{"id":2516,"date":"2014-04-30T13:59:24","date_gmt":"2014-04-30T05:59:24","guid":{"rendered":"http:\/\/wp.kmu.edu.tw\/rd\/?p=2516"},"modified":"2014-05-05T12:34:53","modified_gmt":"2014-05-05T04:34:53","slug":"%e7%a0%94%e7%a9%b6%e6%96%b0%e7%9f%a5-18","status":"publish","type":"post","link":"https:\/\/wp.kmu.edu.tw\/rd\/archives\/2516","title":{"rendered":"\u7814\u7a76\u65b0\u77e5"},"content":{"rendered":"<p style=\"text-align: right\"><a style=\"font-style: normal;text-align: right\" href=\"http:\/\/wp.kmu.edu.tw\/rd\/archives\/2520\">\u56de\u7b2c0020\u671f\u4e3b\u9801<\/a><\/p>\n<h1><span style=\"font-size: x-large;color: #c10000\">\u4e00\u3001\u7814\u7a76\u65b0\u77e5<\/span><\/h1>\n<p><a name=\"ResNew1\"><\/a><\/p>\n<h1><span style=\"color: #0000ff\"><span style=\"color: #0000ff\">Structure of the Mitochondrial Translocator Protein in Complex with a Diagnostic Ligand<br \/>\n<\/span><\/span><\/h1>\n<p>Science Vol. 343 no. 6177 pp. 1363-1366, 2014. DOI:10.1126\/science.1248725 \u0141ukasz Jaremko, Mariusz Jaremko, Karin Giller, Stefan Becker, Markus Zweckstetter<br \/>\n\uff08\u611f\u8b1d\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u91ab\u653e\u7cfb\u7530\u80b2\u5f70\u6559\u6388 \u6458\u8b6f\uff09<\/p>\n<p>\u7d30\u80de\u4e2d\u7c92\u7dda\u9ad4\u662f\u91cd\u8981\u7684\u80fd\u6e90\u4f9b\u61c9\u80de\u5668\uff0c\u4e26\u4e14\u8ca0\u8cac\u751f\u7522\u985e\u56fa\u9187\u6fc0\u7d20\u5982\u777e\u56fa\u916e\u548c\u96cc\u4e8c\u9187\uff0c\u9019\u4e9b\u985e\u56fa\u9187\u6fc0\u7d20\u7684\u751f\u7522\u539f\u6599\u5c31\u662f\u81bd\u56fa\u9187\uff0c\u56e0\u6b64\u81bd\u56fa\u9187\u5fc5\u9808\u5148\u7d93\u7531\u7c92\u7dda\u9ad4\u5916\u819c\u9032\u5165\u7c92\u7dda\u9ad4\u3002TSPO\u88ab\u767c\u73fe\u5728\u7dda\u7c92\u9ad4\u819c\u4e0a\uff0c\u662f\u4e00\u500b\u5206\u5b50\u91cf18 kDa\u7684\u8f38\u9001\u86cb\u767d\uff0c\u529f\u7528\u70ba\u5f15\u5c0e\u81bd\u56fa\u9187\u7684\u9032\u5165\u7c92\u7dda\u9ad4\u3002\u800c\u5728\u529f\u80fd\u4e0a\uff0cTSPO ligands\u61c9\u7528\u65bc\u505a\u70ba\u7c92\u7dda\u9ad4\u529f\u80fd\u8a3a\u65b7\u8207\u6cbb\u7642\u7684\u6307\u6a19\u3002<br \/>\n\u5728\u9019\u9805\u7814\u7a76\u4e2d\uff0c\u4f5c\u8005\u5229\u7528\u9ad8\u89e3\u6790\u6838\u78c1\u5171\u632f\u5149\u8b5c\uff0c\u89e3\u958bTSPO\u86cb\u767d\u7684\u7acb\u9ad4\u7d50\u69cb\uff0c\u4e26\u4e14\u5c07PK11195(\u4e00\u7a2e\u9078\u64c7\u6027\u7d50\u5408\u7684isoquinoline carboxamide\uff0c\u5176\u53ef\u8207 TSPO\u7d50\u5408)\u8207dodecylphosphocholine (DPC)\u6df7\u88fd\u6210\u5fae\u8102\u56ca(micelles)\uff0c\u4f7f\u5176\u8207TSPO\u7522\u751f\u89aa\u548c\u529b\uff0c\u904b\u7528\u9019\u500b\u6280\u8853\u53ef\u4ee5\u5206\u6790\u81bd\u56fa\u9187\u5982\u4f55\u88ab\u904b\u9001\u5230\u7c92\u7dda\u9ad4\uff1b\u800c\u5927\u8166\u5728\u53d7\u50b7\u6216\u767c\u708e\u6642\uff0c\u7d30\u80de\u6703\u751f\u6210\u66f4\u591a\u7684TSPO\uff0c\u56e0\u6b64\u5229\u7528PK11195-DPC\u5fae\u8102\u56ca\u5305\u8986\u8a3a\u65b7\u85e5\u7269\u53ef\u4ee5\u61c9\u7528\u65bc\u795e\u7d93\u65b9\u9762\u75be\u75c5\uff08\u5982\u5927\u8166\u640d\u50b7\u3001\u5e15\u91d1\u68ee\u6c0f\u75c7\u3001\u963f\u8332\u6d77\u9ed8\u75c7\u3001\u7672\u7647\u7b49\uff09\u7684\u8a3a\u65b7\u3002\u9019\u7bc7\u5831\u5c0e\u6307\u51fa\u8f49\u904b\u86cb\u767d\u7d50\u69cb\u7684\u89e3\u6790\uff0c\u6709\u52a9\u65bc\u65b0\u5f0fTSPO\u7d50\u5408\u85e5\u7269\u7684\u958b\u767c\uff0c\u800c\u518d\u7d50\u5408\u5176\u4ed6\u85e5\u7269\u5c07\u6709\u52a9\u65bc\u6cbb\u7642\u4e2d\u6a1e\u795e\u7d93\u65b9\u9762\u7684\u75be\u75c5\u3002<\/p>\n<p style=\"text-align: right\"><a href=\"http:\/\/wp.kmu.edu.tw\/rd\/archives\/2520\">\u56de\u7b2c0020\u671f\u4e3b\u9801<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u56de\u7b2c0020\u671f\u4e3b\u9801 \u4e00\u3001\u7814\u7a76\u65b0\u77e5 Structure of the Mitoch &hellip; <a href=\"https:\/\/wp.kmu.edu.tw\/rd\/archives\/2516\">\u95b1\u8b80\u5168\u6587 <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[28],"tags":[],"class_list":["post-2516","post","type-post","status-publish","format-standard","hentry","category-28"],"_links":{"self":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/2516","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/comments?post=2516"}],"version-history":[{"count":6,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/2516\/revisions"}],"predecessor-version":[{"id":2518,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/2516\/revisions\/2518"}],"wp:attachment":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/media?parent=2516"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/categories?post=2516"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/tags?post=2516"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}