學術著作 (Publications)

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Publications

      1. Yang CW, Yen CH, Chien TM, et al. Excavatolide E triggers oxidative stress-associated apoptosis and DNA damage to inhibit bladder cancer cell proliferation. Mol Biol Rep. 2026;53(1):234. doi:10.1007/s11033-025-11399-x
      2. Yang CW, Chen CY, Yen CH, Shu CW, Lee HY, Chang HW. Threo-2,3-bis-(4-hydroxy-3-methoxyphenyl)-3-methoxypropanol (THMP) Inhibits Bladder Cancer Cell Proliferation via Oxidative Stress-dependent Apoptosis and DNA Damage. Planta Med. 2026;92(05):584-594. doi:10.1055/a-2752-9897
      3. Woramongkolchai N, Chaotham C, Suriya U, et al. Anti-Adipogenic Effects of N-Methylatalaphylline in 3T3-L1 Cells Through Modulation of Metabolic and Mitogenic Signaling Pathways. Int J Mol Sci. 2026;27(9):3914. doi:10.3390/ijms27093914
      4. Mykhailenko O, Gudžinskas Z, Ivanauskas L, et al. Phenolic Profiling and Bioactive Potential of Iris bucharica. Phyton. 2026;95(1):1-10. doi:10.32604/phyton.2026.074209
      5. Manzano JAH, Abellanosa EAM, Aguilar JPP, et al. Dimeric Anthraquinone Rugulosin A Induces Apoptosis in Lung Adenocarcinoma and Targets PI3K/AKT/MAPK Pathways In Silico. ACS Omega. 2026;11(12):18744-18759. doi:10.1021/acsomega.5c09585
      6. Fu H, Yang CY, So PB, Yen CH, Wu TH, Yen FL. Assessment of skin safety and anti-pollution activity of Clitoria ternatea L. (butterfly pea) flower extract. J Ethnopharmacol. 2026;356:120739. doi:10.1016/j.jep.2025.120739
      7. Chen Y, Lin HY, Lin C, et al. Chronic, Environmentally Relevant PM2.5  Exposure Exacerbates Metabolic Dysfunction‐Associated Steatotic Liver Disease and Early‐Stage Renal Dysfunction in a Rodent Model. Kaohsiung J Med Sci. Published online March 28, 2026:e70206. doi:10.1002/kjm2.70206
      8. Chen YN, Lee JW, Chien TM, Yen CH, Chen BH, Chang HW. Plumbagin sensitizes leukemia cells to cisplatin by promoting oxidative stress, apoptosis, and DNA damage. Int J Med Sci. 2026;23(7):2290-2301. doi:10.7150/ijms.124444
      9. Yen CH, Lin CJ, Chen PY, et al. Taming Pancreatic Cancer: Ardisia virens Kurz-Derived 4-Hydroxy-2-Methoxy-6-Tridecylphenyl Acetate as a Potent Tubulin Polymerization Inhibitor for Targeted Pancreatic Ductal Adenocarcinoma Therapy. Int J Med Sci. 2025;22(3):651-661. doi:10.7150/ijms.104112
      10. Yang CJ, Lin YC, Wu HC, et al. Flavonoid–Sesquiterpenoid Hybrids from the Leaves of Syzygium simile and Their Anti-Lipid Droplet Accumulation Activities. J Nat Prod. 2025;88(4):1057-1067. doi:10.1021/acs.jnatprod.5c00157
      11. Shiau JP, Yang CW, Liu W, et al. Excavatolide C has oxidative-stress-dependent antiproliferative and apoptotic effects against breast cancer cells. BMC Cancer. 2025;25(1):1023. doi:10.1186/s12885-025-14276-9
      12. Ou YL, Chen WC, Yen CH, et al. Sofalcone Suppresses Dengue Virus Replication by Activating Heme Oxygenase-1-Mediated Antiviral Interferon Responses. Int J Mol Sci. 2025;26(13):5921. doi:10.3390/ijms26135921
      13. Nguyen MH, Le NTH, Nguyen BQH, et al. In vitro and in silico hybrid approach to unveil triterpenoids from Helicteres hirsuta leaves as potential compounds for inhibiting Nrf2. RSC Adv. 2025;15(3):1915-1923. doi:10.1039/D4RA07646J
      14. Lin HYH, Chen IY, Wang TM, et al. The Role of Mitochondrial AKT1 Signaling in Renal Tubular Injury of Metabolic Syndrome. Kidney Int Rep. 2025;10(3):906-920. doi:10.1016/j.ekir.2024.12.021
      15. Lin CH, Ko HH, Wu JY, et al. Dual activation of AhR and Nrf2 pathways by the natural stilbenoid tapinarof protects against particulate matter-induced skin barrier dysfunction. Toxicol Appl Pharmacol. 2025;505:117559. doi:10.1016/j.taap.2025.117559
      16. Hoa NT, Afzal H, Doan TD, Murtaza A, Yen CH, Chung YC. Utilizing NF-κB Signaling in Porcine Epithelial Cells to Identify a Plant-Based Additive for the Development of a Porcine Epidemic Diarrhea Virus Vaccine. Vet Sci. 2025;12(2):181. doi:10.3390/vetsci12020181
      17. Van TTT, Chang HS, Wu HC, et al. The SAR analysis of dietary polyphenols and their antagonistic effects on bortezomib at physiological concentrations. Front Pharmacol. 2024;15:1403424. doi:10.3389/fphar.2024.1403424
      18. Tran HL, Lai KH, Chang HS, et al. Indigofera suffruticosa aerial parts extract induce G2/M arrest and ATR/CHK1 pathway in Jurkat cells. BMC Complement Med Ther. 2024;24(1):28. doi:10.1186/s12906-023-04325-w
      19. Nguyen MH, Nguyen NYT, Chen YS, Nguyen Le HT, Vo HT, Yen CH. Unveiling the potential of medicinal herbs as the source for in vitro screening toward the inhibition of Nrf2. Heliyon. 2024;10(19):e38411. doi:10.1016/j.heliyon.2024.e38411
      20. Nguyen BQH, Le NTH, Nguyen TYN, Nguyen HKT, Yen CH, Nguyen MH. Hybridisation of in silico and in vitro bioassays for studying the activation of Nrf2 by natural compounds. Sci Rep. 2024;14(1):31222. doi:10.1038/s41598-024-82559-5
      21. Manzano JAH, Abellanosa EA, Aguilar JP, et al. Globospiramine from Voacanga globosa Exerts Robust Cytotoxic and Antiproliferative Activities on Cancer Cells by Inducing Caspase-Dependent Apoptosis in A549 Cells and Inhibiting MAPK14 (p38α): In Vitro and Computational Investigations. Cells. 2024;13(9):772. doi:10.3390/cells13090772
      22. Liu JY, Yen CH, Lin YF, Feng YH, Fang YP. Improving the Thrombocytopenia Adverse Reaction of Belinostat Using Human Serum Albumin Nanoparticles. Int J Nanomedicine. 2024;Volume 19:10785-10800. doi:10.2147/IJN.S475823
      23. Hsu CM, Kao SY, Yen CH, et al. Biomarker potential of nuclear Nrf2 activation in the ABC subtype of diffuse large B‑cell lymphoma. Oncol Lett. 2024;29(1):30. doi:10.3892/ol.2024.14776
      24. Chuang YF, Cheng L, Chang WH, et al. Spatheliachromen mitigates methylglyoxal-induced myotube atrophy by activating Nrf2, inhibiting ubiquitin-mediated protein degradation, and restoring mitochondrial function. Eur J Pharmacol. 2024;984:177070. doi:10.1016/j.ejphar.2024.177070
      25. Chien TM, Yang CW, Yen CH, et al. Excavatolide C/cisplatin combination induces antiproliferation and drives apoptosis and DNA damage in bladder cancer cells. Arch Toxicol. 2024;98(5):1543-1560. doi:10.1007/s00204-024-03699-1
      26. Yu TJ, Shiau JP, Tang JY, et al. Physapruin A Exerts Endoplasmic Reticulum Stress to Trigger Breast Cancer Cell Apoptosis via Oxidative Stress. Int J Mol Sci. 2023;24(10):8853. doi:10.3390/ijms24108853
      27. Wu HC, His HY, Hsiao G, et al. Chemical Constituents and Bioactive Principles from the Mexican Truffle and Fermented Products of the Derived Fungus Ustilago maydis MZ496986. J Agric Food Chem. 2023;71(2):1122-1131. doi:10.1021/acs.jafc.2c08149
      28. Tran HL, Chen YS, Hung HW, et al. Diet Supplementation with Prinsepiae Nux Extract in Broiler Chickens: Its Effect on Growth Performance and Expression of Antioxidant, Pro-Inflammatory, and Heat Shock Protein Genes. Animals. 2023;14(1):73. doi:10.3390/ani14010073
      29. Tai CJ, Chao CH, Ahmed AF, et al. New 3,4-seco-3,19-Dinor- and Spongian-Based Diterpenoid Lactones from the Marine Sponge Spongia sp. Int J Mol Sci. 2023;24(2):1252. doi:10.3390/ijms24021252
      30. Notarte KIR, Quimque MTJ, Macaranas IT, et al. Attenuation of Lipopolysaccharide-Induced Inflammatory Responses through Inhibition of the NF-κB Pathway and the Increased NRF2 Level by a Flavonol-Enriched n -Butanol Fraction from Uvaria alba. ACS Omega. 2023;8(6):5377-5392. doi:10.1021/acsomega.2c06451
      31. Liu IF, Lin TC, Wang SC, et al. Long-term administration of Western diet induced metabolic syndrome in mice and causes cardiac microvascular dysfunction, cardiomyocyte mitochondrial damage, and cardiac remodeling involving caveolae and caveolin-1 expression. Biol Direct. 2023;18(1):9. doi:10.1186/s13062-023-00363-z
      32. Lin HY ‐H., Chang L, Niu S, et al. High risk of renal outcome of metabolic syndrome independent of diabetes in patients with CKD stage 1–4: The ICKD database. Diabetes Metab Res Rev. 2023;39(4):e3618. doi:10.1002/dmrr.3618
      33. Hsu CM, Chang KC, Chuang TM, et al. High G9a Expression in DLBCL and Its Inhibition by Niclosamide to Induce Autophagy as a Therapeutic Approach. Cancers. 2023;15(16):4150. doi:10.3390/cancers15164150
      34. Cheng JH, Wu HC, Yen CH, Hwang TL, Ko HH, Chang HS. Chemical Constituents with Anti-Lipid Droplet Accumulation and Anti-Inflammatory Activity from Elaeagnus glabra. Plants. 2023;12(16):2943. doi:10.3390/plants12162943
      35. Chen WC, Hossen M, Liu W, et al. Grape Seed Proanthocyanidins Inhibit Replication of the Dengue Virus by Targeting NF-kB and MAPK-Mediated Cyclooxygenase-2 Expression. Viruses. 2023;15(4):884. doi:10.3390/v15040884
      36. Chang MS, Lee CY, Liu ES, et al. A Low-Cost, Sensitive Reporter System Using Membrane-Tethered Horseradish Peroxidase for Efficient Gene Expression Analysis. Anal Chem. 2023;95(38):14341-14349. doi:10.1021/acs.analchem.3c02684
      37. Yu TJ, Yen CY, Cheng YB, et al. Physapruin A Enhances DNA Damage and Inhibits DNA Repair to Suppress Oral Cancer Cell Proliferation. Int J Mol Sci. 2022;23(16):8839. doi:10.3390/ijms23168839
      38. Yu TJ, Tang JY, Shiau JP, et al. Gingerenone A Induces Antiproliferation and Senescence of Breast Cancer Cells. Antioxidants. 2022;11(3):587. doi:10.3390/antiox11030587
      39. Yu TJ, Shiau JP, Tang JY, et al. Physapruin A Induces Reactive Oxygen Species to Trigger Cytoprotective Autophagy of Breast Cancer Cells. Antioxidants. 2022;11(7):1352. doi:10.3390/antiox11071352
      40. Yang CW, Chien TM, Yen CH, Wu WJ, Sheu JH, Chang HW. Antibladder Cancer Effects of Excavatolide C by Inducing Oxidative Stress, Apoptosis, and DNA Damage In Vitro. Pharmaceuticals. 2022;15(8):917. doi:10.3390/ph15080917
      41. Wang SH, Chen YS, Lai KH, et al. Prinsepiae Nux Extract Activates NRF2 Activity and Protects UVB-Induced Damage in Keratinocyte. Antioxidants. 2022;11(9):1755. doi:10.3390/antiox11091755
      42. Tseeleesuren D, Hsiao HH, Kant R, et al. The Expression and Prognostic Value of Cancer Stem Cell Markers, NRF2, and Its Target Genes in TAE/TACE-Treated Hepatocellular Carcinoma. Medicina (Mex). 2022;58(2):212. doi:10.3390/medicina58020212
      43. Thepthanee C, Liu CC, Yu HS, et al. Antioxidant Activity and Inhibitory Effects of Black Rice Leaf on the Proliferation of Human Carcinoma Cells. Li WW, ed. BioMed Res Int. 2022;2022(1):7270782. doi:10.1155/2022/7270782
      44. Tai CJ, Ahmed AF, Chao CH, et al. The Chemically Highly Diversified Metabolites from the Red Sea Marine Sponge Spongia sp. Mar Drugs. 2022;20(4):241. doi:10.3390/md20040241
      45. Tai CJ, Ahmed AF, Chao CH, et al. Spongenolactones A–C, Bioactive 5,5,6,6,5-Pentacyclic Spongian Diterpenes from the Red Sea Sponge Spongia sp. Mar Drugs. 2022;20(8):498. doi:10.3390/md20080498
      46. Liu W, Hsu YY, Tang JY, et al. Methanol Extract of Commelina Plant Inhibits Oral Cancer Cell Proliferation. Antioxidants. 2022;11(9):1813. doi:10.3390/antiox11091813
      47. Hu HC, Yu SY, Hung XS, et al. Composition decipherment of Ficus pumila var. awkeotsang and its potential on COVID-19 symptom amelioration and in silico prediction of SARS-CoV-2 interference. J Food Drug Anal. 2022;30(3):440-453. doi:10.38212/2224-6614.3419
      48. Hsu SK, Chu YH, Syue WJ, et al. The Role of Nonapoptotic Programmed Cell Death — Ferroptosis, Necroptosis, and Pyroptosis — in Pancreatic Ductal Adenocarcinoma Treatment. Front Oncol. 2022;12:872883. doi:10.3389/fonc.2022.872883
      49. Hsu CM, Yen CH, Wang SC, et al. Emodin Ameliorates the Efficacy of Carfilzomib in Multiple Myeloma Cells via Apoptosis and Autophagy. Biomedicines. 2022;10(7):1638. doi:10.3390/biomedicines10071638
      50. Hsiao HH, Liu YC, Wang HC, et al. Comparison of a novel lateral-flow device to galactomannan assay at different time periods for detections of invasive aspergillosis. J Formos Med Assoc. 2022;121(10):2123-2129. doi:10.1016/j.jfma.2022.04.011
      51. Chen YC, Yang CW, Chan TF, et al. Cryptocaryone Promotes ROS-Dependent Antiproliferation and Apoptosis in Ovarian Cancer Cells. Cells. 2022;11(4):641. doi:10.3390/cells11040641
      52. Chang YH, Yen CH, Lai CC, Lai HY, Hung HY. Discovery of 5,7-Dimethoxy-2-(3,4,5-trimethoxyphenoxy)-chromen-4-one with Lipid Lowering Effects in Hepatocytes. Pharmaceuticals. 2022;15(4):449. doi:10.3390/ph15040449
      53. Yu TJ, Cheng YB, Lin LC, et al. Physalis peruviana-Derived Physapruin A (PHA) Inhibits Breast Cancer Cell Proliferation and Induces Oxidative-Stress-Mediated Apoptosis and DNA Damage. Antioxidants. 2021;10(3):393. doi:10.3390/antiox10030393
      54. Wang S, Li C, Chang W, et al. Exosome‐derived differentiation antagonizing non‐protein coding RNA with risk of hepatitis C virus‐related hepatocellular carcinoma recurrence. Liver Int. 2021;41(5):956-968. doi:10.1111/liv.14772
      55. Thepthanee C, Liu CC, Yu HS, et al. Evaluation of Phytochemical Contents and In Vitro Antioxidant, Anti-Inflammatory, and Anticancer Activities of Black Rice Leaf (Oryza sativa L.) Extract and Its Fractions. Foods. 2021;10(12):2987. doi:10.3390/foods10122987
      56. Mykhailenko O, Petrikaite V, Korinek M, et al. Pharmacological Potential and Chemical Composition of Crocus sativus Leaf Extracts. Molecules. 2021;27(1):10. doi:10.3390/molecules27010010
      57. Mykhailenko O, Petrikaitė V, Korinek M, et al. Bio-guided bioactive profiling and HPLC-DAD fingerprinting of Ukrainian saffron (Crocus sativus stigmas): moving from correlation toward causation. BMC Complement Med Ther. 2021;21(1):203. doi:10.1186/s12906-021-03374-3
      58. Korinek M, Handoussa H, Tsai YH, et al. Anti-Inflammatory and Antimicrobial Volatile Oils: Fennel and Cumin Inhibit Neutrophilic Inflammation via Regulating Calcium and MAPKs. Front Pharmacol. 2021;12:674095. doi:10.3389/fphar.2021.674095
      59. Kant R, Yang MH, Tseng CH, et al. Discovery of an Orally Efficacious MYC Inhibitor for Liver Cancer Using a GNMT-Based High-Throughput Screening System and Structure–Activity Relationship Analysis. J Med Chem. 2021;64(13):8992-9009. doi:10.1021/acs.jmedchem.1c00093
      60. Hsu SK, Li CY, Lin IL, et al. Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment. Theranostics. 2021;11(18):8813-8835. doi:10.7150/thno.62521
      61. Hsu SK, Cheng KC, Mgbeahuruike MO, et al. New Insight into the Effects of Metformin on Diabetic Retinopathy, Aging and Cancer: Nonapoptotic Cell Death, Immunosuppression, and Effects beyond the AMPK Pathway. Int J Mol Sci. 2021;22(17):9453. doi:10.3390/ijms22179453
      62. Fu H, Yen FL, Huang PH, Yang CY, Yen CH. Oleanolic Acid Nanofibers Attenuated Particulate Matter-Induced Oxidative Stress in Keratinocytes. Antioxidants. 2021;10(9):1411. doi:10.3390/antiox10091411
      63. Du JS, Yen CH, Hsu CM, Hsiao HH. Management of Myeloma Bone Lesions. Int J Mol Sci. 2021;22(7):3389. doi:10.3390/ijms22073389
      64. Chien TM, Wu KH, Chuang YT, et al. Withaferin a Triggers Apoptosis and DNA Damage in Bladder Cancer J82 Cells through Oxidative Stress. Antioxidants. 2021;10(7):1063. doi:10.3390/antiox10071063
      65. Chen YS, Chang HS, Hsiao HH, et al. Identification of Beilschmiedia tsangii Root Extract as a Liver Cancer Cell–Normal Keratinocyte Dual-Selective NRF2 Regulator. Antioxidants. 2021;10(4):544. doi:10.3390/antiox10040544
      66. Yen CH, Hsu CM, Hsiao SY, Hsiao HH. Pathogenic Mechanisms of Myeloma Bone Disease and Possible Roles for NRF2. Int J Mol Sci. 2020;21(18):6723. doi:10.3390/ijms21186723
      67. Yang WS, Lin TY, Chang L, et al. HIV-1 Tat Interacts with a Kaposi’s Sarcoma-Associated Herpesvirus Reactivation-Upregulated Antiangiogenic Long Noncoding RNA, LINC00313, and Antagonizes Its Function. Jung JU, ed. J Virol. 2020;94(3):e01280-19. doi:10.1128/JVI.01280-19
      68. Wu HC, Cheng MJ, Yen CH, et al. Chemical Constituents with GNMT-Promoter-Enhancing and NRF2-Reduction Activities from Taiwan Agarwood Excoecaria formosana. Molecules. 2020;25(7):1746. doi:10.3390/molecules25071746
      69. Mykhailenko O, Korinek M, Ivanauskas L, et al. Qualitative and Quantitative Analysis of Ukrainian Iris Species: A Fresh Look on Their Antioxidant Content and Biological Activities. Molecules. 2020;25(19):4588. doi:10.3390/molecules25194588
      70. Kao YT, Chen YS, Tang KW, et al. Discovery of 4-Anilinoquinolinylchalcone Derivatives as Potential NRF2 Activators. Molecules. 2020;25(14):3133. doi:10.3390/molecules25143133
      71. Kant R, Lu CK, Nguyen HM, et al. 1,2,3,4,6 penta-O-galloyl-β-D-glucose ameliorates high-fat diet-induced nonalcoholic fatty liver disease and maintains the expression of genes involved in lipid homeostasis in mice. Biomed Pharmacother. 2020;129:110348. doi:10.1016/j.biopha.2020.110348
      72. Huang SW, Miller SO, Yen CH, Wang SF. Impact of Genetic Variability in ACE2 Expression on the Evolutionary Dynamics of SARS-CoV-2 Spike D614G Mutation. Genes. 2020;12(1):16. doi:10.3390/genes12010016
      73. Huang HS, Yu HS, Yen CH, Liaw ET. Multiple-Reaction Monitoring Tandem Mass Method for Determination of Phenolics and Water-Soluble Vitamins in Eccoilopus formosanus. Molecules. 2020;25(16):3632. doi:10.3390/molecules25163632
      74. Hu HC, Li CY, Tsai YH, et al. Secondary Metabolites and Bioactivities of Aspergillus ochraceopetaliformis Isolated from Anthurium brownii. ACS Omega. 2020;5(33):20991-20999. doi:10.1021/acsomega.0c02489
      75. Yang MH, Yen CH, Chen YF, et al. Somatic mutations of PREX2 gene in patients with hepatocellular carcinoma. Sci Rep. 2019;9(1):2552. doi:10.1038/s41598-018-36810-5
      76. Yang MH, Liao CC, Hung JH, Lai XT, Yen CH, Chen YMA. Utilizing proteomic approach to identify nuclear translocation related serine kinase phosphorylation site of GNMT as downstream effector for benzo[a]pyrene. J Food Drug Anal. 2019;27(2):603-609. doi:10.1016/j.jfda.2018.12.007
      77. Tang J, Peng S, Cheng Y, et al. Ethyl acetate extract of Nepenthes adrianii x clipeata induces antiproliferation, apoptosis, and DNA damage against oral cancer cells through oxidative stress. Environ Toxicol. 2019;34(8):891-901. doi:10.1002/tox.22748
      78. Tang JY, Li LJ, Ou-Yang F, et al. Ethyl Acetate Extract of Nepenthes ventricosa x maxima Exerts Preferential Killing to Oral Cancer Cells. DNA Cell Biol. 2019;38(8):763-772. doi:10.1089/dna.2018.4436
      79. Kant R, Yen CH, Hung JH, et al. Induction of GNMT by 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranoside through proteasome-independent MYC downregulation in hepatocellular carcinoma. Sci Rep. 2019;9(1):1968. doi:10.1038/s41598-018-37292-1
      80. Huang JW, Chen CJ, Yen CH, Chen YMA, Liu YP. Loss of Glycine N-Methyltransferase Associates with Angiopoietin-Like Protein 8 Expression in High Fat-Diet-Fed Mice. Int J Mol Sci. 2019;20(17):4223. doi:10.3390/ijms20174223
      81. Yen CH, Lai CC, Shia TH, et al. Gynura divaricata attenuates tumor growth and tumor relapse after cisplatin therapy in HCC xenograft model through suppression of cancer stem cell growth and Wnt/β-catenin signalling. J Ethnopharmacol. 2018;213:366-375. doi:10.1016/j.jep.2017.07.019
      82. Yen CH, Hsiao HH. NRF2 Is One of the Players Involved in Bone Marrow Mediated Drug Resistance in Multiple Myeloma. Int J Mol Sci. 2018;19(11):3503. doi:10.3390/ijms19113503
      83. Yen CH, Chang HS, Yang TH, et al. High-Content Screening of a Taiwanese Indigenous Plant Extract Library Identifies Syzygium simile leaf Extract as an Inhibitor of Fatty Acid Uptake. Int J Mol Sci. 2018;19(7):2130. doi:10.3390/ijms19072130
      84. Tseeleesuren D, Kant R, Yen CH, Hsiao HH, Chen YMA. 1,2,3,4,6-Penta-O-Galloyl-Beta-D-Glucopyranoside Inhibits Proliferation of Multiple Myeloma Cells Accompanied with Suppression of MYC Expression. Front Pharmacol. 2018;9:65. doi:10.3389/fphar.2018.00065
      85. Liu Y, Chen C, Yen C, et al. Human immunodeficiency virus Tat‐ TIP 30 interaction promotes metastasis by enhancing the nuclear translocation of Snail in lung cancer cell lines. Cancer Sci. 2018;109(10):3105-3114. doi:10.1111/cas.13768
      86. Hung JH, Li CH, Yeh CH, et al. MicroRNA-224 down-regulates Glycine N-methyltransferase gene expression in Hepatocellular Carcinoma. Sci Rep. 2018;8(1):12284. doi:10.1038/s41598-018-30682-5
      87. Chou CK, Liu W, Hong YJ, et al. Ethyl Acetate Extract of Scindapsus cf. hederaceus Exerts the Inhibitory Bioactivity on Human Non-Small Cell Lung Cancer Cells through Modulating ER Stress. Int J Mol Sci. 2018;19(7):1832. doi:10.3390/ijms19071832
      88. Cheng YB, Liu FJ, Wang CH, et al. Bioactive Triterpenoids from the Leaves and Twigs of Lithocarpus litseifolius and L. corneus. Planta Med. 2018;84(01):49-58. doi:10.1055/s-0043-113826
      89. Yen CH, Lai CC, Liao CC, et al. Characterization of a new murine cell line of sarcomatoid hepatocellular carcinoma and its application for biomarker/therapy development. Sci Rep. 2017;7(1):3052. doi:10.1038/s41598-017-03164-3
      90. Li CH, Yen CH, Chen YF, et al. Characterization of the GNMT-HectH9-PREX2 tripartite relationship in the pathogenesis of hepatocellular carcinoma: GNMT regulates PREX2 level via HectH9. Int J Cancer. 2017;140(10):2284-2297. doi:10.1002/ijc.30652
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      92. Kant R, Yen CH, Lu CK, Lin YC, Li JH, Chen YM. Identification of 1,2,3,4,6-Penta-O-galloyl-β-d-glucopyranoside as a Glycine N-Methyltransferase Enhancer by High-Throughput Screening of Natural Products Inhibits Hepatocellular Carcinoma. Int J Mol Sci. 2016;17(5):669. doi:10.3390/ijms17050669
      93. Wang SF, Tseng SP, Huang SW, et al. Mitochondria Polarization in the Contact Regions of Virus-Infected Effector Cells During Cell-to-Cell Transmission of HIV-1. AIDS Res Hum Retroviruses. 2015;31(2):175-176. doi:10.1089/aid.2014.0328
      94. Lin YT, Yen CH, Chen HL, et al. The serologic decoy receptor 3 (DcR3) levels are associated with slower disease progression in HIV-1/AIDS patients. J Formos Med Assoc. 2015;114(6):498-503. doi:10.1016/j.jfma.2013.01.007
      95. Liao YJ, Fang CC, Yen CH, et al. Niemann-Pick type C2 protein regulates liver cancer progression via modulating ERK1/2 pathway: Clinicopathological correlations and therapeutical implications: Identification of antitumoral protein NPC2 in liver cancer. Int J Cancer. 2015;137(6):1341-1351. doi:10.1002/ijc.29507
      96. Wang SF, Tseng SP, Yen CH, et al. Antibody-dependent SARS coronavirus infection is mediated by antibodies against spike proteins. Biochem Biophys Res Commun. 2014;451(2):208-214. doi:10.1016/j.bbrc.2014.07.090
      97. Li CH, Lin MH, Chu SH, et al. Role of Glycine N-Methyltransferase in the Regulation of T-Cell Responses in Experimental Autoimmune Encephalomyelitis. Mol Med. 2014;20(1):684-696. doi:10.2119/molmed.2014.00133
      98. Huang SW, Wang SF, Lin YT, et al. Patients Infected with CRF07_BC Have Significantly Lower Viral Loads than Patients with HIV-1 Subtype B: Mechanism and Impact on Disease Progression. Paxton WA, ed. PLoS ONE. 2014;9(12):e114441. doi:10.1371/journal.pone.0114441
      99. Yen CH, Lin YT, Chen HL, Chen SY, Chen YMA. The multi-functional roles of GNMT in toxicology and cancer. Toxicol Appl Pharmacol. 2013;266(1):67-75. doi:10.1016/j.taap.2012.11.003
      100. Liao YJ, Lin MW, Yen CH, et al. Characterization of Niemann-Pick Type C2 Protein Expression in Multiple Cancers Using a Novel NPC2 Monoclonal Antibody. Aoki I, ed. PLoS ONE. 2013;8(10):e77586. doi:10.1371/journal.pone.0077586
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