代表著作

Publication List   ORCID ID

2024

50. Catalyst-free Activation of N-C(O) Amide Bonds – Efficient Cascade Synthesis of N-acyl thiocarbamides in Batch and Continuous-Flow

Govindan, K.; Alageswaran J.; Lin, W. -Y.*

Green Chemistry 2024, ASAP

49.Base-promoted triple cleavage of CCl2Br: a direct one-pot synthesis of unsymmetrical oxalamide derivatives

Alageswaran J.; Vijay, T. S.; Govindan, K.;  Liu, Y. -M.; Chen, N.-Q.;  Yeh, T. -W.; Gokulakannan V.; Li, C. -H.; Leung, T. -F.; Lin, W. -Y.*

Chemical Communication  2024,  60, 3079-3082.

48. Silver nitrate promoted synthesis of tetraphenyl derivatives and diaryl ketones

Chen, N.-Q.; Govindan, K.; Alageswaran J.; Lee, Y. J.; Lin, W. -Y.*

ARKIVOC 2024, ASAP. https://doi.org/10.24820/ark.5550190.p012.012

47. PhNCO-enabled synthesis of secondary amides from N-(2-aminophenyl)benzamides

Govindan, K.; Chen, N.-Q.; Alageswaran J.; Lin, W. -Y.*

New Journal of Chemistry, 2024, 48, 1103-1107

2023

46. Photothermal Aza-Michael Addition of Divergent Amines to Vinyl Sulfones: A Method Towards Transition Metal- and Base-Free Medium

Duraisamy, T.; Govindan, K.; Seenivasan, V. T.; Chen, N.-Q.; Liao, Z. -X.; Lin, W. -Y.*

Asian Journal of Organic Chemistry, 2023, 12, e202300367.

45. FeCl₃‐Catalyzed Decyanative [4 + 2] Annulation of α‐Aminonitriles with Alkynes: Access to 2,4-Diaryl Quinolines in Batch and Continuous-Flow Processes

Sathyendran, S.; Muthu, K.; Govindan, K.; Chen, N.-Q.; Lin, W. -Y.; Senadi, G. C.*

Organic Letter. 2023, 25, 4086-4091.

44.  The copper-catalyzed oxidative radical process of site selective C–N bond cleavage in twisted amides: batch and continuous-flow chemistry

Govindan, K.; Chen, N.-Q.; Chen, H.-Y.; Hsu, S. C. N. Lin, W. -Y.*

Catalyst Science and Technology. 2023, 13, 1633 – 1639.

 

43. Iodine-Promoted Oxidative Cyclization of Acylated and Alkylated Derivatives from Epoxides toward the Synthesis of Aza Heterocycles

Alageswaran J.; Govindan, K,; Kannan, V. R.; Seenivasan V. T.; Chen, N. -Q.; Lin, W. -Y.*

Journal of  Organic Chemistry,  2023, 3, 1749-1761.

42.  Preliminary investigation on biological possessions of Saquinavir‐modified quinoline‐derived azadipeptidomimetics

Perumal, G.; Govindan, K,;  Alageswaran J.; Sundaramoorthi, S. ; Lin, W. -Y.*

Journal of the Chinese Chemical Society  2023, 70, 145-158.

2022

41.Visible Light-Promoted Fluorescein/Ni-Catalyzed Synthesis of Bis-(β-Dicarbonyls) using Olefins as a Methylene Bridge Synthon

Palani, P.; Arumugam, A.; Anandan M.; Nutalapati V.; Govindan K.; Lin, W. -Y., Senadi, G. C.*

Asian Journal of Organic Chemistry, 2022, 11, e202200424

40. Metal-Free N–H/C–H Carbonylation by Phenyl Isocyanate: Divergent Synthesis of Six-Membered N-Heterocycles

Govindan, K,;  Alageswaran J.;   Tamilseivan, D.; Chen N.-Q.; Lin, W. -Y.*

Journal of Organic Chemistry, 2022, 87, 8719-8729.

39. DMSO as C1 source under metal-and oxidant-free conditions: NH4SCN mediated synthesis of quinazolinone and dihydroquinazolin-4(1H)-one derivatives

Govindan, K,;  Alageswaran J.;  Chen N.-Q.; Tamilseivan, D.;  Lin, W. -Y.*

Asian Journal of Organic Chemistry, 2022, 11. e202200274

https://doi.org/10.1002/ajoc.202200274

38. Efficient synthesis of symmetrical and unsymmetrical disulfides using a continuous flow method

Lo, Y. -H.; Wang, L. Y.; Tamilseivan, D.; Govindan, K,; Lin, W. -Y.*

Asian Journal of Organic Chemistry, 2022, 11. e202200203

 https://doi.org/10.1002/ajoc.202200203

37. Copper-Catalyzed Oxidative Cyclization of 2-Aminobenzamide Derivatives: Efficient Syntheses of Quinazolinones and Indazolones

Govindan, K,; Tamilseivan, D.; Alageswaran J.; Chandru, G.;  Lin, W. -Y.*

Synthesis, 2022, 54, 1115-1124

2021

36.  Unlocking Amides through Selective C–N Bond Cleavage: Allyl Bromide-Mediated Divergent Synthesis of Nitrogen-Containing Functional Groups

Govindan, K,; Chen, N.-Q.; Chuang, Y. -W.;  Lin, W. -Y.*

Organic Letter  2021, 23, 9419-9424.

35. Copper-Catalyzed Oxidative C−C Cleavage of Carbohydrates: An Efficient Access to Quinazolinone Scaffolds

Philips, A.; Raja D.; Arumugam, A.; Lin, W. -Y.*;  Chandru S. G.*

Asian Journal of Organic Chemistry. 2021, 10,  1795-1810.

34.  Ring Opening/Site Selective Cleavage in N-Acyl Glutarimide to Synthesize Primary Amides

Govindan, K,;  Lin, W. -Y.*

Organic Letter 2021, 23, 1600-1605.

2020

33.  Visible Light-Induced N-methyl Activation of Unsymmetric Tertiary Amines

Perumal, G.;  Kandasamy, M.;  Ganesan, B.;  Govindan, K.;  Sathya, H.;  Hung, M.-Y.;  Chandru S. G.;  Wu, Y.-C.; Lin, W. -Y.*

Tetrahedron 2021, 80, 131891.

32.  Metal-free Synthesis of Benzimidazoles via Oxidative Cyclization of D-Glucose with o-Phenylenediamines in Water

Raja, D.;  Philips, A.;  Palani, P.;  Lin, W. -Y.;  Devikala, S.; Senadi, G. C.*

Journal of Organic Chemistry. 2020, 85, 11531-11540

31.  Copper-catalyzed synthesis of aminoquinolines from β-(2-aminophenyl)-α,β-ynones using DMF as dual synthon

Ganesan, B.;  Govindan, K.;  Senadi, G. C.;  Kandasamy, M.; Lin, W. -Y.*

Chemical Communication, 2020, 56, 6488-6491. DOI: 10.1039/D0CC03033C

30. Determination of the Orientation of Pendants on Rigid‐Rod Polymers

Luh, T. Y.*;  Lin, W. -Y.*; Lai, G. Q.*

Chemistry, An Asian Journal,  2020, 15, 1808-1818.

29. Continuous flow as a benign strategy for the synthesis of Thioesters via selective C-N bond cleavage

Kandasamy, M.;  Amalraj, A. J. J.;  Perumal, G.;  Ganesan, B.;  Senadi, G. C.; Lin, W.-Y.*

Journal of Flow Chemistry 2020, 10, 507-515.

2019

28. In Situ Generation of Alkynylzinc and Its Subsequent Negishi Reaction in a Flow Reactor

Kandasamy, M.;  Huang, Y.-H.;  Ganesan, B.;  Senadi, G. C.; Lin, W.-Y.*

European  Journal of Organic Chemistry. 2019, 4349-4356 (Highlighted in Synfacts,  2019, 15, 0955)

27.  Fast and Efficient Continuous Flow Method for the Synthesis of Ynones and Pyrazoles

Kandasamy, M.;  Ganesan, B.;  Hung, M.-Y.; Lin, W.-Y.*

European  Journal of Organic Chemistry. 2019. 3183-3189 (Highlighted in Synfacts,  2019, 15, 0830)

2018

26. Microwave-assisted Synthesis of Thioesters from Aldehydes and Thiols in Water.

Jhuang, H. S.;  Liu, Y. W.;  Reddy, D. M.;  Tzeng, Y. Z.;  Lin, W. -Y.*; Lee, C. F.,

Journal Chinese Chemical Society 2018, 65 , 24-27.

25. A copper(II)-catalyzed annulative formylation of o-alkynylanilines with DMF: a single-step strategy for 3-formyl indoles

Ganesan, B.;  Senadi, G. C.;  Guo, B.-C.;  Hung, M.-Y.; Lin, W.-Y*.

RSC Advance. 2018, 8, 40968-40973

2016

24.PIFA-Mediated Synthesis of Acylsulfenic Acid Alkyl Esters and Benzoyl Alkyl Disulfides from Thioacids.

Tsai, C.-H.;  Reddy, D. M.;  Hsieh, P.-A.;  Liu, Y.-C.;  Kandasamy, M.;  Lin, W.-Y.*; Lee, C.-F.*

Synthesis 2016, 48, 4459-4464.

23. A High-Throughput Platform for Formulating and Screening Multifunctional Nanoparticles Capable of Simultaneous Delivery of Genes and Transcription Factors.

Liu, Y.; Du, J. J.; Choi, J. S.; Chen, K. J.; Hou, S.; Yan, M.; Lin, W. Y.; Chen, K. S.; Ro, T.; Lipshutz, G. S.; Wu, L.; Shi, L. Q.; Lu, Y. F*.; Tseng, H. R*.; Wang H.

Angew. Chemie. Int. Ed. 2016, 55, 169-173

22.Pretargeted Positron Emission Tomography Imaging That Employs Supramolecular Nanoparticles with in Vivo Bioorthogonal Chemistry.

Hou, S.;  Choi, J. S.;  Garcia, M. A.;  Xing, Y.;  Chen, K. J.;  Chen, Y. M.;  Jiang, Z. K.;  Ro, T.;  Wu, L.;  Stout, D. B.;  Tomlinson, J. S.;  Wang, H.;  Chen, K.;  Tseng, H. R*.; Lin, W. -Y*.

ACS Nano 2016, 10, 1417-1424.

21. Molecular recognition enables nanosubstrate-mediated delivery of gene-encapsulated nanoparticles with high efficiency.

Peng, J.;  Garcia, M. A.;  Choi, J. S.;  Zhao, L.;  Chen, K. J.;  Bernstein, J. R.;  Peyda, P.;  Hsiao, Y. S.;  Liu, K. W.; Lin, W. -Y.;  Pyle, A. D.;  Wang, H.;  Hou, S.; Tseng, H. R*.

ACS Nano 2014, 8, 4621-4629.

20.Improved and optimized one-pot method for N-succinimidyl-4-[F-18] fluorobenzoate ([F-18]SFB) synthesis using microwaves

Li, K. P.;  Hu, M. K.;  Shen, C. K. F.; Lin, W. -Y.;  Hou, S.;  Zhao, L. B.;  Cheng, C. Y.; Shen, D. H.

Appl. Radiat. Isot. 2014, 94, 113-117.

19. On-demand drug release system for in vivo cancer treatment through self-assembled magnetic nanoparticles.

Lee, J. H.;  Chen, K. J.;  Noh, S. H.;  Garcia, M. A.;  Wang, H.; Lin, W. -Y.;  Jeong, H.;  Kong, B. J.;  Stout, D. B.;  Cheon, J.; Tseng, H. R.,

Angewandte Chemie International Edition  2013, 52, 4384-4388.

18.The therapeutic efficacy of camptothecin-encapsulated supramolecular nanoparticles.

Chen, K. J.;  Tang, L.;  Garcia, M. A.;  Wang, H.;  Lu, H.; Lin, W. -Y.;  Hou, S.;  Yin, Q.;  Shen, C. K.;  Cheng, J.; Tseng, H. R.,

Biomaterials 2012, 33, 1162-1169.

17.Strain-Promoted Catalyst-Free Click Chemistry for Rapid Construction of (64)Cu-Labeled PET Imaging Probes

Chen, K.; Wang, X.; Lin, W. -Y.; Shen, C. K.; Yap, L. P.; Hughes, L. D.; Conti, P. S.

Acs Med. Chem Lett. 2012, 3, 1019-1023

16.  Microfluidic-based 18F-labeling of biomolecules for immuno-positron emission tomography

Liu, K.; Lepin, E. J.; Wang, M. W.; Guo, F.; Lin, W.-Y.; Chen, Y. C.; Sirk, S. J.; Olma, S.; Phelps, M. E.; Zhao, X. Z.; Tseng, H. R.; Michael van Dam, R.; Wu, A. M.; Shen, C. K.,

Molecular imaging 2011, 10, 168-76, 1-7.

15.  Microwave-assisted one-pot synthesis of N-succinimidyl-4[ 18F]fluorobenzoate ([(18F]SFB). Journal of visualized experiments :

Hou, S.; Phung, D. L.; Lin, W.-Y.; Wang, M. W.; Liu, K.; Shen, C. K.,

JoVE 2011. 52.  2755.

14. Photothermal effects of supramolecularly assembled gold nanoparticles for the targeted treatment of cancer cells.

Wang, S.; Chen, K. J.; Wu, T. H.; Wang, H.; Lin, W.-Y.; Ohashi, M.; Chiou, P. Y.; Tseng, H. R.,

Angewandte Chemie International Edition 2010, 49, 3777-3781.

13.Microfluidics for positron emission tomography probe development.

Wang, M. W.; Lin, W.-Y; Liu, K.; Masterman-Smith, M.; Kwang-Fu Shen, C.

Molecular imaging 2010, 9, 175-91.

12.  Wang, H.; Liu, K.; Chen, K. J.; Lu, Y.; Wang, S.; Lin, W.-Y.; Guo, F.; Kamei, K.; Chen, Y. C.; Ohashi, M.; Wang, M.; Garcia, M. A.; Zhao, X. Z.; Shen, C. K.; Tseng, H. R., A rapid pathway toward a superb gene delivery system: programming structural and functional diversity into a supramolecular nanoparticle library. ACS nano 2010, 4, 6235-43.

11.  Liu, K.; Wang, H.; Chen, K. J.; Guo, F.; Lin, W.-Y.; Chen, Y. C.; Phung, D. L.; Tseng, H. R.; Shen, C. K., A digital microfluidic droplet generator produces self-assembled supramolecular nanoparticles for targeted cell imaging. Nanotechnology 2010, 21, 445603.

10.  Fang, C.; Wang, Y.; Vu, N. T.; Lin, W.-Y.; Hsieh, Y. T.; Rubbi, L.; Phelps, M. E.; Muschen, M.; Kim, Y. M.; Chatziioannou, A. F.; Tseng, H. R.; Graeber, T. G., Integrated microfluidic and imaging platform for a kinase activity radioassay to analyze minute patient cancer samples. Cancer research 2010, 70, 8299-308.

9.  Wang, Y. J*.; Lin, W.-Y*.; Liu, K.; Lin, R. J.; Selke, M.; Kolb, H. C.; Zhang, N. G.; Zhao, X. Z.; Phelps, M. E.; Shen, C. K. F.; Faull, K. F.; Tseng, H. R., An integrated microfluidic device for large-scale in situ click chemistry screening. Lab Chip 2009, 9, 2281-85. (*equal contribution)

8. A Supramolecular Approach for Preparation of Size-Controlled Nanoparticles.

Wang, H.; Wang, S. T.; Su, H.; Chen, K. J.; Armijo, A. L.; Lin, W.-Y.; Wang, Y. J.; Sun, J.; Kamei, K.; Czernin, J.; Radu, C. G.; Tseng, H. R.

Angewandte Chemie International Edition. 2009, 48, 4344-48.

7. Integrated Microfluidic Reactors.

Lin, W.-Y.; Wang, Y.; Wang, S.; Tseng, H. R.,

Nano today 2009, 4, 470-81.

6. A hydrodynamically focused stream as a dynamic template for site-specific electrochemical micropatterning of conducting polymers.

Hou, S.; Wang, S.; Yu, Z. T. F.; Zhu, N. Q. M.; Liu, K.; Sun, J.; Lin, W.-Y.; Shen, C. K. F.; Fang, X.; Tseng, H. R.,

Angewandte Chemie International Edition. 2008, 47, 1072-1075.

5. A dynamic micromixer for arbitrary control of disguised chemical selectivity.

Coti, K. K.; Wang, Y.; Lin, W.-Y.; Chen, C. C.; Yu, Z. T. F.; Liu, K.; Shen, C. K. F.; Selke, M.; Yeh, A.; Lu, W. X.; Tseng, H. R.,

Chemical Communication 2008, 3426-28.

4. On the tacticity of polynorbornenes with 5,6-endo pendant groups that contain substituted aryl chromophores

Lin, W.-Y.; Wang, H. W.; Liu, Z. C.; Xu, J.; Chen, C. W.; Yang, Y. C.; Huang, S. L.; Yang, H. C.; Luh, T. Y.,

Chemistry Asian Journal 2007, 2, 764-774.

3. A bridging double bond as an electron acceptor for optical nonlinearity of furan-containing [n.2]cyclophenes.

Lin, H. C.; Lin, W.-Y.; Bai, H. T.; Chen, J. H.; Jin, B. Y.; Luh, T. Y.,

Angewandte Chemie International Edition 2007, 46, 897-900.

2. On the Rigidity of Polynorbornenes with Dipolar Pendant Groups.

Lin, W.-Y.; Murugesh, M. G.; Sudhakar, S.; Yang, H. C.; Tai, H. C.; Chang, C. S.; Liu, Y. H.; Wang, Y.; Chen, I. W. P.; Chen, C. H.; Luh, T. Y.,

Chem-Eur. J.  2006, 12, 324-330.

1. Rational design of polymers for optoelectronic interests.                                                  Luh, T. Y.; Chen, R. M.; Hwu, T. Y.; Basu, S.; Shiau, C. W.; Lin, W.-Y.; Jin, B. Y.; Hsu, C. C.,                                         Pure Applied Chemistry 2001, 73, 243-46.

專利

Tseng, H. -R; Wang, J.; Sui, G.; Faull, K.; Wang, Y.; Lin, W.-Y
Integrated Microfluidic Platform for Parallel Screening of a Chemical Library.
PCT Int. Appl, WO 2009009021, 2009.

專書
   Wang, Y.; Lin, W. -Y.; Yu, Z. T. F.; Tseng, H.-R.
Microfluidic Reactors for Sequential and Parallel reactions
Biological Applications of Microfluidic (Editor: Gomez, F. A.) [Chapter 9] Publisher: Wiley VCH. New York, 2009.