63d0\u9ad8\u808c\u819a\u5c0d\u65bc\u50b7\u53e3\u4fee\u5fa9\u6a5f\u5236\u7684\u80fd\u529b\uff0c\u662f\u672a\u4f86\u5546\u696d\u958b\u767c\u7684\u512a\u8cea\u660e\u65e5\u4e4b\u661f\u3002<br \/>\n<img decoding=\"async\" alt=\"\" src=\"http:\/\/wp.kmu.edu.tw\/rd\/files\/2014\/03\/0018PR02-e1393841309914.png\" \/><\/li>\n<\/ul>\n<p><a name=\"PaperRes3\"><\/a><\/p>\n<h1 style=\"font-style: normal\"><span style=\"color: #0000ff\">\uff08\u4e00\uff09\u7d93\u9a57\u5206\u4eab<\/span><\/h1>\n<p><span style=\"color: #0000ff\"><span style=\"color: #3366ff\"><strong>\u5e74\u8f15\u91ab\u5e2b\u5f9e\u4e8b\u7814\u7a76\u7684\u8d77\u6b65<\/strong>\u00a0 \u00a0<\/span> \u00a0<\/span>\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u8f9b\u932b\u748b \u6559\u6388<\/p>\n<p>\u7cd6\u5c3f\u75c5\u548c\u5167\u5206\u6ccc\u5b78\u6703\u6307\u6d3e\u6211\u5728\u4eca\u5e74\u5e74\u6703\u6f14\u8b1b\u300c\u5e74\u8f15\u91ab\u5e2b\u4e4b\u5b78\u8853\u751f\u6daf\u898f\u5283\u300d\uff0c\u6211\u53c3\u8003\u5c08\u66f8\u548c\u5fb5\u8a62\u591a\u4f4d\u5091\u51fa\u7814\u7a76\u5b78\u8005\u5c08\u5bb6\u7684\u610f\u898b\uff0c\u5f59\u6574\u5982\u4e0b\u7684\u6458\u8981\uff0c\u5e0c\u671b\u5c0d\u6709\u5fc3\u4f5c\u7814\u7a76\u7684\u9ad8\u91ab\u5e74\u8f15\u91ab\u5e2b\u6709\u4e00\u4e9b\u5e6b\u52a9\u3002<\/p>\n<p><strong>\uff08\u4e00\uff09\u6709\u7591\u60d1\u548c\u80fd\u601d\u8003\u662f\u5f9e\u4e8b\u7814\u7a76\u7684\u539f\u52d5\u529b<\/strong><\/p>\n<p>\u719f\u8b80\u548c\u5584\u7528\u6559\u79d1\u66f8\u3001\u6307\u5f15\u548c\u671f\u520a\u662f\u8db3\u5920\u6210\u70ba\u7a31\u8077\u7684\u5c08\u79d1\u91ab\u5e2b\uff0c\u4f46\u662f\u6559\u79d1\u66f8\u548c\u6307\u5f15\u7684\u77e5\u8b58\u6642\u6642\u66f4\u65b0\uff0c\u6240\u8b02\u76e1\u4fe1\u66f8\u4e0d\u5982\u7121\u66f8\uff0c\u5728\u9019\u500b\u4eba\u5316\u91ab\u5b78\u6642\u4ee3\uff0c\u8a3a\u6cbb\u75c5\u4eba\u61c9\u7d30\u5fc3\u89c0\u5bdf\uff0c\u5fc3\u5b58\u7591\u60d1\uff0c\u80fd\u767c\u73fe\u554f\u984c\uff0c\u63d0\u51fa\u5408\u7406\u5047\u8a2d\uff0c\u5b78\u6703\u8a2d\u8a08\u548c\u57f7\u884c\u7814\u7a76\uff0c\u7cbe\u65bc\u7d50\u679c\u5206\u6790\uff0c\u6700\u5f8c\u89e3\u6c7a\u554f\u984c\u3002\u9019\u7a2e\u80fd\u7591\u60d1\u548c\u601d\u8003\u7684\u614b\u5ea6\uff0c\u662f\u60f3\u5f9e\u4e8b\u5b78\u8853\u7814\u7a76\u7684\u7b2c\u4e00\u6b65\u3002<\/p>\n<p><strong>\uff08\u4e8c\uff09\u61c9\u5177\u5099\u57fa\u672c\u7684\u7814\u7a76\u6982\u5ff5-\u81e8\u5e8a\u7814\u7a76\u7684\u5206\u985e<\/strong><\/p>\n<p>\u57fa\u672c\u7684\u7814\u7a76\u6982\u5ff5\u5f88\u591a\u9805\uff0c\u672c\u6458\u8981\u53ea\u8ac7\u81e8\u5e8a\u7814\u7a76\u7684\u5206\u985e\uff0c\u6709\u7814\u7a76\u5206\u985e\u7684\u89c0\u5ff5\uff0c\u624d\u6703\u6709\u6b63\u78ba\u7684\u7814\u7a76\u8a2d\u8a08\u548c\u65b9\u6cd5\u3002\u5982\u5716\uff08Schulz KF, Grimes DA, 2006\uff09\u6240\u793a\uff0c\u81e8\u5e8a\u7814\u7a76\u4f9d\u64da\u6709\u7121\u884c\u70ba\u6216\u6cbb\u7642\u4ecb\u5165\uff08intervention\uff09\u53ef\u4ee5\u5206\u70ba\u4e8c\u5927\u985e\uff1a\u5be6\u9a57\u578b\u7814\u7a76\uff08Experimental Study\uff09\u548c\u89c0\u5bdf\u578b\u7814\u7a76\uff08Observational Study\uff09\u3002\u6c92\u6709\u5c0d\u7167\u7d44\u7684\u89c0\u5bdf\u578b\u7814\u7a76\u662f\u70ba\u6558\u8ff0\u578b\u7814\u7a76\uff08Descriptive Study\uff09\uff1b\u6709\u5c0d\u7167\u7d44\u7a31\u70ba\u5206\u6790\u578b\u7814\u7a76\uff08Analytical Study\uff09\u3002<\/p>\n<p>\u5206\u6790\u578b\u7814\u7a76\u5c31\u662f\u63a2\u8a0e\u66b4\u9732\u56e0\u5b50\uff08Exposure factor\uff09\u548c\u7d50\u679c\uff08Outcome\uff09\u7684\u76f8\u95dc\uff0c\u7c21\u55ae\u5730\u8aaa\uff0c\u5c31\u662f\u7814\u7a76\u56e0\u679c\u95dc\u4fc2\u3002\u5206\u6790\u578b\u7814\u7a76\u53ef\u5206\u70ba\u4e09\u7a2e\u3002(1)\u540c\u4e00\u6642\u9593\u9ede\uff0c\u63a2\u8a0e\u56e0\u679c\u95dc\u4fc2\u4e4b\u7814\u7a76\u7a31\u70baCross-Sectional Study\u3002\u4e00\u7fa4\u767c\u751f\u4e8b\u4ef6\uff08Outcome\uff09\u4e4b\u5c0d\u8c61\u548c\u53e6\u4e00\u7fa4\u672a\u767c\u751f\u4e8b\u4ef6\u7684\u5c0d\u7167\u7d44\u4e2d\uff0c\u63a2\u8a0e\u767c\u751f\u4e8b\u4ef6\u7684\u7368\u7acb\u56e0\u7d20\u3002(2)\u73fe\u5728\u767c\u751f\u4e8b\u4ef6\uff08Outcome\uff09\u7684\u67d0\u7814\u7a76\u7fa4\uff0c\u8ffd\u6eaf\u904e\u53bb\u548c\u672c\u4e8b\u4ef6\u6709\u76f8\u95dc\u6027\u7684\u539f\u56e0\uff0c\u7a31\u70baCase-Control Study\uff0c\u9019\u7a2e\u7814\u7a76\u4e5f\u9700\u8981\u4e00\u7fa4\u73fe\u5728\u689d\u4ef6\u76f8\u540c\u800c\u672a\u767c\u751f\u8a72\u4e8b\u4ef6\u7684\u5c0d\u7167\u7d44\u505a\u70ba\u6bd4\u8f03\u3002(3)\u73fe\u5728\u5448\u73fe\u67d0\u56e0\u7d20\u7684\u7814\u7a76\u7d44\u548c\u4e0d\u5448\u73fe\u67d0\u56e0\u7d20\u7684\u5c0d\u7167\u7d44\uff0c\u89c0\u5bdf\u4e00\u6bb5\u6642\u9593\u5f8c\u51fa\u73fe\u67d0\u7d50\u679c\u7684\u56e0\u679c\u95dc\u4fc2\uff0c\u7a31\u70ba\u524d\u77bb\u6027\u7814\u7a76Cohort Study\u3002Cohort Study \u53ef\u4ee5\u518d\u5206\u70ba\u524d\u77bb\u6027\u3001\u56de\u6eaf\u6027\u548c\u96d9\u5411\u6027\u3002<\/p>\n<p>\u81e8\u5e8a\u7684\u5be6\u9a57\u6027\u7814\u7a76\uff08Experimental Study\uff09\u53ef\u4ee5\u7a31\u505a\u81e8\u5e8a\u8a66\u9a57\uff08Clinical trial\uff09\u3002\u4f9d\u64da\u7814\u7a76\u5c0d\u8c61\u662f\u5426\u6709\u4f9d\u64da\u96a8\u6a5f\u5206\u914d\uff0c\u53c8\u5206\u70baRandomised Controlled Study \u548c Non-Randomised Controlled Study\u3002<\/p>\n<p>\u5927\u90e8\u5206\u7684\u52d5\u7269\u548c\u7d30\u80de\u7814\u7a76\u662f\u5be6\u9a57\u6027\u7814\u7a76\u3002<\/p>\n<p><a href=\"http:\/\/wp.kmu.edu.tw\/rd\/files\/2014\/03\/\u96fb\u5b50\u58310181.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-2412\" alt=\"\u96fb\u5b50\u5831018\" src=\"http:\/\/wp.kmu.edu.tw\/rd\/files\/2014\/03\/\u96fb\u5b50\u58310181-300x226.png\" width=\"528\" height=\"399\" srcset=\"https:\/\/wp.kmu.edu.tw\/rd\/files\/2014\/03\/\u96fb\u5b50\u58310181-300x226.png 300w, https:\/\/wp.kmu.edu.tw\/rd\/files\/2014\/03\/\u96fb\u5b50\u58310181-396x300.png 396w, https:\/\/wp.kmu.edu.tw\/rd\/files\/2014\/03\/\u96fb\u5b50\u58310181.png 623w\" sizes=\"auto, (max-width: 528px) 100vw, 528px\" \/><\/a><\/p>\n<p><strong>\uff08\u4e09\uff09\u5e74\u8f15\u91ab\u5e2b\u5982\u4f55\u898f\u5283\u7814\u7a76<\/strong><\/p>\n<p><strong><\/strong>\u5728\u91ab\u5b78\u4e2d\u5fc3\uff0c\u5e74\u8f15\u91ab\u5e2b\u61c9\u5f9e\u4f4f\u9662\u91ab\u5e2b\u5c31\u958b\u59cb\u898f\u5283\u5982\u4f55\u505a\u7814\u7a76\uff0c\uff081\uff09\u719f\u7fd2\u60a8\u91ab\u7642\u9818\u57df\u7684\u5b8c\u6574\u548c\u6700\u65b0\u7684\u77e5\u8b58\u3002\uff082\uff09\u6709\u611b\u5fc3\u800c\u7a4d\u6975\u53bb\u8a3a\u6cbb\u60a8\u7684\u75c5\u4eba\uff0c\u96a8\u6642\u80fd\u63a2\u7d22\u767c\u73fe\u554f\u984c\uff0c\u601d\u8003\u89e3\u6c7a\u65b9\u6cd5\u3002\uff083\uff09\u719f\u7fd2\u60a8\u9818\u57df\u6700\u65b0\u6700\u597d\u7684\u6587\u737b\uff0c\u53c3\u52a0\u79d1\u5167\u7814\u7a76\u6703\uff0c\u570b\u5167\u5916\u91ab\u5b78\u6703\u548c\u51fa\u570b\u9032\u4fee\uff0c\u6700\u597d\u80fd\u5c31\u8b80\u7814\u7a76\u6240\u3002\uff084\uff09\u8b80\u60a8\u9818\u57df\u4ee5\u5916\u9802\u5c16\u7684\u79d1\u5b78\u6587\u737b\uff0c\u624d\u6703\u6709\u5275\u65b0\u548c\u8ca2\u737b\u6027\u7684\u7814\u7a76\u3002\uff085\uff09\u719f\u7fd2\u81e8\u5e8a\u6aa2\u9a57\u7684\u65b9\u6cd5\u3001\u624b\u8853\u6280\u8853\u3001\u85e5\u7269\u4e4b\u85e5\u7406\u6bd2\u7406\u4ee5\u53ca\u7814\u7a76\u65b9\u6cd5\uff0c\u4fee\u7fd2\u7d71\u8a08\u65b9\u6cd5\uff0c\u9019\u4e9b\u662f\u57fa\u672c\u7684\u7814\u7a76\u80fd\u529b\u8a13\u7df4\u3002<\/p>\n<p>\u6240\u4ee5\u5c0d\u5e74\u8f15\u7684\u5c08\u79d1\u91ab\u5e2b\uff0c\u6211\u5011\u5efa\u8b70(1)\u591a\u8b80\u3001\u591a\u807d\u3001\u591a\u554f\uff0c\u5c24\u5176\u662f\u8981\u5e38\u601d\u8003\uff1b(2)\u61c9\u8a72\u9078\u64c7\u81ea\u5df1\u8a3a\u6cbb\u7684\u75be\u75c5\u548c\u75c5\u4eba\u70ba\u7814\u7a76\u4e3b\u984c\uff1b(3)\u61c9\u8a72\u5148\u548c\u8cc7\u6df1\u7684\u512a\u79c0\u7814\u7a76\u8005\u5171\u540c\u7814\u7a76\u3002\u5e7e\u5e74\u5f8c\uff0c\u81ea\u5df1\u80fd\u7368\u7acb\u601d\u8003\uff0c\u975e\u5e38\u719f\u7df4\u7814\u7a76\u65b9\u6cd5\u548c\u8a2d\u8a08\uff0c\u518d\u81ea\u5df1\u6c7a\u5b9a\u6709\u5275\u65b0\u548c\u61c9\u7528\u6027\u7684\u7814\u7a76\u65b9\u5411\uff0c\u80fd\u5920\u89e3\u6c7a\u4f60\u767c\u73fe\u7684\u75c5\u4eba\u5065\u5eb7\u554f\u984c\uff0c\u8ca2\u737b\u4eba\u985e\u5065\u5eb7\u7684\u7814\u7a76\u3002<\/p>\n<p><strong>\uff08\u56db\uff09\u5e74\u8f15\u91ab\u5e2b\u7814\u7a76\u984c\u76ee\u7684\u9078\u64c7<\/strong><\/p>\n<p>\u5728\uff08\u4e09\uff09\u4e2d\u5df2\u660e\u767d\u544a\u8a34\u5927\u5bb6\u600e\u9ebc\u8457\u624b\u505a\u7814\u7a76\u3002\u5e74\u8f15\u5c08\u79d1\u91ab\u5e2b\u5982\u4f55\u9078\u64c7\u7814\u7a76\u984c\uff0c\u6211\u5011\u5efa\u8b70\u5927\u5bb6\u95b1\u8b80Kahn\u6559\u6388\u57281994\u5e745\u6708\u767c\u8868\u5728NEJM\u7684\u4e00\u7bc7\u8ad6\u6587\uff08Picking a research problem-The critical decision\uff09\uff0c\u4ed6\u6709\u5341\u9805\u5efa\u8b70\uff1a<\/p>\n<p>(1)Anticipate the results before doing the first study<\/p>\n<p>(2)Pick an area on the basis of the interest of the outcome<\/p>\n<p>(3)Look for an underoccupied niche that has potential<\/p>\n<p>(4)Go to talks and read papers outside your area of interest<\/p>\n<p>(5)Build on a theme<\/p>\n<p>(6)Find a balance between low-risk and high-risk projects, but always include a high-risk, high-interest project in your portfolio<\/p>\n<p>(7)Be prepared to pursue a project to any depth necessary<\/p>\n<p>(8)Differentiate yourself from your mentor<\/p>\n<p>(9)Do not assume that outstanding, or even good, clinical research is easier than outstanding basic research<\/p>\n<p>(10)Focus,focus,focus<\/p>\n<p><strong>\uff08\u4e94\uff09\u719f\u7fd2\u7d71\u8a08\u65b9\u6cd5<\/strong><\/p>\n<p>\u7814\u7a76\u4e4b\u56e0\u679c\u95dc\u4fc2\u662f\u5426\u6709\u610f\u7fa9\uff0c\u9700\u8981\u5229\u7528\u7d71\u8a08\u65b9\u6cd5\u4f86\u5206\u6790\uff0c\u751f\u7269\u7d71\u8a08\u65b9\u6cd5\u5f88\u591a\uff0c\u5982\u524d\u6240\u8ff0\uff0c\u4e0d\u540c\u7684\u7814\u7a76\u985e\u578b\u6703\u63a1\u7528\u4e0d\u540c\u7684\u7d71\u8a08\u65b9\u6cd5\uff0c\u4e5f\u6703\u56e0\u66b4\u9732\u56e0\u5b50(factor)\u548c\u7d50\u679c\u4e4b\u8b8a\u9805\u7684\u5927\u5c0f\u548c\u6027\u8cea\u800c\u63a1\u7528\u4e0d\u540c\u7684\u7d71\u8a08\uff0c\u719f\u7fd2\u800c\u6b63\u78ba\u3001\u5584\u7528\u7d71\u8a08\u65b9\u6cd5\uff0c\u7814\u7a76\u7684\u7d50\u679c\u6703\u66f4\u4eae\u9e97\u6216\u5275\u65b0\uff0c\u6240\u8b02\u300c\u9ede\u77f3\u6210\u91d1\u300d\u7684\u6548\u679c\u3002\u672c\u6821\u7814\u767c\u8655\u8a2d\u7f6e\u4e4b\u91ab\u5b78\u8cc7\u8a0a\u8207\u7d71\u8a08\u4e2d\u5fc3\u4ee5\u53ca\u9644\u8a2d\u91ab\u9662\u81e8\u5e8a\u7814\u7a76\u90e8\u4e4b\u91ab\u5b78\u7d71\u8a08\u5206\u6790\u5ba4\u53ca\u751f\u7269\u8cc7\u8a0a\u7814\u7a76\u5ba4\u8a2d\u7f6e\u7d71\u8a08\u8aee\u8a62\u53ca\u5206\u6790\u670d\u52d9\uff0c\u5e74\u8f15\u91ab\u5e2b\u61c9\u8a72\u5e38\u5e38\u5229\u7528\u3002<\/p>\n<p><strong>\uff08\u516d\uff09\u91cd\u8996\u5b78\u8853\u502b\u7406\uff0c\u7533\u8acb\u4eba\u9ad4\u8a66\u9a57<\/strong><\/p>\n<p>\u5c0a\u91cd\u548c\u4fdd\u969c\u4eba\u6b0a\u662f\u6c11\u4e3b\u570b\u5bb6\u7684\u57fa\u672c\u61b2\u6cd5\uff0c\u5b78\u8853\u7814\u7a76\u7d55\u5c0d\u9700\u8981\u4fdd\u969c\u75c5\u4eba\u7684\u8eab\u4efd\u548c\u75be\u75c5\u4e4b\u96b1\u79c1\uff0c\u5c24\u5176\u662f\u5be6\u9a57\u578b\u4ecb\u5165\u7814\u7a76\uff0c\u7d55\u5c0d\u4fdd\u969c\u75c5\u4eba\u81f3\u6700\u4f4e\u7684\u526f\u4f5c\u7528\uff0c\u57f7\u884c\u8a08\u756b\u8207\u7814\u7a76\u524d\u5fc5\u9808\u7533\u8acb\u4eba\u9ad4\u8a66\u9a57\u59d4\u54e1\u6703\uff08Institutional Review Board\uff09\u7684\u901a\u904e\u624d\u80fd\u9032\u884c\u7814\u7a76\u3002\u52d9\u5fc5\u6e05\u6e05\u695a\u695a\u89e3\u91cb\u7814\u7a76\u5167\u5bb9\uff0c\u4e26\u7372\u5f97\u75c5\u4eba\u7c3d\u7f72\u7684\u77e5\u60c5\u540c\u610f\u66f8\u624d\u53ef\u9032\u884c\u7814\u7a76\u3002<\/p>\n<p><strong>\uff08\u4e03\uff09\u5584\u7528\u5065\u4fdd\u8cc7\u6599\uff0c\u5b8c\u6210\u570b\u969b\u6ce8\u76ee\u7684\u8ad6\u6587<\/strong><\/p>\n<p>\u6700\u8fd1\u5e7e\u5e74\uff0c\u53f0\u7063\u7814\u7a76\u8005\u5229\u7528\u5168\u570b\u5065\u5eb7\u8cc7\u6599\u767c\u8868\u7684\u8ad6\u6587\u6108\u4f86\u6108\u591a\uff0c\u4e0d\u5c11\u8ad6\u6587\u520a\u767b\u5728\u9802\u5c16\u671f\u520a\uff0c\u88ab\u5f15\u7528\u7684\u6b21\u6578\u4e5f\u9ad8\u65bc\u4e00\u822c\u7684\u8ad6\u6587\uff0c\u986f\u793a\u9019\u4e9b\u8ad6\u6587\u7684\u512a\u8cea\u6027\u548c\u61c9\u7528\u6027\u5f88\u9ad8\u3002\u4f46\u662f\u5065\u4fdd\u8cc7\u6599\u6709\u512a\u9ede\u4e5f\u6709\u7f3a\u9ede\uff0c\u66fe\u6176\u5b5d\u6559\u6388\u6307\u51fa\u5065\u4fdd\u8cc7\u6599\u5eab\u6578\u64da\u7684\u512a\u9ede\u5305\u62ec\uff1a\u5168\u570b\u6027\u7684\u3001\u7814\u7a76\u5c0d\u8c61\u5920\u5927\u3001\u5b8c\u6574\u7684\u7528\u85e5\u53f2\u3001\u652f\u4ed8\u8cbb\u6709\u95dc\u7684\u8a3a\u65b7\u3001\u6aa2\u67e5\u548c\u8cbb\u7528\u3001\u9577\u671f\u6027\u6578\u64da\u548c\u7814\u7a76\u82b1\u8cbb\u5c11\uff1b\u4f46\u662f\u4e5f\u6709\u7f3a\u9ede\uff0c\u5305\u62ec\u4ed8\u8cbb\u95dc\u9023\u7684\u6578\u64da\u3001\u7121\u500b\u4eba\u8a73\u53f2\u3001\u7121\u5be6\u9a57\u6578\u64da\u3001\u7814\u7a76\u8005\u9700\u6709SAS\u7d71\u8a08\u5206\u6790\u80fd\u529b\u3001\u5f71\u97ff\u56e0\u7d20\u3001\u504f\u5dee\u6216\u5bb9\u6613\u932f\u8aa4\u89e3\u8b80\u3002\u6240\u4ee5\u5229\u7528\u5065\u4fdd\u8cc7\u6599\u5fc5\u9808\u5584\u7528\u5176\u512a\u9ede\u907f\u958b\u7f3a\u9ede\u548c\u5c0f\u5fc3\u89e3\u8b80\uff0c\u9ad8\u91ab\u5e74\u8f15\u91ab\u5e2b\u53ef\u4ee5\u5411NHRI\u548c\u9ad8\u91ab\u885b\u751f\u798f\u5229\u90e8\u5728\u91ab\u5b78\u4e2d\u5fc3\u8a2d\u7acb\u7684\u300c\u5065\u4fdd\u8cc7\u6599\u52a0\u503c\u548c\u5354\u4f5c\u4e2d\u5fc3\u300d\u7533\u8acb\u4f7f\u7528\uff08\u7db2\u5740\u5982\u4e0b\uff1ahttp:\/\/cchia.kmu.edu.tw\/\uff09\u3002<\/p>\n<p><strong>\uff08\u516b\uff09\u9b4f\u798f\u5168\u9662\u58eb\u6f14\u8b1b-Thinking Big and Aiming High<\/strong><\/p>\n<p>\u9b4f\u798f\u5168\u9662\u58eb\u57282012\u5e747\u67085\u65e5\u7372\u9078\u70ba\u4e2d\u592e\u7814\u7a76\u9662\u9662\u58eb\uff0c\u81f32011\u5e74\u5171\u767c\u8868434\u7bc7\u8ad6\u6587\uff0c\u88ab\u5f15\u75286646\u6b21\uff0c\u53d7\u9080\u570b\u5916\u6f14\u8b1b550\u6b21\u3002<\/p>\n<p>\u51fa\u570b\u9032\u4fee\u662f\u5b78\u8853\u7814\u7a76\u9081\u5411\u570b\u969b\u821e\u53f0\u6700\u76f4\u63a5\u7684\u9014\u5f91\uff0c\u4ed6\u8aaa\uff1a\u300c\u51fa\u570b\u5b78\u65b0\u7684\uff0c\u53f0\u7063\u6b20\u7f3a\u7684\u3001\u53c8\u80fd\u5c0d\u4eba\u6c11\u6709\u7528\u7684\u6771\u897f\u300d\u3002\u5e74\u8f15\u91ab\u5e2b\u61c9\u7d2e\u7d2e\u5be6\u5be6\u5efa\u7acb\u8a3a\u6cbb\u75c5\u4eba\u7684\u6839\u57fa\u3002\u9b4f\u6559\u63881979-1981\u5e74\u5728\u591a\u502b\u591a\u5927\u5b78\u7814\u7fd2\u525b\u840c\u82bd\u7684\u986f\u5fae\u91cd\u5efa\u624b\u8853\uff0c\u56de\u570b\u5f8c\u518d\u5275\u81ea\u9ad4\u79fb\u690d\u624b\u8853\uff0c\u61c9\u7528\u5230\u4e73\u764c\u3001\u53e3\u8154\u764c\u548c\u982d\u9838\u764c\u75c5\u60a3\uff0c\u8b93\u75c5\u4eba\u4fdd\u7559\u751f\u547d\u3001\u4ee5\u53ca\u9032\u98df\u548c\u8aaa\u8a71\u80fd\u529b\u3002\u9b4f\u6559\u6388\u8aaa\uff1a\u300c\u5f88\u591a\u624b\u8853\u7684\u6539\u826f\u548c\u5275\u65b0\u5176\u5be6\u662f\u6e90\u81ea\u6211\u770b\u5230\u60a3\u8005\u8eab\u5fc3\u7684\u75db\u82e6\u548c\u751f\u547d\u5782\u5371\u7684\u6399\u624e\uff0c\u65bc\u662f\u6211\u7d5e\u76e1\u8166\u6c41\u601d\u6709\u4ec0\u9ebc\u65b0\u7684\u65b9\u6cd5\u53ef\u4ee5\u62ef\u6551\u75c5\u4eba\u7684\u751f\u547d\uff0c\u66f4\u6539\u5584\u4ed6\u5011\u5668\u5b98\u7684\u529f\u80fd\u548c\u5fc3\u9748\u7684\u5065\u5168\u300d\u3002<\/p>\n<p>\u611b\u5fc3\u6fc0\u767c\u9b4f\u6559\u6388\u601d\u8003\u3001\u767c\u73fe\u554f\u984c\u3001\u89e3\u6c7a\u554f\u984c\u3001\u5275\u65b0\u8a3a\u6cbb\u7684\u6280\u8853\u548c\u89c0\u5ff5\uff0c\u5b78\u8853\u767c\u8868\uff0c\u5f71\u97ff\u5168\u4e16\u754c\u5c0d\u75be\u75c5\u8a3a\u6cbb\u7684\u65b0\u7406\u8ad6\u548c\u65b0\u6cbb\u7642\uff0c\u8de8\u8d8a\u6559\u79d1\u66f8\uff0c\u8de8\u51fa\u53f0\u7063\u548c\u9818\u5148\u4e16\u754c\u7684\u5b8f\u89c0\u89c0\u5ff5\uff0c\u662f\u5e74\u8f15\u91ab\u5e2b\u5f9e\u4e8b\u91ab\u7642\u548c\u7814\u7a76\u4e26\u9032\u53ef\u4ee5\u5b78\u7fd2\u7684\u5178\u7bc4\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: right\"><a href=\"http:\/\/wp.kmu.edu.tw\/rd\/archives\/2338\">\u56de\u7b2c0018\u671f\u4e3b\u9801<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u56de\u7b2c0018\u671f\u4e3b\u9801 \u4e8c\u3001\u8ad6\u6587\u8207\u7814\u7a76\u5206\u4eab \uff08\u4e00\uff09\u8ad6\u6587 \u984c\u76ee\uff1a Microemuls &hellip; <a href=\"https:\/\/wp.kmu.edu.tw\/rd\/archives\/2342\">\u95b1\u8b80\u5168\u6587 <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[26],"tags":[],"class_list":["post-2342","post","type-post","status-publish","format-standard","hentry","category-26"],"_links":{"self":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/2342","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/comments?post=2342"}],"version-history":[{"count":10,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/2342\/revisions"}],"predecessor-version":[{"id":2443,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/2342\/revisions\/2443"}],"wp:attachment":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/media?parent=2342"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/categories?post=2342"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/tags?post=2342"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}