李佳陽 教授 (Professor, Chia-Yang Li)

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連絡電話：07-312-1101 ext. 2759 #425

電子信箱：chiayangli@kmu.edu.tw

辦公位置：國際學術研究大樓7樓IR-758室

ORCID:  https://orcid.org/0000-0001-5689-9850

Google Scholar Link: Publication

專長

Cell metabolism

Herbal immunology

NGS and data analysis

Molecular biology

研究方向

1.探討NLRP3發炎體(Inflammasome)活化對腫瘤微環境中的巨噬細胞與癌細胞之調控機轉。

2.探討外泌體(Exosome)在腫瘤微環境中對巨噬細胞與癌細胞之調控作用。

3.利用基因晶片與次世代定序(Next generation sequencing)於轉錄體的研究與應用。

4.探討眼角膜與視網膜發炎與血管新生之分子調控機制。

5.抗發炎藥物的開發。

學歷

國立清華大學 生醫工程與環境科學系 博士

經歷

高雄醫學大學 醫學研究所 教授（2022/02~迄今）

高雄醫學大學 實驗動物中心 主任（2022/08~迄今）

高雄醫學大學 醫學研究所 副教授 (2019/02~2022/01)

高雄醫學大學 環境保護暨職業安全衛生室 生物安全暨輻射防護組 組長 (2019/08~2022/07)

高雄醫學大學 醫學研究所 助理教授 (2016/08~2019/01)

高雄醫學大學 醫學系基因體醫學科 助理教授 (2013/08~2016/07)

美國德州大學西南醫學中心 泌尿科 博士後研究員 (2012/04~2013/07)

國家衛生研究院 感染症與疫苗研究所 博士後研究員 (2010/09~2012/04)

期刊編輯

1. Experimental and Therapeutic Medicine-Spandidos Publications (SCI, Editor, 2019~present)

2. Biomedicines, Special Issue: Novel Strategy for Treating Castration-Resistant Prostate Cancer (SCI, Guest Editor, October, 2020 ~ August, 2021)

3. Technology in Cancer Research & Treatment-SAGE Publications Inc. (SCI, Editorial Review Board Member, November, 2021~present)

實驗室成員

博士生: 李柏延、柳景豑、耿俊閎 (共同指導)、吳欣恩 (國科會龍門計畫補助公費至美國杜克大學進修兩年)、陳垣汝 (國科會龍門計畫補助公費至美國杜克大學進修兩年)、林子傑、張顥瀚 (共同指導)、沈唐浩 (醫師科學家博士學位學程)、黃荺蒨

碩士生:  李聖怡 (碩二)、高子涵 (五年學碩生)

碩士級研究助理: 武氏紅嬸、曾柏揚

學士級研究助理: 林昕儀

大學專題生: 劉語喆 (醫學五)、陳品蓉 (醫學四)、陳廷恩 (醫學四)、王思涵 (醫學四)、陳宥任 (醫學三)、林育昇 (醫學二)、蘇庭禕 (醫學一)、楊子儀 (醫學一)、黃資尹 (醫學一)

畢業生

博士班: 洪永豊 (與日本早稻田大學Prof. Katsuhiko Suzuki共同指導; 目前於日本順天堂大學擔任博士後研究員)、蘇家震 (奇美醫院泌尿科主治醫師)、張祐誠 (高醫眼科副教授)、羅融 (高長眼科醫師)、黃裕凱 (高醫神經外科主治醫師)

研究助理: 邱方彥 (美國杜蘭大學進修博士)、陳凱吟 (列特博生技)、鄭宇荃 (加拿大留學)、凌雪華 (高醫研究助理)

碩士班: 王郁婷 (高醫研究助理)、凃嘉恩 (國防醫學院博士班進修中)、吳欣恩(高醫研究助理)、賴怡欣(國衛院研究助理)、陳垣汝(高醫研究助理)、王秉鈞(補教業)、林子傑 (高醫心臟內科主治醫師)、黃麒涵 (高醫醫研所博士班)、林珈亘 (高醫研究助理)、王穎瑄 (大江生醫)、黃昱維(高榮醫事檢驗師)、蘇宥錡 (陽明交大臨醫所博士班進修中)、陳琬儒 (義大醫院醫檢師)

大學專題生: 鍾怡如 (台大藥理所碩士班)、李岳珊 (成大生化暨分生所)、吳彥萱 (成大微免所)

代表著作

  1. Li CY, Suen JL, Chiang BL, Lee Chao PD, Fang SH. Morin promotes the production of Th2 cytokine by modulating bone marrow-derived dendritic cells. American Journal of Chinese Medicine. 2006 July ;34(4):667-84. (SCI, IF: 2.959 ; 3/24, 12.5% in Integrative & Complementary Medicine)(本人為第一作者)
  2. Li CY, Chiang CS, Tsai ML, Hseu RS, Shu WY, Chuang CY, Sun YC, Chang YS, Lin JG, Chen CS, Huang CL, Hsu IC. Two-sided effect of Cordyceps sinensis on dendritic cells in different physiological stages. Journal of Leukocyte Biology. 2009 Jun;85(6):987-95. (SCI, IF: 4.165 ; 17/70, 24.2% in Hematology)(本人為第一作者)
  3. Li CY, Hou YC, Chao PDL, Shia CS, Hsu IC, Fang SH. Potential Ex-vivo Immunomodulatory Effects of San-Huang-Xie-Xin-Tang and its Component Herbs on Mice and Humans. Journal of Ethnopharmacology. 2010 Feb 3;127(2):292-8. (SCI, IF: 3.055 ; 2/24, 8.3% in Integrative & Complementary Medicine)(本人為第一作者)
  4. Li CY, Lin HC, Hsueh KC, Wu SF, Fang SH. Oral Administration with Lactobacillus salivarius Inhibits the Allergic Airway Response in Mice. Canadian Journal of Microbiology. 2010 May;56(5):373-9. (SCI, IF: 1.335 ; 122/161, 75.7% in Biotechnology & Applied Microbiology)(本人為第一作者)
  5. Cheng WC, Tsai ML, Chang CW, Huang CL, Chen CR, Shu WY, Lee YS, Wang TH, Hong JH, Li CY, Hsu IC. Microarray Meta-analysis Database (M2DB): A Uniformly Pre-processed, Quality Controlled, and Manually Curated Human Clinical Microarray Database. BMC Bioinformatics. 2010, Aug 10;11(1):421. (SCI, IF: 2.435 ; 10/56, 17.8% in Mathematical & Computational Biology)
  6. Cheng WC, Chang CW, Chen CR, Tsai ML, Shu WY, Li CY, Hsu IC. Identification of Reference Genes across Physiological States for qRT-PCR through Microarray. PLoS One. 2011 Feb 24;6(2):e17347. (IF: 3.057 ; 11/63, 17.4% in Multidisciplinary Sciences)
  7. Li CY, Lin HC, Lu JJY, Fang SH. Immunomodulatory effects of lactobacillus and Bifidobacterium on both murine and human mitogen-activated T cells. International Archives of Allergy and Immunology. 2011;156(2):128-36. (SCI, IF: 2.677 ; 12/25, 48.0% in Allergy)(本人為第一作者)
  8. Li CY, Chao LP, Wang SC, Tsai ML, Chang HZ, Fang SH, Liao PC, Ho CL, Chen ST, Chen WC, Chiang CS, Hua KF, Hsu IC. Honokiol Inhibits LPS-induced Maturation and Inflammatory Response on Human Monocyte-derived Dendritic Cells. Journal of Cellular Physiology. 2011 Sep;226(9):2338-49. (SCI, IF: 4.155 ; 12/83, 14.4% in Physiology)(本人為第一作者)
  9. Cheng WC, Shu WY, Li CY, Tsai ML, Chang CW, Chen CR, Cheng HT, Wang TH, Hsu IC. Intra- and Inter-Individual Variance of Gene Expression in Clinical Studies. PLoS One. 2012;7(6):e38650. (IF: 3.057 ; 11/63, 17.4% in Multidisciplinary Sciences)
  10. Li CY, Chiang CS, Cheng WC, Wang SC, Chang HZ, Chen CR, Shu WY, Tsai ML, Hseu RS, Chang CW, Huang CY, Fang SH, Hsu IC. Gene expression profiling of dendritic cells in different physiological stages under Cordyceps sinensis treatment. PLoS One. 2012;7(7):e40824. (IF: 3.057 ; 11/63, 17.4% in Multidisciplinary Sciences)(本人為第一作者)
  11. Yu GY, He GB, Li CY, Tang M, Grivennikov S, Tsai WT, Wu MS, Hsu CW, Tsai Y, Wang HC, Karin M. Hepatic Expression of Hepatitis C Virus RNA-dependent RNA Polymerase Triggers Innate Immune Signaling and Cytokine Production. Molecular Cell. 2012; Oct 26;48(2):313-21. (SCI, IF: 13.958 ; 4/289, 1.3% in Biochemistry & Molecular Biology)
  12. Lin SP, Li CY, Suzuki K, Chang CK, Chou KM, Fang SH. Green tea consumption after intense taekwondo training enhances salivary defense factors and antibacterial capacity. PLoS One. 2014 Jan 30;9(1):e87580. (IF: 3.057 ; 11/63, 17.4% in Multidisciplinary Sciences)
  13. Li CY, Hsu GS, Suzuki K, Ko MH, Fang SH. Salivary Immuno Factors, Cortisol and Testosterone Responses in Athletes of a Competitive 5,000 m Race. Chinese Journal of Physiology. 2015 Aug 31;58(4):263-9. (SCI, IF: 0.962 ; 74/83, 89.1% in Physiology) 加權分數(J): 2分(本人為第一作者)
  14. Suzuki K, Takahashi M, Li CY, Lin SP, Tomari M, Shing C, Fang SH. The acute effects of green tea and carbohydrate co-ingestion on systemic inflammation and oxidative stress during sprint cycling. Applied Physiology Nutrition and Metabolism. 2015 Oct;40(10):997-1003. (SCI, IF: 1.910 ; 26/82, 31.7% in Sport Sciences)
  15. Chung IF, Chen CY, Su SC, Li CY, Wu KJ, Wang HW, Cheng WC. DriverDBv2: A database for human cancer driver gene research. Nucleic Acids Research. 2016 Jan 4;44(D1):D975-9. (IF: 9.202 ; 18/289, 6.2% in Biochemistry and Molecular Biology)
  16. Cheng HT, Chen CR, Li CY, Huang CY, Shu WY, Hsu IC. The Classification of Sini Decoction Pattern in Traditional Chinese Medicine by Gene Expression Profiling. Evidence-based Complementary and Alternative Medicine. 2016;2016:8239817. (IF: 1.931 ; 7/24, 29.1% in Integrative & Complementary Medicine)
  17. Kuo HF, Liu PL, Chong IW, Liu YP, Chen YH, Ku PM, Li CY, Chen HH, Chiang HC, Wang CL, Chen HJ, Chen YC, Hsieh CC. Pigment Epithelium-Derived Factor Mediates Autophagy and Apoptosis in Myocardial Hypoxia/Reoxygenation Injury. PLoS One. 2016 May 24;11(5):e0156059. (IF: 3.057 ; 11/63, 17.4% in Multidisciplinary Sciences)
  18. Tsai WT, Lo YC, Wu MS, Li CY, Kuo YP, Lai YH, Tsai Y, Chen KC, Chuang TH, Yao CH, Lee JC, Hsu LC, Hsu JT, Yu GY. Mycotoxin patulin suppresses innate immune responses by mitochondrial dysfunction and p62/sequestosome-1-dependent mitophagy. Journal of Biological Chemistry. 2016 Sep 9;291(37):19299-311. doi: 10.1074/jbc.M115.686683. (IF: 4.258 ; 71/289, 24.5% in Biochemistry & Molecular Biology)
  19. Ko MH, Li CY, Lee CF, Chang CK, Fang SH. Scratch wound closure of myoblasts and myotubes is reduced by inflammatory mediators. International Wound Journal. 2016 Oct;13(5):680-5. doi: 10.1111/iwj.12346. (SCI, IF: 2.594 ; 13/61, 21.3% in Dermatology)
  20. Chung IF, Chang SJ, Chen CY, Liu SH, Li CY, Chan CH, Shih CC, Cheng WC. YM500v3: a database for small RNA sequencing in human cancer research. Nucleic Acids Res. 2017 Jan 4;45(D1):D925-D931. doi: 10.1093/nar/gkw1084. (IF: 9.202 ; 18/289, 6.2% in Biochemistry and Molecular Biology)
  21. Wang SC, Lai KR, Li CY, Chiang CS, Yu GY, Sakamoto N, Tu WY, Hsieh MH, Huang JF, Chuang WL, Dai CY, Yu ML. The Paradoxical Effects of Different Hepatitis C Viral Loads on Host DNA Damage and Repair Abilities. PLoS One. 2017 Jan 4;12(1):e0164281. doi: 10.1371/journal.pone.0164281. (IF: 3.057 ; 11/63, 17.4% in Multidisciplinary Sciences)
  22. Hung YL, Fang SH, Wang SC, Cheng WC, Liu PL, Su CC, Chen CS, Huang MY, Hua KF, Shen KH, Wang YT, Suzuki K*, Li CY*. Corylin protects LPS-induced sepsis and attenuates LPS-induced inflammatory response. Scientific Reports. 2017 Apr 11;7:46299. (SCI, IF: 5.228 ; 7/67, 10.4% in Multidisciplinary Sciences)(本人為通訊作者)
  23. Li CY, Suzuki K, Hung YL, Yang MS, Yu CP, Lin PS, Hou YC, Fang SH. Aloe Metabolites Protect LPS-induced Sepsis and Attenuate LPS-induced Inflammatory Response by Inhibiting Mitogen-activated Protein Kinase Activation. American Journal of Chinese Medicine. 2017 May 11:1-15. (SCI, IF: 2.959 ; 3/24, 12.5% in Integrative & Complementary Medicine)(本人為第一作者)
  24. Lin KH, Huang MY, Cheng WC, Wang SC, Fang SH, Tu HP, Su CC, Hung YL, Liu PL, Chen CS, Wang YT, Li CY*. RNA-seq transcriptome analysis of breast cancer cell lines under shikonin treatment. Scientific Reports. 2018 Feb 8;8(1):2672. (SCI, IF: 4.259 ; 10/64, 15.6% in Multidisciplinary Sciences)(本人為通訊作者)
  25. Hung YL, Miyazaki H, Fang SH, Li CY, Suzuki K. The structural characteristics of green tea polyphenols on lipopolysaccharide-stimulated RAW cells. Journal of Nutritional Biology. 2018 2(1):151-157.
  26. Tu HP, Li WM, Pasaribu N, Lee SS, Tsai WC, Li CY, Lin GT, Chuang HY, Tung YC. Risk of incident benign prostatic hyperplasia in patients with gout: a retrospective cohort study. Prostate Cancer and Prostatic Diseases. 2018 Jun 1 (SCI, IF: 3.723 ; 13/77, 16.8% in Urology and Nephrology)
  27. Huang MY, Tu CE, Wang SC, Hung YL, Su CC, Fang SH, Chen CS, Liu PL, Cheng WC, Huang YW, Li CY*. Corylin inhibits LPS-induced inflammatory response and attenuates the activation of NLRP3 inflammasome in microglia. BMC Complementary and Alternative Medicine. 2018 Aug 15;18(1):221. (SCI, IF: 2.109; 8/27, 29.6% in Integrative & Complementary Medicine)(本人為通訊作者)
  28. Huang WT, Chong IW, Chen HL, Li CY, Hsieh CC, Kuo HF, Chang CY, Chen YH, Liu YP, Lu CY, Liu YR, Liu PL. Pigment epithelium-derived factor inhibits lung cancer migration and invasion by upregulating exosomal thrombospondin 1. Cancer Letters. 2019 Feb 442(1):287-298. (SCI, IF: 6.508; 29/229, 12.6% in Oncology)
  29. Yang CY, Hung YL, Tang KW, Wang SC, Tseng CH, Tzeng CC, Liu PL, Li CY*, Chen YL*. Discovery of 2-Substituted 3-Arylquinoline derivatives as potential anti-inflammatory agents through inhibition of LPS-induced inflammatory responses in macrophages. Molecules. 2019 Mar 23;24(6). pii: E1162. (SCI, IF: 3.06; 68/172, 39.5% in Chemistry, Multidisciplinary)(本人為通訊作者)
  30. Su CC, Hsieh KL, Liu PL, Yeh HC, Huang SP, Fang SH, Cheng WC, Huang KH, Chiu FY, Lin IL, Huang MY*, Li CY*. AICAR induces apoptosis and inhibits migration and invasion in prostate cancer cells through an AMPK/mTOR-dependent pathway. International Journal of Molecular Sciences. 2019, 20(7), 1647. (SCI, IF: 4.183; 78/298, 26.1% in Biochemistry & Molecular Biology)(本人為通訊作者)
  31. Hung YL, Wang SC, Suzuki K, Fang SH, Chen CS, Cheng WC, Su CC, Yeh HC, Tu HP, Liu PL, Huang MY, Li CY*. Bavachin attenuates LPS-induced inflammatory response and inhibits the activation of NLRP3 inflammasome in macrophages. Phytomedicine. 2019 June 59, 152785. (SCI, IF: 4.18; 1/27, 3.7% in Integrative & Complementary Medicine)(本人為通訊作者)
  32. Kuo HF, Hsieh CC, Wang SC, Chang CY, Hung CH, Kuo PL, Liu YR, Li CY*, Liu PL*. Simvastatin attenuates cardiac fibrosis via regulation of cardiomyocyte-derived exosome secretion. Journal of Clinical Medicine. 2019 June 8(6), 794. (SCI, IF: 5.688; 15/160, 9.3% in Medicine, General & Internal)(本人為通訊作者)
  33. Hsieh CC, Li CY, Hsu CH, Chen HL, Chen YH, Liu YP, Liu YR, Kuo HF*, Liu PL*. Mitochondrial protection by simvastatin against Angiotensin II-mediated heart failure. British Journal of Pharmacology. 2019 Oct;176(19):3791-3804. (SCI, IF: 6.583; 14/267, 5.2% in Pharmacology & Pharmacy)
  34. Liu SH, Shen PC, Chen CY, Hsu AN, Cho YC, Lai YL, Chen FH, Li CY, Wang SC, Chen M, Chung IF, Cheng WC. DriverDBv3: a multi-omics database for cancer driver gene research. Nucleic Acids Research. 2020 Jan 8;48(D1):D863-D870. (IF: 11.147 ; 14/298, 4.6% in Biochemistry and Molecular Biology).
  35. Yeh HC, Li CC, Wen SC, Singla N, Woldu SL, Robyak H, Huang CN, Ke HL, Li WM, Lee HY, Li CY, Yeh BW, Yang SF, Tu HP, Shariat SF, Sagalowsky AI, Raman JD, Lotan Y, Hsieh JT, Margulis V, Wu WJ. Validation of Hyponatremia as a Prognostic Predictor in Multiregional Upper Tract Urothelial Carcinoma. Journal of Clinical Medicine. 2020 Apr 23;9(4):1218. (SCI, IF: 3.303; 35/165, 21.2% in Medicine, General & Internal)
  36. Huang YK, Su YF, Lieu AS, Loh JK, Li CY, Wu CH, Kuo KL, Lin CL. MiR-1271 regulates glioblastoma cell proliferation and invasion by directly targeting the CAMKK2 gene. Neuroscience Letters. 2020 Oct 15;737:135289. (SCI, IF: 2.274; 200/272, 73.5% in Neurosciences)
  37. Chang YC, Lin CW, Chang YS, Chen PH, Li CY, Wu WC, Kao YH. Monounsaturated oleic acid modulates autophagy flux and upregulates angiogenic factor production in human retinal pigment epithelial ARPE-19 cells. Life Sciences. 2020 Oct 15;259:118391. (SCI, IF: 3.647; 76/271, 28.0% in Pharmacology and Pharmacy)
  38. Chuang YC, Chang HM, Li CY, Cui Y, Lee CL, Chen CS. Reactive Oxygen Species and Inflammatory Responses of Macrophages to Substrates with Physiological Stiffness. ACS Applied Materials and Interfaces. 2020 Oct 28;12(43):48432-48441. (SCI, IF: 8.758; 33/314, 10.5% in Materials Science, Multidisciplinary)
  39. Tung YC, Lee MY, Wang YC, Chang CJ, Tsai WC, Lin GT, Li CY, Lee SS, Tu HP. Effect modification of hyperlipidemia and hypertension on the association between type 2 diabetes and gout. Primary Care Diabetes. 2020 Dec 14(6):654-662 (SCI, IF: 2.052; 9/19, 47.3% in Primary Health Care)
  40. Chang WT, Bow YD, Fu PR, Li CY, Wu CY, Chang YH, Teng YN, Li RN, Lu MC, Liu SF, Chiu CC*. A marine terpenoid heteronemin induces both apoptosis and ferroptosis of hepatocellular carcinoma cells and involves ROS and MAPK pathways. Oxidative Medicine and Cellular Longevity. 2021 Jan 4;2021:7689045.(JCR2020, IF: 6.543; 54/195, 27.6% in Cell Biology)
  41. Lai YH, Lee PY, Lu CY,  Liu YR, Wang SC, Liu CC, Chang YC, Chen YH, Su CC, Li CY*, Liu PL*. Thrombospondin 1-induced exosomal proteins attenuate hypoxia-induced paraptosis in corneal epithelial cells and promote wound healing. FASEB Journal. 2021 Jan;35(1):e21200. (JCR2020, IF: 5.191; 14/93, 15.0% in Biology)(本人為通訊作者)
  42. Yeh HC, Li CC, Chien TM, Li CY, Cheng YC, Woldu SL, Robyak H, Huang CN, Ke HL, Li WM, Lee HY, Yeh BW, Yang SF, Tu HP, Sagalowsky AI, Raman JD, Singla N, Margulis V, Lotan Y, Hsieh JT, Wu WJ. Interethnic differences in the impact of body mass index on upper tract urothelial carcinoma following radical nephroureterectomy. World Journal of Urology. 2021 Feb;39(2):491-500.(JCR2020, IF: 4.226; 21/90, 23.3% in Urology and Nephrology)
  43. Chang YS, Chang YC, Chen PH, Li CY, Wu WC, Kao YH. MicroRNA-100 Mediates Hydrogen Peroxide-Induced Apoptosis of Human Retinal Pigment Epithelium ARPE-19 Cells. Pharmaceuticals. 2021 Apr 1;14(4):314. (JCR2020, IF: 5.863; 35/275, 12.7% in Pharmacology & Pharmacy)
  44. Wang SC, Li CY, Chang WT, Cheng WC, Yen CH, Tu WY, Lin ZY, Lin CC, Yeh ML, Huang CF, Huang JF, Dai CY, Chuang WL, Chen YL*, Yu ML*. Exosome-derived differentiation antagonizing non-protein coding RNA with risk of HCV-related hepatocellular carcinoma recurrence. Liver International. 2021 May;41(5):956-968. (JCR2020, IF: 5.828; 25/92, 27.1% in Gastroenterology & Hepatology)
  45. Lin TY, Tsai MC, Tu W, Yeh HC, Wang SC, Huang SP*, Li CY*. Role of the NLRP3 Inflammasome: Insights into Cancer Hallmarks. Frontiers in Immunology. 2021 Feb 3;11:610492. (JCR2020, IF: 7.561; 24/162, 14.8% in Immunology)(本人為通訊作者)
  46. Chang WT, Bow YD, Chen YC, Li CY, Chen J. YF, Chu YC, Teng YN, Li RN, Chiu CC*. The Phenoxyphenol Compound diTFPP Mediates Exogenous C2-Ceramide Metabolism, Inducing Cell Apoptosis Accompanied by ROS Formation and Autophagy in Hepatocellular Carcinoma Cells. Antioxidants. 2021 Mar 5;10(3):394. (JCR2020, IF: 6.312; 11/144, 7.9% in Food science & Technology)
  47. Liu WL, Li CY, Cheng WC, Chang CY, Chen YH, Lu CY, Wang SC, Liu YR, Cheng MH*, Chong IW*, Liu PL*. High Mobility Group Box 1 Promotes Lung Cancer Cell Migration and Motility via Regulation of Dynamin-Related Protein 1. International Journal of Molecular Sciences. 2021 Mar 31;22(7):3628. (JCR2020, IF: 5.923; 67/298, 22.4% in Biochemistry & Molecular Biology)
  48. Liu SH, Hsu KW, Lai YO, Lin YF, Chen FH, Peng PH, Lin LJ, Wu HH, Li CY, Wang SC, Wu MZ, Sher YP*, Cheng WC*. Systematic identification of clinically relevant miRNAs for potential miRNA-based therapy in lung adenocarcinoma. Molecular Therapy-Nucleic Acids. 2021 May 1;25:1-10. (JCR2020, IF: 8.886; 13/140, 9.2% in Medicine, Research & Experimental)
  49. Wang SH, Huang SP, Pan YJ, Hsiao PC, Li CY, Chen LC, Yu CC, Huang CY, Lin VC, Lu TL, Bao BY*. Association between the polygenic liabilities for prostate cancer and breast cancer with biochemical recurrence after radical prostatectomy for localized prostate cancer. American Journal of Cancer Research. 2021 May 15;11(5):2331-2342. (JCR2020, IF: 6.166; 64/242, 26.4% in Oncology)
  50. Su CC, Wang SC, Chen IC, Chiu FY, Liu PL, Huang CH, Huang KH, Fang SH, Cheng WC, Huang SP, Yeh HC, Liu CC, Lee PY, Huang MY, Li CY*. Zerumbone suppresses the LPS-induced inflammatory response and represses activation of the NLRP3 inflammasome in macrophages. Frontiers in Pharmacology. 2021 May 11;12:652860. (JCR2020, IF: 5.810; 39/275, 14.1% in Pharmacology & Pharmacy)(本人為通訊作者)
  51. Su YC, Wen SC, Li CC, Su HC, Ke HL, Li WM, Lee HY, Li CY, Yang SF, Tu HP, Wu WJ,  Yeh HC*. Low Hemoglobin-to-Red Cell Distribution Width Ratio Is Associated with Disease Progression and Poor Prognosis in Upper Tract Urothelial Carcinoma. Biomedicines. 2021 Jun 11;9(6):672. (JCR2020, IF: 6.081; 32/275, 11.6% in Pharmacology & Pharmacy)
  52. Huang CH, Wang SC, Chen IC, Chen YT, Liu PL, Fang SH, Huang SP, Yeh HC, Liu CC, Lee PY, Lin TC, Cheng WC, Su CC, Wu HE, Chen YR, Li CY*. Protective effect of piplartine against LPS-induced sepsis through attenuating the MAPKs/NF-κB signaling pathway and NLRP3 inflammasome activation. Pharmaceuticals. 2021 June 14, 588. (JCR2020, IF: 5.863; 35/275, 12.7% in Pharmacology & Pharmacy)(本人為通訊作者)
  53. Chao J. YC, Chang HC, Jiang JK, Yang CY, Chen FH, Lai YL, Lin WJ, Li CY, Wang SC, Yang MH, Lin YF, Cheng WC*. Using bioinformatics approaches to investigate driver genes and identify BCL7A as a prognostic gene in colorectal cancer. Computational and Structural Biotechnology Journal. 2021 July 19, 3923-3929. (JCR2020, IF: 7.271; 45/298, 15.1% in Biochemistry & Molecular Biology)
  54. Hsu SK, Li CY, Lin IL, Syue WJ, Chen YF, Cheng KC, Teng YN, Lin YH, Yen CH, Chiu CC*. Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment. Theranostics. 2021 Aug 12;11(18):8813-8835. (JCR2020, IF: 11.556; 9/140, 6.4% in Medicine, Research & Experimental)
  55. Lee PY, Liu CC, Wang SC, Chen KY, Lin TZ, Liu PL, Chiu CC, Chen IC, Lai YH, Cheng WC, Chung WJ, Yeh HC, Huang CH, Su CC, Huang SP, Li CY*. Mycotoxin Zearalenone Attenuates Innate Immune Responses and Suppresses NLRP3 Inflammasome Activation in LPS-Activated Macrophages. Toxins. 2021 Aug 25;13(9):593. (JCR2020, IF: 4.546; 21/93, 22.5% in Toxicology)(本人為通訊作者)
  56. Lee PY, Lai YH, Liu PL, Liu CC, Su CC, Chiu FY, Cheng WC, Hsu SL, Cheng KC, Chiu LY, Kao TE, Lin CC, Chang YC, Wang SC*, Li CY*. Toxicity of amantadine hydrochloride on cultured bovine cornea endothelial cells. Scientific Reports. 2021 Sep 16;11(1):18514. (JCR2020, IF: 4.379; 17/73, 23.2% in Multidisciplinary Sciences)(本人為通訊作者)
  57. Hsu CH, Liu IF, Kuo HF, Li CY, Lian WS, Chang CY, Chen YH, Liu WL, Lu CY, Liu YR, Lin TC, Lee TY, Huang CY, Hsieh CC* and Liu PL*. miR-29a-3p/THBS2 axis regulates PAH-induced cardiac fibrosis. International Journal of Molecular Sciences. 2021, 22(19), 10574. (JCR2020, IF: 5.923; 67/298, 22.4% in Biochemistry & Molecular Biology)
  58. Shabangu CS, Siphepho PY, Li CY, Cheng WC, Lu MY, Huang CF, Yeh ML, Dai CY, Huang JF, Chuang WL, Lin ZY, Yu ML, Wang SC*. The Persistence of Hepatitis C Virus Infection in Hepatocytes Promotes Hepatocellular Carcinoma Progression by Pro-Inflammatory Interluekin-8 Expression. Biomedicines. 2021, 9, 1446. (JCR2020, IF: 6.081; 32/275, 11.6% in Pharmacology & Pharmacy)
  59. Kuo HF, Liu IF, Li CY, Tsai CS, Chen YH, Lian WS, Lin TC, Liu YR, Lee TY, Huang CY, Hsieh CC*, Hsu CH*, Lin FY*, Liu PL*. Endocardial endothelial dysfunction and unknown polymor-phic composite accumulation in heart failure. Biomedicines. 2021, 9, 1465. (JCR2020, IF: 6.081; 32/275, 11.6% in Pharmacology & Pharmacy)
  60. Chen IC, Wang SC, Chen YT, Tseng HH, Liu PL, Lin TC, Wu HE, Chen YR, Tseng YH, Hsu JH, Dai ZK, Suen JL*, Li CY*. Corylin ameliorates LPS-induced acute lung injury via sup-pressing the MAPKs and IL-6/STAT3 signaling pathways. Pharmaceuticals. 2021, 14(10), 1046. (JCR2020, IF: 5.863; 35/275, 12.7% in Pharmacology & Pharmacy)(本人為通訊作者)
  61. Teng PC, Huang SP, Liu CH, Lin TY, Cho YC. Lai YL, Wang SC, Yeh HC, Chuu CP, Chen DN, Cheng WC*, Li CY*. Identification of DNA Damage Repair-Associated Prognostic Biomarkers for Prostate Cancer Using Transcriptomic Data Analysis. International Journal of Molecular Sciences. 2021, 22, 11771. (JCR2020, IF: 5.923; 67/298, 22.4% in Biochemistry & Molecular Biology)(本人為通訊作者)
  62. Chien TM, Lee HY, Singla N, Margulis V, Lotan Y, Woldu SL, Huang CN, Li CC, Ke HL, Li WM, Li CY, Huang AM, Yang SF, Tu HP, Wu WJ, Yeh HC*. Prognostic Factors for Contralateral Recurrence of Upper Tract Urothelial Carcinoma after Nephroureterectomy: A Large Multiregional Study. Cancers. 2021 Nov 25;13(23):5935. (JCR2020, IF: 6.639; 51/242, 21.0% in Oncology)
  63. Lai YL, Liu CH, Wang SC, Huang SP, Cho YC, Bao BY, Su CC, Yeh HC, Lee CH, Teng PC, Chuu CP, Chen DN, Li CY*, Cheng WC*. Identification of a steroid hormone-associated gene signature predicting the prognosis of prostate cancer through an integra-tive bioinformatics analysis. Cancers. 2022 Mar 19;14(6):1565. (JCR2021, IF: 6.575; 60/245, 24.4% in Oncology)(本人為通訊作者)
  64. Yeh HC, Su CC, Wu YH, Lee CH, Bao BY, Cheng WC, Wang SC, Liu PL, Chiu CC, Chuu CP, Ke CC, Wu HE, Chen YR, Chung WJ, Huang SP*, Li CY*. Novel insights into the anti-cancer effects of 3-bromopyruvic acid against castration-resistant prostate cancer. European Journal of Pharmacology. 2022 Mar. 29;923:174929. (JCR2021, IF: 5.195; 71/279, 25.4% in Pharmacology & Pharmacy)(本人為通訊作者)
  65. Chen IC, Liu YC, Wu YH, Lo SH, Wang SC, Li CY, Dai ZK, Hsu JH, Yeh CY, Tseng YH. Proteasome Inhibitors Decrease the Viability of Pulmonary Arterial Smooth Muscle Cells by Restoring Mitofusin-2 Expression under Hypoxic Conditions. Biomedicines. 2022 Apr. 9;10(4):873. (JCR2021, IF: 4.757; 86/279, 30.8% in Pharmacology & Pharmacy)
  66. Lin TW, Lee HY, Yang SF, Li CC, Ke HL, Li WM, Li CY, Tu HP, Wu WJ, Yeh HC*. Perineural Invasion is a Powerful Prognostic Factor for Upper Tract Urothelial Carcinoma Following Radical Nephroureterectomy. Annals of Surgical Oncology. 2022 May; 29(5):3306-3317. (JCR2021, IF: 4.339; 37/211, 17.5% in Surgery)
  67. Li CY, Huang SP, Chen YT, Wu HE, Cheng WC, Huang CY, Yu CC, Lin VC, Geng JH, Lu TL, Bao BY. TNFRSF13B is a potential contributor to prostate cancer. Cancer Cell International. 2022 May. 22(1):180. (JCR2021, IF: 6.436; 63/245, 25.7% in Oncology)(本人為第一作者)
  68. Tseng HH, Li CY, Wu ST, Su HH, Wong TH, Wu HE, Chang YW, Huang SK, Tsai EM, Suen JL. Di-(2-ethylhexyl) Phthalate Promotes Allergic Lung Inflammation by Modulating CD8α+ Dendritic Cell Differentiation via Metabolite MEHP-PPARγ Axis. Frontiers in Immunology. 2022 May 19;13:581854. (JCR2021, IF: 8.786; 33/161, 20.4% in Immunology)
  69. Wang BJ, Huang SH, Kao CL, Muller CJF, Wang YP, Chang KH, Wen HC, Yeh CC, Shih LJ, Kao YH, Huang SP, Li CY, Chuu CP. Aspalathus linearis suppresses cell survival and proliferation of enzalutamide-resistant prostate cancer cells via inhibition of c-Myc and stability of androgen receptor. PLoS One. 2022 Jul 1;17(7):e0270803. (JCR2021, IF: 3.752; 29/73, 39.7% in Multidisciplinary Sciences)
  70. Liu CH, Liu SH, Lai YL, Cho YC, Chen FH, Lin LJ, Peng PH, Li CY, Wang SC, Chen JL, Wu HH, Wu MZ, Sher YP, Cheng WC, Hsu KW. Using bioinformatics approaches to identify survival-related oncomiRs as potential targets of miRNA-based treatments for lung adenocarcinoma. Computational and Structural Biotechnology Journal. 2022 Aug 22;20:4626-4635. (JCR2021, IF: 6.155; 70/296, 23.6% in Biochemistry & Molecular Biology)
  71. Lo J, Liu CC, Li YS, Lee PY, Liu PL, Wu PC, Lin TC, Chen CS, Chiu CC, Lai YH, Chang YC, Wu HE, Chen YR, Huang YK, Huang SP, Wang SC*, Li CY*. Punicalagin Attenuates LPS-induced Inflammation and ROS Production in Microglia by Inhibiting the MAPK/NF-κB Signaling Pathway and NLRP3 Inflammasome Activation. Journal of Inflammation Research. 2022 Sep 15;15:5347-5359. (JCR2021, IF: 4.631; 83/161, 51.5% in Immunology)(本人為通訊作者)
  72. Chen YR, Wang SC, Huang SP, Su CC, Liu PL, Cheng WC, Chuu CP, Chen JK, Bao BY, Lee CH, Ke CC, Wu HE, Chang HH, Yeh HC*, Li CY*. Protodioscin inhibits bladder cancer cell migration and growth, and promotes apoptosis through activating JNK and p38 signaling pathways. Biomedicine & Pharmacotherapy. 2022 Dec. 156; 113929 (JCR2021, IF: 7.419; 26/279, 9.3% in Pharmacology & Pharmacy)(本人為通訊作者)
  73. Lai YH, Liu WL, Lee TY, Kuo CW, Liu YR, Huang CY, Chen YH, Chen IL, Wu SZ, Wang SC, Lee PY, Liu CC, Lo J, Chang YC, Kuo HF, Hsieh CC, Li CY*, Liu PL*. Magnolol regulates miR-200c-3p to inhibit epithelial–mesenchymal transition and retinoblastoma progression by modulating the ZEB1/E-cadherin axis in vitro and in vivo. Phytomedicine. 2023 Feb:110:154597. (JCR2022, IF: 7.9; 1/28, 3.5% in Integrative & Complementary Medicine)(本人為通訊作者)
  74. Liu IF, Lin TC, Wang SC, Yen CH, Li CY, Kuo HF, Hsieh CC, Chang CY, Chang CR, Chen YH, Liu YR, Lee TY, Huang CY, Hsu CH, Lin SJ, Liu PL. Long-term administration of Western diet induced metabolic syndrome in mice and causes cardiac microvascular dysfunction, cardiomyocyte mitochondrial damage, and cardiac remodeling involving caveolae and caveolin-1 expression. Biology Direct. 2023 Mar 6;18(1):9. (JCR2022, IF: 5.5; 13/92, 14.1% in Biology)
  75. Chen LC, Huang SP, Shih CT, Li CY, Chen YT, Huang CY, Yu CC, Lin VC, Lee CH, Geng JH, Bao BY. ATP8B1: A prognostic prostate cancer biomarker identified via genetic analysis. Prostate. 2023 May;83(6):602-611. (JCR2022, IF: 2.8; 40/88, 45.4% in Urology & Nephrology)
  76. Lo J, Wu HE, Liu CC, Chang KC, Lee PY, Liu PL, Huang SP, Wu PC, Lin TC, Lai YH, Chang YC, Chen YR, Lee SI, Huang YK, Wang SC*, Li CY*. Nordalbergin exerts anti-neuroinflammatory effects by attenuating MAPK signaling pathway, NLRP3 inflammasome activation and ROS production in LPS-activated BV2 microglia. International Journal of Molecular Sciences. 2023 April 14;24(8):7300.(JCR2022, IF: 5.6; 66/285, 23.1% in Biochemistry & Molecular Biology)(本人為通訊作者)
  77. Huang YK, Chang KC, Li CY, Lieu AS, Lin CL*. AKR1B1 represses glioma cell proliferation through p38 MAPK-mediated Bcl-2/BAX/caspase-3 apoptotic signaling pathways. Current Issues in Molecular Biology. 2023 Apr 13;45(4):3391-3405 (JCR2022, IF: 3.1; 173/285, 60.7% in Biochemistry & Molecular Biology)
  78. Wu HE, Su CC, Wang SC, Liu PL, Cheng WC, Yeh HC, Chuu CP, Chen JK, Bao BY, Lee CH, Ke CC, Chen YR, Yu YH, Huang SP*, Li CY*. Anti-cancer effects of morusin in prostate cancer via inhibition of Akt/mTOR signaling pathway. American Journal of Chinese Medicine. 2023 Apr 29:1-21. (JCR2022, IF: 5.7; 3/28, 10.7% in Integrative & Complementary Medicine)(本人為通訊作者)
  79. Hsu SK, Chen YE, Shu ED, Ko CC, Chang WT, Lin IL, Li CY, Gallego RP, Chiu CC. The Pyroptotic and Nonpyroptotic Roles of Gasdermins in Modulating Cancer Progression and Their Perspectives on Cancer Therapeutics. Archivum Immunologiae et Therapiae Experimentalis. 2023 May 31;71(1):14. (JCR2022, IF: 3.2; 110/161, 68.3% in Immunology)
  80. Yu LY, Hsu CH, Li CY, Hong SY, Chen CR, Chen CS. Evaluating the Biological Effectiveness of Boron Neutron Capture Therapy by Using Microfluidic-Based Pancreatic Tumor Spheroids. Analyst. 2023 Jun 26;148(13):3045-3056. (JCR2022, IF: 4.2; 24/86, 27.9% in Chemistry, Analytical)
  81. Chien HT#, Li CY#, Su WH, Chang KC, Chen CS, Liu YT, Chen CY, Dai CY, Wang SC. Multi-omics profiling of chemotactic characteristics of brain microglia and astrocytoma. Life Sciences. 2023 Jul 5;330:121855. (JCR2022, IF: 6.1; 35/277, 12.6% in Pharmacology & Pharmacy)(本人為第一作者)
  82. Chiu CC, Cheng KC, Lin YH, He CX, Bow YD, Li CY, Wu CY, Wang HD, Sheu SJ. Prolonged Exposure to High Glucose Induces Premature Senescence Through Oxidative Stress and Autophagy in Retinal Pigment Epithelial Cells. Archivum Immunologiae et Therapiae Experimentalis. 2023 Aug 28;71(1):21. (JCR2022, IF: 3.2; 110/161, 68.3% in Immunology)
  83. Yazal T, Lee PY, Chen PR, Chen IC, Liu PL, Chen YR, Tzu-Chieh Lin TC, Chen YT, Huang SP, Yeh HC, Liu CC, Lo J, Wu HE, S Wang SC*, Li CY*. Kurarinone exerts anti-inflammatory effect via reducing ROS production, suppressing NLRP3 inflammasome, and protecting against LPS-induced sepsis. Biomedicine & Pharmacotherapy. 2023 Oct; 167:115619. (JCR2022, IF: 7.5; 23/277, 8.3% in Pharmacology & Pharmacy)(本人為通訊作者)
  84. Jhunjhunwala M, Yu LS, Kuo PC, Li CY, Chen CS*. Tumor-Derived Membrane Vesicles Restrain Migration in Gliomas By Altering Collective Polarization. ACS Applied Bio Materials. 2023 Nov 20;6(11):4764-4774. (JCR2022, IF: 4.7; 68/141, 48.2% in Nanoscience & Nanotechnology)
  85. Sulistyowati E, Huang SE, Cheng TL, Chao YY, Li CY, Chang CW, Lin MX, Lin MC, Yeh JL. Vasculoprotective Potential of Baicalein in Angiotensin II-Infused Abdominal Aortic Aneurysms through Inhibiting Inflammation and Oxidative Stress. International Journal of Molecular Sciences. 2023 24(21), 16004. (JCR2022, IF: 5.6; 66/285, 23.1% in Biochemistry & Molecular Biology)
  86. Liu CH, Lai YL, Shen PC, Liu HC, Tsai MH, Wang YD, Lin WJ, Chen FH, Li CY, Wang SC, Hung MC, Cheng WC. DriverDBv4: A Multi-Omics Integration Database for Cancer Driver Gene Research. Nucleic Acids Research. 2024 Jan 5;52(D1):D1246-D1252. (JCR2022, IF: 14.9; 10/285, 3.5% in Biochemistry & Molecular Biology)
  87. Chen JY, Chang CF, Huang SP, Huang CY, Yu CC, Lin VC, Geng JH, Li CY, Lu TL, Bao BY. Integrated analysis identifies GABRB3 as a biomarker in prostate cancer. BMC Medical Genomics. 2024 Jan 29;17(1):41. (JCR2022, IF: 2.7; 98/171, 57.3% in Genetics & Heredity)
  88. Tsai YC, Huang SP, Cheng WC, Fan YC, Lin YC, Tsai SY, Huang CY, Yu CC, Lin VC, Gen JH, Li CY, Lu TL, Bao BY. Identifying the role of MTHFD1L in prostate cancer progression from genetic analysis and experimental validation. American Journal of Cancer Research. 2024 Jan 15;14(1):169-181. (JCR2022, IF: 5.3; 70/241, 29.0% in Oncology)
  89. Su HH, Cheng CM, Yang YN, Chang YW, Li CY, Wu ST, Lin CC, Wu HE, Suen JL. Acrylamide, an Air Pollutant, Enhances Allergen-Induced Eosinophilic Lung Inflammation via Group 2 Innate Lymphoid Cells. Mucosal Immunology. 2023 Oct 5:S1933-0219(23)00073-9. (JCR2022, IF: 8.0; 29/161, 18.0% in Immunology)
  90. Shabangu CS, Su WH, Li CY, Yu ML, Dai CY, Huang JF, Chuang WL, Wang SC*. Systematic integration of molecular and clinical approaches in HCV‑induced hepatocellular carcinoma. Journal of Translational Medicine. 2024 Mar 12;22(1):268. (JCR2022, IF: 7.4; 29/136, 21.3% in Medicine, Research & Experimental)
  91. Kuo YY, Huo C, Li CY, Chuu CP. Caffeic acid phenethyl ester suppresses the expression of androgen receptor variant 7 via inhibition of CDK1 and AKT. Cancer Gene Therapy. 2024 Mar 13. (JCR2022, IF: 6.4; 22/171, 21.3% in Genetics & Heredity)
  92. Cheng MH, Kuo HF, Chang CY, Chang JC, Liu IF, Hsieh CC, Hsu CH, Li CY, Wang SC, Chen YH, Chang CR, Lee TY, Liu YR, Huang CY, Wu SH, Liu WL, Liu PL. Curcumin regulates pulmonary extracellular matrix remodeling and mitochondrial function to attenuate pulmonary fibrosis by regulating the miR-29a-3p/DNMT3A axis. Biomedicine & Pharmacotherapy. 2024 May; 174:116572. (JCR2022, IF: 7.5; 23/277, 8.3% in Pharmacology & Pharmacy)

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