1. Chien CM, Yang SH, Yang CC, Chang LS, Lin SR*: Cardiotoxin III induces c-Jun N-terminal kinase-dependent apoptosis in HL-60 human leukemia cells. Cell Biochemistry and Function, 2008 Jan-Feb. 26(1), 111-118. (SCI)<\/p>\n
2. Yang SH, Wu ZZ, Chien CM, Lo YH, Wu MJ, Chang LS, Lin SR*: JNK and ERK mitogen-activated protein kinases mediate THDA-induced apoptosis in K562 cells. Cell Biology and Toxicology, 2008 Aug. 24(4), 291-302. (SCI)<\/p>\n
3. Kao PH, Chen KC, Lin SR, Chang LS*: The structural and functional contribution of N-terminal region and His-47 on Taiwan cobra phospholipase A2. Journal of Peptide Science, 2008 Mar. 14(3), 342-348. (SCI)<\/p>\n
4. Chen KC, Chiou YL, Kao PH, Lin SR, Chang LS*: Taiwan cobra cardiotoxins induce apoptotic death of human neuroblastoma SK-N-SH cells mediated by reactive oxygen species generation and mitochondrial depolarization. Toxicon, 2008 Mar.51(4), 624-634. (SCI)<\/p>\n
5. Chien CM, Yang SH, Chang LS, Lin SR*: Involvement of both endoplasmic reticulum- and mitochondria-dependent pathways in cardiotoxin III-induced apoptosis in HL-60 cells. Clinical and Experimental Pharmacology and Physiology, 2008 Sep. 35(9), 1059-1064. (SCI)<\/p>\n
6. Yang SH, Chien CM, Chang LS, Lin SR*: Cardiotoxin III-induced apoptosis is mediated by Ca2+-dependent caspase-12 activation in K562 cells. Journal of Biochemical and Molecular Toxicology, 2008 May-Jun. 22(3), 209-218. (SCI)<\/p>\n
7. Yang SH, Chien CM, Su JC, Chen YL, Chang LS, Lin SR*: Novel indoloquinoline derivative, IQDMA, inhibits STAT5 signaling associated with apoptosis in K562 cells. Journal of Biochemical and Molecular Toxicology, 2008 Nov-Dec. 22(6), 396-404. (SCI)<\/p>\n
8. Chiou YL, Lin SR, Chang LS*: Mutations on N-terminal region of Taiwan cobra phospholipase A(2) result in structurally distorted effects. Journal of Peptide Science, 2008 Aug. 14(8), 890-897. (SCI).<\/p>\n
9. Lo YH, Lin CC, Lin CF, Lin YT, Duh TH, Hong YR, Yang SH, Lin SR, Yang SC, Chang LS, Wu MJ*: 2-(6-aryl-3(Z)-hexen-1,5-diynyl)anilines as a new class of potent antitubulin agents. Journal of Medicinal Chemistry, 2008 May. 51(9), 2682-2688. (SCI)<\/p>\n
10. Chen KC, Lin SR, Chang LS*: Involvement of mitochondrial alteration and reactive oxygen species generation in Taiwan cobra cardiotoxin-induced apoptotic death of human neuroblastoma SK-N-SH cells. Toxicon, 2008 Aug. 52(2), 361-368. (SCI)<\/p>\n
11. Chen KC, Kao PH, Lin SR, Chang LS*: p38 MAPK activation and mitochondrial depolarization mediate the cytotoxicity of Taiwan cobra phospholipase A2 on human neuroblastoma SK-N-SH cells. Toxicology Letters, 2008 Jul. 180(1), 53-58. (SCI)<\/p>\n
12. Chien CM, Yang SH, Lin KL, Chen YL, Chang LS, Lin SR*: Novel indoloquinoline derivative, IQDMA, suppresses STAT5 phosphorylation and induces apoptosis in HL-60 cells. Chemico-Biological Interactions, 2008 Oct. 176(1), 40-47. (SCI)<\/p>\n
13. Tseng KF, Lin CF, Lo YH, Hu YL, Chen LY, Yang SH, Lin SR, Chang LS, Wu MJ*: Synthesis and biological evaluation of novel symmetry bis-enediynes. European Journal of Medicinal Chemistry, 2009 Jan. 44(1), 35-41. (SCI)<\/p>\n
14. Chiu CC, Lin KL, Chien CM, Chang LS, Lin SR*: Effects of cardiotoxin III on NF-kappaB function, proliferation, and apoptosis in human breast MCF-7 cancer cells. Oncology Research, 2009 Sep. 17(7), 311-321. (SCI)<\/p>\n
15. Chen KC, Kao PH, Lin SR, Chang LS*: Upregulation of Fas and FasL in Taiwan cobra phospholipase A2-treated human neuroblastoma SK-N-SH cells through ROS- and Ca2+-mediated p38 MAPK activation. Journal of Cellular Biochemistry, 2009 Jan. 106(1), 93-102. (SCI)<\/p>\n
16. Liu WH, Kao PH, Lin SR, Chang LS*: Membrane-damaging activity with A chain and B chain of beta-bungarotoxin. Toxicon, 2009 Feb. 53(2), 262-268. (SCI)<\/p>\n
17. Liu WH, Kao PH, Chiou YL, Lin SR, Wu MJ, Chang LS*: Catalytic activity-independent pathway is involved in phospholipase A(2)-induced apoptotic death of human leukemia U937 cells via Ca(2+)-mediated p38 MAPK activation and mitochondrial depolarization. Toxicology Letters, 2009 Mar. 185(2), 102-109. (SCI)<\/p>\n
18. Kao PH, Lin SR, Chang LS*: Differential binding to phospholipid bilayers modulates membrane-damaging activity of Naja naja atra cardiotoxins. Toxicon, 2009 Sep. 54(3), 321-328. (SCI)<\/p>\n
19. Kao PH, Lin SR, Wu MJ, Chang LS*: Membrane-bound conformation and phospholipid components modulate membrane-damaging activity of Taiwan cobra cardiotoxins. Toxicon, 2009 Apr. 53(5), 512-518. (SCI)<\/p>\n
20. Su JC, Lin KL, Chien CM, Lu CM, Chen YL, Chang LS, Lin SR*: Novel indoloquinoline derivative, IQDMA, induces G(2)\/M phase arrest and apoptosis in A549 cells through JNK\/p38 MAPK signaling activation. Life Sciences, 2009 Sep. 85(13-14), 505-516. (SCI)<\/p>\n
21. Chien CM, Lin KL, Su JC, Chang LS, Lin SR*: Inactivation of epidermal growth factor receptor and downstream pathways in oral squamous cell carcinoma Ca9-22 cells by cardiotoxin III from Naja naja atra. Journal of Natural Products, 2009 Oct. 72(10), 1735-1740. (SCI)<\/p>\n
22. Tu YS, Duh TH, Tseng CY, Lin YT, Lo YH, Hu YL, Chen CH, Chien CM, Yang SH, Lin SR, Yang SC, Wu MJ*: 1-(2-((Z)-6-(2-(Trifluoromethyl)phenyl)hexa-3-en-1,5-diynyl)phenyl)piperidin-2-one as a new potent apoptosis agent. Bioorganic and Medicinal Chemistry, 2009 Nov. 17(21), 7412-7417. (SCI)<\/p>\n
23. Ping SY, Hour TC, Lin SR, Yu DS*: Taxol synergizes with antioxidants in inhibiting hormal refractory prostate cancer cell growth. Urologic Oncology, 2010 Mar-Apr. 28(2), 170-179. (SCI)<\/p>\n
24. Lin KL, Su JC, Chien CM, Tseng CH, Chen YL, Chang LS, Lin SR*: Naphtho[1,2-b]furan-4,5-dione induces apoptosis and S-phase arrest of MDA-MB-231 cells through JNK and ERK signaling activation. Toxicology in Vitro, 2010 Feb. 24(1), 61-70. (SCI)<\/p>\n
25. Su JC, Lin KL, Chien CM, Tseng CH, Chen YL, Chang LS, Lin SR*: Naphtho[1,2-b]furan-4,5-dione inactivates EGFR and PI3K\/Akt signaling pathways in human lung adenocarcinoma A549 cells. Life Sciences, 2010 Jan. 86(5-6), 207-213. (SCI)<\/p>\n
26. Lin KL, Su JC, Chien CM, Chuang PW, Chang LS, Lin SR*: Down-regulation of the JAK2\/PI3K-mediated signaling activation is involved in Taiwan cobra cardiotoxin III-induced apoptosis of human breast MDA-MB-231 cancer cells. Toxicon, 2010 Jun. 55(7), 1263-1273. (SCI)<\/p>\n
27. Lin KL, Su JC, Chien CM, Tseng CH, Chen YL, Chang LS, Lin SR*: Naphtho[1,2-b]furan-4,5-dione disrupts Janus kinase-2 and induces apoptosis in breast cancer MDA-MB-231 cells. Toxicology in Vitro, 2010 Jun. 24(4), 1158-1167. (SCI)<\/p>\n
28. Kao PH, Lin SR, Chang LS*: Interaction of Naja naja atra cardiotoxin 3 with H-trisaccharide modulates its hemolytic activity and membrane-damaging activity. Toxicon, 2010 Jun. 55(7), 1387-1395. (SCI).<\/p>\n
29. Chien CM, Lin KL, Su JC, Chuang PW, Tseng CH, Chen YL, Chang LS, Lin SR*: Naphtho[1,2-b]furan-4,5-dione induces apoptosis of oral squamous cell carcinoma: involvement of EGF receptor\/PI3K\/Akt signaling pathway. European Journal of Pharmacology, 2010 Jun. 636 (1-3), 52-58. (SCI)<\/p>\n
30. Chiu CC*, Chen JY, Lin KL, Huang CJ, Lee JC, Chen BH, Chen WY, Lo YH, Chen YL, Tseng CH, Chen YL*, Lin SR: p38 MAPK and NF-kappaB pathways are involved in naphtho[1,2-b] furan-4,5-dione induced anti-proliferation and apoptosis of human hepatoma cells. Cancer Letters, 2010 Sep. 295(1), 92-99. (SCI)<\/p>\n
31. Su JC, Lin KL, Chien CM, Chuang PW, Chang LS, Lin SR*: Concomitant inactivation of the epidermal growth factor receptor, phosphatidylinositol 3-kinase\/Akt and Janus tyrosine kinase 2\/signal transducer and activator of transcription 3 signalling pathways in cardiotoxin III-treated A549 cells. Clinical and Experimental Pharmacology and Physiology, 2010 Aug. 37(8), 833-840. (SCI)<\/p>\n
32. Chien CM, Chang SY, Lin KL, Chiu CC, Chang LS, Lin SR*: Taiwan cobra cardiotoxin III inhibits Src kinase leading to apoptosis and cell cycle arrest of oral squamous cell carcinoma Ca9-22 cells. Toxicon, 2010 Sep. 56(4), 508-520. (SCI)<\/p>\n
33. Chiou YL, Kao PH, Liu WH, Lin SR, Chang LS*: Roles of lysine residues and N-terminal alpha-amino group in membrane-damaging activity of Taiwan cobra cardiotoxin 3 toward anionic and zwitterionic phospholipid vesicles. Toxicon, 2010 Feb-Mar. 55(2-3), 256-264. (SCI)<\/p>\n
34. Liu WH, Chen KC, Chiou YL, Lin SR, Chang LS*: Taiwan cobra phospholipase A2 elicits posttranscriptional up-regulation of ADAM17 in human neuroblastoma SK-N-SH cells. Journal of Cellular Biochemistry, 2010 Sep. 111(1), 148-157. (SCI)<\/p>\n
35. Tseng CH, Chen YL, Yang SH, Peng SI, Cheng CM, Han CH, Lin SR, Tzeng CC*: Synthesis and antiproliferative evaluation of certain iminonaphtho[2,3-b]furan derivatives. Bioorganic and Medicinal Chemistry, 2010 Jul. 18(14), 5172-5182. (SCI)<\/p>\n
36. Chiou YL, Lin SR, Chang LS*: Lipid domain formation modulates activities of snake venom phospholipase A2 enzymes. Toxicon, 2010 Dec. 56(8), 1362-1371. (SCI)<\/p>\n
37. Su JC., Lin KL, Chien CM, Tseng CH, Chen YL, Chang LS, Lin SR*: Furano-1, 2-naphthoquinone inhibits EGFR signaling associated with G2\/M cell cycle arrest and apoptosis in A549 cells. Cell Biochemistry and Function, 2010 Dec. 28(8), 695-705. (SCI)<\/p>\n
38. Kao PH, Chiou YL, Lin SR, Chang LS*: Guanidination of notexin alters its membrane-damaging activity in response to shingomyelin and cholesterol. Journal of Biosciences, 2010 Dec. 35(4), 583-593. (SCI)<\/p>\n
39. Chen LW, Kao PH, Fu YS, Lin SR, Chang LS*. Membrane-damaging activity of Taiwan cobra cardiotoxin 3 is responsible for its bactericidal activity. Toxicon. 2011 Jul. 58(1), 46-53. (SCI)<\/p>\n
40. Chiou YL, Lin SR, Chang LS*. Sphingomyelin modulates interfacial binding of Taiwan cobra phospholipase A2. Chemistry and Physics of Lipids. 2011 Jul. 164(5), 378-385. (SCI)<\/p>\n
41. Chiou YL, Chen YJ, Lin SR, Chang LS*. Phospholipase A2 activity-dependent and -independent fusogenic activity of Naja nigricollis CMS-9 on zwitterionic and anionic phospholipid vescles. Toxicon. 2011 Nov. 58(6-7), 518-526. (SCI)<\/p>\n
42. Lin KL, Tsai PC, Hsien CY, Chang LS, Lin SR*. Antimetastatic effect and mechanism of ovatodiolide in MDA-MB-231 human breast cancer cells. Chemico-Biological Interactions, 2011 Nov. 194(2-3), 148-158. (SCI)<\/p>\n
43. Kao PH, Chiou YL, Chen YJ, Lin SR, Chang LS*. Guanidination of notexin promotes its phospholipase A(2) activity-independent fusogenicity on vesicles with lipid-supplied negative curvature. Toxicon. 2012. Jan. 59(1), 47-58. (SCI)<\/p>\n
44. Lin KL, Chien CM, Hsien CY, Tsai PC, Chang LS, Lin SR*. Antimetastatic potential of cardiotoxin III involves inactivation of PI3K\/Akt and p38 MAPK signaling pathways in human breast cancer MDA-MB-231 cells. Life Sciences, 2012. Jan. 90(1-2), 54-65. (SCI)<\/p>\n
45. Lin KL, Chien CM, Tseng CH, Chen YL, Chang LS, Lin SR*. Furano-1,2-naphthoquinone inhibits Src and PI3K\/Akt signaling pathways in Ca9-22 human oral aquamous carcinoma cells. Integrative Cancer Therapies, 2012. In press. (SCI)<\/p>\n
46. Kao PH, Lin SR, Hu WP, Chang LS*. Naja naja atra and Naja nigricollis cardiotoxins induce fusion of Escherichia coli and Staphylococcus aureus membrane-mimicking liposomes. Toxicon, 2012, Sep. 60(3), 367-377. (SCI)<\/p>\n
47. Chiou YL, Lin SR, Hu WP, Chang LS*. Quercetin modulates activities of Taiwan cobra phospholipase A2 via its effects on membrane structure and membrane-bound mode of phospholipase A2 . Journal of Biosciences, 2012 Jun. 37(2), 277-287. (SCI)<\/p>\n
48. Tsai PC, Hsieh CY, Chiu CC, Wang CK, Chang LS, Lin SR*. Cardiotoxin III suppresses MDA-MB-231 cell metastasis through the inhibition of EGF\/EGFR-mediated signaling pathway. Toxicon, 2012. Oct. 60(5), 734-743. (SCI)<\/p>\n
49. Hsieh CY, Tsai PC, Tseng CH, Chen YL, Chang LS, Lin SR*: Inhibition of EGF\/EGFR activation with naphtho[1,2-b]furan-4,5-dione blocks migration and invasion of MDA-MB-231 cells. Toxicology in Vitro, 2013. Feb. 27(1), 1-10. (SCI)<\/p>\n
50. Kao PH, Chen YJ, Yang SY, Lin SR, Hu WP, Chang LS*: Fusogenicity of Naja naja atra cardiotoxin-like basic protein on sphingomyelin vesicles containing oxidized phosphatidylcholine and cholesterol. Journal of Biochemistry, 2013. Feb 19, In press. (SCI)<\/p>\n","protected":false},"excerpt":{"rendered":"
1. Chien CM, Yang SH, Yang CC, Chang LS, … \u95b1\u8b80\u5168\u6587