{"id":902,"date":"2013-01-21T13:49:07","date_gmt":"2013-01-21T05:49:07","guid":{"rendered":"http:\/\/wp.kmu.edu.tw\/rd\/?p=902"},"modified":"2013-02-05T16:08:43","modified_gmt":"2013-02-05T08:08:43","slug":"%e7%a0%94%e7%a9%b6%e6%96%b0%e7%9f%a5-3","status":"publish","type":"post","link":"https:\/\/wp.kmu.edu.tw\/rd\/archives\/902","title":{"rendered":"\u7814\u7a76\u65b0\u77e5"},"content":{"rendered":"<p style=\"text-align: right\"><a href=\"http:\/\/wp.kmu.edu.tw\/rd\/archives\/918\">\u56de\u7b2c0005\u671f\u4e3b\u9801<\/a><\/p>\n<h1>\u4e00\u3001\u7814\u7a76\u65b0\u77e5<\/h1>\n<p><a name=\"ResNew1\"><\/a><\/p>\n<ul>\n<li>\n<h1>How insulin engages its primary binding site on the insulin receptor<br \/>\n\uff08\u9ec3\u555f\u6e05\u6559\u6388\u6458\u8b6f\uff09<\/h1>\n<p>Menting, J. G., Whittaker, J., Margetts, M. B., Whittaker, L. J., Kong, G. K.-W., Smith, B. J.,Watson, C. J., Zakova, L., Kletvikova, E., Jiracek, J., Chan, S. J., Steiner, D. F., Dodson, G. G., Brzozowski, A. M., Weiss, m. A., Ward, C. W., &amp; Lawrence, M. C.Nature 493, 241-245 (2013)<\/p>\n<p>\u80f0\u5cf6\u7d20\u63a5\u53d7\u5668(insulin receptor; IR)\u8a0a\u606f\u5728\u54fa\u4e73\u985e\u751f\u7269\u4f34\u6f14\u8457\u8abf\u63a7\u7d30\u80de\u4ee3\u8b1d\u3001 \u6210\u9577\u3001\u5206\u88c2\u3001\u5206\u5316\u3001\u53ca\u751f\u5b58\u7684\u4e2d\u5fc3\u89d2\u8272\u3002 \u80f0\u5cf6\u7d20\u963b\u6297\u8207\u7b2c\u4e8c\u578b\u7cd6\u5c3f\u75c5\u53caAlzheimer\u75c7\u7684\u767c\u75c5\u6709\u5bc6\u5207\u95dc\u806f\u3002 \u5176\u5728\u4e0d\u540c\u764c\u75c7\u7684\u7570\u5e38\u8a0a\u606f\u5e38\u53ef\u7d93\u7531\u8207type 1 insulin-like growth factor (IGF1R) \u7684cross talk\u52a0\u6df1\u3002 \u96d6\u7136\u904e\u53bb30\u591a\u5e74\u7684\u7814\u7a76\uff0cinsulin\u8207\u5176IR\u7d50\u5408\u7684\u8907\u96dc3D\u7d50\u69cb\u4ecd\u4ee4\u4eba\u56f0\u60d1\u3002\u6b64\u7bc7\u4f5c\u8005\u85c9\u7531truncated IR\u8207insulin\u76844\u500b\u7d50\u6676\u7d50\u69cb\uff0c\u9996\u5148\u5448\u73feinsulin\u8207IR\u6700\u521d\u7d50\u5408\u4f4d\u7f6e\u7684\u4f5c\u7528: insulin\u8207 IR \u7684leucine-rich-repeat domain (L1) \u662f\u5f88\u5f31\u7684\u7d50\u5408\uff0c\u800c\u4e3b\u8981\u662f\u8207 IR \u4e4bC\u7aef \u03b1-chain (\u03b1CT) \u90e8\u4f4d\u4f5c\u7528\u3002\u5728insulin\u8207 IR\u7d50\u5408\u6642, \u7d93\u7531\u5176\u03b2-chain\u5e8f\u5217\u8207\u4f4d\u5728L1\u4e0a\u03b1CT\u7d50\u5408\uff0c\u03b1CT \u90e8\u4f4d\u53d6\u4ee3insulin\u4e4bthe B-chain C\u7aef \u03b2-strand\uff0c\u4f7f\u5176\u9060\u96e2hormone core\uff0c\u9019\u7d50\u679c\u652f\u6301\u4e4b\u524d\u63d0\u51fa\u7684\u6a5f\u5236: insulin\u8207 IR\u7d50\u5408\u5c0e\u81f4\u5176\u69cb\u5f62\u4e0a\u7684\u7f6e\u63db\u3002\u5c0d\u65bcreceptor tyrosine kinases\u5bb6\u65cf\uff0c\u9019\u662f\u500b\u65b0\u7a4e\u7684\u7d50\u5408\u65b9\u5f0f\u3002\u4f5c\u8005\u66f4\u85c9\u7531photo-crosslinking \u6578\u64da\u4f86\u78ba\u5b9a\uff0c\u4e26\u7528isothermal titration calorimetry\u6578\u64da\u4f86\u5256\u6790 hormone\u2013insulin receptor interface\u3002\u7e3d\u7d50\uff0c\u9019\u4e9b\u767c\u73fe\u53ef\u63d0\u4f9b\u89e3\u91cb\u76f8\u95dc\u7684\u6cbb\u7642\u7528insulin\u985e\u4f3c\u7269\u85e5\u7269\u8a2d\u8a08\u8207 IR\u53caIGF1R\u7cfb\u7d71\u7684\u751f\u5316\u6578\u64da\u3002<\/li>\n<\/ul>\n<p style=\"text-align: right\"><a href=\"http:\/\/wp.kmu.edu.tw\/rd\/archives\/918\">\u56de\u7b2c0005\u671f\u4e3b\u9801<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u56de\u7b2c0005\u671f\u4e3b\u9801 \u4e00\u3001\u7814\u7a76\u65b0\u77e5 How insulin engages its &hellip; <a href=\"https:\/\/wp.kmu.edu.tw\/rd\/archives\/902\">\u95b1\u8b80\u5168\u6587 <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[13],"tags":[],"class_list":["post-902","post","type-post","status-publish","format-standard","hentry","category-13"],"_links":{"self":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/902","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/comments?post=902"}],"version-history":[{"count":5,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/902\/revisions"}],"predecessor-version":[{"id":1013,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/posts\/902\/revisions\/1013"}],"wp:attachment":[{"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/media?parent=902"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/categories?post=902"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/rd\/wp-json\/wp\/v2\/tags?post=902"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}