{"id":2687,"date":"2014-08-01T10:53:07","date_gmt":"2014-08-01T02:53:07","guid":{"rendered":"http:\/\/wp.kmu.edu.tw\/rd\/?p=2687"},"modified":"2014-08-04T16:16:26","modified_gmt":"2014-08-04T08:16:26","slug":"%e7%a0%94%e7%a9%b6%e6%96%b0%e7%9f%a5-21","status":"publish","type":"post","link":"https:\/\/wp.kmu.edu.tw\/rd\/archives\/2687","title":{"rendered":"\u7814\u7a76\u65b0\u77e5"},"content":{"rendered":"

\u56de\u7b2c0023\u671f\u4e3b\u9801<\/a><\/p>\n

\u4e00\u3001\u7814\u7a76\u65b0\u77e5<\/span><\/h1>\n

<\/a><\/p>\n

Antagonizing STAT3 Dimerization with a Rhodium(III) Complex
\n<\/span><\/span><\/h1>\n

Angewandte Ehemie-International Edition 53, 1-6, 2014
\nIF: 13.734; Rank:Chemistry, Multidisciplinary, 7\/152, 5.6%
\n\uff08\u611f\u8b1d\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u9999\u7ca7\u54c1\u7cfb\u738b\u60e0\u6c11\u526f\u6559\u6388 \u63d0\u4f9b\uff09<\/p>\n

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\n\u4eca\u5e74\u5728Angewandte Ehemie-International Edition\u7531\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u3001\u9999\u6e2f\u6d78\u6703\u5927\u5b78\u548c\u6fb3\u9580\u5927\u5b78\u5171\u540c\u767c\u8868\u7684\u8ad6\u6587\u7814\u7a76\u88e1\uff0c\u5229\u7528\u92a0\u6240\u5408\u6210\u7684\u74b0\u72c0\u91d1\u5c6c\u8907\u5408\u7269\u80fd\u5728STAT3\u86cb\u767d\u8cea\u88e1SH2\u7d50\u5408\u5340\u57df\u52a0\u4ee5\u6291\u5236\u6d3b\u6027\u3002\u6b64\u5be6\u9a57\u7d93\u7531\u591a\u65b9\u9762\u7684\u6e2c\u8a66\uff0c\u5728\u521d\u6b65\u5be6\u9a57\u5177\u80fd\u5920\u6709\u6548\u6291\u5236STAT3\u8207DNA\u7d50\u5408\u53caSTAT3\u8f49\u9304\u4fe1\u865f\uff0c\u9664\u6b64\u4e4b\u5916\uff0c\u63a5\u8457\u900f\u904e\u4eba\u985e\u9ed1\u8272\u7d20\u7624\u7d30\u80de\u7570\u7a2e\u79fb\u690d\u5230\u5be6\u9a57\u5c0f\u9f20\u9ad4\u4e2d\u6a21\u64ec\u9ed1\u8272\u7d20\u76ae\u819a\u764c\u4f86\u9032\u884c\u7814\u7a76\u767c\u73fe\uff0c\u53ef\u964d\u4f4e\u816b\u7624\u7684\u9ad4\u7a4d\u548c\u91cd\u91cf\uff0c\u9664\u6b64\u4ee5\u5916\u4e5f\u964d\u4f4e\u4e86\u816b\u7624\u5468\u570d\u7684\u8840\u6db2\u6d41\u91cf\uff0c\u56e0\u6b64\u80fd\u9593\u63a5\u6e1b\u5c11\u816b\u7624\u7d44\u7e54\u4e2d\u7684\u8840\u7ba1\u5167\u76ae\u751f\u9577\u56e0\u5b50\uff0c\u5177\u6709\u986f\u8457\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002\u9019\u9805\u7814\u7a76\u8868\u660e\uff0c\u92a0\u6240\u5408\u6210\u7684\u74b0\u72c0\u91d1\u5c6c\u8907\u5408\u7269\u53ef\u4ee5\u88ab\u958b\u767c\u4f5c\u70ba\u6709\u6548STAT3\u6291\u5236\u5291\u5177\u6709\u5f37\u6548\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002
\n\"\"
\nSaving your skin: Reported herein is the first example of a substitutionally inert, Group 9 organometallic compound which serves as a direct inhibitor of the signal transducer and activator of transcription 3 (STAT3) dimerization. The rhodium(III) complex inhibited STAT3 activity in vitro and in vivo and showed potent and selective anticancer activity against melanoma cell lines and melanoma xenografts in an in vivo mouse model.<\/p>\n

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\u56de\u7b2c0023\u671f\u4e3b\u9801 \u4e00\u3001\u7814\u7a76\u65b0\u77e5 Antagonizing STAT3 Dime … \u95b1\u8b80\u5168\u6587 →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[31],"tags":[],"class_list":["post-2687","post","type-post","status-publish","format-standard","hentry","category-31"],"_links":{"self":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/2687","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/comments?post=2687"}],"version-history":[{"count":4,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/2687\/revisions"}],"predecessor-version":[{"id":2703,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/2687\/revisions\/2703"}],"wp:attachment":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/media?parent=2687"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/categories?post=2687"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/tags?post=2687"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}