{"id":728,"date":"2012-12-18T14:49:20","date_gmt":"2012-12-18T06:49:20","guid":{"rendered":"http:\/\/wp.kmu.edu.tw\/rd\/?p=728"},"modified":"2013-01-04T09:51:28","modified_gmt":"2013-01-04T01:51:28","slug":"%e7%a0%94%e7%a9%b6%e6%96%b0%e7%9f%a5-2","status":"publish","type":"post","link":"https:\/\/wp.kmu.edu.tw\/rd\/archives\/728","title":{"rendered":"\u7814\u7a76\u65b0\u77e5"},"content":{"rendered":"<p style=\"text-align: right\"><a href=\"http:\/\/wp.kmu.edu.tw\/rd\/archives\/773\">\u56de\u7b2c0004\u671f\u4e3b\u9801<\/a><\/p>\n<h1>\u4e00\u3001\u7814\u7a76\u65b0\u77e5<\/h1>\n<p><a name=\"ResNew1\"><\/a><\/p>\n<ul>\n<li>\n<h1>Comprehensive and Highly Sensitive Urinary Steroid Hormone Profiling Method Based on Stable Isotope-Labeling Liquid Chromatography\u2013Mass Spectrometry \uff08\u99ae\u5609\u5afb\u526f\u6559\u6388\u6458\u8b6f\uff09\uff09<\/h1>\n<p>Weidong Dai, Qiang Huang, Peiyuan Yin, Jia Li, Jia Zhou, Hongwei Kong, Chunxia Zhao, Xin Lu and Guowang Xu*Analytical Chemistry, 2012, 84, 10245-10251<\/p>\n<p>\u985e\u56fa\u9187\u8377\u723e\u8499\u80fd\u8abf\u63a7\u4eba\u9ad4\u4e2d\u5404\u7a2e\u751f\u7406\u529f\u80fd\uff0c\u56e0\u6b64\u5728\u751f\u7269\u9ad4\u5167\u662f\u500b\u6975\u70ba\u91cd\u8981\u7684\u7269\u8cea\uff0c\u6aa2\u6e2c\u4eba\u9ad4\u4e2d\u985e\u56fa\u9187\u8377\u723e\u8499\u7684\u6fc3\u5ea6\uff0c\u5728\u4e86\u89e3\u76f8\u95dc\u75be\u75c5\u7684\u6a5f\u8f49\u4e0a\u626e\u6f14\u91cd\u8981\u89d2\u8272\u3002\u5728\u6b64\u7bc7\u7814\u7a76\u4e2d\uff0c\u4f5c\u8005\u5011\u7814\u767c\u51fa\u4e00\u500b\u65b0\u7684\u884d\u751f\u8a66\u5291\uff1adeuterium 4-(dimethylamino)-benzoic acid\uff0cd4-DMBA\uff0c\u6b64\u540c\u4f4d\u7d20\u6a19\u8a18\u8a66\u5291\u5f88\u5bb9\u6613\u5c31\u80fd\u8207\u5177\u7fa5\u57fa\u7684\u985e\u56fa\u9187\u8377\u723e\u8499\u53cd\u61c9\uff0c\u800c\u4e14\u80fd\u7a69\u5b9a\u5b58\u5728\u3002\u5229\u7528\u6db2\u76f8\u5c64\u6790\u8cea\u8b5c\u5100(liquid chromatography-mass spectrometry\uff0cLC-MS)\u9032\u884c\u6aa2\u6e2c\u5206\u6790\u3002\u5728\u672c\u7bc7\u7814\u7a76\u4e2d\u6240\u5408\u6210\u51fa\u4f86\u7684\u884d\u751f\u8a66\u5291\uff0c\u4e0d\u50c5\u5982\u540c\u5176\u5b83\u7814\u7a76\u4e2d\u7684\u884d\u751f\u8a66\u5291\uff0c\u80fd\u589e\u52a0estrogens\u548candrogens\u7684\u5075\u6e2c\u654f\u611f\u6027\uff0c\u800c\u4e14\u9084\u80fd\u5168\u9762\u6027\u7684\u91dd\u5c0d\u542b\u7fa5\u57fa\u4e4b\u985e\u56fa\u9187\u8377\u723e\u8499\uff0c\u4f8b\u5982\uff1aandrogens\u3001estrogens\u3001corticoids\u548cprogestogens\uff0c\u63d0\u9ad8\u6aa2\u6e2c\u7684\u9748\u654f\u5ea6\u3002\u6b64\u5916\uff0c\u90e8\u5206\u7121\u6cd5\u8207\u884d\u751f\u8a66\u5291\u9032\u884c\u53cd\u61c9\u7684\u985e\u56fa\u9187\u8377\u723e\u8499\uff0c\u4f8b\u5982\uff1a17\u03b1-hydroxyprogesterone\u3001progesterone\u548candrostenedione\uff0c\u5176\u5728\u884d\u751f\u904e\u7a0b\u4e2d\u4e0d\u6703\u88ab\u7834\u58de\uff0c\u56e0\u6b64\u6700\u5f8c\u4ecd\u53ef\u5229\u7528LC-MS\u88ab\u6aa2\u6e2c\u5206\u6790\u3002\u672c\u7bc7\u7814\u7a76\u5171\u53ef\u6aa2\u6e2c24\u7a2e\u985e\u56fa\u9187\u8377\u723e\u8499\uff0c\u800c\u4e14\u884d\u751f\u5f8c\u5176\u5075\u6e2c\u7684\u654f\u611f\u5ea6\u53ef\u63d0\u9ad8103-104\u500d\uff0c\u56e0\u6b6424\u7a2e\u7684\u985e\u56fa\u9187\u8377\u723e\u8499\u5075\u6e2c\u6975\u9650\u90fd\u53ef\u9054ng\/mL\u6fc3\u5ea6\u4ee5\u4e0b\u3002\u6b64\u65b9\u6cd5\u6210\u529f\u7684\u61c9\u7528\u65bc\u6aa2\u6e2c\u7537\u6027\u3001\u5973\u6027\u548c\u5b55\u5a66\u4e4b\u5c3f\u6db2\u6a23\u672c\u4e2d\u6e38\u96e2\u614b\u7684\u985e\u56fa\u9187\u8377\u723e\u8499\u3002\u7531\u65bc\u985e\u56fa\u9187\u8377\u723e\u8499\u5728\u4eba\u9ad4\u751f\u7406\u6a5f\u8f49\u4e2d\u626e\u6f14\u8457\u5f88\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u56e0\u6b64\u4e00\u500b\u5168\u9762\u6027\u3001\u9748\u654f\u7684\u3001\u5c08\u4e00\u7684\u548c\u7cbe\u78ba\u7684\u65b9\u6cd5\uff0c\u4f86\u5206\u6790\u985e\u56fa\u9187\u8377\u723e\u8499\u4ee3\u8b1d\u9ad4\u80fd\u63d0\u4f9b\u8207\u8377\u723e\u8499\u76f8\u95dc\u7684\u75be\u75c5\u4e4b\u65b0\u898b\u89e3\u3002<\/p>\n<p><img decoding=\"async\" src=\"http:\/\/wp.kmu.edu.tw\/rd\/files\/2012\/12\/DMBA.jpg\" alt=\"\" \/><\/p>\n<p>\u57161. \u53cd\u61c9\u5716\u793a(A)\u5408\u6210\u7a69\u5b9a\u7684\u540c\u4f4d\u7d20\u6a19\u8a18\u8a66\u5291d4-DMBA\uff1b(B)\u5229\u7528DMBA\u884d\u751f\u985e\u56fa\u9187\u8377\u723e\u8499<\/li>\n<\/ul>\n<p><a name=\"ResNew2\"><\/a><\/p>\n<ul>\n<li>\n<h1>\u984c\u76ee\uff1a\u6297\u751f\u7d20\u53ef\u4ee5\u4f5c\u70ba\u5e7d\u9580\u87ba\u65cb\u687f\u83cc-\u76f8\u95dc\u80c3\u7030\u6f2b\u6027\u5927\u578bB\u7d30\u80de\u6dcb\u5df4\u7624\u4e4b\u7b2c\u4e00\u7dda\u6cbb\u7642\u55ce\uff1f(Antibiotics as the first-line therapy for Hp-associated gastric large B-cell lymphoma\uff1f)<br \/>\n\u4f5c\u8005\uff1a\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u66a8\u9644\u8a2d\u91ab\u9662 \u526f\u9662\u9577 \u9673\u7acb\u5b97<\/h1>\n<p>\u6458\u8981\uff1a\u300c\u6297\u751f\u7d20\u53ef\u4ee5\u4f5c\u70ba\u5e7d\u9580\u87ba\u65cb\u687f\u83cc-\u76f8\u95dc\u80c3\u7030\u6f2b\u6027\u5927\u578bB\u7d30\u80de\u6dcb\u5df4\u7624\u4e4b\u7b2c\u4e00\u7dda\u6cbb\u7642\u55ce\uff1f\u7b54\u6848\u53ef\u80fd\u662f\u7684\u300d\uff0c \u9019\u662f2012.05 BLOOD\u671f\u520a\u5c0d\u4f86\u81ea\u81fa\u7063\u5718\u968a\u7814\u7a76\u7684\u6210\u679c&#8211;\u300c\u5e7d\u9580\u87ba\u65cb\u687f\u83cc\u5ed3\u6e05\u7642\u6cd5\u662f\u5e7d\u9580\u87ba\u65cb\u687f\u83cc-\u967d\u6027\u65e9\u671f\u80c3\u7030\u6f2b\u6027\u5927\u578bB\u7d30\u80de\u6dcb\u5df4\u7624\u4e4b\u6709\u6548\u6cbb\u7642 (Helicobacter pylori eradication therapy is effective in the treatment of early- stage H pylori-positive gastric diffuse large B-cell lymphomas) \u300d\u6240\u505a\u7684\u8a55\u8ad6\u6a19\u984c\u3002<br \/>\n\u81fa\u7063\u7814\u7a76\u5718\u968a\u5229\u75281996\u5e74\u958b\u59cb\u7684\u81fa\u7063\u764c\u75c7\u81e8\u5e8a\u7814\u7a76\u5408\u4f5c\u7d44\u7e54(Taiwan Cooperative Oncology Group, TCOG)\u80c3\u9ecf\u819c\u76f8\u95dc\u6dcb\u5df4\u7d44\u7e54\u6dcb\u5df4\u7624(Lymphoma of the mucosa-associated lymphoid tissue type of the stomach\uff0c\u80c3MALT\u6dcb\u5df4\u7624) \u75be\u75c5\u59d4\u54e1\u6703\u7684\u7814\u7a76\u8a08\u5283\uff0c\u4e0d\u50c5\u5c07\u6297\u751f\u7d20\u6cbb\u7642\u300c\u4f4e\u60e1\u6027\u5ea6(low-grade)\u80c3MALT \u6dcb\u5df4\u7624\u300d\u7684\u89c0\u5ff5\u5f15\u9032\u570b\u5167\uff0c\u4e14TCOG\u80c3MALT \u6dcb\u5df4\u7624\u75be\u75c5\u59d4\u54e1\u6703\u8207\u81fa\u5927\u91ab\u9662\u5718\u968a\u57fa\u65bc\u55ae\u4e00\u6709\u6548\u6cbb\u7642\u7684\u75c5\u4f8b\u89c0\u5bdf\uff0c\u540c\u6642\u958b\u59cb\u57f7\u884c\u53e6\u4e00\u524d\u77bb\u6027 (prospective) \u81e8\u5e8a\u8a66\u9a57\uff0c\u63a2\u8a0e\u5e7d\u9580\u87ba\u65cb\u687f\u83cc\u5ed3\u6e05\u5728\u300c\u9ad8\u60e1\u6027\u5ea6(high-grade)\u80c3MALT \u6dcb\u5df4\u7624 \u300d\u2013 \u7d44\u7e54\u5b78\u4e0b\uff0c\u5177\u7fa4\u805a\u6027\u7684\u5927\u7d30\u80de\u8f49\u578b\u6216\u7a31\u9ad8\u60e1\u6027\u5ea6\u8f49\u578b (large-cell or high-grade transformation) \u7684\u80c3MALT \u6dcb\u5df4\u7624\u7684\u53ef\u80fd\u7642\u6548\u3002\u5f8c\u8005\u8a08\u5283\u6210\u679c\u8ad6\u6587\u6536\u9304\u4e86\uff0c\u81f3\u4eca\u5168\u4e16\u754c\u6700\u5927\u578b\u4ee5\u6297\u751f\u7d20\u6cbb\u7642 \u300c\u9ad8\u60e1\u6027\u5ea6\u80c3MALT \u6dcb\u5df4\u7624\u300d\u7684\u75c5\u4f8b\u6578(JCO 2001; JNCI 2005) \uff0c\u5176\u7d50\u679c\u986f\u793a\uff0c\u8fd160%\u5e7d\u9580\u87ba\u65cb\u687f\u83cc\u967d\u6027\u7684\u65e9\u671f\u9ad8\u60e1\u6027\u5ea6(high-grade)\u80c3MALT \u6dcb\u5df4\u7624\u63a5\u53d7\u6297\u751f\u7d20\u6cbb\u7642\u5f8c\uff0c\u53ef\u7372\u5f97\u8207\u4f4e\u60e1\u6027\u5ea6\u80c3MALT \u6dcb\u5df4\u7624\u76f8\u8fd1\u7684\u7a69\u5b9a(durable)\u7d44\u7e54\u5b78\u5b8c\u5168\u7de9\u89e3\u3002\u9019\u9805\u767c\u73fe\u5f37\u529b\u5730\u6311\u6230\u300c\u542b\u6709\u7fa4\u805a\u6027\u8f49\u578b\u5927\u7d30\u80de\u4e4b\u9ad8\u60e1\u6027\u5ea6\u80c3MALT \u6dcb\u5df4\u7624\uff0c\u6216\u6839\u64daWHO\u6dcb\u5df4\u7624\u8aee\u8a62\u59d4\u54e1\u6703\u5efa\u8b70\uff0c\u7a31\u4e4b\u70ba\u5177MALT\u8868\u5fb5\u4e4b\u7030\u6f2b\u6027\u5927\u578bB\u7d30\u80de\u6dcb\u5df4\u7624 [(Diffuse Large B Cell Lymphoma with features of MALT, DLBCL(MALT)]\uff0c \u5747\u5df2\u55aa\u5931\u5e7d\u9580\u87ba\u65cb\u687f\u83cc\u4f9d\u5b58\u6027(Helicobacter pylori dependence)\uff0c\u6545\u61c9\u63a5\u53d7\u7d30\u80de\u6bd2\u6bba\u5316\u5b78\u846f\u7269\u6cbb\u7642\uff0c\u800c\u4e0d\u61c9\u50c5\u7d66\u8207\u6297\u751f\u7d20\u6cbb\u7642\u300d\u7684\u89c0\u5ff5\u3002<br \/>\n\u6700\u8fd1\uff0c \u81fa\u7063\u7814\u7a76\u5718\u968a\u53c8\u5c07\u5e7d\u9580\u87ba\u65cb\u687f\u83cc\u5ed3\u6e05\u7642\u6cd5\u4e4b\u61c9\u7528\u63a8\u9032\u81f3\u7d44\u7e54\u5b78\u4e0b\u4e0d\u5177MALT\u8868\u5fb5\u7684\u55ae\u7d14\u6216\u539f\u767c\u6027\u80c3\u7030\u6f2b\u6027\u5927\u578b\uff22\u7d30\u80de\u6dcb\u5df4\u7624 (pure or de novo gastric DLBCL)\uff0c\u4e26\u5c07\u5176\u7642\u6548\u7684\u56de\u9867\u6027\u5206\u6790\u767c\u8868\u65bc2012.05 BLOOD \u671f\u520a\uff0c\u7d50\u679c\u986f\u793a\u65e9\u671f\u80c3\u7030\u6f2b\u6027\u5927\u578b\uff22\u7d30\u80de\u6dcb\u5df4\u7624\uff0c\u4e0d\u8ad6\u662f\u5426\u6709\u7d44\u7e54\u5b78\u8b49\u64da\u986f\u793a\u5176\u6e90\u81eaMALT\u6dcb\u5df4\u7624\uff0c\u6709\u8fd1\u516d\u6210\u7684\u60a3\u8005\u53ef\u5728\u6297\u751f\u7d20\u6cbb\u7642\u4e0b\uff0c\u7372\u5f97\u6dcb\u5df4\u7624\u7d44\u7e54\u5b78\u5b8c\u5168\u7de9\u89e3\u3002\u540c\u671fBLOOD\u671f\u520a\u8a55\u8ad6\u5c08\u5bb6\uff0c\u4f3c\u4e4e\u57fa\u65bc\u9019\u300c\u81fa\u7063\u7d93\u9a57\u300d\u52c9\u5f37\u63a5\u53d7\u6b64\u4e00\u7d50\u679c\u3002\u96d6\u7136\u81fa\u7063\u7814\u7a76\u5718\u968a\u904e\u53bb\u5341\u6578\u5e74\u4e2d\u6301\u7e8c\u767c\u8868\u76f8\u95dc\u7684\u81e8\u5e8a\u53ca\u8f49\u8b6f\u7814\u7a76\u6210\u679c\uff0c\u767c\u8868\u65bc\u5305\u62ec JCO, BLOOD, JNCI, CANCER RESEARCH\u7b49\u8457\u540d\u671f\u520a\uff0c\u4f46\u662f\u8a55\u8ad6\u5c08\u5bb6\u5c0d\u5229\u7528\u6297\u751f\u7d20\u6cbb\u7642\u5e7d\u9580\u87ba\u65cb\u687f\u83cc\u967d\u6027\u7684\u80c3\u7030\u6f2b\u6027\u5927\u578b\uff22\u7d30\u80de\u6dcb\u5df4\u7624\u7684\u7406\u5ff5\uff0c\u986f\u7136\u4ecd\u62b1\u6301\u61f7\u7591\u800c\u4e26\u672a\u5b8c\u5168\u4fe1\u670d\uff0c\u8a8d\u70ba\u6b64\u4e00\u7d50\u679c\u4ecd\u6709\u5f85\u9032\u4e00\u6b65\u7684\u524d\u77bb\u6027\u81e8\u5e8a\u8a66\u9a57\u52a0\u4ee5\u8b49\u5be6\u3002\u96d6\u7136\u9019\u662f\u500b\u5408\u7406\u7684\u7d50\u8ad6\uff0c\u4f46\u662f\u5fc5\u9808\u6ce8\u610f\u7684\u662f\uff0c\u897f\u65b9\u570b\u5bb6\u53d7\u9650\u65bc\u5176\u91ab\u7642\u9ad4\u7cfb\uff0c\u591a\u6578\u5c6c\u516c\u91ab\u5236\u5ea6\uff0c\u983b\u7e41\u5730\u5b89\u6392\u5167\u8996\u93e1\u6aa2\u67e5\u4e26\u4e0d\u5bb9\u6613\uff0c\u56e0\u6b64\u5728\u8003\u616e\u7121\u6cd5\u65e9\u671f\u5075\u6e2c\u5c0d\u5e7d\u9580\u87ba\u65cb\u687f\u83cc\u5ed3\u6e05\u7642\u6cd5\u7121\u6548\u7684\u80c3\u7030\u6f2b\u6027\u5927\u578b\uff22\u7d30\u80de\u6dcb\u5df4\u7624\u53ef\u80fd\u767c\u751f\u5feb\u901f\u5730\u60e1\u5316\uff0c\u6703\u5ef6\u8aa4\u60a3\u8005\u7684\u5316\u5b78\u85e5\u7269\u6216\u653e\u5c04\u7dda\u6cbb\u7642\u800c\u5f71\u97ff\u5176\u9810\u5f8c\uff0c\u6545\u985e\u4f3c\u7684\u524d\u77bb\u6027\u7814\u7a76\u5728\u6b50\u7f8e\u570b\u5bb6\u5747\u672a\u80fd\u6709\u6548\u57f7\u884c \u3002<br \/>\n\u7136\u800c\u81fa\u7063\u7814\u7a76\u5718\u968a\u57fa\u65bc\u9577\u671f\u7684\u81e8\u5e8a\u89c0\u5bdf\u8207\u5805\u6301\uff0c\u7d42\u65bc\u7372\u5f97\u4e86\u6b63\u5411\u56de\u61c9\u30022012.11 BLOOD\u520a\u51fa\u4e00\u7bc7\u7531 \u7fa9\u5927\u5229\u53ca\u5967\u570b\u5b78\u8005\u767c\u8868\u7684\u7c21\u77ed\u8ad6\u6587\uff0c\u63cf\u8ff0\u7b2c\u4e00\u500b\u5728\u897f\u65b9\u570b\u5bb6\u57f7\u884c\u300c\u4ee5\u5e7d\u9580\u87ba\u65cb\u687f\u83cc\u5ed3\u6e05\u7642\u6cd5\u4f5c\u70ba\u5c40\u9650\u671f\u5225\u80c3\u7030\u6f2b\u6027\u5927\u578b\uff22\u7d30\u80de\u6dcb\u5df4\u7624\u552f\u4e00\u6cbb\u7642\u7684\u591a\u4e2d\u5fc3\u7b2c\u4e8c\u671f\u81e8\u5e8a\u8a66\u9a57 (Helicobacter pylori eradication as exclusive treatment for limited-stage gastric diffuse large B-cell lymphoma: results of a multicenter phase 2 trial)\u300d\u3002\u6b64\u4e00\u7814\u7a76\u65bc2003 \u2013 2006\u5e74\u9593\u5171\u6536\u9304\u4e8616\u4f4d\u7b2cI \u2013 IIE-1\u671f\u7684\u5e7d\u9580\u87ba\u65cb\u687f\u83cc\u967d\u6027\u4e4b\u80c3\u7030\u6f2b\u6027\u5927\u578b\uff22\u7d30\u80de\u6dcb\u5df4\u7624\uff0c\u5176\u4e2d5\u4f4d\u816b\u7624\u7d44\u7e54\u5b78\u5167\u5177MALT\u7279\u5fb5\uff0c\u53e611\u4f4d\u7684\u816b\u7624\u5247\u5426\u3002\u5e7d\u9580\u87ba\u65cb\u687f\u83cc\u5ed3\u6e05\u5f8c\uff0c8\u4f4d (50%) \u60a3\u8005\u80c3\u6dcb\u5df4\u7624\u7372\u5f97\u5b8c\u5168\u7de9\u89e3\uff0c\u53e6\u6709 3\u4f4d\u5247\u7372\u5f97\u90e8\u4efd\u7de9\u89e3\uff0c\u5f8c\u8005\u4e2d\u5169\u4f4d\u60a3\u8005\u5247\u5728\u63a5\u53d7rituximab\u5f8c\u4ea6\u7372\u5b8c\u5168\u7de9\u89e3\u3002\u6574\u9ad4\u800c\u8a00\uff0c\u5728\u672a\u63a5\u53d7\u624b\u8853\u5207\u9664\u6216\u7d30\u80de\u6bd2\u6bba\u5316\u5b78\u6cbb\u7642\u7684\u60c5\u6cc1\u4e0b\uff0c10\u4f4d\u60a3\u8005\u53ef\u7372\u5b8c\u5168\u7de9\u89e3 (\u5b8c\u5168\u7de9\u89e3\u7387\u70ba63%\uff0c95%\u4fe1\u8cf4\u5340\u9593\u70ba39% -87%)\u3002\u6b50\u6d32\u5b78\u8005\u7d50\u8ad6\uff0c\u4ed6\u5011\u7684\u7814\u7a76\u7d50\u679c\u8207\u81fa\u7063\u7814\u7a76\u5718\u968a\u8005\u76f8\u4f3c\uff0c\u4e14\u4f9d\u64da\u9019\u5169\u500b\u7814\u7a76\u7d50\u679c\uff0c\u7372\u5f97\u4e00\u500b\u91cd\u8981\u7684\u7d50\u8ad6\uff0d\u300c\u4fdd\u7559\u5316\u5b78-\u653e\u5c04\u7dda\u6cbb\u7642\u4f5c\u70ba\u6297\u751f\u7d20\u7642\u6548\u4e0d\u4f73\u60a3\u8005\u7684\u5f8c\u7e8c\u6cbb\u7642\uff0c \u5e7d\u9580\u87ba\u65cb\u687f\u83cc\u5ed3\u6e05\u61c9\u53ef\u4f5c\u70ba\u80c3\u7030\u6f2b\u6027\u5927\u578b\uff22\u7d30\u80de\u6dcb\u5df4\u7624\u7b2c\u4e00\u7dda\u6cbb\u7642\u7684\u9078\u9805\u300d\u3002<br \/>\n\u8a18\u5f972009\u5e7411\u670820-21\u65e5\uff0c\u5728\u502b\u6566\u5b78\u9662\u5927\u5b78(University College London, UCL)\u8209\u884c\u7684\u6b50\u6d32\u80c3\u8178\u9053\u6dcb\u5df4\u7624\u5b78\u6703(European Gastrointestinal Lymphoma Society, EGILS)\u5e74\u6703\u4e2d\uff0cMALT \u6dcb\u5df4\u7624\u75be\u75c5\u985e\u5225\u7684\u767c\u73fe\u8005\uff0cProfessor Isaacson\u5728\u5927\u6703\u4e3b\u984c\u6f14\u8b1b \u300cMALT lymphoma: unanswered questions\u300d\u4e2d\uff0c\u5f15\u7528\u4e3b\u8981\u4f86\u81ea\u81fa\u7063\u7814\u7a76\u5718\u968a\u8ad6\u6587\u7684\u6578\u64da\uff0c\u63d0\u51fa\u4e00\u500b\u554f\u984c\u300c\u6211\u4eec\u80fd\u5426\u4ee5\u6297\u751f\u7d20\u6cbb\u7652\u80c3\u8178\u9053\u7030\u6f2b\u6027\u5927\u7d30\u80de\u6dcb\u5df4\u7624? (Can we cure GI DLBCL with antibiotics?)\u300d\uff0c\u4e26\u8cea\u7591\u70ba\u4f55\u8840\u6db2\u75c5\u5b78\u8005\u81f3\u4eca\u4ecd\u80fd\u7121\u8996\u65bc57%\u7684\u7d44\u7e54\u5b78\u5b8c\u5168\u7de9\u89e3\u7387\uff0c\u800c\u5805\u6301\u6297\u751f\u7d20\u4e0d\u61c9\u505a\u70ba\u80c3\u7030\u6f2b\u6027\u5927\u7d30\u80de\u6dcb\u5df4\u7624(DLBCL)\u7684\u7b2c\u4e00\u7dda\u6cbb\u7642\u3002\u5982\u4eca\uff0c\u81ea\u5f9e\u81fa\u7063\u7814\u7a76\u5718\u968a\u65bc2001\u5e74\u767c\u8868\u7b2c\u4e00\u7bc7\u5e7d\u9580\u87ba\u65cb\u687f\u83cc\u5ed3\u6e05\u5728\u9ad8\u60e1\u6027\u5ea6MALT\u6dcb\u5df4\u7624\uff08\u80c3\u8178\u9053\u7030\u6f2b\u6027\u5927\u7d30\u80de\u6dcb\u5df4\u7624\uff09\u7684\u6cbb\u7642\u6210\u7e3e\uff0c\u81f3\u4eca\u5df2\u662f12\u5e74\u4e86\uff0c\u7531\u4e00\u500b\u75c5\u4f8b\u500b\u6848\u7684\u89c0\u5bdf\uff0c\u7d93\u7531\u7814\u7a76\u4eba\u54e1\u8d77\u59cb\u7684\u524d\u77bb\u6027\u81e8\u5e8a\u8a66\u9a57 (investigator-initiated prospective clinical trial)\u52a0\u4ee5\u8b49\u5be6\uff0c\u53ca\u5c0d\u81ea\u5df1\u89c0\u5bdf\u7d50\u679c\u7684\u5805\u6301\uff0c\u6b64\u4e00\u6210\u679c\u6700\u7d42\u5f97\u4ee5\u5c0d\u4ee5\u6297\u751f\u7d20\u6cbb\u7642\u80c3\u8178\u9053\u7030\u6f2b\u6027\u5927\u7d30\u80de\u6dcb\u5df4\u7624\u7684\u53ef\u80fd\u6027\u63d0\u4f9b\u5f37\u529b\u4f50\u8b49\uff0c\u800c\u7372\u570b\u969b\u5b78\u754c\u7684\u80af\u5b9a\uff0c\u4e26\u4e14\u6216\u5c07\u6539\u8b8a\u65e9\u671f\u80c3\u7030\u6f2b\u6027\u5927\u7d30\u80de\u6dcb\u5df4\u7624\u7684\u6a19\u6e96\u6cbb\u7642\u3002\u9019\u61c9\u4e5f\u662f\u53e6\u985e\u7684\u81fa\u7063\u4e4b\u5149\u5427\uff01DNA\u640d\u50b7\u85e5\u7269\u662f\u76ee\u524d\u816b\u7624\u6cbb\u7642\u7684\u7b2c\u4e00\u7dda\u85e5\u7269\uff0c\u9019\u985e\u85e5\u7269\u53ef\u4ee5\u5f88\u5feb\u7684\u6d3b\u5316ATM\u548cATR\u78f7\u9178\u6fc0\u9176\u9032\u800c\u6d3b\u5316\u5176\u4e0b\u6e38\u7684\u5169\u500b\u78f7\u9178\u6fc0\u9176Chk1\u548cChk2\uff0c\u9019\u4e00\u7cfb\u5217\u7684\u6d3b\u5316\u53cd\u61c9\u5373\u7a31\u70baDNA\u640d\u50b7\u53cd\u61c9\uff0c\u7d30\u80de\u555f\u52d5\u9019\u6a5f\u5236\u900f\u904e\u505c\u6b62\u7d30\u80de\u5468\u671f\u3001\u4fee\u5fa9\u640d\u50b7\u3001\u548c\u8b93\u640d\u50b7\u7d30\u80de\u6b7b\u4ea1\uff0c\u5f97\u4ee5\u7dad\u6301\u57fa\u56e0\u9ad4\u7684\u5b8c\u6574\u6027\u3002\u904e\u53bb\u7814\u7a76\u4ee5\u85e5\u7269\u6291\u5236ATR\u6d3b\u5316\u80fd\u5728\u5177\u6709p53\u548cATM\u7f3a\u5931\u7684\u816b\u7624\u4e2d\u9020\u6210\u5408\u6210\u81f4\u6b7b\u6548\u61c9 (synthetic lethal effect)\uff0c\u986f\u793a\u9019\u500b\u6291\u5236\u7b56\u7565\u53ef\u4ee5\u6539\u5584DNA\u640d\u50b7\u85e5\u7269\u7684\u654f\u611f\u6027\u3002\u672c\u7bc7\u7814\u7a76\u767c\u73fe\u5929\u7136\u7269protoapigenone (WYC02)\u548c\u5176\u5408\u6210\u884d\u751f\u7269WYC0209\u5c0d\u65bc\u591a\u7a2e\u816b\u7624\u7d30\u80de\u682a\u90fd\u6709\u6bd2\u6bba\u4f5c\u7528\uff1bWYC02\u6703\u9020\u6210\u6709\u7d72\u5206\u88c2CHO\u7d30\u80de\u4e4b\u67d3\u8272\u9ad4\u7570\u5e38\uff0c\u4f46\u537b\u6c92\u6709\u50cf\u5176\u4ed6\u81f4\u7a81\u5291\u6709\u5f15\u8d77\u660e\u986f\u7684DNA\u640d\u50b7\u53cd\u61c9\u3002\u66f4\u9032\u4e00\u6b65\u63a2\u8a0e\u5f8c\u767c\u73fe\uff0c\u9019\u985e\u5316\u5408\u7269\u53cd\u800c\u662f\u6291\u5236DNA\u640d\u50b7\u53cd\u61c9\uff0cWYC02\u548cWYC0209\u80fd\u7279\u7570\u6027\u6291\u5236ATR\u4e0b\u6e38\u7684Chk1\u548cFANCD2\u6d3b\u5316\u4f5c\u7528\uff0c\u5c0dChk2\u6d3b\u5316\u6c92\u6709\u5f71\u97ff\u3002\u85c9\u6b64\u4f5c\u7528\uff0c\u4f4e\u5291\u91cf\u7684WYC\u85e5\u7269\u5373\u80fd\u6291\u5236ATR\u4e0b\u6e38\u76f8\u95dc\u8a0a\u606f\u529f\u80fd\uff0c\u4f8b\u5982 S\/M\u548cG2\/M\u76e3\u67e5\u9ede\uff0c\u548cDNA\u96d9\u80a1\u65b7\u88c2\u4fee\u5fa9\u529f\u80fd\uff1b\u9664\u6b64\u4ee5\u5916\uff0c\u6211\u5011\u4e5f\u5728\u7d30\u80de\u57f9\u990a\u548c\u5c0f\u9f20\u7570\u690d\u816b\u7624\u5169\u500b\u6a21\u5f0f\u8b49\u5be6\uff0c\u7576\u5408\u4f75\u8655\u7406cisplatin\u6642\uff0cWYC\u53ef\u4ee5\u589e\u52a0\u764c\u75c7\u7d30\u80de\u6216\u816b\u7624\u5c0d\u5f15\u8d77DNA\u80a1\u5167\u4ea4\u53c9\u93c8\u7d50\u85e5\u5291 (interstrand cross-link-generating agents) \u7684\u654f\u611f\u6027\u3002\u672c\u7814\u7a76\u7684\u7d50\u679c\u8b49\u5be6WYC02\u548cWYC0209\u53ef\u4ee5\u6291\u5236ATR\u8a0a\u606f\u50b3\u905e\uff0c\u7279\u5225\u53ef\u4ee5\u7528\u4f86\u91dd\u5c0d\u76e3\u67e5\u9ede\u7279\u5225\u6d3b\u5316\u7684\u816b\u7624\uff0c\u63d0\u9ad8\u56e0oncogene\u6d3b\u5316\u800c\u5feb\u901f\u5206\u88c2\u816b\u7624\u7684\u85e5\u7269\u654f\u611f\u6027\uff0c\u6216\u6539\u5584\u816b\u7624\u5c0d\u65bcDNA\u5e72\u64fe\u85e5\u7269\u7684\u6297\u6027\u3002<\/li>\n<\/ul>\n<p style=\"text-align: right\"><a href=\"http:\/\/wp.kmu.edu.tw\/rd\/archives\/773\">\u56de\u7b2c0004\u671f\u4e3b\u9801<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u56de\u7b2c0004\u671f\u4e3b\u9801 \u4e00\u3001\u7814\u7a76\u65b0\u77e5 Comprehensive and Highl &hellip; <a href=\"https:\/\/wp.kmu.edu.tw\/rd\/archives\/728\">\u95b1\u8b80\u5168\u6587 <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[12],"tags":[],"class_list":["post-728","post","type-post","status-publish","format-standard","hentry","category-12"],"_links":{"self":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/728","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/comments?post=728"}],"version-history":[{"count":13,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/728\/revisions"}],"predecessor-version":[{"id":749,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/728\/revisions\/749"}],"wp:attachment":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/media?parent=728"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/categories?post=728"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/tags?post=728"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}