{"id":730,"date":"2012-12-18T14:50:17","date_gmt":"2012-12-18T06:50:17","guid":{"rendered":"http:\/\/wp.kmu.edu.tw\/rd\/?p=730"},"modified":"2013-01-03T15:50:04","modified_gmt":"2013-01-03T07:50:04","slug":"%e8%ab%96%e6%96%87%e5%88%86%e4%ba%ab-2","status":"publish","type":"post","link":"https:\/\/wp.kmu.edu.tw\/rd\/archives\/730","title":{"rendered":"\u8ad6\u6587\u5206\u4eab"},"content":{"rendered":"

\u56de\u7b2c0004\u671f\u4e3b\u9801<\/a><\/p>\n

\u4e8c\u3001\u8ad6\u6587\u5206\u4eab<\/h1>\n
  • \u984c\u76ee\uff1a
    \nInhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link-Generating Agents In Vitro and In Vivo <\/strong>\uff08\u738b\u60e0\u541b\u52a9\u7406\u6559\u6388\u63d0\u4f9b\u6458\u8981\uff09
    \nMOLECULAR CANCER THERAPEUTICS 11(7)1443-1453 JUL2012\uff08IF=5.226\uff09<\/span>
    \n\u4f5c\u8005\uff1aWang, HC; Lee, AYL; Chou, WC; Wu, CC; Tseng, CN; Liu, KYT; Lin, WL; Chang, FR;Chuang, DW; Hunyadi, A; Wu, YC<\/span>DNA\u640d\u50b7\u85e5\u7269\u662f\u76ee\u524d\u816b\u7624\u6cbb\u7642\u7684\u7b2c\u4e00\u7dda\u85e5\u7269\uff0c\u9019\u985e\u85e5\u7269\u53ef\u4ee5\u5f88\u5feb\u7684\u6d3b\u5316ATM\u548cATR\u78f7\u9178\u6fc0\u9176\u9032\u800c\u6d3b\u5316\u5176\u4e0b\u6e38\u7684\u5169\u500b\u78f7\u9178\u6fc0\u9176Chk1\u548cChk2\uff0c\u9019\u4e00\u7cfb\u5217\u7684\u6d3b\u5316\u53cd\u61c9\u5373\u7a31\u70baDNA\u640d\u50b7\u53cd\u61c9\uff0c\u7d30\u80de\u555f\u52d5\u9019\u6a5f\u5236\u900f\u904e\u505c\u6b62\u7d30\u80de\u5468\u671f\u3001\u4fee\u5fa9\u640d\u50b7\u3001\u548c\u8b93\u640d\u50b7\u7d30\u80de\u6b7b\u4ea1\uff0c\u5f97\u4ee5\u7dad\u6301\u57fa\u56e0\u9ad4\u7684\u5b8c\u6574\u6027\u3002\u904e\u53bb\u7814\u7a76\u4ee5\u85e5\u7269\u6291\u5236ATR\u6d3b\u5316\u80fd\u5728\u5177\u6709p53\u548cATM\u7f3a\u5931\u7684\u816b\u7624\u4e2d\u9020\u6210\u5408\u6210\u81f4\u6b7b\u6548\u61c9 (synthetic lethal effect)\uff0c\u986f\u793a\u9019\u500b\u6291\u5236\u7b56\u7565\u53ef\u4ee5\u6539\u5584DNA\u640d\u50b7\u85e5\u7269\u7684\u654f\u611f\u6027\u3002\u672c\u7bc7\u7814\u7a76\u767c\u73fe\u5929\u7136\u7269protoapigenone (WYC02)\u548c\u5176\u5408\u6210\u884d\u751f\u7269WYC0209\u5c0d\u65bc\u591a\u7a2e\u816b\u7624\u7d30\u80de\u682a\u90fd\u6709\u6bd2\u6bba\u4f5c\u7528\uff1bWYC02\u6703\u9020\u6210\u6709\u7d72\u5206\u88c2CHO\u7d30\u80de\u4e4b\u67d3\u8272\u9ad4\u7570\u5e38\uff0c\u4f46\u537b\u6c92\u6709\u50cf\u5176\u4ed6\u81f4\u7a81\u5291\u6709\u5f15\u8d77\u660e\u986f\u7684DNA\u640d\u50b7\u53cd\u61c9\u3002\u66f4\u9032\u4e00\u6b65\u63a2\u8a0e\u5f8c\u767c\u73fe\uff0c\u9019\u985e\u5316\u5408\u7269\u53cd\u800c\u662f\u6291\u5236DNA\u640d\u50b7\u53cd\u61c9\uff0cWYC02\u548cWYC0209\u80fd\u7279\u7570\u6027\u6291\u5236ATR\u4e0b\u6e38\u7684Chk1\u548cFANCD2\u6d3b\u5316\u4f5c\u7528\uff0c\u5c0dChk2\u6d3b\u5316\u6c92\u6709\u5f71\u97ff\u3002\u85c9\u6b64\u4f5c\u7528\uff0c\u4f4e\u5291\u91cf\u7684WYC\u85e5\u7269\u5373\u80fd\u6291\u5236ATR\u4e0b\u6e38\u76f8\u95dc\u8a0a\u606f\u529f\u80fd\uff0c\u4f8b\u5982 S\/M\u548cG2\/M\u76e3\u67e5\u9ede\uff0c\u548cDNA\u96d9\u80a1\u65b7\u88c2\u4fee\u5fa9\u529f\u80fd\uff1b\u9664\u6b64\u4ee5\u5916\uff0c\u6211\u5011\u4e5f\u5728\u7d30\u80de\u57f9\u990a\u548c\u5c0f\u9f20\u7570\u690d\u816b\u7624\u5169\u500b\u6a21\u5f0f\u8b49\u5be6\uff0c\u7576\u5408\u4f75\u8655\u7406cisplatin\u6642\uff0cWYC\u53ef\u4ee5\u589e\u52a0\u764c\u75c7\u7d30\u80de\u6216\u816b\u7624\u5c0d\u5f15\u8d77DNA\u80a1\u5167\u4ea4\u53c9\u93c8\u7d50\u85e5\u5291 (interstrand cross-link-generating agents) \u7684\u654f\u611f\u6027\u3002\u672c\u7814\u7a76\u7684\u7d50\u679c\u8b49\u5be6WYC02\u548cWYC0209\u53ef\u4ee5\u6291\u5236ATR\u8a0a\u606f\u50b3\u905e\uff0c\u7279\u5225\u53ef\u4ee5\u7528\u4f86\u91dd\u5c0d\u76e3\u67e5\u9ede\u7279\u5225\u6d3b\u5316\u7684\u816b\u7624\uff0c\u63d0\u9ad8\u56e0oncogene\u6d3b\u5316\u800c\u5feb\u901f\u5206\u88c2\u816b\u7624\u7684\u85e5\u7269\u654f\u611f\u6027\uff0c\u6216\u6539\u5584\u816b\u7624\u5c0d\u65bcDNA\u5e72\u64fe\u85e5\u7269\u7684\u6297\u6027\u3002<\/li>\n

    \u56de\u7b2c0004\u671f\u4e3b\u9801<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

    \u56de\u7b2c0004\u671f\u4e3b\u9801 \u4e8c\u3001\u8ad6\u6587\u5206\u4eab \u984c\u76ee\uff1a Inhibition of ATR-D … \u95b1\u8b80\u5168\u6587 →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[12],"tags":[],"class_list":["post-730","post","type-post","status-publish","format-standard","hentry","category-12"],"_links":{"self":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/730","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/comments?post=730"}],"version-history":[{"count":11,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/730\/revisions"}],"predecessor-version":[{"id":754,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/730\/revisions\/754"}],"wp:attachment":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/media?parent=730"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/categories?post=730"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/tags?post=730"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}