{"id":3460,"date":"2016-10-07T10:30:50","date_gmt":"2016-10-07T02:30:50","guid":{"rendered":"http:\/\/wp.kmu.edu.tw\/rd\/?p=3460"},"modified":"2016-12-02T02:56:27","modified_gmt":"2016-12-01T18:56:27","slug":"%e7%a0%94%e7%a9%b6%e6%96%b0%e7%9f%a5-35","status":"publish","type":"post","link":"https:\/\/wp.kmu.edu.tw\/rd\/archives\/3460","title":{"rendered":"\u7814\u7a76\u65b0\u77e5"},"content":{"rendered":"<p style=\"text-align: right\"><a style=\"font-style: normal;text-align: right\" href=\"http:\/\/wp.kmu.edu.tw\/rd\/archives\/3458\">\u56de\u7b2c0038\u671f\u4e3b\u9801<\/a><\/p>\n<p><a name=\"ResNew1\"><\/a><\/p>\n<h1><span style=\"color: #0000ff\"><span style=\"color: #0000ff\">\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b78\u5bb6\u5927\u9685\u826f\u5178\u7814\u7a76\u7d30\u80de\u81ea\u566c\u7368\u5f972016 \u5e74\u8afe\u8c9d\u723e\u751f\u91ab\u734e<br \/>\n<\/span><\/span><\/h1>\n<p>2016 \u5e74\u8afe\u8c9d\u723e\u751f\u7406\u5b78\u6216\u91ab\u5b78\u734e\uff08\u7c21\u7a31\u751f\u91ab\u734e\uff09\u7531\u4f86\u81ea\u65e5\u672c\u6771\u4eac\u5de5\u696d\u5927\u5b78\u7684\u5927\u9685\u826f\u5178\u6559\u6388\u55ae\u7368\u7372\u5f97\uff0c\u4ed6\u6240\u767c\u8868\u7684\u7d30\u80de\u81ea\u566c\u4f5c\u7528\u7814\u7a76\u5728\u751f\u7269\u5b78\u5404\u9818\u57df\u90fd\u6709\u8457\u91cd\u8981\u5f71\u97ff\u53ca\u8ca2\u737b\u3002\u81ea\u566c\u4f5c\u7528\u7684\u5931\u5e38\u548c\u5df4\u91d1\u68ee\u6c0f\u75c7\u3001\u7b2c\u4e8c\u578b\u7cd6\u5c3f\u75c5\u4ee5\u53ca\u8a31\u591a\u56e0\u8001\u5316\u6240\u7522\u751f\u7684\u751f\u7406\u529f\u80fd\u5931\u8abf\u6709\u95dc\uff0c\u81ea\u566c\u4f5c\u7528\u7684\u57fa\u56e0\u7a81\u8b8a\u53ef\u80fd\u9020\u6210\u57fa\u56e0\u75be\u75c5\uff0c\u82e5\u81ea\u566c\u4f5c\u7528\u53d7\u5230\u64fe\u4e82\u4e5f\u53ef\u80fd\u548c\u764c\u75c7\u76f8\u95dc\u3002\u96d6\u7136\u81ea\u566c\u4f5c\u7528\u5df2\u7d93\u5728 50 \u5e74\u524d\u4fbf\u70ba\u4eba\u6240\u77e5\uff0c\u4f46\u5b83\u7684\u91cd\u8981\u6027\u4ee5\u53ca\u5c0d\u65bc\u751f\u7406\u5b78\u4ee5\u53ca\u91ab\u85e5\u885b\u751f\u9818\u57df\u7684\u5f71\u97ff\u537b\u4e00\u76f4\u5230\u5927\u9685\u826f\u5178 1990 \u5e74\u4ee3\u7684\u7814\u7a76\u624d\u771f\u6b63\u958b\u59cb\u53d7\u5230\u91cd\u8996\uff0c\u4e5f\u8b93\u4ed6\u5728\u4eca\u5e74\u5f97\u5230\u8afe\u8c9d\u723e\u751f\u7406\u5b78\u6216\u91ab\u5b78\u734e\u3002<\/p>\n<h1><span style=\"color: #0000ff\"><span style=\"color: #0000ff\">\u81ea\u566c\u4f5c\u7528\u4ecb\u7d39<br \/>\n<\/span><\/span><\/h1>\n<p>\u81ea\u566c\u4f5c\u7528\uff08autophagy\uff09\u662f\u7d30\u80de\u964d\u89e3\u56de\u6536\u80de\u5167\u7269\u8cea\u7684\u91cd\u8981\u6a5f\u5236\uff0c\u8d77\u521d\u662f 1960 \u5e74\u4ee3\u7684\u79d1\u5b78\u5bb6\u767c\u73fe\u7d30\u80de\u80fd\u5920\u81ea\u884c\u5206\u89e3\u80de\u5167\u7684\u7269\u8cea\u3002\u5728\u81ea\u566c\u4f5c\u7528\u4e2d\uff0c\u7d30\u80de\u4e2d\u6703\u5f62\u6210\u50cf\u888b\u5b50\u4e00\u6a23\u7684\u56ca\u6ce1\u7d50\u69cb\uff0c\u5c07\u80de\u5167\u5f85\u5206\u89e3\u7684\u7269\u8cea\u5305\u8d77\u4f86\u4e26\u904b\u9001\u5230\u5c08\u9580\u9032\u884c\u964d\u89e3\u7684\u80de\u5668\u6eb6\u9176\u9ad4\uff08lysosome\uff09\u4e2d\uff0c\u800c\u6eb6\u9176\u9ad4\u6703\u5c07\u7d30\u80de\u5167\u4e0d\u9700\u8981\u7684\u7269\u8cea\u964d\u89e3\u3002\u904e\u5f80\u79d1\u5b78\u5bb6\u5c0d\u65bc\u6b64\u73fe\u8c61\u4e86\u89e3\u5f88\u6709\u9650\uff0c\u76f4\u5230 1990 \u5e74\u4ee3\u5927\u9685\u826f\u5178\u85c9\u7531\u4e00\u9023\u4e32\u4ee4\u4eba\u8b9a\u5606\u7684\u7cbe\u5f69\u5be6\u9a57\uff0c\u5728\u5546\u696d\u9175\u6bcd\u83cc\u4e2d\u627e\u51fa\u81ea\u566c\u4f5c\u7528\u4e2d\u95dc\u9375\u7684\u57fa\u56e0\uff0c\u624d\u8b93\u5b78\u754c\u958b\u59cb\u4e86\u89e3\u81ea\u566c\u4f5c\u7528\u9019\u500b\u7d30\u80de\u5167\u91cd\u8981\u7684\u6a5f\u5236\u3002<br \/>\n\u5927\u9685\u826f\u5178\u7684\u7814\u7a76\u8b93\u7d30\u80de\u5167\u56de\u6536\u5206\u89e3\u5ee2\u68c4\u7269\u8cea\u7684\u79d8\u5bc6\u958b\u59cb\u5448\u73fe\u5728\u4e16\u4eba\u773c\u524d\uff0c\u4e5f\u70ba\u4e4b\u5f8c\u5927\u91cf\u7684\u76f8\u95dc\u7814\u7a76\u63d0\u4f9b\u91cd\u8981\u7684\u57fa\u790e\uff0c\u9664\u6b64\u4e4b\u5916\uff0c\u7d30\u80de\u5167\u7684\u56de\u6536\u6a5f\u5236\u5c0d\u65bc\u751f\u7406\u5b78\u7b49\u5176\u4ed6\u9818\u57df\u7814\u7a76\u4e5f\u6709\u8457\u91cd\u8981\u610f\u7fa9\uff0c\u8209\u4f8b\u4f86\u8aaa\uff0c\u7d30\u80de\u8655\u5728\u71df\u990a\u4e0d\u826f\u7684\u74b0\u5883\u4e4b\u4e2d\u5982\u4f55\u8abf\u7bc0\u81ea\u8eab\u751f\u7406\u529f\u80fd\u904b\u4f5c\uff0c\u6216\u8005\u5728\u7d30\u80de\u53d7\u5230\u5916\u4f86\u75c5\u539f\u5165\u4fb5\u6642\u5982\u4f55\u53cd\u61c9\uff0c\u9019\u4e9b\u904e\u7a0b\u90fd\u548c\u81ea\u566c\u4f5c\u7528\u6709\u8457\u975e\u5e38\u5bc6\u5207\u7684\u95dc\u9023\u3002<br \/>\n\u65e9\u5728 1950 \u5e74\u4ee3\uff0c\u79d1\u5b78\u5bb6\u5c31\u767c\u73fe\u7d30\u80de\u5167\u5b58\u5728\u8457\u4e00\u7a2e\u65b0\u767c\u73fe\u7684\u80de\u5668\uff0c\u80de\u5668\u88e1\u9762\u5305\u542b\u4e86\u80fd\u5920\u5206\u89e3\u86cb\u767d\u8cea\u3001\u91a3\u985e\u548c\u8102\u8cea\u7684\u5404\u7a2e\u9175\u7d20\uff0c\u529f\u80fd\u5c31\u50cf\u662f\u7d30\u80de\u5206\u89e3\u80de\u5167\u7269\u8cea\u7684\u56de\u6536\u7ad9\uff0c\u4e5f\u5c31\u662f\u6211\u5011\u5f8c\u4f86\u6240\u77e5\u9053\u7684\u6eb6\u9176\u9ad4\u3002\u6eb6\u9176\u9ad4\u7531\u6bd4\u5229\u6642\u79d1\u5b78\u5bb6 Christian de Duve \u767c\u73fe\uff0c\u4ed6\u4e5f\u56e0\u6b64\u8ca2\u737b\u69ae\u7372 1974 \u5e74\u8afe\u8c9d\u723e\u751f\u91ab\u734e\u3002<br \/>\n\u4e4b\u5f8c\u5728 1960 \u5e74\u4ee3\uff0c\u79d1\u5b78\u5bb6\u9032\u4e00\u6b65\u767c\u73fe\u5728\u6eb6\u9176\u9ad4\u4e2d\u53ef\u627e\u5230\u7d30\u80de\u5927\u90e8\u5206\u7684\u7d44\u6210\u6210\u5206\uff0c\u6709\u6642\u5019\u751a\u81f3\u53ef\u4ee5\u5305\u542b\u5b8c\u6574\u7684\u7d30\u80de\u80de\u5668\uff0c\u9019\u4e5f\u5c31\u986f\u793a\u4e86\u7d30\u80de\u662f\u6709\u7b56\u7565\u5730\u5728\u5c07\u4e00\u5305\u4e00\u5305\u7684\u7269\u8cea\u904b\u9001\u5230\u6eb6\u9176\u9ad4\u5206\u89e3\u3002\u800c\u63a5\u4e0b\u4f86\u7684\u751f\u5316\u53ca\u986f\u5fae\u93e1\u5206\u6790\u53c8\u767c\u73fe\u7d30\u80de\u4e2d\u9084\u5b58\u5728\u53e6\u4e00\u7a2e\u7d30\u80de\u904b\u8f38\u80de\u5668\uff0c\u8ca0\u8cac\u5c07\u5f85\u5206\u89e3\u7269\u8cea\u904b\u9001\u5230\u6eb6\u9176\u9ad4\u9032\u884c\u5206\u89e3\uff0c\u4e5f\u5c31\u662f\u5f8c\u4f86\u6240\u7a31\u7684\u81ea\u566c\u9ad4\uff08autophagosome\uff09\uff0c\u4e4b\u5f8c Christian de Duve \u4fbf\u5c07\u9019\u4e00\u9023\u4e32\u7684\u904e\u7a0b\u7a31\u70ba\u81ea\u566c\u4f5c\u7528\u3002<br \/>\n\u5728 1970 \u81f3 1980 \u5e74\u4ee3\u4e4b\u9593\uff0c\u79d1\u5b78\u5bb6\u5011\u53c8\u6ce8\u610f\u5230\u7d30\u80de\u5167\u53e6\u4e00\u500b\u80fd\u964d\u89e3\u86cb\u767d\u8cea\u7684\u7cfb\u7d71\u3002\u9019\u500b\u7cfb\u7d71\u88ab\u7a31\u70ba\u86cb\u767d\u9176\u9ad4\uff08Proteasome\uff09\uff0c\u7576\u6642\u7814\u7a76\u6cdb\u7d20\u8abf\u7bc0\u7684\u86cb\u767d\u8cea\u964d\u89e3\u7684 Aaron Ciechanover\u3001Avram Hershko \u53ca Irwin Rose \u4e5f\u56e0\u6b64\u5f97\u5230 2004 \u5e74\u7684\u8afe\u8c9d\u723e\u5316\u5b78\u734e\u3002\u86cb\u767d\u9176\u9ad4\u80fd\u5920\u9ad8\u6548\u7387\u7684\u5c07\u86cb\u767d\u8cea\u4e00\u500b\u63a5\u4e00\u500b\u7684\u964d\u89e3\uff0c\u4f46\u9019\u500b\u6a5f\u5236\u4e26\u6c92\u6709\u8fa6\u6cd5\u89e3\u91cb\u7d30\u80de\u5982\u4f55\u8655\u7406\u5927\u5206\u5b50\u86cb\u767d\u8cea\u8907\u5408\u7269\u4ee5\u53ca\u8001\u820a\u7684\u80de\u5668\u3002\u6b64\u6642\u79d1\u5b78\u5bb6\u4fbf\u958b\u59cb\u731c\u60f3\u81ea\u566c\u4f5c\u7528\u6216\u8a31\u5c31\u662f\u9019\u500b\u554f\u984c\u7684\u7b54\u6848\uff0c\u4f46\u81ea\u566c\u4f5c\u7528\u5206\u89e3\u80de\u5668\u4ee5\u53ca\u5927\u5206\u5b50\u86cb\u767d\u8cea\u7684\u6a5f\u5236\u4ecd\u4e0d\u6e05\u695a\u3002<\/p>\n<h1><span style=\"color: #0000ff\"><span style=\"color: #0000ff\">\u81ea\u566c\u4f5c\u7528\u662f\u7d30\u80de\u5167\u63a7\u7ba1\u54c1\u8cea\u7684\u6a5f\u5236<br \/>\n<\/span><\/span><\/h1>\n<p>\u5927\u9685\u826f\u5178\u66fe\u7d93\u5728\u8a31\u591a\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\u6709\u6240\u8ca2\u737b\uff0c\u4f46\u81ea\u5f9e 1988 \u5e74\u64c1\u6709\u81ea\u5df1\u7684\u5be6\u9a57\u5ba4\u4e4b\u5f8c\uff0c\u4ed6\u5c31\u5c08\u6ce8\u65bc\u4eba\u985e\u7d30\u80de\u80fd\u5920\u548c\u6eb6\u9176\u9ad4\u7d50\u5408\u7684\u6db2\u80de\u4e2d\u86cb\u767d\u8cea\u7684\u964d\u89e3\u7814\u7a76\u3002\u5728\u7814\u7a76\u67d0\u4e9b\u8907\u96dc\u7684\u7d30\u80de\u751f\u7406\u4ee3\u8b1d\u9014\u5f91\u4e2d\u7279\u5b9a\u57fa\u56e0\u7684\u904e\u7a0b\u4e2d\uff0c\u7531\u65bc\u9175\u6bcd\u83cc\u7684\u7814\u7a76\u76f8\u5c0d\u5bb9\u6613\u9032\u884c\uff0c\u56e0\u6b64\u7d93\u5e38\u5728\u7814\u7a76\u4e2d\u505a\u70ba\u4eba\u985e\u7d30\u80de\u7684\u6a21\u578b\uff0c\u4f46\u5927\u9685\u826f\u5178\u7684\u7814\u7a76\u537b\u5728\u9019\u500b\u90e8\u5206\u9047\u5230\u4e86\u4e00\u5927\u969c\u7919\u3002\u56e0\u70ba\u9175\u6bcd\u83cc\u592a\u5c0f\uff0c\u7d30\u80de\u5167\u90e8\u69cb\u9020\u5728\u986f\u5fae\u93e1\u4e0b\u96e3\u4ee5\u8fa8\u5225\uff0c\u4f7f\u5f97\u5927\u9685\u826f\u5178\u7576\u6642\u4e00\u5ea6\u7121\u6cd5\u78ba\u5b9a\u9175\u6bcd\u83cc\u7d30\u80de\u4e2d\u662f\u5426\u4e5f\u6703\u767c\u751f\u81ea\u566c\u4f5c\u7528\u3002<br \/>\n\u7576\u6642\u4ed6\u5047\u8a2d\u5982\u679c\u5728\u81ea\u566c\u4f5c\u7528\u5df2\u7d93\u88ab\u6d3b\u5316\u7684\u72c0\u614b\u4e0b\uff0c\u5e72\u64fe\u6253\u65b7\u6db2\u5305\u4e2d\u7684\u964d\u89e3\u7a0b\u5e8f\uff0c\u6216\u8a31\u5c31\u80fd\u5920\u5728\u986f\u5fae\u93e1\u4e0b\u89c0\u5bdf\u5230\u7d30\u80de\u5167\u81ea\u566c\u9ad4\u5728\u6db2\u80de\u4e2d\u805a\u7a4d\u7684\u73fe\u8c61\u3002\u65bc\u662f\u4ed6\u5229\u7528\u6db2\u80de\u5167\u7f3a\u4e4f\u964d\u89e3\u9175\u7d20\u7684\u7a81\u8b8a\u9175\u6bcd\u83cc\uff0c\u5c07\u7d30\u80de\u57f9\u990a\u65bc\u7f3a\u4e4f\u990a\u5206\u7684\u74b0\u5883\u4e2d\u4ee5\u523a\u6fc0\u81ea\u566c\u4f5c\u7528\u767c\u751f\uff0c\u7d50\u679c\u5728\u5e7e\u5c0f\u6642\u5167\u5c31\u89c0\u5bdf\u5230\u7d30\u80de\u6db2\u80de\u4e2d\u5145\u6eff\u4e86\u6c92\u6709\u88ab\u964d\u89e3\u7684\u5c0f\u56ca\u6ce1\u3002\u9019\u4e9b\u5c0f\u56ca\u6ce1\u7684\u78ba\u5c31\u662f\u5927\u9685\u826f\u5178\u60f3\u8981\u89c0\u5bdf\u7684\u81ea\u566c\u9ad4\uff0c\u4e5f\u5c31\u8b49\u660e\u4e86\u9175\u6bcd\u83cc\u4e2d\u4e5f\u6703\u6709\u81ea\u566c\u4f5c\u7528\u767c\u751f\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u4ed6\u5728\u9019\u9805\u5be6\u9a57\u4e2d\u5f97\u5230\u4e86\u627e\u51fa\u53c3\u8207\u81ea\u566c\u4f5c\u7528\u57fa\u56e0\u7684\u65b9\u6cd5\uff0c\u66f4\u5728 1992 \u5e74\u767c\u8868\u4e86\u9019\u9805\u7a81\u7834\u6027\u7684\u7814\u7a76\u6210\u679c\u3002<br \/>\n\u5927\u9685\u826f\u5178\u63a5\u8457\u4ee5\u4ed6\u6240\u8a2d\u8a08\u7684\u9019\u682a\u9175\u6bcd\u83cc\u9032\u4e00\u6b65\u5be6\u9a57\uff0c\u6309\u7167\u4ed6\u7684\u5047\u8a2d\uff0c\u4e00\u65e6\u53c3\u8207\u81ea\u566c\u4f5c\u7528\u7684\u91cd\u8981\u57fa\u56e0\u88ab\u6291\u5236\uff0c\u81ea\u566c\u9ad4\u4fbf\u4e0d\u6703\u6709\u805a\u7a4d\u7684\u73fe\u8c61\uff0c\u65bc\u662f\u4ed6\u4ee5\u80fd\u5920\u96a8\u6a5f\u5f15\u767c\u57fa\u56e0\u591a\u8655\u7a81\u8b8a\u7684\u5316\u5408\u7269\u8655\u7406\u9175\u6bcd\u83cc\u7d30\u80de\uff0c\u518d\u63a5\u8457\u8a98\u5c0e\u7d30\u80de\u7684\u81ea\u566c\u4f5c\u7528\uff0c\u7d93\u904e\u4e00\u5e74\u7684\u7814\u7a76\uff0c\u6210\u529f\u627e\u5230\u7b2c\u4e00\u500b\u81ea\u566c\u4f5c\u7528\u4e2d\u95dc\u9375\u7684\u57fa\u56e0\u3002<br 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\/>\n\u8f49\u8f09\u81ea\u79d1\u6280\u65b0\u5831 <a href=\"http:\/\/technews.tw\/2016\/10\/04\/yoshinori-ohsumi-nobel-prize\/\">http:\/\/technews.tw\/2016\/10\/04\/yoshinori-ohsumi-nobel-prize\/<\/a><\/p>\n<p style=\"text-align: right\"><a href=\"http:\/\/wp.kmu.edu.tw\/rd\/archives\/3458\">\u56de\u7b2c0038\u671f\u4e3b\u9801<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u56de\u7b2c0038\u671f\u4e3b\u9801 \u65e5\u672c\u5206\u5b50\u751f\u7269\u5b78\u5bb6\u5927\u9685\u826f\u5178\u7814\u7a76\u7d30\u80de\u81ea\u566c\u7368\u5f972016 \u5e74\u8afe\u8c9d\u723e\u751f &hellip; <a href=\"https:\/\/wp.kmu.edu.tw\/rd\/archives\/3460\">\u95b1\u8b80\u5168\u6587 <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[46],"tags":[],"class_list":["post-3460","post","type-post","status-publish","format-standard","hentry","category-46"],"_links":{"self":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/3460","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/comments?post=3460"}],"version-history":[{"count":5,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/3460\/revisions"}],"predecessor-version":[{"id":3480,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/3460\/revisions\/3480"}],"wp:attachment":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/media?parent=3460"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/categories?post=3460"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/tags?post=3460"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}