{"id":2452,"date":"2014-04-02T09:42:50","date_gmt":"2014-04-02T01:42:50","guid":{"rendered":"http:\/\/wp.kmu.edu.tw\/rd\/?p=2452"},"modified":"2014-04-03T17:00:27","modified_gmt":"2014-04-03T09:00:27","slug":"%e8%ab%96%e6%96%87%e7%a0%94%e7%a9%b6%e8%88%87%e5%88%86%e4%ba%ab-11","status":"publish","type":"post","link":"https:\/\/wp.kmu.edu.tw\/rd\/archives\/2452","title":{"rendered":"\u8ad6\u6587\u7814\u7a76\u8207\u5206\u4eab"},"content":{"rendered":"<p style=\"text-align: right\"><a href=\"http:\/\/wp.kmu.edu.tw\/rd\/archives\/2448\">\u56de\u7b2c0019\u671f\u4e3b\u9801<\/a><\/p>\n<h1><span style=\"font-size: x-large;color: #c10000\">\u4e8c\u3001\u8ad6\u6587\u8207\u7814\u7a76\u5206\u4eab<\/span><\/h1>\n<p><a name=\"PaperRes1\"><\/a><\/p>\n<h1><span style=\"color: #0000ff\">\uff08\u4e00\uff09\u8ad6\u6587<\/span><\/h1>\n<ul>\n<li><span style=\"color: #3366ff\">\u984c\u76ee\uff1a<strong><br \/>\nIsophilippinolide A arrests cell cycle progression and induces apoptosis for anticancer inhibitory agents in human melanoma cells.<\/strong><\/span><\/li>\n<\/ul>\n<ul>\n<li>\u4f5c\u8005\uff1a Wang HM1, Chen CY, Wu PF. J Agric Food Chem. 2014 Feb 5;62(5):1057-65. doi: 10.1021\/jf403730z. Epub 2014 Jan 23<br \/>\n\uff08\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u738b\u60e0\u6c11\u526f\u6559\u6388\u63d0\u4f9b\u6458\u8981\uff09<\/li>\n<\/ul>\n<ul>\n<li>\u6709\u6c92\u6709\u66fe\u60f3\u904e\uff0c\u6709\u5929\u8d70\u5728\u8def\u4e0a\uff0c\u8eab\u65c1\u4e00\u68f5\u904e\u773c\u5373\u5fd8\u7684\u6a39\u7adf\u7136\u4e5f\u80fd\u5c0d\u8eab\u9ad4\u7684\u5065\u5eb7\u6709\u6240\u5e6b\u52a9\uff0c\u7f8e\u767d\u3001\u6297\u6c27\u5316\uff0c\u751a\u81f3\u662f\u6297\u764c\uff1f<br \/>\nCinnamomum philippinense\uff0c\u83f2\u5f8b\u8cd3\u6a1f\u6a39\uff0c\u591a\u9577\u65bc\u83f2\u5f8b\u8cd3\u53ca\u5357\u81fa\u7063\uff0c\u70ba\u53f0\u7063\u7684\u539f\u751f\u690d\u7269\u3002\u51fa\u65bc\u5c0d\u6b64\u7684\u597d\u5947\uff0c\u6211\u5011\u7279\u5225\u6536\u96c6\u83f2\u5f8b\u8cd3\u6a1f\u6a39\u4e4b\u6839\u90e8\uff0c\u5c07\u4e4b\u8403\u53d6\u5f8c\u5206\u96e2\u51fa\u56db\u7a2e\u5316\u5408\u7269\uff0c\u5206\u5225\u70ba\u4e09\u7a2e\u65b0\u7684\u4e01\u5167\u916f\uff0cisophilippinolide A, philippinolide A, \u53ca philippinolide B\uff0c\u4ee5\u53ca\u4e00\u5df2\u77e5\u4e4b\u91af\u80fa\uff0dcinnaretamine\u3002\u5728\u7d93\u904e\u4e00\u7cfb\u5217\u7684\u6297\u6c27\u5316\u5be6\u9a57\u5f8c\u767c\u73fe\uff0ccinnaretamine \u5177\u5f37\u800c\u6709\u529b\u7684\u6297\u6c27\u5316\u6d3b\u6027\u53ca\u9084\u539f\u81ea\u7531\u57fa\u7684\u80fd\u529b\uff0c\u4e14\u56db\u7a2e\u5316\u5408\u7269\u7686\u6709\u80fd\u5c07\u91d1\u5c6c\u87af\u5408\u7684\u7279\u6027\uff0c\u4ee5\u6e1b\u5c11\u81ea\u7531\u57fa\u7684\u5f62\u6210\u3002\u63a5\u8457\u63a2\u7a76\u5728\u7f8e\u767d\u7684\u6548\u7528\u4e0a\uff0c\u5176\u80fd\u6291\u5236 L-tyrosine \u8f49\u8b8a\u6210 L-dopa\u6642\u9032\u884c\u7684\u7fa5\u5316\u4f5c\u7528\u800c\u9054\u5230\u6e1b\u5c11\u9ed1\u8272\u7d20\u5f62\u6210\u7684\u76ee\u7684\u3002\u65b0\u5947\u7684\u662f\uff0c\u5728\u6b64\u56db\u7a2e\u5316\u5408\u7269\u4e2d\uff0c isophilippinolide A \u7adf\u5177\u6709\u80fd\u5c0d\u6297A375.S2\u9ed1\u8272\u7d20\u7624\u7d30\u80de\u7684\u6548\u7528\uff0c\u6839\u64daWestern blotting\u7684\u7d50\u679c\u986f\u793a\uff0cisophilippinolide A\u80fd\u8a98\u5c0eA375.S2\u7522\u751f caspase-dependent \u7d30\u80de\u51cb\u4ea1\u86cb\u767d\uff0c\u5f15\u767c\u76f8\u95dc\u8def\u5f91\uff0c\u6291\u5236\u7d30\u80de\u751f\u9577\u5c0e\u81f4\u764c\u5316\u7d30\u80de\u7684\u51cb\u4ea1\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0cisophilippinolide A\u5c0d\u65bc\u4eba\u985e\u7684\u771f\u76ae\u53ca\u8868\u76ae\u7d30\u80de\u53ea\u6709\u9bae\u5c11\u7684\u7d30\u80de\u6bd2\u6027\uff0c\u80fd\u6e1b\u5c11\u85e5\u7269\u5c0d\u4eba\u9ad4\u7522\u751f\u7684\u526f\u4f5c\u7528\u3002\u9ed1\u8272\u7d20\u7624\u76ee\u524d\u7684\u6cbb\u7642\u65b9\u5f0f\u5305\u542b\u624b\u8853\u3001\u5316\u7642\u53ca\u653e\u5c04\u6027\u6cbb\u7642\uff0c\u4f46\u4ecd\u7121\u6cd5\u63d0\u9ad8\u75c5\u60a3\u4e4b\u5b58\u6d3b\u7387\uff0c\u56e0\u6b64\u50cfisophilippinolide A \u5929\u7136\u6cbb\u764c\u85e5\u7269\u7684\u8f14\u52a9\u53ca\u767c\u5c55\u5c31\u986f\u5f97\u76f8\u7576\u91cd\u8981\u3002\u6700\u5f8c\uff0c\u82e5\u6b64\u56db\u7a2e\u5177\u751f\u7269\u6d3b\u6027\u4e4b\u5316\u5408\u7269\u80fd\u6210\u529f\u5c55\u73fe\u5176\u5229\u7528\u50f9\u503c\uff0c\u5c07\u80fd\u5927\u91cf\u61c9\u7528\u65bc\u5316\u599d\u54c1\u4e2d\u529f\u6548\u6027\u539f\u6599\u958b\u767c\u3001\u4fdd\u5065\u98df\u54c1\u53ca\u91ab\u85e5\u65b9\u9762\u4e4b\u767c\u5c55\u3002Figure 1. Proposed schematic diagram of isophilippinolide A biofunctions.<br \/>\n<img decoding=\"async\" alt=\"\" src=\"http:\/\/wp.kmu.edu.tw\/rd\/files\/2014\/04\/019001-e1396404025282.png\" \/><\/li>\n<\/ul>\n<p><a name=\"PaperRes2\"><\/a><\/p>\n<ul>\n<li><span style=\"color: #3366ff\">\u984c\u76ee\uff1a<strong><br \/>\nBetel-quid dependence domains and syndrome associated with betel-quid ingredients among chewers: an Asian multi-country evidence.<\/strong><\/span><\/li>\n<\/ul>\n<ul>\n<li>\u4f5c\u8005\uff1a Lee CH, Chiang SL, Ko AM, Hua CH, Tsai MH, Warnakulasuriya S, Ibrahim SO, Sunarjo, Zain RB, Ling TY, Huang CH, Lane HY, Lin CC, Ko YC* Addiction. 2014 Mar 20. doi: 10.1111\/add.12530. [Epub ahead of print]\n\uff08\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u674e\u5efa\u5b8f\u6559\u6388\u63d0\u4f9b\u6458\u8981\uff09<\/li>\n<\/ul>\n<ul>\n<li>\u80cc\u666f\u8207\u76ee\u7684\uff1a\u6ab3\u6994\u5167\u542b\u7cbe\u795e\u4f5c\u7528\u6027\u4e4b\u7269\u8cea\uff0c\u7136\u800c\uff0c\u6ab3\u6994\u4f9d\u8cf4\u6027\u65bc\u6ab3\u6994\u56bc\u98df\u8005\u4e4b\u7279\u8cea\u8207\u75c7\u5019\u6240\u77e5\u6709\u9650\u3002\u672c\u7814\u7a76\u8a55\u4f30\u53c3\u8207\u4e9e\u6d32\u6ab3\u6994\u7814\u7a76\u806f\u76df\u4e4b\u516d\u500b\u4e9e\u6d32\u570b\u5bb6\u4e4b\u6ab3\u6994\u56bc\u98df\u8005\u7684\u6ab3\u6994\u4f9d\u8cf4\u72c0\u6cc1\uff0c\u5206\u6790\u8207\u4f9d\u8cf4\u6027\u4e4b\u7279\u8cea\u53ca\u75c7\u5019\u6709\u95dc\u4e4b\u6ab3\u6994\u6210\u4efd\uff0c\u4e26\u63a2\u8a0e\u5404\u570b\u6ab3\u6994\u4f9d\u8cf4\u6027\u4e4b\u76f8\u95dc\u56e0\u7d20\u3002\u7814\u7a76\u8a2d\u8a08\uff1a\u6a6b\u8de8\u516d\u500b\u4e9e\u6d32\u570b\u5bb6\u4e4b\u6a2a\u65b7\u5f0f\u6ab3\u6994\u806f\u5408\u7814\u7a76\u3002<br \/>\n\u7814\u7a76\u8a2d\u5b9a\uff1a\u53f0\u7063\u3001\u4e2d\u570b\u5927\u9678\u3001\u5370\u5c3c\u3001\u99ac\u4f86\u897f\u4e9e\u3001\u65af\u91cc\u862d\u5361\u548c\u5c3c\u6cca\u723e\u4e4b\u591a\u500b\u4e9e\u6d32\u7fa4\u9ad4\u3002<br \/>\n\u53c3\u8207\u8005\uff1a\u516d\u500b\u4e9e\u6d32\u6ab3\u6994\u7814\u7a76\u806f\u76df\u570b\u5bb6\u5206\u5225\u4ee5\u591a\u6b65\u9a5f\u96a8\u6a5f\u62bd\u6a23\u6cd5\u9078\u51fa\u4e4b\u516d\u500b\u96a8\u6a5f\u6a23\u672c\u4e4b\u6ab3\u6994\u56bc\u98df\u8005(n=2078)\u3002<br \/>\n\u6e2c\u91cf\u65b9\u6cd5\uff1a\u4f7f\u7528DSM-IV\u548cICD-10\u4e4b\u8a3a\u65b7\u65b9\u6cd5\uff0c\u8a55\u4f30\u6ab3\u6994\u56bc\u98df\u8005\u4e4b\u6ab3\u6994\u4f9d\u8cf4\u72c0\u6cc1\u3002<br \/>\n\u7814\u7a76\u767c\u73fe\uff1a\u6ab3\u6994\u4e0d\u542b\u83f8\u8349\u4e4b\u56bc\u98df\u8005\u8207\u542b\u83f8\u8349\u4e4b\u56bc\u98df\u8005\u65bc\u516d\u500b\u4e9e\u6d32\u570b\u5bb6\u4e4b12\u500b\u6708\u7684\u6ab3\u6994\u4f9d\u8cf4\u7387\u5206\u5225\u70ba12.5-92.6%\u548c47.9-99.3% (P = 0.023)\u3002\u6dfb\u52a0\u77f3\u7070\u4e4b\u7121\u83f8\u6ab3\u6994\u7684\u56bc\u98df\u8005\u76f8\u8f03\u65bc\u4e0d\u542b\u77f3\u7070\u4e4b\u7121\u83f8\u6ab3\u6994\u7684\u56bc\u98df\u8005\u5177\u6709\u986f\u8457\u8f03\u9ad8\u7684\u6ab3\u6994\u4f9d\u8cf4\u7387(23.3-95.6% vs. 4.0%, P &lt;= 0.001)\u3002\u53f0\u7063\u8207\u4e2d\u570b\u5927\u9678\u6e56\u5357\u7701\u4e4b\u6ab3\u6994\u56bc\u98df\u8005\u5747\u8a8d\u53ef\u5177\u6709\u8f03\u9ad8\u6bd4\u4f8b\u7684\u201c\u82b1\u8cbb\u9577\u6642\u9593\u7684\u5480\u56bc\u201d\u4e4b\u4f9d\u8cf4\u6027\u7279\u8cea\u3002\u5c3c\u6cca\u723e\u8207\u5370\u5c3c\u4e4b\u6ab3\u6994\u56bc\u98df\u8005\u5177\u6709\u8f03\u9ad8\u7684\u6ab3\u6994\u4f9d\u8cf4\u7387\uff0c\u4e14\u201c\u8010\u53d7\u6027\u201d\u8207\u201c\u6212\u65b7\u6027\u201d\u70ba\u5169\u5730\u56bc\u98df\u8005\u4e4b\u4e3b\u8981\u4f9d\u8cf4\u6027\u7279\u8cea\u3002\u99ac\u4f86\u897f\u4e9e\u8207\u65af\u91cc\u862d\u5361\u4e4b\u6ab3\u6994\u56bc\u98df\u8005\u5f62\u6210\u53e6\u4e00\u7fa4\u8207\u201c\u6e34\u671b\u201d\u6709\u95dc\u7684\u4f9d\u8cf4\u96c6\u7fa4\u3002\u5728\u65af\u91cc\u862d\u5361\uff0c\u6ab3\u6994\u56bc\u98df\u6578\u91cf\u89e3\u91cb90.5% (P &lt; 0.023)\u542b\u83f8\u6ab3\u6994\u8207\u7121\u83f8\u6ab3\u6994\u56bc\u98df\u8005\u4e4b\u9593\u6ab3\u6994\u4f9d\u8cf4\u7387\u7684\u5dee\u7570\u6027\uff0c\u4e26\u4e14\u53ef\u80fd\u70ba\u83f8\u8349\u884d\u751f\u4e4b\u7cbe\u795e\u4f5c\u7528\u8207\u6ab3\u6994\u4f9d\u8cf4\u6027\u4e4b\u9593\u7684\u4e2d\u4ecb\u56e0\u5b50\u3002<br \/>\n\u7814\u7a76\u7d50\u8ad6\uff1aDSM-IV\u6a19\u6e96\u9069\u7528\u65bc\u5177\u9ad8\u6ab3\u6994\u56bc\u98df\u6bd4\u4f8b\u7684\u4e9e\u88d4\u793e\u5340\uff0c\u66f4\u4f55\u6cc1\u6b64\u4e9b\u5730\u5340\u4e4b\u56bc\u98df\u8005\u4f7f\u7528\u542b\u83f8\u8207\u542b\u77f3\u7070\u4e4b\u6ab3\u6994\u3002\u7121\u83f8\u6ab3\u6994\u5c0d\u6ab3\u6994\u4f9d\u8cf4\u6027\u5177\u7368\u7acb\u6548\u61c9\uff0c\u800c\u542b\u83f8\u6ab3\u6994\u53ef\u80fd\u63d0\u5347\u6210\u766e\u7684\u4f5c\u7528\u3002<\/li>\n<\/ul>\n<p style=\"text-align: right\"><a href=\"http:\/\/wp.kmu.edu.tw\/rd\/archives\/2448\">\u56de\u7b2c0019\u671f\u4e3b\u9801<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u56de\u7b2c0019\u671f\u4e3b\u9801 \u4e8c\u3001\u8ad6\u6587\u8207\u7814\u7a76\u5206\u4eab \uff08\u4e00\uff09\u8ad6\u6587 \u984c\u76ee\uff1a Isophilipp &hellip; <a href=\"https:\/\/wp.kmu.edu.tw\/rd\/archives\/2452\">\u95b1\u8b80\u5168\u6587 <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[27],"tags":[],"class_list":["post-2452","post","type-post","status-publish","format-standard","hentry","category-27"],"_links":{"self":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/2452","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/comments?post=2452"}],"version-history":[{"count":6,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/2452\/revisions"}],"predecessor-version":[{"id":2508,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/2452\/revisions\/2508"}],"wp:attachment":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/media?parent=2452"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/categories?post=2452"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/tags?post=2452"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}