Welcome to The Jeh-Jeng Wang Group

Lab: Bioorganic Chemistry Laboratory (N842)

Tel: 886-7-3121101 ext. 2275

Fax: 886-7-3125339

E-mail: jjwang@kmu.edu.tw

 

Education and Experience:

  • B.S., Chemistry, National Chung-Hsing University, Taiwan (1975-1979)
  • Ph.D., Chemistry, The Ohio State Univ. USA (1983-1989)
  • Teaching Assistant, National Chung-Hsing University, Taiwan (1981-1983)
  • Postdoctoral fellow, College of Pharmacy, Univ. of Texas at Austin (1989-1991)
  • Associate Professor, Department of Medicinal and Applied Chemistry, Kaohsiung Medical University (1991-2001
  • Professor, Department of Medicinal and Applied Chemistry, Kaohsiung Medical University (2001-).
  • Director, Preparatory Office of Department of Biotechnology, Kaohsiung Medical University (2002-2003).
  • Chairman, Department of Biotechnology, Kaohsiung Medical University (2003-2004).
  • Dean, College of Life Sciences, Kaohsiung Medical University (2006 -2012).

Research Interests:

  • Design and synthesis of biological active compounds.
  • Organic reaction study.
  • Chemical biology.

 

Publications :

  1. Vishal Suresh Kudale, Ching-Piao Chu , and Jeh-Jeng Wang*, “Selective C3-nitrosation of imidazopyridines using AgNO3 as the NO source.” New J. Chem., 2022, Accepted Manuscript.
  2. Mohana Reddy Mutra, Jing Li, Yu-Ting Chen and Jeh-Jeng Wang*, “Time-Atom Economical Regio-and Chemoselective Radical Cyclization of Unactivated 1,6-Enynes under Metal- and Oxidant-free Conditions.” Chem. Eur. J. 2022,28, e202200742.
  3. Mohana Reddy Mutra and Jeh-Jeng Wang*, “Photoinduced ynamide structural reshuffling and functionalization. ” Nature Communications, 2022, 13, 2345.
  4. Babasaheb Sopan Gore, Chiao-Ying Kuo and  Jeh-Jeng Wang*, “ Visible light-assisted Ni-/Ir-catalysed atom-economic synthesis of spiro[furan-3,10 -indene] derivatives. ” Commun., 2022, 58, 4087-4090.
  5. Vishal Suresh Kudale, Sheng Zheng, Sheng-Hua Huang, Yu-Lun Chang and Jeh-Jeng Wang*, “ A Metal-Free Strategy for the Cross-Dehydrogenative Coupling of the 1, 3-Dicarbonyl Compounds with 2-Methoxyethanol ” Biomol. Chem., 2022, 20, 1226-1230.
  6. Sebastian Yu, Ling-Hau Li, Chih-Hung Lee, Palaniraja Jeyakannu, Jeh-Jeng Wang, Chien-Hui Hong*, “Arsenic leads to autophagy of keratinocytes by increasing aquaporin 3 expression”,Scientific Reports 2021, 11, 17523.
  7. Vishal Suresh Kudale, Mohana Reddy Mutra, Ching-Piao Chu, and Jeh-Jeng Wang*, “Unusual C3-Acetylation of Quinoxalin-2(1H)-one via Oxidative C–C and C–O Bond Cleavages of PEG-400”, & Biomol. Chem. 2021, 19, 5567-5571.
  8. Babasaheb Sopan Gore, Jun-Hao Lin, and Jeh-Jeng Wang*, “An Unraveling Innate Substrate-Controlled Arylation and Bicyclization of 1,5-Enynes with α,β Conjugates: Synthesis of Substituted Benzo[a]fluorenes”, Green Chem. 2021, 23, 4144-4149.
  9. Muhammad Zulfajri, Ganesh Kumar Dhandabani, Hui-Fen Chen, Jeh-Jeng Wang*, and Genin Gary Huang*, “A Simple Visible Recognition Method for Copper Ions Using Dibenzo[b,j][1,10]Phenanthroline Scaffold as a Colorimetric Sensor”, Chemosensors 2021, 9, 7.
  10. Ming-Mao Gong, Chia-Yen Dai, Scott Severance, Chi-Ching Hwang, Bo-Kai Fang, Heng-Bo Lin, Chien-Hui Huang, Chi-Wi Ong, Jeh-Jeng Wang, Pei-Lun Lee and Tzu-Pin Wang*, “Bioorthogonally Synthesized and Disulfide-Containing Fluorescence Turn-On Chemical Probe for Measurements of Butyrylcholinesterase Activity and Inhibition in the Presence of Physiological Glutathione”, Catalysts 2020, 10, 1169.
  11. Babasaheb Sopan Gore, Chun-Hsien Chiang, Chein Chung Lee, Yi-Lun Shih, and Jeh-Jeng Wang*, “De Novo Protocol for the Construction of Benzo[a]fluorenes via Nitrile/Alkene Activation”, Lett. 2020, 22, 7848-7852.
  12. Babasaheb Sopan Gore, Chiao-Ying Kuo, Amol Milind Garkhedkar, Yu-Lun Chang, and Jeh-Jeng Wang*, “Metal-Free Solvent/Base-Switchable Divergent Synthesis of Multisubstituted Dihydrofurans”, Lett. 2020, 22, 6160-6165.
  13. Palaniraja Jeyakannu, Gopal Chandru Senadi, Chun-Hsien Chiang, Ganesh Kumar Dhandabani, Yu-Ching Chang, Jeh-Jeng Wang*, “An Efficient Approach to Functionalized Indoles from λ3-Iodanes via Acyloxylation and Acyl Transfer”, Syn. & Cat. 2020, 362, 14, 2911-2920.
  14. Vishal Suresh Kudalea and Jeh-Jeng Wang*, “Metal-free C–H methylation and acetylation of heteroarenes with PEG-400”, Green Chem. 2020, 22, 3506-3511.
  15. Amol Milind Garkhedkar, Babasaheb Sopan Gore, Wan-Ping Hu, and Jeh-Jeng Wang*, “Lewis Acid Catalyzed Atom-Economic Synthesis of C2-Substituted Indoles from o-Amido Alkynols”, Lett. 2020, 22, 3531-3536.
  16. Mohana Reddy Mutra, Vishal Suresh Kudale, Wu-Hsun Tsai and Jeh-Jeng Wang*, “Alkene Versus Alkyne Reactivity in Unactivated 1,6-Enynes: Regio- and Chemoselective Radical Cyclization with Chalcogens under metal- and oxidant-free conditions”, Green Chem. 2020, 22, 2288-2300.
  17. Amol Milind Garkhedkar, Ya-Chi Chiang, Gopal Chandru Senadi, Jeh-Jeng Wang, and Wan-Ping Hu*, “DBU-Promoted Synthesis of 1,3-Benzoxazines from Geminal Dibromo Olefins: Applications to the Construction of o-Amido Phenacyl Bromides”, ChemistrySelect 2020, 5, 3778-3783.
  18. Ganesh Kumar Dhandabani, Chia-Ling Shih, and Jeh-Jeng Wang*, “Acid-Promoted Intramolecular Decarbonylative Coupling Reactions of Unstrained Ketones: A Modular Approach to Synthesis of Acridines and Diaryl Ketones”, Lett. 2020, 22, 1955-1960.
  19. Mohana Reddy Mutra, Ganesh Kumar Dhandabani, Jing Li, and Jeh-Jeng Wang*, “Regio- and Chemoselective Synthesis of Nitrogen-Containing Heterocycles via the Oxidative Cascade Cyclization of Unactivated 1,n-Enynes”, , 2020, 56, 2051-2054.
  20. Babasahe Sopan Gore, Chein Chung Lee, Jessica Lee, and Jeh-Jeng Wang*, “Copper-Catalyzed Synthesis of Substituted 4-Quinolones using Water as a Benign Reaction Media: Application for the Construction of Oxolinic Acid and BQCA”, Syn. & Cat. 2019, 361, 3373-3386.
  21. Ganesh Kumar Dhandabani, Mohana Reddy Mutra, and Jeh-Jeng Wang*, “FeCl3-Promoted ring size-dictating diversity-oriented synthesis (DOS) of N-heterocycles using in situ-generated cyclic imines and enamines”, , 2019, 55, 7542-7545.
  22. Gopal Chandru Senadi, Vishal Suresh Kudale, and Jeh-Jeng Wang*, “Sustainable Methine Sources for the Synthesis of Heterocycles under Metal- and Peroxide-Free Conditions”, Green Chem. 2019, 21, 970-985.
  23. Ganesh Kumar Dhandabani, Mohana Reddy Mutra, and Jeh-Jeng Wang*, “Palladium-Catalyzed Regioselective Synthesis of 1-Benzoazepine Carbonitriles from o-Alkynylanilines via 7-endo-dig Annulation and Cyanation”, Syn. & Cat. 2018, 360, 4754-4763.
  24. Mohana Reddy Mutra, Ganesh Kumar Dhandabani, and Jeh-Jeng Wang*, “Mild Access to N-Formylation of Primary Amines using Ethers as C1 Synthons under Metal-Free Conditions”, Syn. & Cat. 2018, 360, 3960-3968.
  25. Gopal Chandru Senadi, and Jeh-Jeng Wang*, “p-TsOH promoted synthesis of benzo-fused O-heterocycles from alkynols via ring contraction and C–O scission strategy”, Green Chem. 2018, 20, 3420-3425.
  26. Gopal Chandru Senadi, Bing-Chun Guo, Yu-Ching Chang, Wan-Ping Hu and Jeh-Jeng Wang*, “Synthesis of Fused-Pyrazines via Palladium-Catalyzed Double Benzyl Isocyanide Insertion and Cross-Dehydrogenative Coupling”, Syn. & Cat. 2018, 360, 491-501.
  27. Wan-Ping Hu*, Kung-Kai Kuo, Gopal Chandru Senadi, Long-Sen Chang and Jeh-Jeng Wang, “Photodynamic Therapy Using Indolines-Fused-Triazoles Induces Mitochondrial Apoptosis in Human Non-Melanoma BCC Cells” Anticancer Research, 2017, 37, 10, 5499-5055.
  28. Gopal Chandru Senadi, Mutra Mohana Reddy, Ting-Yi Lu and Jeh-Jeng Wang*, “Oximes as a Recyclable Template for the Synthesis of Ureas and Carbamates by an In Situ Generation of Carbamoyl Oximes”, Green Chem. 2017, 19, 4272-4277.
  29. Babasaheb Sopan Gore, Gopal Chandru Senadi, Amol Milind Garkhedkar and Jeh-Jeng Wang*, “Efficient Approach to Amide Bond Formation with Nitriles and Peroxides: One-pot Access to Boronated β-Ketoamides”, Syn. & Cat. 2017, 359, 3014-3021.
  30. Gopal Chandru Senadi, Ji-Qi Wang, Babasaheb Sopan Gore, and Jeh-Jeng Wang*, “Pd(dba)2/tBuONO-Catalyzed Cyclization of o-Alkynylanilines with tBuONO: Synthesis and Applications of Indazole 2-oxides”, Syn. & Cat. 2017, 359, 2747-2753.
  31. Siva Senthil Kumar Boominathan, and Jeh-Jeng Wang*, “Rapid access to indeno[1,2-c]quinolines via Brønsted-Acid Catalyzed Cascade Reaction”, Syn. & Cat. 2017, 359, 1844-1848.
  32. Gopal Chandru Senadi, Ting-Yi Lu, Ganesh Kumar Dhandabani, and Jeh-Jeng Wang*, “Palladium-Catalyzed Double-Isocyanide Insertion via Oxidative N-O Cleavage of Acetyl Oximes: Syntheses of 2H-Pyrrol-2-imines”, Lett. 2017, 19, 1172-1175.
  33. Siva Senthil Kumar Boominathan, Mutra Mohana Reddy, Ruei-Jhih Hou, Hui-Fen Chena and Jeh-Jeng Wang*, “A simple and efficient method for constructing azepino[4,5-b]indole derivatives via acid catalysis”, & Biomol. Chem. 2017, 15, 1872-1875.
  34. Amol Milind Garkhedkar, Gopal Chandru Senadi, and Jeh-Jeng Wang*, “ZnBr2‑Mediated Cascade Reaction of o-Alkoxy Alkynols: Synthesis of Indeno[1,2-c]chromenes”, Lett. 2017, 19, 488-491.
  35. Siva K. Reddy Kotla, Jaya Kishore Vandavasi, Jeh-Jeng Wang, Keykavous Parang, and Rakesh K. Tiwari*, “Palladium-Catalyzed Intramolecular Cross-Dehydrogenative Coupling: Synthesis of Fused Imidazo[1,2 a]pyrimidines and Pyrazolo[1,5‑a]pyrimidines”, ACS Omega. 2017, 2, 11-19.
  36. Gopal Chandru Senadi, Ganesh Kumar Dhandabani, Wan-Ping Hu and Jeh-Jeng Wang*, “Metal-free annulation/aerobic oxidative dehydrogenation of cyclohexanones with o-acylanilines: efficient syntheses of acridines”, Green Chem. 2016, 18, 6241-6245.
  37. Kung-Kai Kuo, Siva Senthil Kumar Boominathan, Jaya Kishore Vandavasi, Jia-Shing Hsiao, Jeh-Jeng Wang, and Wan-Ping Hu*, “Copper-Catalyzed One-pot Process to Construct Triazole-Linked Urea Derivatives”, Synthetic Comm. 2016, 46, 1612-1618.
  38. Gopal Chandru Senadi, Bing-Chun Guo, Wan-Ping Hu, and Jeh-Jeng Wang*, “Iodine-promoted cyclization of N-propynyl amides and N-allyl amides via sulfonylation and sulfenylation”, 2016, 52, 11410-11413.
  39. Siva Senthil Kumar Boominathan, Ruei-Jhih Hou, Wan-Ping Hu, Po-Jui Huang, and Jeh-Jeng Wang*, “A palladium catalyzed domino approach to 2,3-disubstituted benzofurans via intermolecular carbopalladation/C(sp3)-H functionalization/isomerization sequence”, Syn. & Cat. 2016, 358, 2984-2989.
  40. Chung-Yu Chen, Gopal Chandru Senadi, Mei-Chun Liu, and Jeh-Jeng Wang*, “Halogenation of Arenes via an In situ Generated Hypohalous Acid from m-CPBA and HX: Mechanistic Insights from Cyclic Voltammetry”, Chemistryselect 2016, 1, 2207-2211.
  41. Gopal Chandru Senadi, Babasaheb Sopan Gore, Wan-Ping Hu, and Jeh-Jeng Wang*, “BF3-Etherate-Promoted Cascade Reaction of 2-Alkynylanilines with Nitriles: One-Pot Assembly of 4-Amido-Cinnolines”, Lett. 2016, 18, 2890-2893.
  42. Gopal Chandru Senadi, Jie-Ming Liao, Kung-Kai Kuo, Jian-Cheng Lin, Long-Sen Chang, Jeh-Jeng Wang, Wan-Ping Hu,* “Design, Synthesis and Antimetastatic Evaluation of 1-benzothiazolylphenylbenzotriazoles for Photodynamic Therapy in Oral Cancer Cells”, MedChemComm 2016, 7, 1151-1158.
  43. Jia-Heng Jiang, Siva Senthil Kumar Boominathan, Wan-Ping Hu, Chung-Yu Chen, Jaya Kishore Vandavasi, Ying-Ting Lin, and Jeh-Jeng Wang*, “Sequential, One-Pot Access to Arylated Benzoquinones/Naphthoquinones from Phenols/Naphthols”, J. Org. Chem. 2016, (13), 2284-2289.
  44. Yu-Wei Chou, Gopal Chandru Senadi, Chung-Yu Chen, Kung-Kai Kuo, Ying-Ting Lin, Jeh-Jeng Wang, Jia-Hau Lee, Ya-Ching Wang, Wan-Ping Hu,* “Design and synthesis of pyrrolobenzodiazepine-gallic hybrid agents as p53-dependent and -independent apoptogenic signaling in melanoma cells”, Euro. J. Med. Chem. 2016, 109, 59-74.
  45. Siva Senthil Kumar Boominathan, and Jeh-Jeng Wang*, “A Palladium and Copper Catalyzed Synthesis of Dihydro[1,2-b]indenoindole-9-ol and Benzofuro[3,2-b]indolines: Metal Controlled Intramolecular C-C and C-O Bond Forming Reactions”, Euro. J (Hot Paper). 2015, 21, 17044-17050.
  46. W-Ping Hu, Chia-Chen Hsu, Ya-Ching Wang, Gopal Chandru Sendai, Kung-Kai Kuo, Jen-Fon Jen and Jeh-Jeng Wang*, “Bis(phenylidenebenzeneamine)-1-disulfide Derivatives Induce Autophagy in Melanoma cells Through a Mitochondria-mediated Pathway”, Anticancer Research 2015, 35, 6075-6080.
  47. Jaya Kishore Vandavasi, Wan-Ping Hu, Gopal Chandru Senadi, Hui-Ting Chen, Hsing-Yin Chen, Kuang-Chan Hsieh, and Jeh-Jeng Wang*, “Aryl l3-iodane-mediated 6-exo–trig cyclization for synthesizing highly substituted chiral morpholines”, Syn. & Cat. 2015, 357, 2788-2794.
  48. Gopal Chandru Senadi, Wan-Ping Hu, Amol Milind Garkhedkar, Siva Senthil Kumar Boominathan and Jeh-Jeng Wang*, “Palladium(II)-catalysed regioselective synthesis of 3,4-disubstituted quinolines and 2,3,5-trisubstitutedpyrroles from alkenes via anti-Markovnikovselectivity”, , 2015, 51, 13795-13798.
  49. Ping-Fan Chen, Kung-Kai Kuo, Jaya Kishore Vandavasi, Siva Senthil Kumar Boominathan, Chung-Yu Chen and Jeh-Jeng Wang*, “Metal-free cycloaddition to synthesize naphtho[2,3-d][1,2,3]triazole-4,9-diones”, & Biomol. Chem. 2015, 13, 9261-9266.
  50. Siva Senthil Kumar Boominathan, Chung-Yu Chen, Po-Jui Huang, Ruei-Jhih Hou, Jeh-Jeng Wang*, “A Sequential One-pot Approach to 1,2,4,5-Tetrasubstituted-2H-imidazole Synthesis from Disubstituted Alkynes”, New J. Chem. 2015, 39, 6914-6918.
  51. Jaya Kishore Vandavasi, Wan-Ping Hu, Siva Senthil Kumar Boominathan, Bing-Chun Guo, Cheng-Tien Hsiao and Jeh-Jeng Wang*, “Au (I)-Catalyzed Synthesis of 8-Oxabicyclo[3.2.1]oct-2-enes and 9-Oxabicyclo[3.3.1]nona-2,6-dienes from Enynol via Oxonium/Prins-type Cyclization”, , 2015, 51, 12435-12438.
  52. Jaya Kishore Vandavasi, Cheng-Tien Hsiao, Wan-Ping Hu, Siva Senthil Kumar Boominathan, and J. Wang*, “Silver (I)-Catalyzed Tandem Approach to b-Ketoamides”, Euro. J. Org. Chem. 2015, 3171-3177.
  53. Balaji D. Barve, Yang-Chang Wu, Mohamed El-Shazly, Michal Korinek, Yuan-Bin Cheng, J. Wang*, Fang-Rong Chang*, “Copper-catalyzed selective C_O bond formation by oxidative a-C(sp3)-H/O-H coupling between ethers and salicylaldehydes”, Tetrahedron 2015, 71, 2290-2297.
  54. Gopal Chandru Senadi, Wan-Ping Hu, Ting-Yi Lu, Amol Garkhedkar, Jaya Kishore Vandavasi, and J. Wang*, “I2-TBHP-Catalyzed Oxidative Cross-coupling of N-sulfonyl hydrazones and Isocyanides to5-aminopyrazoles”, Org. Lett. 2015, 17, 1521-1524.
  55. Siva Senthil Kumar Boominathan, Gopal Chandru Senadi, Jaya Kishore Vandavasi, Jeff Yi-Fu Chen, and J. Wang*, “An Iron Catalyzed Cascade Approach to Benzo[b]carbazoles Synthesis followed by 1,4-Sulfonyl migration”, Chem. Euro. J. 2015, 21, 3193-3197.
  56. Gopal Chandru Senadi, Wan-Ping Hu, Siva Senthil Kumar Boominathan, and J. Wang*, “Palladium(0)-Catalyzed Single and Double Isonitrile Insertion: AFacile Synthesis of Benzofurans, Indoles, and Isatins”, Chem. Euro. J. 2015, 21, 998-1003.
  57. -S. Wu, H.-Y. Kuo, W.-P. Hu, J. J. Wang, A.-H. Fang and L.-Y. Tien, “The ultraviolet A-activated photosensitizer 2-(4-aminophenyl)-7-methoxybenzothiazole suppresses proliferation and induces apoptosis of keloid fibroblasts: a potential adjunctive therapy for keloids”, Clinical and Experimental Dermatology 2015, 40, 63–70.
  58. Jaya Kishore Vandavasi, Wan-Ping Hu, Cheng-Tien Hsiao, Gopal Chandru Senadi, J. Wang*, “A New Approach for Fused Isoindolines via hexadehydro-Diels-Alder Reaction (HDDA) by Fe (0) Catalysis ”, RSC Advances 2014, 57547-57552.
  59. K. Vandavasi, W. P. Hu, G. C. Senadi, S. S. K. Boominathan, H. Y. Chen,* and J. J. Wang*, “A K2CO3 mediated regioselective synthesis of indole/pyrrole-fused 1,4-oxazines: An unexpected indole-fused azlactone synthesis”, Euro. J. Org. Chem. 2014, 6219-622.
  60. Yin-Kai Chen, Gopal Chandru Senadi, Chih-Hung Lee, Yi-Min Tsai, Yan-Ren Chen, Wan-ping Hu,* Yu-Wei Chou, Kung-Kai Kuo, and Jeh-Jeng Wang*, “Apoptosis Induced by 2 Aryl Benzothiazoles-Mediated Photodynamic Therapy in Melanomas via Mitochondrial Dysfunction”, Chem. Res. Toxico. 2014, 27, 1187-119.
  61. S. K. Boominathan, W. P. Hu, G. C. Senadi, J. K. Vandavasi, and J. J. Wang*, “A one-pot hypoiodite catalysed oxidative cycloetherification approach to benzoxazoles”, ChemComm., 2014, 50, 6726–6728.
  62. D. Barve, Y. C. Wu, M. El-Shazly, D. W. Chuang, Y. B. Cheng, J. J. Wang*, and F. R. Chang*, “Copper-Catalyzed Oxidative Coupling of Formamides with Salicylaldehydes: Synthesis of Carbamates in the Presence of a Sensitive Aldehyde Group”, J. Org. Chem. 2014, 15, 3206-3214.
  63. El-Shazly, B. D. Barve, M. Korinek, J.R. Liou, D. W. Chuang, Y. B. Cheng, M. F. Hou, J. J. Wang, Y. C. Wu*, and F. R. Chang*,, “Insights on the Isolation, Biological Activity and Synthetic Protocols of Enyne Derivatives”, Current Topics in Medicinal Chemistry, 2014, 14, 1076–1093.
  64. D. Barve, Y. C. Wu, M. El-Shazly, M. Korinek, Y. B. Cheng, J. J. Wang*, and F. R. Chang*, “Iron-Catalyzed Oxidative Direct α-C−H Bond Functionalization of Cyclic Ethers: Selective C−O Bond Formation in the Presence of a Labile Aldehyde Group”, Org. Lett. 2014, 16, 1912-1915.
  65. Y. Chen, W. P. Hu, P. C. Yan, G. C. Senadi, and J. J. Wang*, “Metal Free, Acid-Promoted Synthesis of Imidazole Derivatives via Multi-Component Reaction” , Org. Lett. 2013, 15, 6116-6119.
  66. C. Senadi, W. P. Hu, S. S. K. Boominathan, and J. J. Wang*, “Nickel or Palladium Catalyzed Stereoselective Synthesis of Tetrasubstituted Olefinic Indoline Fused Triazoles: Extension to Spiroindoline Core”, Adv. Syn. & Cat. 2013, 355, 3679-3693.
  67. S. K. Boominathan, W. P. Hu, G. C. Senadi, and J. J. Wang*, “Silver(I)-Catalyzed Conia-Ene Reaction: Synthesis of 3-Pyrrolines via 5-Endo-Dig Cyclization”, Adv. Syn. & Cat. 2013, 355, 3570-3574.
  68. Y. Chen, P. H. Lee, Y. Y. Lin, W. T. Yu, W. P. Hu,* Chia-Chen Hsu, Y. T. Lin, L. S. Chang, C. T. Hsiao, J. J. Wang*, Mei-Ing Chung, “Synthesis, DNA-binding Abilities and Anticancer Activities of Triazole-Pyrrolo[2,1-c][1,4] benzodiazepines Hybrid Scaffolds”, Bioorg. Med. Chem. Lett. 2013, 23, 6854-6859.
  69. Y. Chen, W. P. Hu, M. C. Liu, P. C. Yan, and J. J. Wang*, M. I. Chung, “Efficient Synthesis of Quinazolines with Hypervalent Iodine as a Catalyst”, Tetrahedron 2013, 69, 9735-9741.
  70. K. Vandavasi, K. K. Kuo, W. P. Hu, H. C. Shen, W. S. Lo, and J. J. Wang*, “A Convenient Method to Construct (Z)-O xazines via 6-Exo-dig Iodocylization and Synthesis of Indolin-3-one” Org. & Biomol. Chem. 2013, 11, 6520-6525.
  71. Y. Hsieh, W. C. Lee, G. C. Senadi, W. P. Hu*, J. J. Liang, T. R. Tsai, Y. W. Chou, K. K. Kou, C. Y. Chen, and J. J. Wang*, “Discovery, Synthetic Methodology and Biological Evaluation for Anti-Photoaging Activity of Bicyclic[1,2,3]Triazoles: In Vitro and in Vivo Studies”, J. Med. Chem. 2013, 56, 5422-5435.
  72. Y. Chen, Y. K. Chen, J. J. Wang, C. C. Hsu, F. Y. Tsai, P. J. Sung, H. C. Lin, L. S. Chang, W. P. Hu*, “DC-81-enediyne induces apoptosis of human melanoma A375 cells: Involvement of the ROS, p38 MAPK, and AP-1 signaling pathways”, Cell Biology and Toxicology 2013, 29, 85-99.
  73. Y. Chen, C. H. Yang, W. P. Hu, J. K. Vandavasi, M. I. Chung, and J. J. Wang*, “Synthesis of Fused Triazolo[4,5-d] Quinoline/ Chromene/ Thiochromene Derivates via Palladium Catalysis Mediated by Tetrabutylammonium Iodide”, RSC Advances, 2013, 3, 2710-2719.
  74. D. Barve, Y. C. Wu, M. El-Shazly, D. W. Chunag, Y. M. Chung, Y. H. Tsai, S. F. Wu, M. Korinek, Y. C. Du, C. T. Hsieh, J. J. Wang,* and F. R. Chang*, “Synthesis of Carbamates by Direct C-H Bond Activation of Formamides”, Eur. J. Org. Chem. 2012, 6760-6766.
  75. C. Senadi, W. P. Hu, J. S. Xiao, J. K. Vandavasi, C. Y. Chenc and J. J. Wang*, “Facile Selective and Regiocontrolled Synthesis of Oxazolines and Oxazoles Mediated by ZnI2 and FeCl3”, Org. Lett. 2012, 14, 4478-4481, Selected as Highlights in Current Synthetic Organic Chemistry. SYNFACTS, 2012, 8(12), 1362.
  76. F. Su, W. P. Hu, J. K. Vandavasi, C. C. Liao, C. Y. Hung, and J. J. Wang*, “Ortho-Amide-Directed Oxidation of Internal Aryl Alkyne Mediated by Cerium(IV) Ammonium Nitrate”, SYNLETT. 2012, 2132-2136.
  77. C. Lee, H. C. Shen, W. P. Hu, W. S. Lo, C. Murali, J. K. Vandavasi, and J. J. Wang*, “Iodine catalyzed, stereo and regio selective synthesis of 4-arylidine-4H-benzo[d][1,3]oxazines and their applications for the synthesis of quinazoline-3-oxides”, Adv. Syn. & Cat. 2012, 354, 2218-2228.
  78. K. Vandavasi, W. P. Hu, H. Y. Chen, G. C. Senadi, C. Y. Chen, and J. J. Wang*, “A New Approach to 1,4-Oxazines and 1,4-Oxazepines via Base-Promoted Exo Mode Cyclization of Alkynyl Alcohols: Mechanism and DFT Studies”, Org. Lett. 2012, 14, 3134-3137, Selected as Highlights in Current Synthetic Organic Chemistry. SYNFACTS, 2012, 8(9), 1011.
  79. K. Vandavasi, C. Murali, W. P. Hu, C. Y. Chen, and J. J. Wang*, “Efficient Synthesis of Unsymmetrical Disulfides”, Tetrahedron 2011, 67, 8895-8901.
  80. C. Hsieh, W. P. Hu. H. S. Yu, W. C. Wu, L. S. Chang, Y. H. Kao,* J. J. Wang*, “A DC-81-indole conjugate agent suppresses melanoma A375 cell migration partially via interrupting VEGF production and stromal cell-derived factor-1a-mediated signaling” 2011, Toxico. Applied Pharmacology 2011, 255, 150-159.
  81. J. Chen, J. J. Wang, L S. Chang, “Naja nigricollis CMS-9 enhances mitochondria-mediated death pathway in adaphostin-treated human leukemia U937 cells”, Clin Exp Pharmacol Physiol. 2011, 38, 755-763.
  82. C. Wang, W. Y. Li, D. C. Wu, , J. J. Wang, C. H. Wu, J. J. Liao, C. K. Lin, “In vitro activity of 2-methoxy-1,4-naphthoquinone and stigmasta-7,22-diene-3β-ol from Impatiens balsamina L. against multiple antibiotic-resistant Helicobacter pylori”, Evidence-based complementary and alternative medicine: eCAM (2011),2011, 704721.
  83. S. Lo, W. P. Hu, H. P. Lo, C. Y. Chen, C. L. Kao, J. K. Vandavasi, and J. J. Wang*, “Synthesis of Sulfur-Sulfur Bond Formation from Thioamides Promoted by 2,3-Dichloro-5,6-dicyanobenzoquinone” Org. Lett. 2010, 12, 5570-5572.
  84. P. Hu, Y. K. Chen, C. C. Liao, H.S. Yu, Y. M. Tsai, S. M. Huang, F. Y. Tsai, H. C. Shen, L. S. Chang, J. J. Wang*, “Synthesis, and biological evaluation of 2-(4-aminophenyl)benzothiazole derivatives as photosensitizing agents”, Bioorg. Med. Chem. 2010, 18, 6197-6207.
  85. J. Chen, W. H. Liu, P. H. Kao, J. J. Wang, L. S. Chang, “Involvement of p38 MAPK- and JNK-modulated expression of Bcl-2 and Bax in Naja nigricollis CMS-9-induced apoptosis of human leukemia K562 cells”, Toxicon 2010, 55, 1306-1316.
  86. L. Chiou, J. J. Wang, L. S. Chang, “Effect of cholesterol on membrane-damaging activity of Naja nigricollis toxin toward phospholipid vesicles”, Toxicon 2009, 54, 772-778.
  87. H. Lee, W. P. Hu, C. H. Hong, H.S. Yu, W. T. Liao, C. Y. Cheng, Y. L. Chen, B. S. Chen, G. S. Chen, J. J. Wang*, “Pyrrolo[2,1-c][1,4]benzodiazepine and indole conjugate (IN6CPBD) has better efficacy and superior safety than the mother compound DC-81 in suppressing the growth of established melanoma in vivo”, Chem-Biological Interaction 2009, 180, 360-367.
  88. P. Hu, J. J. Liang, C. L. Kao, Y. C. Chen, C. Y. Chen, F. Y. Tsai, M. J. Wu, Y. L. Chen, J. J. Wang*, “Synthesis and antitumor activity of novel enediyne-linked pyrrolo[2,1-c] [1,4]benzodiazepine hybrids”, Bioorg. Med. Chem. 2009, 17, 1172-1180.
  89. P. Hu, F. Y. Tsai, H.S. Yu, P. J. Sung, L. S. Chang, J. J. Wang*, “Induction of apoptosis by DC-81-indole conjugate agent Thruogh NF-кB and AP-1”, Chem. Res. Toxico. 2008, 21, 1330-1336.
  90. S. Chang, J. J. Wang, Y. C. Cheng; W. M. Chou, “Genetic organization of Bungarus multicinctus protease inhibitor-like proteins”, Toxicon 2008, 51, 1490-1495.
  91. P. Hu, H. S. Yu, Y. R. Chen, Y. M. Tsai, Y. K. Chen, C. C. Liao, L. S. Chang, J. J. Wang*, “Synthesis and biological evaluation of thiobenzanilides as anticancer agents”, Bioorg. Med. Chem. 2008, 16, 5295-5302.
  92. C. Cheng, J. J. Wang, L. S. Chang, “B Chain is a Functional Subunit of -Bungarotoxin for Inducing Apoptotic Death of Human Neuroblastoma SK-N-SH cells” Toxicon 2008, 51, 304-315.
  93. L. Chiou, Y. C. Cheng, P. H. Kao, J. J. Wang, L. S. Chang, “Mutations on the N-Terminal Region Abolish Differentially the Enzymatic Activity, Membrane-damaging Activity and Cytotoxicity of Taiwan Cobra Phospholipase A2.” Toxicon 2008, 51, 270-279.
  94. P. Hu, J. J. Wang, C. L. Yu, C. C. Lan, G. S. Chen, H. S. Yu, “Helium-Neon Laser Induces Human Melanoma Cell Proliferation, Which Correlates with Alterations in Mitochondrial Membrane Potential and ATP Synthesis”, J Invest Dermatol. 2007, 127, 2048.
  95. P. Hu, H.S. Yu, P. J. Sung, F. Y. Tsai, Y. K. Shen, L. S. Chang, J. J. Wang*, “DC-81-Indole Conjugate Agent Induces Apoptosis in Human Melanoma A375 Cells”, Chem. Res. Toxico. 2007, 20, 905-912.
  96. F. Chen, L. J. Juang, T. C. Hsu, J. J. Wang, L. F. Wang, “Diacid Architecture Effect on the Synthesis and Microstructure Rigid-Rod Poly(benzobisthiazoles)”, Polymer International 2006, 55, 1450-1455.
  97. P. Chen, A. F. Ahmed, C. F Dai, C. K. Lu,; W. P. Hu, J. J. Wang, J.H. Sheu, “Sinugibberosides A-E, new terpenoids with cyclic peroxyhemiketal from the soft coral Sinularia gibberosa”, Tetrahedron 2006,  62,  6802-6807.
  98. J. Wang*, Y. K. Shen, W. P. Hu, M. C. Hsieh, F. L. Lin, M. K. Hsu, M. H. Hsu “Design, Synthesis, and Biological Evaluation of Pyrrolo[2,1-c] [1,4]benzodiazepinene and Indole Conjugates as Anticancer Agents”, J. Med. Chem. 2006, 49,1442-1449.
  1. J. Sung, W. P. Hu, L. S. Fang, T. Y. Fan, J. J. Wang “Briarenol A, a New Diterpenoid from a Gorgonian Briareum SP. (Briareiae)”, Nat. Prod. Res. 2005, 19, 689-694.
  2. F. Lin, Y. H. Lo, M. C. Hsieh, Y. H, Chen, J. J. Wang, and M. J. Wu, “Cytotoxicities, cell cycle and caspase evaluations of 1,6-diaryl-3(Z)-hexen-1,5-diynes, 2-(6-aryl-3(Z)-hexen-1,5-diynyl)anilines and their derivatives” Bioorg. & Med. Chem 2005, 13, 3565-3575.
  3. J. Sung, W. P. Hu S. L. Wu, T. Y. Fan, J. H. Su, L. S. Fang, J. J. Wang, and J. H. Sheu “Briaexcavatolides X-Z, Three New Briarane-related Derivatives from the Gorgonian Coral Briareum excavatum” Tetrahedron 2004, 60, 8975~8979.
  4. P. Hu, P. C. Tsai, M. K. Hsu and J. J. Wang*, “Novel Borane Reduction of Ether-Protected Aromatic Lactams”, J. Org. Chem. 2004, 69, 3983~3985.
  5. P. Hu, J. J. Wang*, S. M. Huang and H. S. Yu, “Involvement of Cytotoxicity and Variation of the Mitochondrial Membrane Potential Induced by Hybrid Agent”, Drug Development Res. 2004, 61, 1~5.
  6. H. Sheu, L. F. Huang, S. P. Chen, Y. L. Yang, P. J. Sung, G. H. Wang, J. H. Su, C. H. Chao, W. P. Hu and J. J. Wang, “Hippuristerones E-I, New Polyoxygenated Steroids from the Gorgonian Coral Isis hippuris”, J. Nat. Prod. 2003, 66, 917~921.
  7. C. Shen, C. Y. Chen, C. V. S. Prakash, J. J. Wang and M. C. Hung, “Monocyclic Diterpene Benzenoids from Taiwanese Marine Sponge Strongylophora durissima”, Chin. Pharm. J. 2003, 55, No. 2, 135~140.
  8. P. Hu, H. S. Yu, Y. C. Chen and J. J. Wang*, “Biological Evaluuation an antibiotic DC-81-Indole Conjugate Agent in Human Melanoma Cell”, The Kaohsiung Journal of Medical Sciences, 2003, 19, 6~12.
  9. P. Hu, H. S. Yu, M. C. Hsieh, Y. C. Chen and J. J. Wang*, “Evaluation of DNA-Binding Ability of Antibiotic DC-81-indole Conjugates by Restriction endonuclease BamHI and Molecular Modeling Studies”, Chin. Pharm. J. 2002, 54, No. 6, 465~470.
  10. J. Cheng, B. Jayaprakasam, T. Ishikawa, H. Seki, I. L. Tsai, J. J. Wang and I. S. Chen, “Chemical and cytotoxic Constituents from the Stem of Machilus zuihoensis”, Helv. Chim. Acta. 2002, 85, 1909~1914.
  11. C. Chen, L. F. Wang, J. J. Wang, T. C. Hsu, and C. F. Chen, “Diacid Architecture Effect on the Synthesis and Microstructure Rigid-Rod Poly(benzobisimidazoles)”, J. Materials Sci.. 2002, 37, 4109~4115.
  12. S. Chang, S. J. Lin, J. J. Wang, and C. C. Chang, “Probing the Structural diversities of Long Neurotoxins by fluorescence quenching studies”, J. Protein Chem. 2001, 20, 115~121.
  13. P. Hu, J. J. Wang*, F. L. Lin, Y. C. Lin, S. R. Lin and M.H. Hsu, “An Efficient Synthesis of Pyrrolo[2,1-c]- [1,4]benzodiazepine. Synthesis of the Antibiotic DC-81”, J. Org. Chem. 2001, 66, 2881~2883.
  14. P. Hu, J, J. Wang* and P. C. Tsai, “Novel Examples of 3-Aza-Grob Fragmentation”, J. Org. Chem. 2000, 65, 4208~4209.
  15. S. Chang, S. J. Lin, J. J. Wang, W. P. Hu, B. N. Wu and H. B. Huang, “Structure-function studies on Taiwan Cobra Long Neurotoxin Homolog”, Biochimica et Biophysica Acta. 2000, 1480, 293~301.
  16. C. Shen, M. C. Hung, C. V. S. Prakash and J. J. Wang, “New Medroditerpenoids from a Taiwanese Marine Sponge Strongylophora durissima”, J. Chin. Chem. Soc. 2000, 47, 567~570.
  17. J. Wang* and W. P. Hu, “Novel 2-Aza-Grob Fragmentation in Hydride Reduction of Ether-Protected Aromatic Lactams”, J. Org. Chem. 1999, 64, 5725~5727.
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  2. J. Wang*, W. P. Hu, H. W. Chung, L. F. Wang and M. H. Hsu, “A New and Novel Amide Bond Cleavage of N-methoxymethylpyrrolo[2,1-c][1,4]benzodiazepine-5,11-diones by Hydrde Reduction via 3-Aza-Grob Fragementation”, Tetrahedron 1998, 54, 13149~13154.
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  2. C. Chang, T. R. Tsai, J. J. Wang, C. N. Lin and K. W. Kuo, “The Rhamnose Moiety of Solamargine Plays a Crucial Role in Triggering Cell Death by Apoptosis”, Biochem. Bioph. Res. Commum. 1998, 242, 21~25.
  3. K. Hsieh, T. H. Lee, J. P. Wang, J. J. Wang and C. N. Lin, “Synthesis and Anti-inflammatory Effect of Chalcones and Related Compounds”, Pharmaceutical Research 1998, 15, 39~46.
  4. N. Lin, P. L. Huang, C. M. Lu, R. R. Wu, W. P. Hu, and J. J. Wang, “Polygonapholine, an Alkaloid with a Novel Skeleton, Isolated from Polygonatum alte-lobatum”, Tetrahedron 1997, 53, 2025~2028.
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