{"id":2450,"date":"2014-04-02T09:41:34","date_gmt":"2014-04-02T01:41:34","guid":{"rendered":"http:\/\/wp.kmu.edu.tw\/rd\/?p=2450"},"modified":"2014-04-03T16:47:19","modified_gmt":"2014-04-03T08:47:19","slug":"%e7%a0%94%e7%a9%b6%e6%96%b0%e7%9f%a5-17","status":"publish","type":"post","link":"https:\/\/wp.kmu.edu.tw\/rd\/archives\/2450","title":{"rendered":"\u7814\u7a76\u65b0\u77e5"},"content":{"rendered":"<p style=\"text-align: right\"><a style=\"font-style: normal;text-align: right\" href=\"http:\/\/wp.kmu.edu.tw\/rd\/archives\/2448\">\u56de\u7b2c0019\u671f\u4e3b\u9801<\/a><\/p>\n<h1><span style=\"font-size: x-large;color: #c10000\">\u4e00\u3001\u7814\u7a76\u65b0\u77e5<\/span><\/h1>\n<p><a name=\"ResNew1\"><\/a><\/p>\n<h1><span style=\"color: #0000ff\"><span style=\"color: #0000ff\">Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling<\/span><\/span><\/h1>\n<p>Nature Communications5,Article number:3472doi:10.1038\/ncomms4472 Received10 January 2014 Accepted 19 February 2014 Published 25 March 2014<br \/>\nWan-Jiun Chen, Chao-Chi Ho, Yih-Leong Chang, Hsuan-Yu Chen, Chih-An Lin, Thai-Yen Ling, Sung-Liang Yu, Shin-Sheng Yuan, Yu-Ju Louisa Chen, Chien-Yu Lin, Szu-Hua Pan, Han-Yi Elizabeth Chou, Yu-Ju Chen, Gee-Chen Chang, Wen-Cheng Chu, Yee-Ming Lee, Jen-Yi Lee, Pei-Jung Lee, Ker-Chau Li, Huei-Wen Chen et al.<br \/>\n\uff08\u611f\u8b1d\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u91ab\u5b78\u7814\u7a76\u6240 \u5b6b\u662d\u73b2\u526f\u6559\u6388 \u6458\u8b6f\uff09<\/p>\n<p>\u76ee\u524d\u6cbb\u7642\u764c\u75c7\u91cd\u8981\u7684\u65b9\u5411\u662f\u91dd\u5c0d\u764c\u75c7\u5e79\u7d30\u80de\uff0c\u4f46\u662f\u764c\u75c7\u5e79\u7d30\u80de\u5982\u4f55\u5728\u6d3b\u9ad4\u5167\u7dad\u6301\u5176\u7279\u6027\uff0c\u4e00\u76f4\u9084\u662f\u672a\u77e5\u7684\u8b0e\uff0c\u800c\u4e14\u4e5f\u5f88\u96e3\u5229\u7528\u9ad4\u5916\u5be6\u9a57\u4f86\u6df1\u5165\u7814\u7a76\u3002\u5982\u4eca\u6211\u5011\u5efa\u7acb\u4e00\u5957\u9ad4\u5916\u5171\u540c\u57f9\u990a\u7cfb\u7d71\uff0c\u5229\u7528\u4f86\u81ea\u75c5\u4eba\u7684CD90+\u7e96\u7dad\u6bcd\u7d30\u80de\u8207Oct3\/4+\/Nanog+\u764c\u75c7\u5e79\u7d30\u80de\u7684\u5171\u540c\u57f9\u990a\uff0c\u4f86\u4e86\u89e3\u816b\u7624\u6240\u5728\u7684\u5fae\u74b0\u5883\u4e2d\uff0c\u5982\u4f55\u7dad\u6301\u764c\u75c7\u5e79\u7d30\u80de\u7684\u672c\u8cea\u3002\u85c9\u7531\u8f49\u9304\u8cea\u9ad4\u5b78\u7684\u7814\u7a76\u65b9\u6cd5\uff0c\u6211\u5011\u767c\u73fe\u4e86\u7531CD90+\u7e96\u7dad\u6bcd\u7d30\u80de\u6240\u5206\u6ccc\u7528\u4f86\u7dad\u6301\u764c\u75c7\u5e79\u7d30\u80de\u7279\u6027\u7684\u7d30\u80de\u6fc0\u7d20\u7db2\u7d61\uff0c\u5176\u4e2d\u7e96\u7dad\u6bcd\u7d30\u80de\u6240\u5206\u6ccc\u4e4bIGF-II\uff08insulin-like growth factor-II\uff09\uff0c\u53ef\u4f7f\u764c\u75c7\u7d30\u80de\u7684IGF1R\u8a0a\u606f\u50b3\u905e\u8def\u5f91\u6d3b\u5316\uff0c\u9032\u800c\u4f7f\u764c\u75c7\u5e79\u7d30\u80de\u8868\u73feNanog\u5206\u5b50\uff0c\u4e26\u4e14\u7dad\u6301\u5176\u5e79\u7d30\u80de\u7279\u6027\uff0c\u800c\u9019\u500b\u8a0a\u606f\u50b3\u905e\u8def\u5f91\u53ef\u4ee5\u7528\u4f86\u9810\u6e2c\u7b2c\u4e00\u671f\u975e\u5c0f\u7d30\u80de\u80ba\uff08non-small cell lung cancer\uff09\u764c\u75c5\u4eba\u7684\u6574\u9ad4\u5b58\u6d3b\u7387\u8207\u7121\u5fa9\u767c\u5b58\u6d3b\u7387\uff0c\u82e5\u963b\u65b7IGF-II\/IGF1R\u7684\u8a0a\u606f\u50b3\u905e\u8def\u5f91\uff0c\u5247\u4f7f\u764c\u75c7\u5e79\u7d30\u80de\u4e0d\u6703\u8868\u73feNanog\u5206\u5b50\uff0c\u4e14\u96e3\u4ee5\u7dad\u6301\u5176\u5e79\u7d30\u80de\u7279\u6027\u3002\u6211\u5011\u7684\u7814\u7a76\u8b49\u660e\u75c5\u7076\u65c1\u7684\u7e96\u7dad\u6bcd\u7d30\u80de\u662f\u7dad\u6301\u764c\u75c7\u5e79\u7d30\u80de\u7279\u6027\u7684\u95dc\u9375\uff0c\u800c\u91dd\u5c0d\u4e8c\u8005\u9593\u4ea4\u63db\u7684\u7d30\u80de\u6fc0\u7d20\u8a0a\u606f\uff0c\u53ef\u80fd\u662f\u6cbb\u7642\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684\u65b0\u65b9\u5411\u3002<\/p>\n<p style=\"text-align: right\"><a href=\"http:\/\/wp.kmu.edu.tw\/rd\/archives\/2448\">\u56de\u7b2c0019\u671f\u4e3b\u9801<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u56de\u7b2c0019\u671f\u4e3b\u9801 \u4e00\u3001\u7814\u7a76\u65b0\u77e5 Cancer-associated fibro &hellip; <a href=\"https:\/\/wp.kmu.edu.tw\/rd\/archives\/2450\">\u95b1\u8b80\u5168\u6587 <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[27],"tags":[],"class_list":["post-2450","post","type-post","status-publish","format-standard","hentry","category-27"],"_links":{"self":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/2450","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/comments?post=2450"}],"version-history":[{"count":7,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/2450\/revisions"}],"predecessor-version":[{"id":2480,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/2450\/revisions\/2480"}],"wp:attachment":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/media?parent=2450"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/categories?post=2450"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/tags?post=2450"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}