{"id":467,"date":"2012-11-22T13:29:23","date_gmt":"2012-11-22T05:29:23","guid":{"rendered":"http:\/\/wp.kmu.edu.tw\/rd\/?p=467"},"modified":"2012-11-28T15:53:55","modified_gmt":"2012-11-28T07:53:55","slug":"%e7%a0%94%e7%a9%b6%e6%96%b0%e7%9f%a5","status":"publish","type":"post","link":"https:\/\/wp.kmu.edu.tw\/rd\/archives\/467","title":{"rendered":"\u7814\u7a76\u65b0\u77e5"},"content":{"rendered":"<p style=\"text-align: right\"><a href=\"http:\/\/wp.kmu.edu.tw\/rd\/archives\/420\">\u56de\u7b2c0003\u671f\u4e3b\u9801<\/a><\/p>\n<h1>\u4e00\u3001\u7814\u7a76\u65b0\u77e5<\/h1>\n<h1>2012\u8afe\u8c9d\u723e\u5316\u5b78\u734e\u5f97\u734e\u4e3b\u984c: G\u86cb\u767d\u8cea\u8026\u5408\u53d7\u9ad4\u4e4b\u4ecb\u7d39\uff08\u9673\u9038\u592b\u526f\u6559\u6388\u6458\u8b6f\uff09<\/h1>\n<p>The Seven Pillars of Molecular Pharmacology:GPCR Research Honored with Nobel Prize for Chemistry<br \/>\nAngew Chem Int Ed Engl. 2012 Nov 5. doi: 10.1002\/anie.201208565.Hausch F, Holsboer F.<\/p>\n<p>\u9472\u5d4c\u65bc\u7d30\u80de\u819c\u4e0a\u7684G\u86cb\u767d\u8cea\u8026\u5408\u53d7\u9ad4 (G-protein-coupled receptors, GPCRs) \u662f\u81ea\u7136\u754c\u4e2d\u6700\u5ee3\u6cdb\u904b\u7528\u7684\u8a0a\u606f\u50b3\u905e\u8def\u5f91\u4e4b\u4e00\uff0c\u8ca0\u8cac\u4f86\u81ea\u7d30\u80de\u5916\u3001\u7d30\u80de\u9593\u3001\u8207\u9ad4\u5167\u9577\u8ddd\u96e2\u7b49\u5404\u7a2e\u4e0d\u540c\u8a0a\u606f\u50b3\u905e\u3002\u76ee\u524d\u6211\u5011\u5c0d\u65bcG\u86cb\u767d\u8cea\u8026\u5408\u53d7\u9ad4\u4e4b\u5206\u5b50\u6a5f\u8f49\u80fd\u6709\u6df1\u5165\u7684\u7406\u89e3\u5f97\u6b78\u529f\u65bcKobilka \u53ca Lefkowitz\u5169\u4f4d\u79d1\u5b78\u5bb6\u3002<\/p>\n<p>G\u86cb\u767d\u8cea\u8026\u5408\u53d7\u9ad4\u4e4b\u547d\u540d\u7531\u65bc\u5b83\u501f\u7531\u7d30\u80de\u5167GTP\u7d50\u5408\u86cb\u767d\u50b3\u905e\u8a0a\u606f\u800c\u5f97\u3002\u56e0\u70ba\u5b83\u5011\u7684\u591a\u80bd\u93c8\u5728\u7d30\u80de\u819c\u9593\u7a7f\u8d8a\u4e03\u6b21\uff0cG\u86cb\u767d\u8cea\u8026\u5408\u53d7\u9ad4\u53c8\u88ab\u7a31\u70ba\u4e03\u6b21\u7a7f\u819c\u53d7\u9ad4(7TM receptor)\u3002\u9019\u4e9b\u900f\u904eG\u86cb\u767d\u8cea\u8026\u5408\u53d7\u9ad4\u50b3\u905e\u8a0a\u865f\u7684\u7d30\u80de\u5916\u523a\u6fc0\u53ef\u4ee5\u662f\u80dc\u80bd\u3001\u8cc0\u723e\u8499\u3001\u916f\u8cea\u3001\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\u3001\u96e2\u5b50\u3001\u6c23\u5473\u7b49\u3002G\u86cb\u767d\u8cea\u8026\u5408\u53d7\u9ad4\u905e\u8a0a\u9019\u4e9b\u8a0a\u606f\u81f3\u7d30\u80de\u5167\uff0c\u96a8\u5f8c\u5f15\u767c\u4e00\u9023\u4e32\u53cd\u61c9\uff0c\u6700\u5f8c\u4f7f\u7d30\u80de\u505a\u51fa\u4e00\u500b\u9069\u7576\u7684\u7d30\u80de\u751f\u7406\u53cd\u61c9\u3002\u5927\u7d04\u6709\u4e00\u5343\u500b\u4eba\u985e\u57fa\u56e0\u8ca0\u8cac\u88fd\u9020G\u86cb\u767d\u8cea\u8026\u5408\u53d7\u9ad4\uff0c\u4e8b\u5be6\u4e0a\u8a31\u591a\u7d30\u80de\u751f\u7406\u904e\u7a0b\u90fd\u4ef0\u8cf4\u8a72\u53d7\u9ad4\uff0c\u6bd4\u5982\u814e\u4e0a\u817a\u7d20\u53d7\u9ad4\u3001\u591a\u5df4\u80fa\u53d7\u9ad4\u3001\u7d44\u7e54\u80fa\u53d7\u9ad4\u3001\u8996\u7d2b\u7d05\u8cea\u5149\u53d7\u9ad4\uff0c\u9084\u6709\u8a31\u591a\u5473\u89ba\u53ca\u55c5\u89ba\u53d7\u9ad4\u3002\u56e0\u6b64\uff0cG\u86cb\u767d\u8cea\u8026\u5408\u53d7\u9ad4\u4e5f\u6210\u70ba\u91cd\u8981\u85e5\u7269\u7814\u767c\u7684\u6a19\u9776\u3002<\/p>\n<p>69\u6b72\u4efb\u6559\u65bc\u7f8e\u570b\u675c\u514b\u5927\u5b78\u7684Lefkowitz\u9996\u5148\u5229\u7528\u653e\u5c04\u6027\u4fc3\u9032\u914d\u9ad4\uff0c\u8ffd\u8e64\u814e\u4e0a\u817a\u7531\u7d30\u80de\u5916\u50b3\u905e\u81f3\u7d30\u80de\u5167\u7684\u8def\u5f91\uff0c\u5f8c\u4f86\u751a\u81f3\u628a\u814e\u4e0a\u817a\u7d20\u53d7\u9ad4\u5f9e\u7d44\u7e54\u4e2d\u5206\u96e2\u7d14\u5316\u51fa\u4f86\uff0c\u4e26\u9032\u4e00\u6b65\u89e3\u958b\u5176\u7acb\u9ad4\u7d50\u69cb\u3002\u7136\u800cLefkowitz\u5c0dG\u86cb\u767d\u8cea\u8026\u5408\u53d7\u9ad4\u7684\u7814\u7a76\u8ca2\u737b\u53e6\u4e00\u6ce2\u9ad8\u6f6e\uff0c\u4f86\u81ea\u4ed6\u7576\u6642\u7684\u535a\u58eb\u5f8c\u7814\u7a76\u54e1Kobilka\u300257\u6b72\u73fe\u4efb\u6559\u65bc\u7f8e\u570b\u53f2\u4e39\u798f\u5927\u5b78\u7684Kobilka\u9806\u5229\u9078\u6b96\u4e00\u7cfb\u5217\u814e\u4e0a\u817a\u7d20\u53d7\u9ad4\u57fa\u56e0\uff0c\u4e26\u9032\u800c\u767c\u73fe\u4e03\u500b\u7a7f\u819c\u87ba\u65cb\u7684\u7368\u7279\u7d50\u69cb\uff0c\u6700\u5f8c\u8b49\u5be6\u6240\u6709G\u86cb\u767d\u8cea\u8026\u5408\u53d7\u9ad4\u5bb6\u65cf\u6210\u54e1\u90fd\u5177\u5099\u8a72\u7d50\u69cb\u540c\u6e90\u6027\u3002<\/p>\n<p>Lefkowitz \u53ca Kobilka \u7684\u7814\u7a76\u63d0\u4f9b\u4e86\u85e5\u7269\u5316\u5b78\u5bb6\u4e00\u500b\u66f4\u6df1\u5165\u4e86\u89e3\u6a19\u9776\u86cb\u767d\u8207\u4ed6\u5011\u6240\u8a2d\u8a08\u7684\u85e5\u7269\u4e4b\u4ea4\u4e92\u4f5c\u7528\u7684\u6a5f\u6703\uff0c\u6709\u52a9\u958b\u767c\u6e1b\u5c11\u526f\u4f5c\u7528\u4e4b\u85e5\u7269\u3002\u96a8\u8457\u79d1\u5b78\u65e5\u65b0\u6708\u7570\uff0c\u4eba\u985e\u8ce6\u4e88G\u86cb\u767d\u8cea\u8026\u5408\u53d7\u9ad4\u66f4\u591a\u5275\u65b0\u4e4b\u89d2\u8272\u8207\u529f\u80fd\u5c07\u6307\u65e5\u53ef\u5f85\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: right\"><a href=\"http:\/\/wp.kmu.edu.tw\/rd\/archives\/420\">\u56de\u7b2c0003\u671f\u4e3b\u9801<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u56de\u7b2c0003\u671f\u4e3b\u9801 \u4e00\u3001\u7814\u7a76\u65b0\u77e5 2012\u8afe\u8c9d\u723e\u5316\u5b78\u734e\u5f97\u734e\u4e3b\u984c: G\u86cb\u767d\u8cea\u8026\u5408\u53d7 &hellip; <a href=\"https:\/\/wp.kmu.edu.tw\/rd\/archives\/467\">\u95b1\u8b80\u5168\u6587 <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-467","post","type-post","status-publish","format-standard","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/467","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/comments?post=467"}],"version-history":[{"count":14,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/467\/revisions"}],"predecessor-version":[{"id":518,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/467\/revisions\/518"}],"wp:attachment":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/media?parent=467"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/categories?post=467"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/tags?post=467"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}