研究著作

2013

  1. Chen YL, Tseng CH, Lo YC, Lin RW, Chen CF, Wang GJ, Ho ML, Tzeng CC “Synthesis of aminoalkoxy substituted 4,5-diphenylisoxazole derivatives as potential anti-osteoporotic agents” Med, Chem. 2013, in pressed. (SCI, IF2011 = 1.496, 42/59 = 71.2%)
  2. Lin KL, Chien CM, Tseng CH, Chen YL, Chang LS, Lin SR “Furano-1,2-Naphthoquinone Inhibits src and pi3k/akt Signaling Pathways in ca9-22 Human Oral Squamous Carcinoma Cells” Integr. Cancer Ther. 2012, in pressed. (SCI, IF2011 = 2.136, 6/22 = 27.3%)
  3. Tseng CH, Cheng CM, Tzeng CC, Peng SI, Yang CL, Chen YL* “Synthesis and Anti-inflammatory Evaluations of β-Lapachone Derivatives”, Bioorg. Med. Chem. 2013, 21, 523-531. (SCI, IF2011 = 2.921; R/C = 21/59, CHEMISTRY, MEDICINAL)
  4. Hsieh CY, Tsai PC, Tseng CH, Chen YL, Chang LS, Lin SR* “Inhibition of EGF/EGFR activation with naphtho[1,2-b]furan-4,5-dione blocks migration and invasion of MDA-MB-231 cells” Toxicology in Vitro, 2013, 27, 1-10.
  5. Tseng CH, Chen YL, Hsu CY, Chen TC, Cheng CM, Tso HC, Lu YJ, Tzeng CC* “Synthesis and antiproliferative evaluation of 3-phenylquinolinylchalcone derivatives against non-small cell lung cancers and breast cancers” Eur. J. Med. Chem. 2013, 59, 274-282. (SCI, IF2011 = 3.346; R/C = 13/59, CHEMISTRY, MEDICINAL)

2012

  1. Liu WH, Chen YL, Chang LS “CIL-102 induces matrix metalloproteinase-2 (MMP-2)/MMP-9 down-regulation via simultaneous suppression of genetic transcription and mRNA stability” Int. J. Biochem. Cell Biol. 2012, 44, 2212-2222. (SCI, IF2011 = 4.634, 67/289 = 23.2%)
  2. Tseng CH, Li CY, Chiu CC, Hu HT, Han CH, Chen YL,* Tzeng CC* “Combretastatin A-4 Derivatives: Synthesis and Evaluation of 2,4,5-Triaryl-1H– imidazoles as Potential Agents Against H1299 (Non-small Cell Lung Cancer Cell)” Mol. Divers. 2012, 16(4), 697-709. (SCI, IF2011 = 3.153, 9/71 = 12.7%)
  3. Fang YP, Wu PC, Huang YB, Tzeng CC, Chen YL, Hung YH, Tsai MJ, Tsai YH “Modification of polyethylene glycol onto solid lipid nanoparticles encapsulating a novel chemotherapeutic agent (PK-L4) to enhance solubility for injection delivery” Int. J. Nanomed. 2012, 7, 4995-5005. (SCI, IF2011 = 3.130; R/C = 70/261,  PHARMACOLOGY & PHARMACY)
  4. Chang MY, Tai HY, Chen YL, Hsu RT “Synthesis of 1,3-diaryl-1H-benzo[g]indazoles” Tetrohedron, 2012, 68, 7941-7948. (SCI, IF2011 = 3.025, 16/56 = 28.6%)
  5. Chang MY, Wu MH, Chen YL “Synthesis of dihydrobenzoimidazo[2,1-a]isoquinolines” Tetrahedron Letts. 2012, 53, 4156-4160. (SCI, IF2011 = 2.683, 19/56 = 33.9%)
  6. Chang MY, Huang YP, Lee TW, Chen YL “Synthesis of dizocilpine” Tetrohedron, 2012, 68, 3283-3287. (SCI, IF2011 = 3.025, 16/56 = 28.6%)
  7. Tsai YR, Huang LJ, Lee MR, Chen YL, Kuo SC, Tzeng CC, Hsu MF, Wang JP “The signaling mechanisms mediating the inhibitory effect of TCH-1116 on formyl peptide-stimulated superoxide anion generation in neutrophils” Eur. J. Pharm. 2012, 682, 171-180. (SCI, IF2011 = 2.516, 108/261 = 41.4%)
  8. Fang YP, Wu PC, Tzeng CC, Chen YL, Lin HL, Tsai YH “A New Antitumor Agent, (3-chloro-7-methoxyfuro[2,3-b]-quinolin-4-yl)-(4-methoxyphenyl) amine, Loaded in Solid Lipid Nanoparticles: Characterization and Pharmacokinetics” Curr. Nanosci., 2012, 8, 266-273. (SCI, IF2011 = 1.776, 76/231 = 32.9%)
  9. Tseng CH, Chen YL, Yang CL, Cheng CM, Han CH, Tzeng CC “Synthesis of 6-Substituted 9-Methoxy-11H-indeno[1,2-c]quinoline-11-one Derivatives as Potential Anticancer Agents” Bioorg. Med. Chem. 2012, 20, 4397-4404. (SCI, IF2011 = 2.921, 17/56 = 30.4%)
  10. Tseng CH, Tzeng CC, Shih PK, Yang CN, Chuang YC, Peng SI, Lin CS, Wang JP, Cheng CM, Chen YL* “Identification of Furo[3′,2′:3,4]naphtho[1,2-d]imidazole Derivatives as Orally Active and Selective Inhibitors of  Microsomal Prostablandin E2 Synthase-1 (mPGES-1)” Mol. Divers. 2012, 16, 215-229. (SCI, IF2011 = 3.153, 9/71 = 12.7%)

2011

  1. Tseng CH, Tzeng CC, Chung KY, Kao CL, Hsu CY, Cheng CM, Hung KS, Chen YL* “Synthesis and antiproliferative evaluation of 6-aryl-11-iminoindeno[1,2-c]quinoline derivatives” Bioorg. Med. Chem. 2011, 19, 7653-7663. (SCI, IF2010 = 2.978, 15/54)
  2. Chang MY, Tai HY, Chen YL “Synthesis of rodocaine.” Tetrahedron 2011, 67, 7673-7680. (SCI, IF2010 = 3.011, 14/56)
  3. Kao CL, Tang YH, Lin YC, Chiu LT, Chen HT, Hsu SC, Hsieh KC, Lu CY, Chen YL “Copper complex of a pyridine-modified poly(amidoamine) dendrimer as a chemical nuclease: synthetic and catalytic study.” Nanomedicine 2011, 7, 273-276. (SCI, IF2010 = 6.202, 12/160)
  4. Chang MY, Lee MF, Chen YL “Synthesis of tetrahydrobenzoisoquinolinols, tetrahydropyrindines, and hexahydroquinolines from 4-aryltetrahydropyridines.” Tetrahedron 2011, 67, 4552-4558. (SCI, IF2010 = 3.011, 14/56)
  5. Chen YW, Chen YL, Tseng CH, Liang CC, Yang CN, Yao YC, Lu PJ, Tzeng CC “Synthesis, Pharmacokinetic, and Anticancer Evaluations of Certain 4-Anilinofuro[2,3-b]quinoline Derivatives” J. Med. Chem. 2011, 54, 4446-4461. (SCI, IF2010 = 5.207, 3/54)
  6. Chen PY, Wang TP, Chiang MY, Huang KS, Tzeng CC, Chen YL, Wang EC “Environmentally benign syntheses of flavanones” Tetrahedron, 2011, 67, 4155-4160. (SCI, IF2010 = 3.011, 14/56)
  7. Tseng CH, Lin RW, Chen YL, Wang GJ, Ho ML, Tzeng CC* “Discovery of Indeno[1,2-c]quinoline Derivatives as Inhibitors of Osteoclastogenesis Induced by Receptor Activator of NF-kB Ligand (RANKL)” J. Med. Chem. 2011, 54, 3103-3107. (SCI, IF2010 = 5.207, 3/54)
  8. Tseng CH, Chen YL, Chung KY, Wang CH, Peng SI, Cheng CM, Tzeng CC* “Synthesis and antiproliferative evaluation of 2,3-diarylquinoline derivatives” Org. Biomol. Chem. 2011, 9, 3205-3216. (SCI, IF2010 = 3.451, 12/56)
  9. Lee CL, Huang CH, Wang HC, Chuang DW, Wu MJ, Wang SY, Hwang TL, Wu CC, Chen YL, Chang FR, Wu YC. “First total synthesis of antrocamphin A and its analogs as anti-inflammatory and anti-platelet aggregation agents.” Org. Biomol. Chem. 2011, 9, 70-73. (SCI, IF2010 = 3.451, 12/56)

2010

  1. Su JC, Lin KL, Chien CM, Tseng CH, Chen YL, Chang LS, Lin SR “Furano-1,2-naphthoquinone inhibits EGFR signaling associated with G2/M cell cycle arrest and apoptosis in A549 cells” Cell Biochem. Funct. 2010, 28, 695–705. (SCI, IF2008 = 1.515, 213/283)
  2. Chang MY, Lin CH, Chen YL, Hsu RT, Chang CY “Pd2(dba)3-promoted synthesis of 3-N-substituted 4-aryl-1,2,3,6-tetrahydropyridine” Tetrahedron Lett. 2010, 51, 4886-4889. (SCI, IF2008 = 2.568, 21/55)
  3. Tseng CH, Tzeng CC, Yang CL, Lu PJ, Chen HL, Li HY, Chuang YC, Yang CN, Chen YL* “Synthesis and antiproliferative evaluation of certain indeno[1,2-c]quinoline derivatives. Part 2” J. Med. Chem. 2010, 53, 6164-6179. (SCI, IF2009 = 4.802, 3/46)
  4. Tseng CH, Chen YL, Yang SH, Peng SI, Cheng CM, Han CH, Lin SR, Tzeng CC* “Synthesis and antiproliferative evaluation of certain iminonaphtho[2,3-b]furan derivatives” Bioorg. Med. Chem. 2010, 18, 5172-5182. (SCI, IF2009 = 2.822, 17/46)
  5. Chiu CC,* Chen JYF, Lin KL, Huang CJ, Chen WY, Han LY, Tseng CH, Chen YL,* Lin SR “p38 MAPK and NFκB pathways are involved in Naphtho[1,2-b] furan-4,5-dione induced anti-proliferation and apoptosis of human hepatoma cells” Cancer Lett. 2010, 295, 92-99. (SCI, IF2009 = 3.741, 52/166)
  6. Lin KL, Su JC, Chien CM, Tseng CH, Chen YL, Chang LS, Lin SR  “Naphtho[1,2-b]furan-4,5-dione disrupts Janus kinase-2 and induces apoptosis in breast cancer MDA-MB-231 cells” Toxicol. In Vitro, 2010, 24, 1158-1167. (SCI, IF2009 = 2.060, 44/77)
  7. Chien CM, Lin KL, Su JC, Chuang PW, Tseng CH, Chen YL, Chang LS, Lin SR “Naphtho[1,2-b]furan-4,5-dione induces apoptosis of oral squamous cell carcinoma: Involvement of EGF receptor/PI3K/Akt signaling pathway” Eur. J. Pharmacol. 2010, 636, 52-58. (SCI, IF2008 = 2.787, 78/219)
  8. Yang PM, Huang WC, Lin YC, Huang WY, Wu HA, Chen WL, Chang YF, Chou CW, Tzeng CC, Chen YL, Chen CC “Loss of IKK beta activity increases p53 stability and p21 expression leading to cell cycle arrest and apoptosis” J. Cell. Mol. Med. 2010, 14, 687-698. (SCI, IF2008 = 5.114, 8/83)
  9. Chang MY, Lin CH, Chen YL, Hsu RT, Chang CY “BF3-promoted synthesis of spiroindenyl heterocycles” Tetrahedron Lett. 2010, 51, 3154-3158. (SCI, IF2008 = 2.568, 21/55)
  10. Chang MY, Lin CH, Chen YL, Chang CY, Hsu RT “BF3-Promoted Synthesis of Diarylhexahydrobenzo[f]isoquinoline” Org. Lett.. 2010, 12, 1176-1179. (SCI, IF2008 = 5.128, 4/55)
  11. Lu CM, Chen YL, Chen HL, Chen CA, Lu PJ, Yang CN, Tzeng CC* “Synthesis and Antiproliferative Evaluation of Certain Indolo[3,2-c]quinoline Derivatives” Bioorg. Med. Chem. 2010, 18, 1948-1957. (SCI, IF2009 = 2.822, 17/46)
  12. Su JC, Lin KL, Chien CM, Tseng CH, Chen YL, Chang LS, Lin SR “Naphtho[1,2-b]furan-4,5-dione inactivates EGFR and PI3K/Akt signaling pathways in human lung adenocarcinoma A549 cells” Life Sci. 2010, 86, 207-213. (SCI, IF2008 = 2.583, 33/83)
  13. Chang MY, Lin CH, Chen YL “Selenium dioxide-mediated methoxyhydroxylation of cyclic arylolefin” Tetrahedron Lett. 2010, 51, 1430-1433. (SCI, IF2008 = 2.568, 21/55)
  14. Lin KL, Su JC, Chien CM, Tseng CH, Chen YL,* Chang LS, Lin SR*  “Naphtho[1,2-b]furan-4,5-dione induces apoptosis and S-phase arrest of MDA-MB-231 cells through JNK and ERK signaling activation” Toxicol. In Vitro, 2010, 24, 61-70. (SCI, IF2009 = 2.060, 44/77)
  15. Chang FS, Chen WC, Wang CH, Tzeng CC, Chen YL* “Synthesis and antiproliferative evaluations of certain 2-phenylvinylquinoline (2-styrylquinoline) and 2-furanylvinylquinoline derivatives” Bioorg. Med. Chem. 2010, 18, 124-133. (SCI, IF2009 = 2.822, 17/46)
  16. Yang CL, Tseng CH, Chen YL, Lu CM, Kao CL, Wu MH, Tzeng CC “Identification of benzofuro[2,3-b]quinoline derivatives as a new class of antituberculosis agents” Eur. J. Med. Chem. 2010, 45, 602-607. (SCI, IF2009 = 3.269, 10/46)

2009

  1. Su JC, Lin KL, Chien CM, Lu CM, Chen YL, Chang LS, Lin SR* “Novel indoloquinoline derivative, IQDMA, induces G2/M phase arrest and apoptosis in A549 cells through JNK/p38 MAPK signaling activation” Life Sci. 2009, 85, 505-516. (SCI, IF2008 = 2.583, 33/83)
  2. Tseng CH, Chen YL, Chung KY, Cheng CM, Wang CH, Tzeng CC* “Synthesis and antiproliferative evaluation of 6-arylindeno[1,2-c]quinoline derivatives” Bioorg. Med. Chem. 2009, 17, 7465-7476. (SCI, IF2008 = 3.078, 12/55)
  3. Wu PC, Huang YB, Chang CK, Chen YL, Tzeng CC, Tsai YH* “Highly sensitive quantitative analysis of 1-[3-(Furo[3,2-c]quinolin-4-ylamino)phenyl]-

ethanone oxime, a new antitumor agent, in rat plasma by LC with electrochemical detection” Chromatographia. 2009, 70, 265-269. (SCI, IF2008 = 1.312, 44/70)

  1. Tseng CH, Lin CS, Shih PK, Tsao LT, Wang JP, Cheng CM, Tzeng CC, Chen YL* “Furo[3′,2′:3,4]naphtho[1,2-d]imidazole Derivatives as Potential Inhibitors of Inflammatory Factors in Sepsis” Bioorg. Med. Chem. 2009, 17, 6773-6779. (SCI, IF2008 = 3.078, 12/55)
  2. Hsien KC, Chen HT, Chen YC, Chen YL, Lu CY, Kao CL* “Pyridoxal 5′-Phosphate Binding in Lysine-Modified PAMAM Dendrimers: A Biomimetic Approach” Org. Lett.. 2009, 11, 3526-3529. (SCI, IF2008 = 5.128, 4/55)
  3. Tseng CH, Chen YL, Lu CM, Wang CK, Tsai YT, Lin RW, Chen CF, Chang YF, Wang GJ, Ho ML, Tzeng CC* “Synthesis and Anti-osteoporotic Evaluation of Certain 3-Amino-2-hydroxypropoxyisoflavone Derivatives” Eur. J. Med. Chem. 2009, 44, 3621-3626. (SCI, IF2008 = 2.882, 13/40)
  4. Lee CH, Hu WP, Hong CH, Yu HS, Liao WT, Chen CY, Chen YL, Chen BH, Chen GS, Wang JJ* “Pyrrolo[2,1-c][1,4]benzodiazepine and indole conjugate (IN6CPBD) has better efficacy and superior safety than the mother compound DC-81 in suppressing the growth of established melanoma in vivo” Chem.-Biol. Interact., 2009, 180(3), 360-367. (SCI, IF2008 = 3.007, 18/75)
  5. Chen YL, Chen YW, Lo WF, Kao CL, Liu YS, Yao CW, Tzeng CC* “Synthesis and antimycobacterial evaluation on arylsulfonyl and arylcarbonyl derivatives of ofloxacin” J. Chin. Chem. Soc., 2009, 55, 374-380. (SCI, IF2008 = 0.770, 80/125)
  6. Huang YL, Cheng YH, Hsien KC, Chen YL, Kao CL* “Concise bromodecarboxylation of cinnamic acids to b-bromostyrenes” Tetrahrdron Lett. 2009, 50, 1834-1837. (SCI, IF2008 = 2.538, 21/55)
  7. Hu WP, Liang JJ, Kao CL, Chen YC, Chen CY, Tsai FY, Wu MJ, Chang LS, Chen YL, Wang JJ* “Synthesis and antitumor activity of novel enediyne-linked pyrrolo[2,1-c][1,4]benzodiazepine hybrids” Bioorg. & Med. Chem. 2009, 17, 1172-1180. (SCI, IF2008 = 3.078, 12/55)

2008

  1. Yang SH, Chien CM, Su JC, Chen YL, Chang LS, Lin SR “Novel indoloquinoline derivative, IQDMA, inhibits STAT5 signaling associated with apoptosis in K562 cells” J. of Biochem.. Mol. Toxic. 2008, 22, 396-404.
  2. Chien CM, Yang SH, Lin KL, Chen YL, Chang LS, Lin SR “Novel indoloquinoline derivative, IQDMA, suppresses STAT5 phosphorylation and induces apoptosis in HL-60 cells” Chem.-Biol. Interact. 2008, 176, 40-47.
  3. Tseng CH, Chen YL, Lu PJ, Yang CN, Tzeng CC “Synthesis and antiproliferative evaluation of certain indeno[1,2-c]quinoline derivatives” Bioorg. & Med. Chem. 2008, 16, 3151-3162. (SCI, IF2007 = 2.662)
  4. Chen YL, Lin HC, Yang CN, Lu PJ, Tzeng CC “Synthesis and antiproliferative evaluation of 4-anilino-n-methoxyfuro[2,3-b]quinoline derivatives (n = 6, 7). Part 5” Chem. & Biodiv. 2008, 4, 267-278.

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