{"id":2935,"date":"2014-03-20T11:19:25","date_gmt":"2014-03-20T03:19:25","guid":{"rendered":"http:\/\/wp.kmu.edu.tw\/schoolmag\/?p=2935"},"modified":"2014-10-20T13:23:29","modified_gmt":"2014-10-20T05:23:29","slug":"%e5%be%ae%e5%b0%8frna%e6%87%89%e7%94%a8%e6%96%bc%e6%80%a5%e6%80%a7%e7%bc%ba%e8%a1%80%e6%80%a7%e4%b8%ad%e9%a2%a8%e4%b9%8b%e6%b2%bb%e7%99%82","status":"publish","type":"post","link":"https:\/\/wp.kmu.edu.tw\/schoolmag\/2014\/03\/20\/%e5%be%ae%e5%b0%8frna%e6%87%89%e7%94%a8%e6%96%bc%e6%80%a5%e6%80%a7%e7%bc%ba%e8%a1%80%e6%80%a7%e4%b8%ad%e9%a2%a8%e4%b9%8b%e6%b2%bb%e7%99%82\/","title":{"rendered":"\u5fae\u5c0fRNA\u61c9\u7528\u65bc\u6025\u6027\u7f3a\u8840\u6027\u4e2d\u98a8\u4e4b\u6cbb\u7642"},"content":{"rendered":"<p align=\"right\"><strong>\u91ab\u5b78\u9662\u57fa\u56e0\u9ad4\u91ab\u5b78\u79d1\u3000\u5353\u5919\u822a \u6559\u6388\u3001\u738b\u6c38\u677e\u3001\u912d\u6b23\u82b8<\/strong><a href=\"http:\/\/wp.kmu.edu.tw\/schoolmag\/files\/2014\/10\/41-19.pdf\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/wp.kmu.edu.tw\/schoolmag\/files\/2014\/10\/btn_pdf.jpg\" alt=\"btn_pdf\" width=\"32\" height=\"32\" class=\"alignleft size-full wp-image-4451\" \/><\/a><\/p>\n<p>\u5fae\u5c0fRNA (microRNA)\u70ba\u8fd1\u5341\u5e74\u4f86\u751f\u7269\u91ab\u5b78\u754c\u6700\u91cd\u8981\u7684\u767c\u73fe\u4e4b\u4e00\uff0c\u5f9e1998\u5e74\u767c\u8868\u5176\u4e3b\u8981\u529f\u80fd\u5f8c\uff0c\u96a8\u5373\u65bc2006\u5e74\u7372\u5f97\u8afe\u8c9d\u723e\u91ab\u5b78\u734e\u3002\u5fae\u5c0fRNA\u4fc2\u70ba\u751f\u7269\u9ad4\u5167\u81ea\u884c\u5408\u6210\u7684\u5c0f\u7247\u6bb5RNA\uff0c\u5176\u9577\u5ea6\u7d0421-23\u500b\u6838\u82f7\u9178\uff0c\u5728\u6f14\u5316\u4e0a\u76f8\u7576\u7a69\u5b9a\u3002\u5fae\u5c0fRNA\u7531\u9ad4\u5167DNA\u9032\u884c\u8f49\u9304\u4f5c\u7528\uff0c\u537b\u4e0d\u8f49\u8b6f\u6210\u86cb\u767d\u8cea\uff0c\u4f46\u5177\u6709\u8abf\u7bc0\u751f\u7269\u767c\u80b2\u751f\u9577\u4e4b\u4f5c\u7528\u3002\u76ee\u524d\u5df2\u77e5\u4eba\u985e\u57fa\u56e0\u7d44\u4e2d\u5927\u7d04\u67091400\u7a2e\u5fae\u5c0fRNA\u3002<\/p>\n<p>\u8166\u8840\u7ba1\u75be\u75c5\u5c45\u53f0\u7063\u5341\u5927\u6b7b\u56e0\u7684\u7b2c3\u4f4d\uff0c\u4e5f\u662f\u80a2\u9ad4\u6b98\u969c\u4e4b\u4e3b\u8981\u539f\u56e0\uff0c\u5c0d\u793e\u6703\u8cc7\u6e90\u8207\u91ab\u7642\u7167\u8b77\u4e4b\u6d88\u8017\u66f4\u662f\u5de8\u5927\u3002\u5982\u4f55\u4ee5\u85e5\u7269\u505a\u70ba\u7a4d\u6975\u6cbb\u7642\u4ee5\u6e1b\u5c11\u4e2d\u98a8\u5f8c\u7684\u6b98\u969c\uff0c\u8207\u9810\u9632\u8166\u8840\u7ba1\u75be\u75c5\u7684\u767c\u751f\uff0c\u662f\u975e\u5e38\u91cd\u8981\u4e4b\u8ab2\u984c\u3002\u53f0\u7063\u6bcf\u5e74\u7d04\u67092-3 \u842c\u4eba\u4e2d\u98a8\uff0c\u7f3a\u8840\u6027\u4e2d\u98a8\u4f54\u6240\u6709\u4e2d\u98a8\u768475\uff05\u3002\u76ee\u524dFDA\u552f\u4e00\u6838\u51c6\u7684\u7f3a\u8840\u6027\u4e2d\u98a8\u6cbb\u7642\u85e5\u7269\u662f\u8840\u6813\u6eb6\u89e3\u5291tPA(tissue plasminogen activator)\u3002tPA\u53ef\u4ee5\u758f\u901a\u8840\u7ba1\uff0c\u7136\u800c\u5b83\u53ef\u80fd\u9020\u6210\u8166\u51fa\u8840\u800c\u66f4\u60e1\u5316\u75c5\u60c5\u53ca\u5f15\u8d77\u56b4\u91cd\u526f\u4f5c\u7528\uff0ctPA\u5728\u81e8\u5e8a\u4f7f\u7528\u7387\u53ea\u67092~5%\uff0c\u4e5f\u5c31\u662f\u8aaa95%\u4ee5\u4e0a\u7684\u7f3a\u8840\u6027\u4e2d\u98a8\u75c5\u4eba\u4e26\u6c92\u6709\u63a5\u53d7\u91dd\u5c0d\u4e2d\u98a8\u7684\u7279\u6b8a\u6cbb\u7642\u3002\u56e0\u6b64\u767c\u5c55\u53e6\u4e00\u985e\u4e2d\u98a8\u6cbb\u7642\u85e5\u7269\u6709\u5176\u81e8\u5e8a\u53ca\u7522\u696d\u4e4b\u9700\u6c42\u3002<\/p>\n<p>\u5728\u570b\u5bb6\u751f\u6280\u91ab\u85e5\u578b\u79d1\u6280\u8a08\u756b\u652f\u6301\u4e0b\uff0c\u7b46\u8005\u8207\u5718\u968a\u4e4b\u738b\u6c38\u677e\u535a\u58eb\u8207\u912d\u6b23\u82b8\u5c0f\u59d0\u5229\u7528\u6700\u65b0\u7684\u751f\u7269\u6280\u8853\u4ee5\u53ca\u751f\u7269\u8cc7\u8a0a\u5b78\u767c\u73fe\u4e00\u500b\u751f\u7269\u9ad4\u5167\u5fae\u5c0fRNA\uff0c\u53ef\u4ee5\u8abf\u63a7\u56e0\u7f3a\u8840\u6027\u4e2d\u98a8\u6240\u9020\u6210\u4e4b\u795e\u7d93\u7d30\u80de\u53d7\u640d\uff0c\u6291\u5236\u795e\u7d93\u7d30\u80de\u4e00\u9023\u4e32\u76f8\u95dc\u7d30\u80de\u6b7b\u4ea1\u5206\u5b50\u4e4b\u8a0a\u606f\u50b3\u905e\uff0c\u6709\u6548\u6e1b\u5c11\u795e\u7d93\u7d30\u80de\u6b7b\u4ea1\uff0c\u5177\u6709\u6539\u5584\u4e2d\u98a8\u7652\u5f8c\u4e4b\u6062\u5fa9\u7a0b\u5ea6\u8207\u4fdd\u8b77\u8166\u795e\u7d93\u7642\u6548\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u9019\u500b\u5fae\u5c0fRNA\u4e0d\u6703\u5f71\u97ff\u6eb6\u8840\u6216\u8840\u5c0f\u677f\u529f\u80fd\uff0c\u56e0\u6b64\u53ef\u80fd\u4e0d\u6703\u50cftPA\u6703\u9020\u6210\u8166\u51fa\u8840\u7684\u56b4\u91cd\u526f\u4f5c\u7528\u3002\u6240\u4ee5\uff0c\u82e5\u4ee5\u81e8\u5e8a\u4e0a\u6838\u51c6\u4e4b\u5948\u7c73\u4f5c\u70ba\u8f09\u9ad4\u651c\u5e36\u6b64\u5fae\u5c0fRNA\uff0c\u6709\u53ef\u80fd\u767c\u5c55\u6210\u70ba\u4e00\u500b\u65b0\u7684\u6cbb\u7642\u6025\u6027\u7f3a\u8840\u6027\u8166\u4e2d\u98a8\u7684\u85e5\u7269\u3002\u4e26\u4e14\u6709\u53ef\u80fd\u914d\u5408rtPA\u4e00\u8d77\u4f7f\u7528\uff0c\u85c9\u8457\u4e0d\u540c\u7684\u6a5f\u8f49\u64f4\u5927\u7642\u6548\u3002<\/p>\n<p>\u5fae\u5c0fRNA\u6cbb\u7642\u4e4b\u512a\u52e2: (1) \u88fd\u5099\u7c21\u55ae\uff0c\u5fae\u5c0fRNA\u53ef\u8f15\u6613\u5730\u4ee5\u5408\u6210\u3002(2). \u6bd2\u6027\u5c0f\uff0c\u7531\u65bc\u5fae\u5c0fRNA\u7684\u7d44\u6210\u5143\u4ef6\u662f\u9ad4\u5167\u672c\u4f86\u5c31\u6709\u7684\u6838\u9178\uff0c\u800c\u4e14\u5fae\u5c0fRNA\u53c8\u6c92\u6709\u4e00\u822c\u85e5\u7269\u5e38\u898b\u7684\u6b21\u7d1a\u4ee3\u8b1d\u7269\u3002\u5c24\u5176\u6cbb\u7642\u6025\u6027\u7f3a\u8840\u6027\u4e2d\u98a8\uff0c\u53ea\u6709\u77ed\u671f\u7d66\u85e5\uff0c\u56e0\u6b64\u9810\u671f\u85e5\u7269\u7684\u6bd2\u6027\u61c9\u4e0d\u662f\u5927\u7684\u554f\u984c\u3002(3) .\u00a0\u00a0\u00a0\u00a0\u00a0 \u4ee3\u8b1d\u7522\u7269\u751f\u7269\u53ef\u5bb9\u6027\u9ad8, \u81ea\u7136\u7684\u5fae\u5c0fRNA\u3001\u5176\u985e\u4f3c\u7269 (analogue) \u6216\u7528\u4f86\u964d\u4f4e\u9ad4\u5167\u5fae\u5c0fRNA\u4e4b\u53cd\u80a1(anti-sense)\u90fd\u662f\u4ee5\u6838\u9178\u6216\u6838\u9178\u4fee\u98fe\u7269\u505a\u70ba\u55ae\u4f4d\u6210\u5206\u3002\u56e0\u9019\u4e9b\u55ae\u4f4d\u6210\u5206\u90fd\u5df2\u88ab\u8b49\u5be6\u7121\u5bb3\u65bc\u4eba\u9ad4\uff0c\u56e0\u6b64\u4ee5\u5fae\u5c0fRNA\u70ba\u57fa\u790e\u7684\u85e5\u7269\uff0c\u53ef\u80fd\u6bd4\u4e00\u4e9b\u5408\u6210\u6216\u4e0d\u5b58\u5728\u65bc\u4eba\u9ad4\u7684\u5c0f\u5206\u5b50\u85e5\u7269\u4f86\u7684\u5b89\u5168\u3002<\/p>\n<p>\u76ee\u524d\u6211\u5011\u5718\u968a\u5df2\u64c1\u6709\u5168\u7403\u591a\u9805\u667a\u6167\u8ca1\u7522\u6b0a(IP)\u4e4b\u4fdd\u8b77\uff0c\u5305\u62ec\u4e16\u754c\u5e03\u5c40PCT(\u5c08\u5229\u5408\u4f5c\u689d\u7d04, Patent Cooperation Treaty)\u8207\u6578\u500b\u76f8\u95dc\u5c08\u5229\uff0c\u4e26\u4e14\u7372\u5f97\u751f\u6280\u91ab\u85e5\u754c\u6700\u9ad8\u69ae\u8b7d\u570b\u5bb6\u65b0\u5275\u734e\u4e4b\u300c\u5091\u51fa\u5b78\u7814\u6280\u8853\u300d\u80af\u5b9a\u3002\u7814\u7a76\u6210\u679c\u66f4\u5c07\u5728\u885b\u798f\u90e8\u7684\u652f\u6301\u4e0b\u9081\u5411\u81e8\u5e8a\u524d\u7814\u7a76\u968e\u6bb5\uff0c\u540c\u6642\u6709\u6578\u5bb6\u570b\u5167\u751f\u6280\u88fd\u85e5\u5927\u5ee0\u8207\u6211\u5011\u6d3d\u8ac7\u5408\u4f5c\u8207\u6280\u8f49\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u91ab\u5b78\u9662\u57fa\u56e0\u9ad4\u91ab\u5b78\u79d1\u3000\u5353\u5919\u822a \u6559\u6388\u3001\u738b\u6c38\u677e\u3001\u912d\u6b23\u82b8 \u5fae\u5c0fRNA (microRNA)\u70ba\u8fd1\u5341\u5e74\u4f86\u751f\u7269\u91ab\u5b78\u754c\u6700\u91cd\u8981\u7684 &hellip; <a href=\"https:\/\/wp.kmu.edu.tw\/schoolmag\/2014\/03\/20\/%e5%be%ae%e5%b0%8frna%e6%87%89%e7%94%a8%e6%96%bc%e6%80%a5%e6%80%a7%e7%bc%ba%e8%a1%80%e6%80%a7%e4%b8%ad%e9%a2%a8%e4%b9%8b%e6%b2%bb%e7%99%82\/\" class=\"more-link\">\u95b1\u8b80\u5168\u6587 <span class=\"screen-reader-text\">\u5fae\u5c0fRNA\u61c9\u7528\u65bc\u6025\u6027\u7f3a\u8840\u6027\u4e2d\u98a8\u4e4b\u6cbb\u7642<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":126,"featured_media":2937,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2935","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/wp.kmu.edu.tw\/schoolmag\/wp-json\/wp\/v2\/posts\/2935","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.kmu.edu.tw\/schoolmag\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wp.kmu.edu.tw\/schoolmag\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/schoolmag\/wp-json\/wp\/v2\/users\/126"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/schoolmag\/wp-json\/wp\/v2\/comments?post=2935"}],"version-history":[{"count":5,"href":"https:\/\/wp.kmu.edu.tw\/schoolmag\/wp-json\/wp\/v2\/posts\/2935\/revisions"}],"predecessor-version":[{"id":4481,"href":"https:\/\/wp.kmu.edu.tw\/schoolmag\/wp-json\/wp\/v2\/posts\/2935\/revisions\/4481"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/schoolmag\/wp-json\/wp\/v2\/media\/2937"}],"wp:attachment":[{"href":"https:\/\/wp.kmu.edu.tw\/schoolmag\/wp-json\/wp\/v2\/media?parent=2935"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/schoolmag\/wp-json\/wp\/v2\/categories?post=2935"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wp.kmu.edu.tw\/schoolmag\/wp-json\/wp\/v2\/tags?post=2935"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}