CV

Shioulan Chen

  (Shiou-Lan Chen) 副 教 授

國防醫學院 醫學科學研究所  博 士

  • 高雄醫學大學 醫學院 醫學研究所 神經暨精神醫學組
  • Tel: :+886-7-3121101 ext 5092 ext 434
  • E-mail: shioulan@kmu.edu.tw

學 術 經 歷 :

  • 副教授      高雄醫學大學 醫學院 醫學研究所
  • 助理教授   高雄醫學大學 醫學院 醫學研究所
  • 助理教授   高雄醫學大學 醫學院 醫學系 神經學科
  • 專案助理教授  國立成功大學 醫學院 精神醫學科
  • 博士後研究員  國立成功大學 醫學院 精神醫學科
  • 訪問學者          美國明尼蘇達大學 醫學院 藥理所

專    長 : 

  • Opiate tolerance and addiction
  • Neuronal degenerative disease

獲    :

  • 國防醫學院 博士生 獎學金  (2002-2004)
  • 神經科學會議 優秀論文獎   (2003)
  • 王民寧基金會  優秀論文獎  (2008)
  • 高雄醫學大學  研究績優教師 (2016)
  • 高雄醫學大學  教學績優教師 (2017)
  • 高雄醫學大學  校級優良導師 (2017)

研究計劃 :

  • 科技部 (主持人探討發炎反應及其分子表現和類鴉片藥物成癮行為之關係 (2014~2016)
  • 高醫頂尖計畫 (主持人) 以神經免疫觀點探討血脂異常所扮演之神經退化作用及機轉 (2016)
  • 科技部 優秀年輕學者計畫 (主持人探討高血脂及陰電性極低密度脂蛋白所導致之神經退化機轉-行為神經分子生物之研究 (2016~2019)
  • 科技部 腦科學計畫 : 探索陰電性脂蛋白和阿茲海默症的新連結: 從分子機轉至臨床證據; 子計劃主持人: 從細胞及動物模型探討陰電性脂蛋白在阿茲海默症的病理生理角色 (2017~2018)

代表性論文著作

    1. Chen SL, Huang EY, Chow LH, Tao PL (2005). Dextromethorphan differentially affects opioid antinociception in rats. J. Pharmacol., 2005, 144(3), 400-404. (SCI; IF: 4.409, Ranking: 35/261)
    2. Chen SL, Ma HI, Han JM, Tao PL, Law PY, Loh H.H. DsAAV type 2-mediated gene transfer of MORS196A-EGFP into spinal cord as a pain management paradigm. Proc Natl Acad Sci U S A. 2008 Jan, 104 (50), 20096-101. (SCI; IF: 9.681, Ranking: 3/55).
    3. Chen SL, Ma H.I., Han J.M., Lu RB, Tao PL*, Law P.Y., Loh H.H. Antinociceptive effects of morphine and naloxone in mu-opioid receptor knockout mice transfected with the MORS196A gene. Journal of biomedical science, 2010 Apr, 17:28. (SCI, IF: 1.98, Ranking: 63/112)
    4. Chen SL, Hsu KY, Huang EYK, Lu RB, Tao PL*. Low doses of dextromethorphan attenuate morphine-induced rewarding via the sigma-1 receptor at ventral tegmental area in rats. Drug and Alcohol Dependence. 2011 Sep. 117 (2-3):164-9. (SCI, IF: 3.383, Ranking: 3/14, Substance Abuse)
    5. Chen SL, Tao PL, Chu CH, Chen SH, Hong JS, Lu RB*. Low-dose memantine attenuated morphine addictive behavior through its anti-inflammation and neurotrophic effects in rats. Journal of Neuroimmune Pharmacology. 2012 Jun. 7(2):444-53. Epub 2011 Dec 29. (IF:4.58, R/C: 30/261)
    6. Wang TY, Lee SY, Chen SL, Chen SH, Chu CH, Huang SY, Tzeng NS, Chang YH, Wang CL, Lee IH, Yeh TL, Yang YK, Lu RB*. The aldehyde dehydrogenase 2 gene is associated with heroin dependence. Drug and Alcohol Dependence. 2012 Jan 1;120(1-3):220-4. (SCI, IF: 3.383)
    7. Chang YH, Chen SL, Chen SH, Chu CH, Lee SY, Yang HF, Tzeng NS, Lee IH, Chen PS, Yeh TL, Huang SY, Chou KR, Yang YK, Ko HC, Lu RB*, Angst J. Low anxiety disorder comorbidity rate in bipolar disorders in Han Chinese in Taiwan. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2012 Jan, 36 (1):194-7. Epub 2011 Oct 5 (SCI, IF: 3.247)
    8. Lee SY, Chen SL, Chang YH, Chen SH, Huang SY, Tzeng NS, Wang CL, Lin SH, Lee IH, Yeh TL; Yang YK; Lu RB*. The ALDH2 and 5-HT2A Genes Interacted in Bipolar-I but not Bipolar-II Disorder. Progress of Neuro-Psyhcopharmacology and Biological Psychiatry. 2012 Apr., 38: 247–251. (SCI, IF: 3.247)
    9. Chang YH, Chen SL, Lee SY, Hsu YW, Wu JY, Chen SH, Chu CH, Lee IH, Yeh TL, Tzeng NS, Huang SY, Yang YK, Lu RB*. Neuropsychological functions in bipolar disorders I and II with qnd without comorbid alcohol dependence. Prog Neuropsychopharmacol Biol Psy. 2012, 37(2):211-6. (SCI, IF:3.247)
    10. Lee SY, Chen SL, Chang YH, Chen SH, Chu CH, Huang SY, Tzeng NS, Wang CL, Lee IH, Yeh TL, Yang YK, Lu RB*. The DRD2/ANKK1 gene is associated with response to add-on dextromethorphan treatment in bipolar disorder. Journal of Affective Disorders. 2012 May, 138(3):295–300. (SCI, IF: 3.517)
    11. Chen SL, Lee SY, Chang YH, Chen SH, Chu CH, Tzeng NS, Lee IH, Chen PS , Yeh TL, Huang SY, Yang YK, Lu RB*. Inflammation in patients with schizophrenic: the therapeutic benefits of risperidone plus add-on dextromethorphan. Journal of Neuroimmune Pharmacology. 2012 Sep. 7(3):656–664. (IF:4.58)
    12. Lee SY; Chen SL; Chen SH; Chu CH; Chang YH; Lin SH; Huang SY; Tzeng NS; Kuo PH; Lee IH; Yeh TL; Yang YK; Lu RB*. Interaction of the DRD3 and BDNF Gene variants in Subtyped Bipolar Disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2012 Dec 3;39(2):382-7. (SCI, IF:3.247)
    13. Lu RB, Chen SL, Lee SY, Chang YH, Chen SH, Chu CH, Tzeng NS, Lee IH, Chen PS, Yeh TL, Huang SY, Yang YK, Hong JS*. Neuroprotective and neurogenesis agent for treating bipolar II disorder: Add-on memantine to mood stabilizer works. Medical Hypotheses. 2012 Aug; 79(2):280-3. (SCI, IF:1.15)
    14. Chen SL, Lee SY, Tao PL, Chang YH, Chen SH, Chu CH, Chen PS, Lee IH, Yeh TL, Yang YK, Hong JS, Lu RB*. Dextromethorphan Attenuated Inflammation and Combined Opioid Use in Humans Undergoing Methadone Maintenance Treatment. Journal of Neuroimmune Pharmacology. 2012, Dec. 7:1025–1033. DOI 10.1007/s11481-012-9400-1. (IF:4.58)
    15. Lee SY, Chen SL, Wang YS, Chang YH, Huang SY, Tzeng NS, Lee IH, Yeh TL, Yang YK, Lu RB*.COMT and BDNF interacted in bipolar II disorder not comorbid with anxiety disorder. Behav Brain Res. 2013 Jan, 237:243-248.
    16. Lee SY, Chen SL, Chang YH, Chen PS, Huang SY, Tzeng NS, Wang YS, Wang LJ, Lee IH, Wang TY, Yeh TL, Yang YK, Hong JS, Lu RB*. Inflammation’s Association with Metabolic Profiles before and after a Twelve-Week Clinical Trial in Drug-Naïve Patients with Bipolar II Disorder. PLOS One.  2013, 27;8(6):e66847.
    17. Lee SY, Chen SL, Chang YH, Chen PS, Huang SY, Tzeng NS, Wang YS, Wang LJ, Lee IH, Yeh TL, Yang YK, Lu RB, Hong JS*. Add-on memantine to valproate treatment increased HDL-C in bipolar II disorder. J Psychiatr Res. 2013, 47(10):1343-8. (SCI, IF: 4.066)
    18. Chang YH, Lee SY, Chen SL, Tzeng NS, Wang TY, Hui Lee I, See Chen P, Huang SY, Kuang Yang Y, Ko HC, Lu RB. Genwtic variants of the BDNF and DRD3 genes in bipolar disorder comorbid with anxiety disorder. J Affect Disord. 2013,151 (3): 967-972
    19. Lee SY, Chen SL, Chang YH, Lu RB.Variation of types of alcoholism: Review and subtypes identified in Han Chinese. Prog Neuropsychopharmacol Biol Psychiatry. 2014; 48:36-40. (IF: 4.025)
    20. Lee SY, Chen SL, Chang YH, Chen SH, Chu CH, Huang SY, Tzeng NS, Wang CL, Wang LJ, Lee IH, Yeh TL, Yang YK, Lu RB. Genotype variant associated with add-on memantine in bipolar II disorder. Int J Neuropsychopharmacol. 2014 Jun, 17:189-197 (IF: 5.264)
    21. Wang TY, Lee SY, Chen SL, Chang YH, Chen SH, Huang SY, Tzeng NS, Wang CL, Yeh PH, Chen KC, Lee IH, Yeh TL, Yang YK and Lu RB*. Gender-specific association of the SLC6A4 and DRD2 gene variants in bipolar disorder. Int J Neuropsychopharmaco. 2014, 17, 211–222. (IF: 5.264)
    22. Chen SL*, Lee SY, Chang YH, Chu CH, Chen SH, Wang TY, Chen PS, Lee IH, Yang YK, Hong JS, Lu RB*. The BDNF Val66Met polymorphism and plasma BDNF level in Han Chinese patients with bipolar disorder, and schizophrenia. Prog in Neuro-Psyhcopharmaco and Bio Psychiatry. 2014; 51:99-104. (IF: 4.025).
    23. Lee SY, Chen SL, Chang YH, Chen PS, Huang SY, Taeng, Yang YK, Hong JS, Lu RB*. The effects of add-on low-dose memantine on cytokine levels in bipolar II depression: a 12-week double-blind, randomized controlled trial. J Clin Psychopharmacol. 2014; 34 (3):337-43. (IF: 3.761).
    24. Chen SL, Lee SY, Chang YH, Chen PS, Lee IH, Wang TY, Chen KC, Yang YK, Hong JS, Lu RB*. Therapeutic effects of add-on low-dose dextromethorphan plus valproic acid in bipolar disorder. Eur Neuropsychopharmaco. 2014; 24(11):1753-9 (IF: 5.539)
    25. Chen SL, Lee SY, Chang YH, Wang TY, Chen PS, Yang YK, Hong JS & Lu RB*. The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in heroin-dependent Han Chinese patients. Scientific Report. 2015, 5:8148. (IF: 5.228).
    26. Lee SY, Chen SL (co-first author), Chang YH, Chen PS, Huang SY, Tzeng NS, Wang LJ, Lee HI, Wang TY, Chen KC, Yang YK, Hong JS & Lu RB*. Low-dose memantine attenuated methadone dose in opioid dependent patients: a 12-week double-blind randomized controlled trial. Scientific Reports. 2015, 19;5:10140. (IF: 5.228)
    27. Lee SY, Chen SL, Chang YH, Chu CH, Chen SH, Chen PS, Huang SY, Tzeng NS, Wang LJ, Lee HI, Wang TY, Chen KC, Yang YK, Hong JS, Lu RB*. A Placebo-Controlled Trial of Dextromethorphan as an Adjunct in Opioid-Dependent Patients Undergoing Methadone Maintenance Treatment. International Journal of Neuropsychopharmacology. 2015; 18(7). (IF: 4.333)
    28. Chang YH, Chen SL, Lee SY, Chen PS, Wang TY, Lee HI, Chen KC, Yang YK, Hong JS & Lu RB*. Low-dose add-on memantine treatment may improve cognitive performance and self-reported health conditions in opioid-dependent patients undergoing methadone-maintenance-therapy. Scientific Reports. 2015; 5:9708. (IF: 5.228)
    29. Wang LJ, Lee SY, Chen SL, Chang YH, Chen PS, Huang SY, Tzeng NS, Chen KC, Lee IH, Wang TY, Yang YK, Lu RB*. A potential interaction between COMT and MTHFR genetic variants in Han Chinese patients with bipolar II disorder. Scientific Reports 2015; 5:8813. (IF: 5.228).
    30. Lee SY, Chen SL, Chang YH, Chen PS, Huang SY, Tzeng NS, Wang LJ, Lee IH, Wang TY, Chen KC, Yang YK, Hong JS, Lu RB. ALDH2 polymorphism associated with attenuating negative symptoms in patients with schizophrenia treated with add-on dextromethorphan. J Psychiatr Res. 2015; 69:50-6. (IF: 4.465)
    31. Wang TY, Lee SY, Chen SL, Chung YL, Li CL, Chang YH, Wang LJ, Chen PS, Chen SH, Chu CH, Huang SY, Tzeng NS, Hsieh TH, Chiu YC, Lee IH, Chen KC, Yang YK, Hong JS, Lu RB*. The Differential Levels of Inflammatory Cytokines and BDNF among Bipolar Spectrum Disorders. Int J Neuropsychopharmacol. 2016; 19 (8): 1-8. (IF: 4.712)
    32. Lee SY, Wang TY, Chen SL, Chang YH, Chen PS, Huang SY, Tzeng NS, Wang LJ, Lee IH, Chen KC, Yang YK, Yang YH, Lu RB, Chen CS*. The correlation between plasma brain-derived neurotrophic factor and cognitive function in bipolar disorder is modulated by the BDNF Val66Met polymorphism. Scientific Reports, 2016, 6:37950. (IF: 5.228).
    33. Wang TY, Lee SY, Chen SL, Chang YH, Wang LJ, Chen PS, Yang YK, Hong JS, Lu RB*.  Comparing clinical responses and the biomarkers of BDNF and cytokines between subthreshold bipolar disorder and bipolar II disorder. Scientific Reports. 2016; 6:27431. (IF: 5.228)
    34. Chang TT, Chen SL, Chang YH, Chen PS, Chu CHm Chen SHm Huang SY, Tzeng NS, Yang YK, Hong JS, Lu RB, Lee SY*. The DRD3 Ser9Gly Polymorphism Predicted Metabolic Change in Drug-Naive Patients With Bipolar II Disorder. Medicine. 2016; 95(24):e3488. (IF: 1.803)
    35. Lu RB, Lee SY, Wang TY, Chang YH, Chen PS, Chu CH, Yang YK, Hong JS, Chen SL*. Long-term heroin use was associated with the downregulation of systemic platelets, BDNF, and TGF-β1, and it contributed to the disruption of executive function in Taiwanese Han Chinese. 2017. Drug and Alcohol Dependence 179:139-145. (SCI, IF: 3.222)
    36. Lee SY, Chen SL, Wang TY, Chang YH, Chen PS, Huang SY, Tzeng NS, Wang LJ, Lee IH, Chen KC, Yang YK, Lu RB. The COMT Val158Met Polymorphism Is Associated With Response to Add-on Dextromethorphan Treatment in Bipolar Disorder. J. Clin Psychopharmacol. 2017; 37(1):94-98. (IF: 2.891)
    37. Chang SL, Chen SL*. Plasma cholesterol and low density lipoprotein correlated to the progression of depressive symptoms in Han Chinese patients with schizophrenia. 2018 (under review).
    38. Liu YC, Hsiao HT, Wang J CF, Wen TC, Lu RB, Chen SL*. A hint of pain biomarkers -The downregulation of TGF-β1 and BDNF in cerebral spinal fluid and plasma in acute and chronic pain patients. 2018 (under submission).

國際會議 (5 年內):

    1. Chen SL, Tao PL, Lu RB*, 2012. Dextromethorphan attenuate inflammatory and dependence in opioid dependent patients. Neuroscience meeting (New Orleans, USA)
    2. Chen SL, Lee SY, Lu RB*, 2013. The BDNF Val66Met polymorphism and plasma BDNF levels in Han Chinese patients with bipolar disorder, schizophrenia, and heroin dependency.Neuroscience meeting  (San Diego, USA ).
    3. Chen SL, Lee SY, Chang YH, Chen PS, Wang TY, Lu RB*, 2014. Therapeutic effects of add-on low-dose dextromethorphan plus valproic acid in bipolar disorder. Asian-Pacific Society for Neurochemistry (Kaohsiung, Taiwan).
    4. Chen SL*, Chang YH, Wang TY, Lu RB*, 2014. The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese patients with heroin use. Neuroscience meeting (Washington DC, USA ).
    5. Chen SL*, Lu RB*, 2015. Long term opioid use induces systemic inflammation and down regulation of TGF-β1 and BDNF. Neuroscience meeting (Chicago, USA)
    6. Chen SL*, Lee HC, Chou MC, Ke LY, Lai CL, Chen CH*, Liu CK*, 2016. Very low density-lipoprotein induced neuronal inflammation and cognitive dysfunction in mice. Neuroscience meeting (San Diego, USA)
    7. Li CL, Lin YS, Lee HC, Chen CH, Chen SL*. 2017. Negative charged very low density lipoprotein induced neuronal inflammation and cognitive dysfunction in vitro and in vivo. University of Cologne-Kaohsiung Medical University Joint Symposium (Kaohsiung, Taiwan)
    8. Chen SL, Lee SY, Wang TY, Li CL, Lu RB*. 2017. Plasma BDNF levels correlated to the executive function and platelet counts but not BDNF Val66Met polymorphism in Han Chinese with long term heroin used. Asia Pacific Society for alcohol and addiction research. (Taipei, Taiwan) (invited speaker)
    9. Chen SL,, Lin YS, Chou MC, Lee HC, Chen CH, Liu CK. Very low density lipoprotein from metabolic syndrome patients induces glia cell activation and cognitive impairment in mice. 2018 Federation of Europe Neuroscience Societies (FENS) meeting (Berlin, Germany)

國內會議 (5 年內):

  1. Chen, SL, Lee, SY, Chang, YH, Yang, SC, Lu RB* (2012). Plasma Brain-Derived Neurotrophic Factor Level in Han Chinese Patients with Bipolar Disorder and Schizophrenia. The 27th Joint Annual Conference of Biomedical sciences, Taiwan R.O.C. P874.
  2. Chen SL, Lee SY, Chang YH, Lu RB* (2012). Dextromethorphan attenuate inflammatory and dependence in opioid dependent patients. Taiwan Neuroscience Meeting (Academia Sinica, Taipei, Taiwan R.O.C.)
  3. Chen SL, Lee SY, Chang YH, Lu RB* (2013). Therapeutic Benefits of Low-Dose Dextromethorphan Plus Valproic Acid in Bipolar Disorder. The 28th Joint Annual Conference of Biomedical sciences, Taiwan R.O.C. P508.
  4. Chen SL, Lee SY, Lu RB* (2013).The BDNF Val66Met polymorphism and plasma BDNF levels in Han Chinese patients with bipolar disorder, schizophrenia, and heroin dependency. Taiwan Neuroscience Meeting, National Yang-Ming University, Taipei, Taiwan R.O.C., P44
  5. Chen SL, Ma HI, Han JM, Tao PL, Law PY and Loh HH. (2016) DsAAV mediated gene transfer of mutant μ-opioid receptors as a pain management paradigm. The 31th Joint Annual Conference of Biomedical sciences, Taipei, Taiwan R.O.C. (invited speaker)

 

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